Faculty of Pharmaceutical Sciences

Research Output

2004

Anti-monocyte chemoattractant protein-1 gene therapy prevents dimethylnitrosamine-induced hepatic fibrosis in rats.

Tsuruta, S., Nakamuta, M., Enjoji, M., Kotoh, K., Hiasa, K., Egashira, K. & Nawata, H., Nov 2004, In : International journal of molecular medicine. 14, 5, p. 837-842 6 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Anti-monocyte chemoattractant protein-1 gene therapy protects against focal brain ischemia in hypertensive rats

Kumai, Y., Ooboshi, H., Takada, J., Kamouchi, M., Kitazono, T., Egashira, K., Ibayashi, S. & Iida, M., Dec 2004, In : Journal of Cerebral Blood Flow and Metabolism. 24, 12, p. 1359-1368 10 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Antimonocyte chemoattractant protein-1 gene therapy reduces experimental in-stent restenosis in hypercholesterolemic rabbits and monkeys

Ohtani, K., Usui, M., Nakano, K., Kohjimoto, Y., Kitajima, S., Hirouchi, Y., Li, X. H., Kitamoto, S., Takeshita, A. & Egashira, K., Aug 1 2004, In : Gene Therapy. 11, 16, p. 1273-1282 10 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Blockade of vascular endothelial growth factor suppresses experimental restenosis after intraluminal injury by inhibiting recruitment of monocyte lineage cells

Ohtani, K., Egashira, K., Hiasa, K. I., Zhao, Q., Kitamoto, S., Ishibashi, M., Usui, M., Inoue, S., Yonemitsu, Y., Sueishi, K., Sata, M., Shibuya, M. & Sunagawa, K., Oct 19 2004, In : Circulation. 110, 16, p. 2444-2452 9 p.

Research output: Contribution to journalArticle

111 Citations (Scopus)

Bone marrow-derived monocyte chemoattractant protein-1 receptor CCR2 is critical in angiotensin II-induced acceleration of atherosclerosis and aneurysm formation in hypercholesterolemic mice.

Ishibashi, M., Egashira, K., Zhao, Q., Hiasa, K. I., Ohtani, K., Ihara, Y., Charo, I. F., Kura, S., Tsuzuki, T., Takeshita, A. & Sunagawa, K., Nov 2004, In : Arteriosclerosis, thrombosis, and vascular biology. 24, 11, p. e174-178

Research output: Contribution to journalArticle

118 Citations (Scopus)

Bone marrow mononuclear cell therapy limits myocardial infarct size through vascular endothelial growth factor

Hiasa, K. I., Egashira, K., Kitamoto, S., Ishibashi, M., Inoue, S., Ni, W., Zhao, Q., Nagata, S., Katoh, M., Sata, M. & Takeshita, A., May 1 2004, In : Basic Research in Cardiology. 99, 3, p. 165-172 8 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

cAMP-response element-binding protein mediates tumor necrosis factor-α-induced vascular smooth muscle cell migration

Ono, H., Ichiki, T., Fukuyama, K., Iino, N., Masuda, S., Egashira, K. & Takeshita, A., Sep 1 2004, In : Arteriosclerosis, thrombosis, and vascular biology. 24, 9, p. 1634-1639 6 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Cholesterol-lowering independent regression and stabilization of atherosclerotic lesions by pravastatin and by antimonocyte chemoattractant protein-1 therapy in nonhuman primates

Kitamoto, S., Nakano, K., Hirouchi, Y., Kohjimoto, Y., Kitajima, S., Usui, M., Inoue, S. & Egashira, K., Aug 1 2004, In : Arteriosclerosis, thrombosis, and vascular biology. 24, 8, p. 1522-1528 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Critical role of monocyte chemoattractant protein-1 receptor CCR2 on monocytes in hypertension-induced vascular inflammation and remodeling

Ishibashi, M., Hiasa, K. I., Zhao, Q., Inoue, S., Ohtani, K., Kitamoto, S., Tsuchihashi, M., Sugaya, T., Charo, I. F., Kura, S., Tsuzuki, T., Ishibashi, T., Takeshita, A. & Egashira, K., May 14 2004, In : Circulation research. 94, 9, p. 1203-1210 8 p.

