Research Output 1976 2020

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2019

Study of the inducible cross-linking reaction to mRNA and the effect on the translation

Kikuta, K., Taniguchi, Y. & Sasaki, S., Jan 1 2019, In : Chemical and Pharmaceutical Bulletin. 67, 8, p. 877-883 7 p.

Research output: Contribution to journalArticle

Open Access
Cross Reactions
Derivatives
Messenger RNA
Oligoribonucleotides
Uracil
Acridines
Chemiluminescence
Choline
Hydrogen peroxide
Hydrogen Peroxide
1 Citation (Scopus)

Synthesis of 12- O-Mono- and Diglycosyl-oxystearates, a New Class of Agonists for the C-type Lectin Receptor Mincle

Van Huy, L., Tanaka, C., Imai, T., Yamasaki, S. & Miyamoto, T., Oct 1 2019, In : ACS Medicinal Chemistry Letters. 10, 1, p. 44-49 6 p.

Research output: Contribution to journalArticle

C-Type Lectins
Macrophages
NFATC Transcription Factors
Structure-Activity Relationship
Green Fluorescent Proteins
Oligonucleotides
Pseudouridine
Derivatives
Uracil
Oligodeoxyribonucleotides

Synthesis of All Stereoisomers of Monomeric Spectomycin A1/A2 and Evaluation of Their Protein SUMOylation-Inhibitory Activity

Nomura, Y., Thuaud, F., Sekine, D., Ito, A., Maeda, S., Koshino, H., Hashizume, D., Muranaka, A., Cruchter, T., Uchiyama, M., Ichikawa, S., Matsuda, A., Yoshida, M., Hirai, G. & Sodeoka, M., Jun 21 2019, In : Chemistry - A European Journal. 25, 35, p. 8387-8392 6 p.

Research output: Contribution to journalArticle

Stereoisomerism
Isomers
Stereochemistry
Proteins
Optical rotation
1 Citation (Scopus)

Synthesis of All Stereoisomers of RK460 and Evaluation of Their Activity and Selectivity as Abscisic Acid Receptor Antagonists

Mikame, Y., Yoshida, K., Hashizume, D., Hirai, G., Nagasawa, K., Osada, H. & Sodeoka, M., Mar 7 2019, In : Chemistry - A European Journal. 25, 14, p. 3496-3500 5 p.

Research output: Contribution to journalArticle

Abscisic Acid
Stereochemistry
Stereoisomerism
Agrochemicals
Lead compounds
3 Citations (Scopus)

Synthesis of CH 2 -Linked α(1,6)-Disaccharide Analogues by α-Selective Radical Coupling C-Glycosylation

Kiya, N., Hidaka, Y., Usui, K. & Hirai, G., Mar 15 2019, In : Organic letters. 21, 6, p. 1588-1592 5 p.

Research output: Contribution to journalArticle

Glycosylation
Glycoconjugates
Disaccharides
carbohydrates
linkages

Synthesis of the deuterated thymidine-d9 and deuterated oligonucleotides

Taniguchi, Y., Cao, X. & Sasaki, S., Sep 19 2019, In : Tetrahedron Letters. 60, 38, 151037.

Research output: Contribution to journalArticle

Oligonucleotides
Thymidine
Glycosylation
Sugars
DNA

Synthesis of γ-N-modified 8-oxo-2’-deoxyguanosine triphosphate and its characterization

Thavoncharoensub, N., Maruyama, K., Heh, C. H., Hoong Leong, K., Shi, H., Shigematsu, Y., Sasaki, S. & Taniguchi, Y., Aug 3 2019, In : Nucleosides, Nucleotides and Nucleic Acids. 38, 8, p. 578-589 12 p.

Research output: Contribution to journalArticle

DNA-Directed DNA Polymerase
Nucleotides
DNA Replication
Reactive Oxygen Species
Repair
Thioguanine
Polyamines
Ligands
Repair
DNA

The association of tobacco use with prescription of muscle relaxants, benzodiazepines, and opioid analgesics for non-cancer pain

Takaki, H., Ieiri, I., Shibuta, H., Onozuka, D. & Hagihara, A., Jan 9 2019, In : American Journal on Addictions.

