Research Output 1976 2020

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2020

Scandium(III) Triflate Catalyzed Direct Synthesis of N-Unprotected Ketimines

Kondo, Y., Kadota, T., Hirazawa, Y., Morisaki, K., Morimoto, H. & Ohshima, T., Jan 3 2020, In : Organic Letters. 22, 1, p. 120-125 6 p.

Research output: Contribution to journalArticle

Scandium
scandium
nitrogen compounds
synthesis
glycine
2019
1 Citation (Scopus)

2-Oxo-histidine-containing dipeptides are functional oxidation products

Ihara, H., Kakihana, Y., Yamakage, A., Kai, K., Shibata, T., Nishida, M., Kenichi, Y. & Uchida, K., Jan 1 2019, In : Journal of Biological Chemistry. 294, 4, p. 1279-1289 11 p.

Research output: Contribution to journalArticle

Carnosine
Dipeptides
Histidine
Oxidation
Antioxidants

A Convenient Preparation Method for Benzophenone Imine Catalyzed by Tetrabutylammonium Fluoride

Kondo, Y., Morisaki, K., Hirazawa, Y., Morimoto, H. & Ohshima, T., Aug 16 2019, In : Organic Process Research and Development. 23, 8, p. 1718-1724 7 p.

Research output: Contribution to journalArticle

Imines
imines
fluorides
preparation
synthesis

A deletion in the Ctns gene causes renal tubular dysfunction and cystine accumulation in LEA/Tohm rats

Shimizu, Y., Yanobu-Takanashi, R., Nakano, K., Hamase, K., Shimizu, T. & Okamura, T., Feb 13 2019, In : Mammalian Genome. 30, 1-2, p. 23-33 11 p.

Research output: Contribution to journalArticle

Cystine
Kidney
Glucose
Cystinosis
Genes

Alginate immobilization of Morus alba L. cell suspension cultures improved the accumulation and secretion of stilbenoids

Inyai, C., Boonsnongcheep, P., Komaikul, J., Sritularak, B., Tanaka, H. & Putalun, W., Jan 30 2019, In : Bioprocess and Biosystems Engineering. 42, 1, p. 131-141 11 p.

Research output: Contribution to journalArticle

Morus
Alginate
Resveratrol
Immobilized Cells
Immobilization

Alpha-mangostin ameliorates bleomycin-induced pulmonary fibrosis in mice partly through activating adenosine 5′-monophosphate-activated protein kinase

Li, R. S., Xu, G. H., Cao, J., Liu, B., Xie, H. F., Ishii, Y. & Zhang, C. F., Jan 1 2019, In : Frontiers in Pharmacology. 10, 1305.

Research output: Contribution to journalArticle

Open Access
Pulmonary Fibrosis
Bleomycin
Adenosine Monophosphate
Protein Kinases
Lung

A method to induce hen egg lysozyme-specific humoral immune tolerance in mice by pre-exposition with the protein's oligomers

Ohkuri, T., Yuge, N., Sato, K. & Ueda, T., Dec 1 2019, In : Biochemistry and Biophysics Reports. 20, 100679.

Research output: Contribution to journalArticle

Open Access
Immune Tolerance
Oligomers
Antibodies
Anti-Idiotypic Antibodies
Proteins
1 Citation (Scopus)

Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides: Mechanistic Investigation and Application to a Microwave Flow Process

Noshita, M., Shimizu, Y., Morimoto, H., Akai, S., Hamashima, Y., Ohneda, N., Odajima, H. & Ohshima, T., Apr 19 2019, In : Organic Process Research and Development. 23, 4, p. 588-594 7 p.

Research output: Contribution to journalArticle

hydrazine
Ammonium Compounds
Amides
amides
Salts
1 Citation (Scopus)

An indirect competitive enzyme-linked immunosorbent assay toward the standardization of Pueraria candollei based on its unique isoflavonoid, kwakhurin

Yusakul, G., Togita, R., Minami, K., Chanpokapaiboon, K., Juengwatanatrakul, T., Putalun, W., Tanaka, H., Sakamoto, S. & Morimoto, S., Mar 1 2019, In : Fitoterapia. 133, p. 23-28 6 p.

