Research Output 1976 2020

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2018
1 Citation (Scopus)

Contribution of the clock gene DEC2 to VEGF mRNA upregulation by modulation of HIF1α protein levels in hypoxic MIO-M1 cells, a human cell line of retinal glial (Müller) cells

Kusunose, N., Akamine, T., Kobayashi, Y., Yoshida, S., Kimoto, K., Yasukochi, S., Matsunaga, N., Koyanagi, S., Ohdo, S. & Kubota, T., Jan 1 2018, (Accepted/In press) In : Japanese Journal of Ophthalmology.

Research output: Contribution to journalArticle

Neuroglia
Vascular Endothelial Growth Factor A
Up-Regulation
Cell Line
Messenger RNA

Crystallization of Human Erythrocyte Band 3, the anion exchanger, at the International Space Station “KIBO”

Hatae, H., Inaka, K., Okamura, R., Furubayashi, N., Kamo, M., Kobayashi, T., Abe, Y., Iwata, S. & Hamasaki, N., Oct 15 2018, In : Analytical Biochemistry. 559, p. 91-93 3 p.

Research output: Contribution to journalArticle

Chloride-Bicarbonate Antiporters
Space stations
Crystallization
Blood
Erythrocytes

Detection and inhibition of redox reaction and lipid derived radicals

Yamada, K-I., Jan 1 2018, In : Drug Delivery System. 33, 3, p. 197-203 7 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Lipids
Free Radicals
Animal Models
Carcinogenesis

Development of a colloidal gold nanoparticle-based immunochromatographic strip for the one-step detection of miroestrol and puerarin

Krittanai, S., Kitisripanya, T., Udomsin, O., Tanaka, H., Sakamoto, S., Juengwatanatrakul, T. & Putalun, W., Nov 1 2018, In : Biomedical Chromatography. 32, 11, e4330.

Research output: Contribution to journalArticle

Gold Colloid
Nanoparticles
Pueraria
Rejuvenation
Immunosorbents

Development of a Competitive Time-Resolved Fluoroimmunoassay for Paclitaxel

Cui, Q., Tanaka, H., Shoyama, Y., Ye, H. T., Li, F., Tian, E. W., Wu, Y. S. & Chao, Z., May 1 2018, In : Phytochemical Analysis. 29, 3, p. 284-289 6 p.

Research output: Contribution to journalArticle

Fluoroimmunoassay
paclitaxel
Taxus
taxes
Paclitaxel
3 Citations (Scopus)

Development of an immunochromatographic strip incorporating anti-mitragynine monoclonal antibody conjugated to colloidal gold for kratom alkaloids detection

Limsuwanchote, S., Putalun, W., Tanaka, H., Morimoto, S., Keawpradub, N. & Wungsintaweekul, J., Jul 1 2018, In : Drug Testing and Analysis. 10, 7, p. 1168-1175 8 p.

Research output: Contribution to journalArticle

Gold Colloid
alkaloid
Alkaloids
antibody
gold
9 Citations (Scopus)
Amino Acids
Fluids
Liquids
High Pressure Liquid Chromatography
L Forms
1 Citation (Scopus)
Carbonyl compounds
Rhodium
Catalysts
Proton transfer
Thalidomide
1 Citation (Scopus)

Diacylglycerol kinase β induces filopodium formation via its C1, catalytic and carboxy-terminal domains and interacts with the Rac1-GTPase-activating protein, β2-chimaerin

Maeda, Y., Shibata, K., Akiyama, R., Murakami, Y., Takao, S., Murakami, C., Takahashi, D., Sakai, H. & Sakane, F., Sep 26 2018, In : Biochemical and Biophysical Research Communications. 504, 1, p. 54-60 7 p.