Research output: Contribution to journalArticle

Tobacco Use
Benzodiazepines
Opioid Analgesics
Prescriptions
Pain
1 Citation (Scopus)

The augmented expression of the cytidine deaminase gene by 5-azacytidine predicts therapeutic efficacy in myelodysplastic syndromes

Murakami, Y., Kimura, Y., Kawahara, A., Mitsuyasu, S., Miyake, H., Tohyama, K., Endo, Y., Yoshida, N., Imamura, Y., Watari, K., Ono, M., Okamura, T. & Kuwano, M., Mar 19 2019, In : Oncotarget. 10, 23, p. 2270-2281 12 p.

Research output: Contribution to journalArticle

Cytidine Deaminase
Azacitidine
Myelodysplastic Syndromes
Genes
Therapeutics

The evolution of surgical treatment for gastrointestinal cancers

Maehara, Y., Soejima, Y., Yoshizumi, T., Kawahara, N., Oki, E., Saeki, H., Akahoshi, T., Ikegami, T., Yamashita, Y. I., Furuyama, T., Sugimachi, K., Harada, N., Tagawa, T., Harimoto, N., Itoh, S., Sonoda, H., Ando, K., Nakashima, Y., Nagao, Y., Yamashita, N. & 17 others, Kasagi, Y., Yukaya, T., Kurihara, T., Tsutsumi, R., Takamori, S., Sasaki, S., Ikeda, T., Yonemitsu, Y., Fukuhara, T., Kitao, H., Iimori, M., Kataoka, Y., Wakasa, T., Suzuki, M., Teraishi, K., Yoshida, Y. & Mori, M., Nov 1 2019, In : International Journal of Clinical Oncology. 24, 11, p. 1333-1349 17 p.

Research output: Contribution to journalArticle

Gastrointestinal Neoplasms
Neoplasms
Chromosomal Instability
Stomach
Therapeutics

The isolation of new pore-forming toxins from the sea anemone actinia fragacea provides insights into the mechanisms of actinoporin evolution

Morante, K., Bellomio, A., Viguera, A. R., González-Mañas, J. M., Tsumoto, K. & Caaveiro, J. M. M., Jul 10 2019, In : Toxins. 11, 7, toxins11070401.

Research output: Contribution to journalArticle

Open Access
Actinium
Sea Anemones
Proteins
Species Specificity
Protein Stability

Thionoesters as 1,2-Dipolarophiles for [4+2] Cycloaddition with Cyclobutanones

Matsumoto, Y., Tsuji, T., Nakatake, D., Yazaki, R. & Ohshima, T., Jul 1 2019, In : Asian Journal of Organic Chemistry. 8, 7, p. 1071-1074 4 p.

Research output: Contribution to journalArticle

Cycloaddition
Carbon Monoxide
Biological Products
Ketones
Carbon

Three-Dimensional High-Performance Liquid Chromatographic Determination of Asn, Ser, Ala, and Pro Enantiomers in the Plasma of Patients with Chronic Kidney Disease

Furusho, A., Koga, R., Akita, T., Mita, M., Kimura, T. & Hamase, K., Sep 17 2019, In : Analytical chemistry. 91, 18, p. 11569-11575 7 p.

Research output: Contribution to journalArticle

Enantiomers
Plasmas
Amino Acids
Liquids
Plasma (human)
4 Citations (Scopus)

Transcription factor MafB contributes to the activation of spinal microglia underlying neuropathic pain development

Tozaki-Saitoh, H., Masuda, J., Kawada, R., Kojima, C., Yoneda, S., Masuda, T., Inoue, K. & Tsuda, M., Apr 2019, In : GLIA. 67, 4, p. 729-740 12 p.