Research output: Contribution to journalArticle

Pueraria
Enzyme-Linked Immunosorbent Assay
Estrogen Replacement Therapy
Bovine Serum Albumin
Limit of Detection

A novel mode of DnaA-DnaA interaction promotes ADP dissociation for reactivation of replication initiation activity

Sugiyama, R., Kasho, K., Miyoshi, K., Ozaki, S., Kagawa, W., Kurumizaka, H. & Katayama, T., Dec 2 2019, In : Nucleic acids research. 47, 21, p. 11209-11224 16 p.

Research output: Contribution to journalArticle

Open Access
Adenosine Diphosphate
Protein Subunits
Adenosine Triphosphate
Structural Models
Cell Cycle

Anti-allergic activity of polyphenolic compounds isolated from olive mill wastes

Mwakalukwa, R., Ashour, A., Amen, Y., Niwa, Y., Tamrakar, S., Miyamoto, T. & Shimizu, K., Jul 1 2019, In : Journal of Functional Foods. 58, p. 207-217 11 p.

Research output: Contribution to journalArticle

Anti-Allergic Agents
Olea
Inhibitory Concentration 50
polyphenols
Calcium Channels

Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis

Touyama, K., Khan, M., Aoki, K., Matsuda, M., Hiura, F., Takakura, N., Matsubara, T., Harada, Y., Hirohashi, Y., Tamura, Y., Gao, J., Mori, K., Kokabu, S., Yasuda, H., Fujita, Y., Watanabe, K., Takahashi, Y., Maki, K. & Jimi, E., Nov 1 2019, In : Journal of Cellular Biochemistry. 120, 11, p. 18793-18804 12 p.

Research output: Contribution to journalArticle

Bone
Homeostasis
Bone and Bones
Osteoclasts
Osteogenesis

Characterization of α-synuclein N-terminal domain as a novel cellular phosphatidic acid sensor

Yamada, H., Mizuno, S., Honda, S., Takahashi, D. & Sakane, F., Jan 1 2019, (Accepted/In press) In : FEBS Journal.

Research output: Contribution to journalArticle

Synucleins
Phosphatidic Acids
Sensors
Diacylglycerol Kinase
Cell membranes

Cytotoxicity of trifluridine correlates with the thymidine kinase 1 expression level

Kataoka, Y., Iimori, M., Niimi, S., Tsukihara, H., Wakasa, T., Saeki, H., Oki, E., Maehara, Y. & Kitao, H., Dec 1 2019, In : Scientific reports. 9, 1, 7964.

Research output: Contribution to journalArticle

Open Access
Trifluridine
thymidine kinase 1
Colorectal Neoplasms
DNA
Clustered Regularly Interspaced Short Palindromic Repeats
1 Citation (Scopus)

Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload

Nishimura, A., Shimoda, K., Tanaka, T., Toyama, T., Nishiyama, K., Shinkai, Y., Numaga-Tomita, T., Yamazaki, D., Kanda, Y., Akaike, T., Kumagai, Y. & Nishida, M., Jan 1 2019, In : Science Signaling. 12, 587, eaaw1920.

Research output: Contribution to journalArticle

Filamins
Hemodynamics
Cardiac Myocytes
Oxidation-Reduction
Rats

Development of a simple and rapid method for the detection of isomiroestrol in Pueraria candollei by an immunochromatographic strip test

Chaingam, J., Kitisripanya, T., Krittanai, S., Sakamoto, S., Tanaka, H. & Putalun, W., Jun 14 2019, In : Journal of Natural Medicines. 73, 3, p. 577-583 7 p.

Research output: Contribution to journalArticle

Pueraria
Standardization
Benzopyrans
Gold Colloid
Immunosorbents
4 Citations (Scopus)

Development of Turn-On Probes for Acids Triggered by Aromaticity Enhancement Using Tricyclic Amidine Derivatives

Matsumoto, S., Fuchi, Y., Usui, K., Hirai, G. & Karasawa, S., Jun 7 2019, In : Journal of Organic Chemistry. 84, 11, p. 6612-6622 11 p.