Research output: Contribution to journalArticle

Diacylglycerol Kinase
GTPase-Activating Proteins
Pseudopodia
Cell membranes
Spine
2 Citations (Scopus)

Different expression systems resulted in varied binding properties of anti-paclitaxel single-chain variable fragment antibody clone 1C2

Yusakul, G., Sakamoto, S., Nuntawong, P., Tanaka, H. & Morimoto, S., Jan 1 2018, In : Journal of Natural Medicines. 72, 1, p. 310-316 7 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Paclitaxel
Bombyx
Clone Cells
Escherichia coli
7 Citations (Scopus)

Dimethyl fumarate ameliorates chemotherapy agent-induced neurotoxicity in vitro

kawashiri, T., Miyagi, A., Shimizu, S., Shigematsu, N., Kobayashi, D. & Shimazoe, T., Jun 1 2018, In : Journal of Pharmacological Sciences. 137, 2, p. 202-211 10 p.

Research output: Contribution to journalArticle

oxaliplatin
Drug Therapy
Fumarates
PC12 Cells
Cultured Cells
3 Citations (Scopus)

Discovery and Optimization of Inhibitors of the Parkinson's Disease Associated Protein DJ-1

Tashiro, S., Caaveiro, J. M. M., Nakakido, M., Tanabe, A., Nagatoishi, S., Tamura, Y., Matsuda, N., Liu, D., Hoang, Q. Q. & Tsumoto, K., Sep 21 2018, In : ACS Chemical Biology. 13, 9, p. 2783-2793 11 p.

Research output: Contribution to journalArticle

X Ray Crystallography
Oxidation-Reduction
Disease Progression
X ray crystallography
Assays
4 Citations (Scopus)

Discovery of 2-[(E)-2-(7-fluoro-3-methylquinoxalin-2-yl)vinyl]-6-pyrrolidin- 1-yl-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine hydrochloride as a highly selective PDE10A inhibitor

Kadoh, Y., Miyoshi, H., Matsumura, T., Tanaka, Y., Hongu, M., Kimura, M., Takedomi, K., Omori, K., Kotera, J., Sasaki, T., Kobayashi, T., Taniguchi, H., Watanabe, Y., Kojima, K., Sakamoto, T., Himiyama, T. & Kawanishi, E., Jan 1 2018, In : Chemical and Pharmaceutical Bulletin. 66, 3, p. 243-250 8 p.

Research output: Contribution to journalArticle

Pyrans
Neurons
Amines
Phosphodiesterase 5 Inhibitors
Quinoxalines
2 Citations (Scopus)

Effects of Derinat on ischemia-reperfusion-induced pressure ulcer mouse model

Liu, J., Rybakina, E. G., Korneva, E. A. & Noda, M., Oct 2018, In : Journal of Pharmacological Sciences. 138, 2, p. 123-130 8 p.

Research output: Contribution to journalArticle

Pressure Ulcer
Reperfusion
Ischemia
Alprostadil
Salmon

Effects of using the adherence score sheet according to application timing in improving medication adherence in SETSUYAKU-BAG campaign

Kobayashi, D., Koyanagi, K., Kubota, T., Maruyama, M., Miisho, T., Kaneko, E., Kawanami, M., Kihara, T., Takaki, J., Nakashiba, T., Nagatomi, S., Seo, T., Tanaka, T. & Shimazoe, T., Jan 1 2018, In : Yakugaku Zasshi. 138, 12, p. 1549-1559 11 p.

Research output: Contribution to journalArticle

Medication Adherence
Pharmacists
Chronic Disease
Outpatients
Pharmacies
4 Citations (Scopus)
Plasma (human)
3-Hydroxybutyric Acid
High performance liquid chromatography
Lactic Acid
Enantiomers
2 Citations (Scopus)

Endogenous Membrane Receptor Labeling by Reactive Cytokines and Growth Factors to Chase Their Dynamics in Live Cells

Takaoka, Y., Uchinomiya, S., Kobayashi, D., Endo, M., Hayashi, T., Fukuyama, Y., Hayasaka, H., Miyasaka, M., Ueda, T., Shimada, I. & Hamachi, I., Jun 14 2018, In : Chem. 4, 6, p. 1451-1464 14 p.