Research output: Contribution to journalArticle

MafB Transcription Factor
Peripheral Nerve Injuries
Microglia
Neuralgia
Hypersensitivity

Triterpenoid saponins from the root bark of haplocoelum congolanum

Pertuit, D., Mitaine-Offer, A. C., Miyamoto, T., Tanaka, C., Tran, D. K., Delaude, C. & Lacaille-Dubois, M. A., May 2019, In : Natural product communications. 14, 5

Research output: Contribution to journalArticle

Open Access
triterpenoid saponins
Saponins
bark
Acids
acids

Triterpenoid saponins from the stem bark of pentaclethra eetveldeana

Pertuit, D., Kapundu, M., Mitaine-Offer, A. C., Miyamoto, T., Tanaka, C., Delaude, C. & Lacaille-Dubois, M. A., Jan 1 2019, In : Natural product communications. 14, 7

Research output: Contribution to journalArticle

Open Access
Pentaclethra
triterpenoid saponins
Saponins
Mass Spectrometry
bark

TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy

Sudi, S. B., Tanaka, T., Oda, S., Nishiyama, K., Nishimura, A., Sunggip, C., Mangmool, S., Numaga-Tomita, T. & Nishida, M., Dec 1 2019, In : Scientific reports. 9, 1, 9785.

Research output: Contribution to journalArticle

Open Access
Cardiac Myocytes
Malnutrition
Atrophy
Adenosine Triphosphate
Reactive Oxygen Species
1 Citation (Scopus)

TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN

Numaga-Tomita, T., Shimauchi, T., Oda, S., Tanaka, T., Nishiyama, K., Nishimura, A., Birnbaumer, L., Mori, Y. & Nishida, M., Sep 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 9, p. 9785-9796 12 p.

Research output: Contribution to journalArticle

Cell membranes
Vascular Smooth Muscle
Membrane Potentials
Smooth Muscle Myocytes
Muscle

Two new polyhydroxylated steroids from Egyptian soft coral Heteroxenia fuscescens (Fam.; Xeniidae)

Abdelkarem, F. M., Desoky, E. E. K., Nafady, A. M., Allam, A. E., Mahdy, A., Ashour, A., Mohamed, G. A., Miyamoto, T. & Shimizu, K., Jan 1 2019, In : Natural Product Research.

Research output: Contribution to journalArticle

Anthozoa
Fluorouracil
Inhibitory Concentration 50
steroids
inhibitory concentration 50

UDP-Glucuronosyltransferase (UGT)-mediated attenuations of cytochrome P450 3A4 activity: UGT isoform-dependent mechanism of suppression

Miyauchi, Y., Tanaka, Y., Nagata, K., Yamazoe, Y., Mackenzie, P. I., Yamada, H. & Ishii, Y., Jan 1 2019, (Accepted/In press) In : British Journal of Pharmacology.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Glucuronosyltransferase
Protein Isoforms
Dexamethasone
Baculoviridae

Δ 9 -Tetrahydrocannabinol elicited 22-kHz ultrasonic vocalization changes after air puff stimulus through CB 1 receptor in adult rats

Myose, T., Shirakawa, A., Irie, K., Yamashita, Y., Nakano, T., Takase, Y., Matsuo, K., Satho, T., Tuchihashi, R., Kinjo, J., Tanaka, H., Morimoto, S., Funada, M., Sano, K. & Mishima, K., May 14 2019, In : Neuroscience Letters. 701, p. 132-135 4 p.

Research output: Contribution to journalArticle

Dronabinol
Ultrasonics
Air
rimonabant
Cannabinoid Receptors
2018
6 Citations (Scopus)

3-Mono-Substituted BINOL Phosphoric Acids as Effective Organocatalysts in Direct Enantioselective Friedel–Crafts-Type Alkylation of N-Unprotected α-Ketiminoester

Yonesaki, R., Kondo, Y., Akkad, W., Sawa, M., Morisaki, K., Morimoto, H. & Ohshima, T., Oct 12 2018, In : Chemistry - A European Journal. 24, 57, p. 15211-15214 4 p.