Research output: Contribution to journalArticle

Amidines
Fluorescence
Protonation
Quantum yield
Derivatives
1 Citation (Scopus)
Open Access
oxaliplatin
Peripheral Nervous System Diseases
Rodentia
Hyperalgesia
Neoplasms

Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect

kawashiri, T., Shimizu, S., Shigematsu, N., Kobayashi, D. & Shimazoe, T., Jul 1 2019, In : Journal of Pharmacological Sciences. 140, 3, p. 291-294 4 p.

Research output: Contribution to journalArticle

Open Access
oxaliplatin
Neuroprotective Agents
Peripheral Nervous System Diseases
Cultured Cells
Nerve Degeneration

Dosing Time-Dependent Changes in the Anti-tumor Effect of xCT Inhibitor Erastin in Human Breast Cancer Xenograft Mice

Shiromizu, S., Yamauchi, T., Kusunose, N., Matsunaga, N., Koyanagi, S. & Ohdo, S., Jan 1 2019, In : Biological and Pharmaceutical Bulletin. 42, 11, p. 1921-1925 5 p.

Research output: Contribution to journalArticle

Open Access
Heterografts
Breast Neoplasms
Neoplasms
Cysteine
Cystine
1 Citation (Scopus)

D -Serine reflects kidney function and diseases

Hesaka, A., Sakai, S., Hamase, K., Ikeda, T., Matsui, R., Mita, M., Horio, M., Isaka, Y. & Kimura, T., Dec 1 2019, In : Scientific reports. 9, 1, 5104.

Research output: Contribution to journalArticle

Open Access
Kidney Diseases
Serine
Chronic Renal Insufficiency
Kidney
Amino Acids

Effect of digital labels on electronic medical records for reducing the use of benzodiazepine receptor agonists

Shin, K., Kobayashi, D., Kawashiri, T., Ikari, K., Mitsuyasu, H., Murakami, T., Tsutsumi, K., Kanazawa, Y., Kamimura, H. & Shimazoe, T., Jan 1 2019, In : Yakugaku Zasshi. 139, 11, p. 1449-1456 8 p.

Research output: Contribution to journalArticle

Open Access
Electronic Health Records
GABA-A Receptors
Prescriptions
Pharmacists
Delirium
4 Citations (Scopus)

Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers

Mori, D., Kashihara, Y., Yoshikado, T., Kimura, M., Hirota, T., Matsuki, S., Maeda, K., Irie, S., Ieiri, I., Sugiyama, Y. & Kusuhara, H., Feb 1 2019, In : Drug metabolism and pharmacokinetics. 34, 1, p. 78-86 9 p.

Research output: Contribution to journalArticle

Sulfates
Healthy Volunteers
Genotype
fluvastatin
Pharmaceutical Preparations

Effects of magnesium oxide on pharmacokinetics of L-dopa/carbidopa and assessment of pharmacodynamic changes by a model-based simulation

Kashihara, Y., Terao, Y., Yoda, K., Hirota, T., Kubota, T., Kimura, M., Matsuki, S., Hirakawa, M., Irie, S. & Ieiri, I., Mar 6 2019, In : European Journal of Clinical Pharmacology. 75, 3, p. 351-361 11 p.

Research output: Contribution to journalArticle

Magnesium Oxide
Carbidopa
Levodopa
Pharmacokinetics
Meta-Analysis

Effects of Substituents on the Properties of Metal-Free MRI Contrast Agents

Shiraishi, R., Kaneko, T., Usui, K., Naganuma, T., Iizuka, N., Morishita, K., Kobayashi, S., Fuchi, Y., Matsuoka, Y., Hirai, G., Yamada, K. I. & Karasawa, S., Dec 10 2019, In : ACS Omega. 4, 24, p. 20715-20723 9 p.