Research output: Contribution to journalArticle

151 Citations (Scopus)

Development of new gene therapy strategies: a grand design for frontier medicine

Yonemitsu, Y. & Sueishi, K., Jan 1 2004, In : Fukuoka igaku zasshi = Hukuoka acta medica. 95, 10, p. 258-264 7 p.

Research output: Contribution to journalReview article

Endothelial dysfunction and coronary atherosclerosis

Kitamoto, S. & Egashira, K., Mar 1 2004, In : Current Drug Targets - Cardiovascular and Haematological Disorders. 4, 1, p. 13-22 10 p.

Research output: Contribution to journalReview article

12 Citations (Scopus)

Essential role of PDGFRα-p70S6K signaling in mesenchymal cells during therapeutic and tumor angiogenesis in vivo role of PDGFRα during angiogenesis

Tsutsumi, N., Yonemitsu, Y., Shikada, Y., Onimaru, M., Tanii, M., Okano, S., Kaneko, K., Hasegawa, M., Hashizume, M., Maehara, Y. & Sueishi, K., May 14 2004, In : Circulation research. 94, 9, p. 1186-1194 9 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Essential role of vascular endothelial growth factor and Flt-1 signals in neointimal formation after periadventitial injury

Zhao, Q., Egashira, K., Hiasa, K. I., Ishibashi, M., Inoue, S., Ohtani, K., Tan, C., Shibuya, M., Takeshita, A. & Sunagawa, K., Dec 1 2004, In : Arteriosclerosis, thrombosis, and vascular biology. 24, 12, p. 2284-2289 6 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Essential role of vascular endothelial growth factor in angiotensin II-induced vascular inflammation and remodeling

Zhao, Q., Ishibashi, M., Hiasa, K. I., Tan, C., Takeshita, A. & Egashira, K., Sep 1 2004, In : Hypertension. 44, 3, p. 264-270 7 p.

Research output: Contribution to journalArticle

135 Citations (Scopus)

Gene therapy: its history, current status, and future perspectives

Yonemitsu, Y. & Sueishi, K., Jan 1 2004, In : Fukuoka igaku zasshi = Hukuoka acta medica. 95, 4, p. 81-88 8 p.

Research output: Contribution to journalReview article

Gene Therapy via Blockade of Monocyte Chemoattractant Protein-1 for Renal Fibrosis

Wada, T., Furuichi, K., Sakai, N., Iwata, Y., Kitagawa, K., Ishida, Y., Kondo, T., Hashimoto, H., Ishiwata, Y., Mukaida, N., Tomosugi, N., Matsushima, K., Egashira, K. & Yokoyama, H., Apr 1 2004, In : Journal of the American Society of Nephrology. 15, 4, p. 940-948 9 p.

Research output: Contribution to journalArticle

143 Citations (Scopus)

Growth pattern correlates with the distribution of basement membrane and prognosis in lung adenocarcinoma

Matsuo, Y., Hashimoto, S., Koga, T., Yonemitsu, Y., Yoshino, I., Sugimachi, K., Honda, H., Masuda, K. & Sueishi, K., Aug 2004, In : Pathology Research and Practice. 200, 7-8, p. 517-529 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Hypertensive Myocardial Fibrosis and Diastolic Dysfunction: Another Model of Inflammation?

Kuwahara, F., Kai, H., Tokuda, K., Takeya, M., Takeshita, A., Egashira, K. & Imaizumi, T., Apr 1 2004, In : Hypertension. 43, 4, p. 739-745 7 p.