Research output: Contribution to journalArticle

Phosphoric Acids
Enantioselectivity
Alkylation
Phosphoric acid
Catalysts
1 Citation (Scopus)

Abnormalities of the serotonergic system in diacylglycerol kinase δ-deficient mouse brain

Lu, Q., Komenoi, S., Usuki, T., Takahashi, D. & Sakane, F., Mar 18 2018, In : Biochemical and Biophysical Research Communications. 497, 4, p. 1031-1037 7 p.

Research output: Contribution to journalArticle

Diacylglycerol Kinase
Brain
Obsessive-Compulsive Disorder
Knockout Mice
Serotonin
Sorbitol
Neuralgia
Sciatic Nerve
Medical problems
Diabetic Neuropathies
2 Citations (Scopus)

Alleviation of fatty liver in a rat model by enhancing N 1 -methylnicotinamide bioavailability through aldehyde oxidase inhibition

Takeuchi, K., Yokouchi, C., Goto, H., Umehara, K., Yamada, H. & Ishii, Y., Dec 9 2018, In : Biochemical and Biophysical Research Communications. 507, 1-4, p. 203-210 8 p.

Research output: Contribution to journalArticle

Open Access
Aldehyde Oxidase
Fatty Liver
Liver
Biological Availability
Rats
3 Citations (Scopus)

A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair

Bharti, S. K., Sommers, J. A., Awate, S., Bellani, M. A., Khan, I., Bradley, L., King, G. A., Seol, Y., Vidhyasagar, V., Wu, Y., Abe, T., Kobayashi, K., Shin-Ya, K., Kitao, H., Wold, M. S., Branzei, D., Neuman, K. C. & Brosh, R. M., Jul 6 2018, In : Nucleic acids research. 46, 12, p. 6238-6256 19 p.

Research output: Contribution to journalArticle

Fanconi Anemia
DNA
Aphidicolin
Bleomycin
G-Quadruplexes
2 Citations (Scopus)

A Monoclonal Antibody-Based Enzyme-Linked Immunosorbent Assay for Determination of Homoharringtonine

Pongkitwitoon, B., Sakamoto, S., Nagamitsu, R., Putalun, W., Tanaka, H. & Morimoto, S., Feb 28 2018, In : Planta medica. 84, 14, p. 1038-1044 7 p.

Research output: Contribution to journalArticle

Immunosorbents
Assays
Enzyme-Linked Immunosorbent Assay
Monoclonal Antibodies
Enzymes
26 Citations (Scopus)
Cyclopropanes
Cycloaddition
Catalysis
Iron
tetrahydrothiophene
1 Citation (Scopus)

Angiotensin-II regulates dosing time-dependent intratumoral accumulation of macromolecular drug formulations via 24-h blood pressure rhythm in tumor-bearing mice

Matsunaga, T., Matsunaga, N., Kusunose, N., Ikeda, E., Okazaki, H., Kakimoto, K., Hamamura, K., Koyanagi, S. & Ohdo, S., Mar 25 2018, In : Biochemical and Biophysical Research Communications. 498, 1, p. 86-91 6 p.

Research output: Contribution to journalArticle

Bearings (structural)
Drug Compounding
Blood pressure
Angiotensin II
Tumors
6 Citations (Scopus)

A novel engineered interchain disulfide bond in the constant region enhances the thermostability of adalimumab Fab

Nakamura, H., Oda-Ueda, N., Ueda, T. & Ohkuri, T., Jan 1 2018, In : Biochemical and Biophysical Research Communications. 495, 1, p. 7-11 5 p.

Research output: Contribution to journalArticle

Disulfides
Pichia
Adalimumab
Computer Simulation
Yeast
1 Citation (Scopus)

Antioxidant nitroxides protect hepatic cells from oxidative stress-induced cell death

Shinto, S., Matsuoka, Y., Yamato, M. & Yamada, K. I., Mar 2018, In : Journal of Clinical Biochemistry and Nutrition. 62, 2, p. 132-138 7 p.