Research output: Contribution to journalArticle

Open Access
Magnetic resonance
Contrast Media
Gadolinium
Metals
Imaging techniques
Open Access
DNA-Directed DNA Polymerase
DNA Polymerase I
Adenosine
Nucleotides
Derivatives
3 Citations (Scopus)

Efficacy of DPP-4 inhibitors, GLP-1 analogues, and SGLT2 inhibitors as add-ons to metformin monotherapy in T2DM patients: a model-based meta-analysis

Inoue, H., Tamaki, Y., Kashihara, Y., Muraki, S., Kakara, M., Hirota, T. & Ieiri, I., Feb 2019, In : British journal of clinical pharmacology. 85, 2, p. 393-402 10 p.

Research output: Contribution to journalArticle

Glucagon-Like Peptide 1
Metformin
Hypoglycemic Agents
Type 2 Diabetes Mellitus
Meta-Analysis

Electron Microscopic Detection of Single Membrane Proteins by a Specific Chemical Labeling

Tabata, S., Jevtic, M., Kurashige, N., Fuchida, H., Kido, M., Tani, K., Zenmyo, N., Uchinomiya, S., Harada, H., Itakura, M., Hamachi, I., Shigemoto, R. & Ojida, A., Dec 20 2019, In : iScience. 22, p. 256-268 13 p.

Research output: Contribution to journalArticle

Open Access
Labeling
Membrane Proteins
Electrons
Electron microscopy
Proteins

Elevation of endocannabinoids in the brain by synthetic cannabinoid JWH-018: mechanism and effect on learning and memory

Li, R. S., Fukumori, R., Takeda, T., Song, Y., Morimoto, S., Kikura-Hanajiri, R., Yamaguchi, T., Watanabe, K., Aritake, K., Tanaka, Y., Yamada, H., Yamamoto, T. & Ishii, Y., Jul 3 2019, In : Scientific reports. 9, 1, 1 p., 9621.

Research output: Contribution to journalArticle

Open Access
Endocannabinoids
Cannabinoids
Learning
Brain-Derived Neurotrophic Factor
Brain

Elucidation of N1-methyladenosine as a potential surrogate biomarker for drug interaction studies involving renal organic cation transporters

Miyake, T., Mizuno, T., Takehara, I., Mochizuki, T., Kimura, M., Matsuki, S., Irie, S., Watanabe, N., Kato, Y., Ieiri, I., Maeda, K., Ando, O. & Kusuhara, H., Jan 1 2019, In : Drug Metabolism and Disposition. 47, 11, p. 1270-1280 11 p.

Research output: Contribution to journalArticle

Drug Interactions
Cations
Biomarkers
Kidney
Pharmaceutical Preparations

Enhancement of saccharothriolide production and discovery of a new metabolite, saccharothriolide C 2 , by combined-culture of Saccharothrix sp. and Tsukamurella pulmonis

Jiang, Y., Lu, S., Hirai, G., Kato, T., Onaka, H. & Kakeya, H., Apr 11 2019, In : Tetrahedron Letters. 60, 15, p. 1072-1074 3 p.

Research output: Contribution to journalArticle

Mycolic Acids
Metabolites
Bacteria
Open Access
Escherichia coli Proteins
Cell Division
Proteins
AT Rich Sequence
DNA Polymerase III

Estradiol regulation of P-glycoprotein expression in mouse kidney and human tubular epithelial cells, implication for renal clearance of drugs

Kanado, Y., Tsurudome, Y., Omata, Y., Yasukochi, S., Kusunose, N., Akamine, T., Matsunaga, N., Koyanagi, S. & Ohdo, S., Nov 12 2019, In : Biochemical and Biophysical Research Communications. 519, 3, p. 613-619 7 p.

Research output: Contribution to journalArticle

P-Glycoprotein
Estradiol
Digoxin
Epithelial Cells
Kidney
1 Citation (Scopus)

Evaluation of the immunomodulatory effects of fucoidan derived from cladosiphon okamuranus tokida in mice

Tomori, M., Nagamine, T., Miyamoto, T. & Iha, M., Sep 24 2019, In : Marine Drugs. 17, 10, 547.