Research output: Contribution to journalArticle

203 Citations (Scopus)

Inhibition of neointimal hyperplasia after balloon injury by cis-element 'decoy' of early growth response gene-1 in hypercholesterolemic rabbits

Ohtani, K., Egashira, K., Usui, M., Ishibashi, M., Hiasa, K. I., Zhao, Q., Aoki, M., Kaneda, Y., Morishita, R. & Takeshita, A., Jan 1 2004, In : Gene Therapy. 11, 2, p. 126-132 7 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Initial Clinical Cases of the Use of a NF-κB Decoy at the Site of Coronary Stenting for the Prevention of Restenosis

Suzuki, J. I., Ito, H., Gotoh, R., Morishita, R., Egashira, K. & Isobe, M., Mar 1 2004, In : Circulation Journal. 68, 3, p. 270-271 2 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Intracoronary Artery Gene Transfer Using the REMEDY Catheter: Case Studies in Pigs and Humans

Gotoh, R., Suzuki, J. I., Ito, H., Egashira, K., Morishita, R. & Isobe, M., May 19 2004, In : Japanese Journal of Interventional Cardiology. 19, 2, p. 144-149 6 p.

Research output: Contribution to journalArticle

Monocyte Chemoattractant Protein-1 is an Essential Inflammatory Mediator in Angiotensin II-Induced Progression of Established Atherosclerosis in Hypercholesterolemic Mice

Ni, W., Kitamoto, S., Ishibashi, M., Usui, M., Inoue, S., Hiasa, K. I., Zhao, Q., Nishida, K. I., Takeshita, A. & Egashira, K., Mar 1 2004, In : Arteriosclerosis, thrombosis, and vascular biology. 24, 3, p. 534-539 6 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)

NO and atherosclerosis

Ohtani, K. & Egashira, K., Sep 2004, In : Nippon rinsho. Japanese journal of clinical medicine. 62 Suppl 9, p. 544-547 4 p.

Research output: Contribution to journalReview article

Novel anti-inflammatory actions of amlodipine in a rat model of arteriosclerosis induced by long-term inhibition of nitric oxide synthesis

Kataoka, C., Egashira, K., Ishibashi, M., Inoue, S., Ni, W., Ken-Ichi, H., Kitamoto, S., Usui, M. & Takeshita, A., Feb 1 2004, In : American Journal of Physiology - Heart and Circulatory Physiology. 286, 2 55-2

Research output: Contribution to journalArticle

55 Citations (Scopus)

SOC1 inhibits HPV-E7-mediated transformation by inducing degradation of E7 protein

Kamio, M., Yoshida, T., Ogata, H., Douchi, T., Nagata, Y., Inoue, M., Hasegawa, M., Yonemitsu, Y. & Yoshimura, A., Apr 15 2004, In : Oncogene. 23, 17, p. 3107-3115 9 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

The relative contributions of each subset of ocular infiltrated cells in experimental choroidal neovascularisation

Tsutsumi-Miyahara, C., Sonoda, K. H., Egashira, K., Ishibashi, M., Qiao, H., Oshima, T., Murata, T., Miyazaki, M., Charo, I. F., Hamano, S. & Ishibashi, T., Sep 1 2004, In : British Journal of Ophthalmology. 88, 9, p. 1217-1222 6 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization

Miyoshi, K., Wakioka, T., Nishinakamura, H., Kamio, M., Yang, L., Inoue, M., Hasegawa, M., Yonemitsu, Y., Komiya, S. & Yoshimura, A., Jul 22 2004, In : Oncogene. 23, 33, p. 5567-5576 10 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Vascular endothelial growth factor - Basic science and its clinical implications

Celec, P. & Yonemitsu, Y., Oct 1 2004, In : Pathophysiology. 11, 2, p. 69-75 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2003

Anti-monocyte chemoattractant protein-1 gene therapy attenuates renal injury induced by protein-overload proteinuria

Shimizu, H., Maruyama, S., Yuzawa, Y., Kato, T., Miki, Y., Suzuki, S., Sato, W., Morita, Y., Maruyama, H., Egashira, K. & Matsuo, S., Jun 1 2003, In : Journal of the American Society of Nephrology. 14, 6, p. 1496-1505 10 p.

Research output: Contribution to journalArticle

113 Citations (Scopus)

Anti-monocyte chemoattractant protein-1 gene therapy for cardiovascular diseases.