Research output: Contribution to journalArticle

Oxidative stress
Cell death
Hepatocytes
Oxidative Stress
Cell Death
1 Citation (Scopus)

A recombinant fab antibody against kwakhurin as a tool for sensitive indirect competitive ELISA

Chanpokapaiboon, K., Khoonrit, P., Yusakul, G., Juengwatanatrakul, T., Putalun, W., Tanaka, H., Sakamoto, S. & Morimoto, S., Jan 1 2018, In : Current Pharmaceutical Biotechnology. 19, 14, p. 1170-1176 7 p.

Research output: Contribution to journalArticle

Enzyme-Linked Immunosorbent Assay
Antibodies
Monoclonal Antibodies
Pueraria
kwakhurin

Assessing the effects of prescription adjustment and medication non-adherence associated with medication efficacy classifications from leftover drugs through the setsuyaku-bag campaign

Kobayashi, D., Koyanagi, K., Kubota, T., Sakamoto, Y., Kihara, T., Miisho, T., Kasaki, T., Kunitake, M., Takeshita, F., Ando, E., Baba, T., Seo, T., Tanaka, T. & Shimazoe, T., Jan 1 2018, In : Yakugaku Zasshi. 138, 10, p. 1313-1322 10 p.

Research output: Contribution to journalArticle

Social Adjustment
Medication Adherence
Prescriptions
Pharmaceutical Preparations
Health Expenditures
7 Citations (Scopus)

Assessing the Heterogeneity of the Fc-Glycan of a Therapeutic Antibody Using an engineered FcγReceptor IIIa-Immobilized Column

Kiyoshi, M., Caaveiro, J. M. M., Tada, M., Tamura, H., Tanaka, T., Terao, Y., Morante, K., Harazono, A., Hashii, N., Shibata, H., Kuroda, D., Nagatoishi, S., Oe, S., Ide, T., Tsumoto, K. & Ishii-Watabe, A., Dec 1 2018, In : Scientific Reports. 8, 1, 3955.

Research output: Contribution to journalArticle

Polysaccharides
Antibodies
Column chromatography
Cytotoxicity
Immunoglobulin G
3 Citations (Scopus)

Astrocytic Ca2+ responses in the spinal dorsal horn by noxious stimuli to the skin

Yoshihara, K., Matsuda, T., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., May 1 2018, In : Journal of Pharmacological Sciences. 137, 1, p. 101-104 4 p.

Research output: Contribution to journalArticle

Astrocytes
Skin
Automatic Data Processing
Photons
Formaldehyde
1 Citation (Scopus)

Bioconjugation with Thiols by Benzylic Substitution

Watanabe, K. & Ohshima, T., Mar 15 2018, In : Chemistry - A European Journal. 24, 16, p. 3959-3964 6 p.

Research output: Contribution to journalArticle

Muramidase
Sulfhydryl Compounds
Substitution reactions
Enzymes
Kinetics
1 Citation (Scopus)

BubR1 insufficiency impairs angiogenesis in aging and in experimental critical limb ischemic mice

Okadome, J., Matsumoto, T., Yoshiya, K., Matsuda, D., Tamada, K., Onimaru, M., Nakano, K., Egashira, K., Yonemitsu, Y. & Maehara, Y., Aug 2018, In : Journal of Vascular Surgery. 68, 2, p. 576-586.e1

Research output: Contribution to journalArticle

Extremities
Ambulatory Surgical Procedures
Muscles
Ischemia
Vascular Endothelial Growth Factor A
2 Citations (Scopus)

Capecitabine reverses tumor escape from anti-VEGF through the eliminating CD11bhigh/Gr1high myeloid cells

Iwai, T., Harada, Y., Saeki, H., Oki, E., Maehara, Y. & Yonemitsu, Y., Apr 1 2018, In : Oncotarget. 9, 25, p. 17620-17630 11 p.

Research output: Contribution to journalArticle

Tumor Escape
Myeloid Cells
Vascular Endothelial Growth Factor A
Neoplasms
Granulocyte Colony-Stimulating Factor
11 Citations (Scopus)

Catalytic Enantioselective Decarboxylative Mannich-Type Reaction of N-Unprotected Isatin-Derived Ketimines

Sawa, M., Miyazaki, S., Yonesaki, R., Morimoto, H. & Ohshima, T., Sep 7 2018, In : Organic Letters. 20, 17, p. 5393-5397 5 p.