Research output: Contribution to journalArticle

Open Access
Humoral Immunity
Cellular Immunity
Macrophages
Cell Proliferation
Phaeophyta
2 Citations (Scopus)

Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure

Igawa, T., Kishikawa, S., Abe, Y., Yamashita, T., Nagai, S., Shiroishi, M., Shinozaki, C., Tanaka, H., Tozaki-Saitoh, H., Tsuda, M., Inoue, K. & Ueda, T., Mar 15 2019, In : Purinergic Signalling. 15, 1, p. 27-35 9 p.

Research output: Contribution to journalArticle

Purinergic P2X4 Receptors
Monoclonal Antibodies
Antibodies
Purinergic P2X Receptors
Head

Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure

Igawa, T., Kishikawa, S., Abe, Y., Yamashita, T., Nagai, S., Shiroishi, M., Shinozaki, C., Tanaka, H., Tozaki-Saitoh, H., Tsuda, M., Inoue, K. & Ueda, T., Jan 25 2019, In : Purinergic Signalling.

Research output: Contribution to journalArticle

Purinergic P2X4 Receptors
Monoclonal Antibodies
Antibodies
Purinergic P2X Receptors
Head

Expression, Purification, and Characterization of Human Diacylglycerol Kinase ζ

Saito, T., Takahashi, D. & Sakane, F., Mar 19 2019, In : ACS Omega. 4, 3, p. 5540-5546 7 p.

Research output: Contribution to journalArticle

Open Access
Diacylglycerol Kinase
Purification
Enzymes
Dichroism
Agglomeration

Hederagenin glycosides from the fruits of Blighia unijugata

Petit, B., Mitaine-Offer, A. C., Delaude, C., Miyamoto, T., Tanaka, C. & Lacaille-Dubois, M. A., Jun 1 2019, In : Phytochemistry. 162, p. 260-269 10 p.

Research output: Contribution to journalArticle

Blighia
Glycosides
Fruits
glycosides
Fruit

Hyperactivation of proprioceptors induces microglia-mediated long-lasting pain in a rat model of chronic fatigue syndrome

Yasui, M., Menjyo, Y., Tokizane, K., Shiozawa, A., Tsuda, M., Inoue, K. & Kiyama, H., Mar 30 2019, In : Journal of neuroinflammation. 16, 1, 67.

Research output: Contribution to journalArticle

Open Access
Chronic Fatigue Syndrome
Microglia
Pain
Neurons
Spinal Cord
1 Citation (Scopus)

Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes

Nishiyama, K., Numaga-Tomita, T., Fujimoto, Y., Tanaka, T., Toyama, C., Nishimura, A., Yamashita, T., Naoya, M., Satoru, K., Azuma, Y. T., Ibuki, Y., Uchida, K., Ohdo, S. & Nishida, M., Sep 1 2019, In : British Journal of Pharmacology. 176, 18, p. 3723-3738 16 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Doxorubicin
Tobacco Smoke Pollution
Proteins
Pharmaceutical Preparations

Identification of candidate molecular targets of the novel antineoplastic antimitotic NP-10

Yokoyama, T., Yukuhiro, M., Iwasaki, Y., Tanaka, C., Sankoda, K., Fujiwara, R., Shibuta, A., Higashi, T., Motoyama, K., Arima, H., Yoshida, K., Sugimoto, N., Morimoto, H., Kosako, H., Ohshima, T. & Fujita, M., Dec 1 2019, In : Scientific reports. 9, 1, 16825.

Research output: Contribution to journalArticle

Open Access
Antimitotic Agents
Antineoplastic Agents
polyoxyethylene(10)nonylphenyl ether
Karyopherins
HCT116 Cells
5 Citations (Scopus)

Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy

Fujita, S., Hirota, T., Sakiyama, R., Baba, M. & Ieiri, I., Feb 2019, In : Journal of Neurochemistry. 148, 3, p. 373-385 13 p.