Kitamoto, S. & Egashira, K., Sep 2003, In : Expert review of cardiovascular therapy. 1, 3, p. 393-400 8 p.

Research output: Contribution to journalReview article

28 Citations (Scopus)

Apoptosis induced by inhibition of cyclic AMP response element-binding protein in vascular smooth muscle cells

Tokunou, T., Shibata, R., Kai, H., Ichiki, T., Morisaki, T., Fukuyama, K., Ono, H., Iino, N., Masuda, S., Shimokawa, H., Egashira, K., Imaizumi, T. & Takeshita, A., Sep 9 2003, In : Circulation. 108, 10, p. 1246-1252 7 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Disparity of MCP-1 mRNA and protein expressions between the carotid artery and the aorta in WHHL rabbits: One aspect involved in the regional difference in atherosclerosis

Tanaka, E., Shimokawa, H., Kamiuneten, H., Eto, Y., Matsumoto, Y., Morishige, K., Koike, G., Yoshinaga, M., Egashira, K., Tokunaga, O., Shiomi, M. & Takeshita, A., Feb 1 2003, In : Arteriosclerosis, thrombosis, and vascular biology. 23, 2, p. 244-250 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Downregulation of vascular angiotensin II type 1 receptor by thyroid hormone

Fukuyama, K., Ichiki, T., Takeda, K., Tokunou, T., Iino, N., Masuda, S., Ishibashi, M., Egashira, K., Shimokawa, H., Hirano, K., Kanaide, H. & Takeshita, A., Mar 1 2003, In : Hypertension. 41, 3 I, p. 598-603 6 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Gene therapy expressing amino-terminal truncated monocyte chemoattractant protein-1 prevents renal ischemia-reperfusion injury

Furuichi, K., Wada, T., Iwata, Y., Kitagawa, K., Kobayashi, K. I., Hashimoto, H., Ishiwata, Y., Tomosugi, N., Mukaida, N., Matsushima, K., Egashira, K. & Yokoyama, H., Apr 1 2003, In : Journal of the American Society of Nephrology. 14, 4, p. 1066-1071 6 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)
36 Citations (Scopus)

Intramuscular gene transfer of FGF-2 attenuates endothelial dysfunction and inhibits intimal hyperplasia of vein grafts in poor-runoff limbs of rabbit

Shoji, T., Yonemitsu, Y., Komori, K., Tanii, M., Itoh, H., Sata, S., Shimokawa, H., Hasegawa, M., Sueishi, K. & Maehara, Y., Jul 1 2003, In : American Journal of Physiology - Heart and Circulatory Physiology. 285, 1 54-1, p. H173-H182

Research output: Contribution to journalArticle

21 Citations (Scopus)

In vivo delivery of glial cell-derived neurotrophic factor across the blood-brain barrier by gene transfer into brain capillary endothelial cells

Jiang, C., Koyabu, N., Yonemitsu, Y., Shimazoe, T., Watanabe, S., Naito, M., Tsuruo, T., Ohtani, H. & Sawada, Y., Aug 10 2003, In : Human Gene Therapy. 14, 12, p. 1181-1191 11 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Molecular Mechanism and Role of Endothelial Monocyte Chemoattractant Protein-1 Induction by Vascular Endothelial Growth Factor

Yamada, M., Kim, S., Egashira, K., Takeya, M., Ikeda, T., Mimura, O. & Iwao, H., Nov 1 2003, In : Arteriosclerosis, thrombosis, and vascular biology. 23, 11, p. 1996-2001 6 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

Molecular mechanisms mediating inflammation in vascular disease: Special reference to monocyte chemoattractant protein-1

Egashira, K., Mar 1 2003, In : Hypertension. 41, 3 II, p. 834-841 8 p.

Research output: Contribution to journalArticle

137 Citations (Scopus)

Monocyte chemoattractant protein-1 increases microglial infiltration and aggressiveness of gliomas

Platten, M., Kretz, A., Naumann, U., Aulwurm, S., Egashira, K., Isenmann, S. & Weller, M., Sep 1 2003, In : Annals of Neurology. 54, 3, p. 388-392 5 p.