Research output: Contribution to journalArticle

Isatin
synthesis
AG-041R
ketimine
1 Citation (Scopus)

Changes in HER2 expression and amplification status following preoperative chemotherapy for gastric cancer

Shu, S., Iimori, M., Nakanishi, R., Jogo, T., Saeki, H., Oki, E. & Maehara, Y., Nov 1 2018, In : In Vivo. 32, 6, p. 1491-1498 8 p.

Research output: Contribution to journalArticle

Chemotherapy
Stomach Neoplasms
Amplification
Drug Therapy
Epidermal Growth Factor Receptor
1 Citation (Scopus)

Characterization of changes in HbA1c in patients with and without secondary failure after metformin treatments by a population pharmacodynamic analysis using mixture models

Tamaki, Y., Maema, K., Kakara, M., Fukae, M., Kinoshita, R., Kashihara, Y., Muraki, S., Hirota, T. & Ieiri, I., Dec 1 2018, In : Drug metabolism and pharmacokinetics. 33, 6, p. 264-269 6 p.

Research output: Contribution to journalArticle

Metformin
Population
Therapeutics
Electronic Health Records
Glycosylated Hemoglobin A
Oligonucleotides
Nucleic Acids
Genes
DNA sequences
Nucleosides
11 Citations (Scopus)

Chemoselective Catalytic Dehydrogenative Cross-Coupling of 2-Acylimidazoles: Mechanistic Investigations and Synthetic Scope

Tanaka, T., Hashiguchi, K., Tanaka, T., Yazaki, R. & Ohshima, T., Sep 7 2018, In : ACS Catalysis. 8, 9, p. 8430-8440 11 p.

Research output: Contribution to journalArticle

phosphine
Carbon
Iron
Chemical activation
Alkanes
1 Citation (Scopus)

Chronopharmacology based on molecular clock

Ohdo, S., Jan 1 2018, In : Oral Therapeutics and Pharmacology. 37, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Genes
Drug Therapy
Pharmaceutical Preparations
Sleep
Chronotherapy
1 Citation (Scopus)

Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function /631/80/105 /631/208/199 /38 /38/35 /38/109 /38/77 /13/51 /13/109 article

Tsurudome, Y., Koyanagi, S., Kanemitsu, T., Katamune, C., Oda, M., Kanado, Y., Kato, M., Morita, A., Tahara, Y., Matsunaga, N., Shibata, S. & Ohdo, S., Dec 1 2018, In : Scientific reports. 8, 1, 9072.

Research output: Contribution to journalArticle

Circadian Clocks
Fatty Acid Transport Proteins
Liver
Transcriptional Activation
Membrane Proteins
17 Citations (Scopus)

Clinical significance of programmed cell death-ligand 1 expression and the immune microenvironment at the invasive front of colorectal cancers with high microsatellite instability

Korehisa, S., Oki, E., Iimori, M., Nakaji, Y., Shimokawa, M., Saeki, H., Okano, S., Oda, Y. & Maehara, Y., Feb 15 2018, In : International Journal of Cancer. 142, 4, p. 822-832 11 p.

Research output: Contribution to journalArticle

Microsatellite Instability
Colorectal Neoplasms
Cell Death
Ligands
CD274 Antigen
1 Citation (Scopus)

Clinical Significance of the Wild Type p53-Induced Phosphatase 1 Expression in Invasive Breast Cancer

Inoue, Y., Yamashita, N., Kitao, H., Tanaka, K., Saeki, H., Oki, E., Oda, Y., Tokunaga, E. & Maehara, Y., Aug 2018, In : Clinical Breast Cancer. 18, 4, p. e643-e650

Research output: Contribution to journalArticle

Protein Phosphatase 1
Phosphoric Monoester Hydrolases
Phosphoprotein Phosphatases
Magnesium
Breast Neoplasms