Research output: Contribution to journalArticle

oxaliplatin
Peripheral Nervous System Diseases
Spinal Ganglia
Platinum
Pharmaceutical Preparations

Identification of lipophilic ligands of Siglec5 and -14 that modulate innate immune responses

Suematsu, R., Miyamoto, T., Saijo, S., Yamasaki, S., Tada, Y., Yoshida, H. & Miyake, Y., Jan 1 2019, In : Journal of Biological Chemistry. 294, 45, p. 16776-16788 13 p.

Research output: Contribution to journalArticle

Open Access
Sialic Acid Binding Immunoglobulin-like Lectins
Innate Immunity
Ligands
Lipids
N-Acetylneuraminic Acid

Improvement of stilbenoid production by 2-hydroxypropyl-β-cyclodextrin in white mulberry (Morus alba L.) callus cultures

Komaikul, J., Kitisripanya, T., Likhitwitayawuid, K., Sritularak, B., Tanaka, H. & Putalun, W., Oct 2 2019, In : Natural Product Research. 33, 19, p. 2762-2769 8 p.

Research output: Contribution to journalArticle

stilbenoids
Morus
Morus alba
cyclodextrins
Bony Callus
1 Citation (Scopus)

Induction of cell fusion/apoptosis in anaplastic thyroid carcinoma in orthotopic mouse model by urokinase-specific oncolytic Sendai virus

Miyagawa, Y., Araki, K., Yamashita, T., Tanaka, S., Tanaka, Y., Tomifuji, M., Ueda, Y., Yonemitsu, Y., Shimada, H. & Shiotani, A., Jan 1 2019, In : Head and Neck. 41, 9, p. 2873-2882 10 p.

Research output: Contribution to journalArticle

Oncolytic Viruses
Sendai virus
Cell Fusion
Urokinase-Type Plasminogen Activator
Apoptosis
2 Citations (Scopus)

Inhibiting the MCM8-9 complex selectively sensitizes cancer cells to cisplatin and olaparib

Morii, I., Iwabuchi, Y., Mori, S., Suekuni, M., Natsume, T., Yoshida, K., Sugimoto, N., Kanemaki, M. T. & Fujita, M., Mar 2019, In : Cancer Science. 110, 3, p. 1044-1053 10 p.

Research output: Contribution to journalArticle

Open Access
Cisplatin
Platinum Compounds
Neoplasms
Papillomaviridae
DNA Helicases
1 Citation (Scopus)
Bacterial DNA
Single-Stranded DNA
DNA Replication
Dimers
Escherichia coli

Investigation of the endoplasmic reticulum localization of UDP-glucuronosyltransferase 2B7 with systematic deletion mutants

Miyauchi, Y., Kimura, S., Kimura, A., Kurohara, K., Hirota, Y., Fujimoto, K., Mackenzie, P. I., Tanaka, Y. & Ishii, Y., May 1 2019, In : Molecular Pharmacology. 95, 5, p. 551-562 12 p.

Research output: Contribution to journalArticle

Glucuronosyltransferase
Endoplasmic Reticulum
lysyllysine
Calnexin
Microscopy
2 Citations (Scopus)

In Vivo Imaging of the Intra-and Extracellular Redox Status in Rat Stomach with Indomethacin-Induced Gastric Ulcers Using Overhauser-Enhanced Magnetic Resonance Imaging

Yasukawa, K., Shigemi, R., Kanbe, T., Mutsumoto, Y., Oda, F., Ichikawa, K., Yamada, K-I., Tun, X. & Utsumi, H., Jan 1 2019, In : Antioxidants and Redox Signaling. 30, 9, p. 1147-1161 15 p.

Research output: Contribution to journalArticle

Stomach Ulcer
Indomethacin
Oxidation-Reduction
Rats
Stomach
2 Citations (Scopus)

Isolation and identification of new anthraquinones from Rhamnus alaternus L and evaluation of their free radical scavenging activity

Ben Ammar, R., Miyamoto, T., Chekir-Ghedira, L., Ghedira, K. & Lacaille-Dubois, M. A., Jan 17 2019, In : Natural Product Research. 33, 2, p. 280-286 7 p.

Research output: Contribution to journalArticle

Rhamnus
Anthraquinones
anthraquinones
Scavenging
Free Radicals