Research output: Contribution to journalArticle

141 Citations (Scopus)

Preservation of endothelial function by the HMG-CoA reductase inhibitor fluvastatin through its lipid-lowering independent antioxidant properties in atherosclerotic rabbits

Mitani, H., Egashira, K., Ohashi, N., Yoshikawa, M., Niwa, S., Nonomura, K., Nakashima, A. & Kimura, M., Jun 12 2003, In : Pharmacology. 68, 3, p. 121-130 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Pulmonary capillary hemangiomatosis with severe pulmonary hypertension

Ito, K., Ichiki, T., Ohi, K., Egashira, K., Ohta, M., Taguchi, K. & Takeshita, A., Sep 1 2003, In : Circulation Journal. 67, 9, p. 793-795 3 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Recombinant Sendai virus provides a highly efficient gene transfer into human cord blood-derived hematopoietic stem cells

Jin, C. H., Kusuhara, K., Yonemitsu, Y., Nomura, A., Okano, S., Takeshita, H., Hasegawa, M., Sueishi, K. & Hara, T., Feb 1 2003, In : Gene Therapy. 10, 3, p. 272-277 6 p.

Research output: Contribution to journalReview article

30 Citations (Scopus)

Recombinant Sendai virus vectors for activated T lymphocytes

Okano, S., Yonemitsu, Y., Nagata, S., Sata, S., Onimaru, M., Nakagawa, K., Tomita, Y., Kishihara, K., Hashimoto, S., Nakashima, Y., Sugimachi, K., Hasegawa, M. & Sueishi, K., Aug 1 2003, In : Gene Therapy. 10, 16, p. 1381-1391 11 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Simian immunodeficiency virus-based lentivirus vector for retinal gene transfer: A preclinical safety study in adult rats

Ikeda, Y., Goto, Y., Yonemitsu, Y., Miyazaki, M., Sakamoto, T., Ishibashi, T., Tabata, T., Ueda, Y., Hasegawa, M., Tobimatsu, S. & Sueishi, K., Jul 1 2003, In : Gene Therapy. 10, 14, p. 1161-1169 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Simian lentiviral vector-mediated retinal gene transfer of pigment epithelium-derived factor protects retinal degeneration and electrical defect in Royal College of Surgeons rats

Miyazaki, M., Ikeda, Y., Yonemitsu, Y., Goto, Y., Sakamoto, T., Tabata, T., Ueda, Y., Hasegawa, M., Tobimatsu, S., Ishibashi, T. & Sueishi, K., Aug 1 2003, In : Gene Therapy. 10, 17, p. 1503-1511 9 p.

Research output: Contribution to journalReview article

70 Citations (Scopus)

Stress and vascular responses: Anti-inflammatory therapeutic strategy against atherosclerosis and restenosis after coronary intervention

Kitamoto, S., Egashira, K. & Takeshita, A., Mar 1 2003, In : Journal Pharmacological Sciences. 91, 3, p. 192-196 5 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

The critical role of ocular-infiltrating macrophages in the development of choroidal neovascularization

Tsutsumi, C., Sonoda, K. H., Egashira, K., Qiao, H., Hisatomi, T., Nakao, S., Ishibashi, M., Charo, I. F., Sakamoto, T., Murata, T. & Ishibashi, T., Jul 1 2003, In : Journal of Leukocyte Biology. 74, 1, p. 25-32 8 p.

Research output: Contribution to journalArticle

204 Citations (Scopus)

The role of nitric oxide in ischemic heart disease

Kitamoto, S. & Egashira, K., May 2003, In : Nippon rinsho. Japanese journal of clinical medicine. 61 Suppl 5, p. 853-859 7 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Vitamin C improves attenuated angiotensin II-induced endothelium-dependent vasodilation in human forearm vessels

Hirooka, Y., Eshima, K., Setoguchi, S., Kishi, T., Egashira, K. & Takeshita, A., Dec 1 2003, In : Hypertension Research. 26, 12, p. 953-959 7 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)