Research output: Contribution to journalArticle

Labeling
Intercellular Signaling Peptides and Proteins
Cytokines
membrane
Membranes
1 Citation (Scopus)

Enhancement effect on the chemiluminescence of acridinium esters under neutral conditions

Nakazono, M. & Nanbu, S., Mar 2018, In : Luminescence. 33, 2, p. 345-348 4 p.

Research output: Contribution to journalArticle

Chemiluminescence
Luminescence
Esters
Acridines
Derivatives
1 Citation (Scopus)

Enzyme linked immunosorbent assay for total potent estrogenic miroestrol and deoxymiroestrol of Pueraria candollei, a Thai herb for menopause remedy

Yusakul, G., Kitisripanya, T., Juengwatanatrakul, T., Sakamoto, S., Tanaka, H. & Putalun, W., Jun 1 2018, In : Journal of Natural Medicines. 72, 3, p. 641-650 10 p.

Research output: Contribution to journalArticle

Pueraria
Immunosorbents
Menopause
Assays
Enzyme-Linked Immunosorbent Assay

Epithelial cell adhesion molecule expression in hepatic stem/progenitor cells is controlled by the molecular clock system

Kimura, H., Naoya, M., Kakimoto, K., Watanabe, M., Tsuruta, A., Kusunose, N., Shiromizu, S., Satoru, K. & Ohdo, S., Sep 5 2018, In : Biochemical and Biophysical Research Communications. 503, 2, p. 1063-1069 7 p.

Research output: Contribution to journalArticle

Liver Regeneration
Cell Adhesion Molecules
Stem cells
Clocks
Hepatocytes
11 Citations (Scopus)

Epithelial Paradox: Clinical Significance of Coexpression of E-cadherin and Vimentin With Regard to Invasion and Metastasis of Breast Cancer

Yamashita, N., Tokunaga, E., Iimori, M., Inoue, Y., Tanaka, K., Kitao, H., Saeki, H., Oki, E. & Maehara, Y., Oct 2018, In : Clinical Breast Cancer. 18, 5, p. e1003-e1009

Research output: Contribution to journalArticle

Vimentin
Cadherins
Breast Neoplasms
Neoplasm Metastasis
Neoplasms
2 Citations (Scopus)

Evaluation of simultaneous binding of Chromomycin A3 to the multiple sites of DNA by the new restriction enzyme assay

Murase, H., Noguchi, T. & Sasaki, S., Jun 1 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 10, p. 1832-1835 4 p.

Research output: Contribution to journalArticle

Chromomycin A3
DNA Restriction Enzymes
Enzyme Assays
Assays
DNA
3 Citations (Scopus)
diacylglycerol kinase
Diacylglycerol Kinase
Baculoviridae
Purification
Insects
1 Citation (Scopus)

Fluorescence tumor-imaging using a thermo-responsive molecule with an emissive aminoquinoline derivative

Araki, T., Fuchi, Y., Murayama, S., Shiraishi, R., Oyama, T., Aso, M., Aoki, I., Kobayashi, S., Yamada, K. I. & Karasawa, S., Oct 2 2018, In : Nanomaterials. 8, 10, 782.

Research output: Contribution to journalArticle

Aminoquinolines
Tumors
Fluorescence
Derivatives
Imaging techniques

Genome-wide analysis of the spatiotemporal regulation of firing and dormant replication origins in human cells

Sugimoto, N., Maehara, K., Yoshida, K., Ohkawa, Y. & Fujita, M., Jul 27 2018, In : Nucleic Acids Research. 46, 13, p. 6683-6696 14 p.

Research output: Contribution to journalArticle

Spatio-Temporal Analysis
Replication Origin
Chromatin
Transcription Initiation Site
Genome
13 Citations (Scopus)
Spatio-Temporal Analysis
Replication Origin
Chromatin
Transcription Initiation Site
Genome
3 Citations (Scopus)

Genotoxic Responses of Mitochondrial Oxygen Consumption Rate and Mitochondrial Semiquinone Radicals in Tumor Cells

Yamamoto, K., Yasui, H., Bo, T., Yamamori, T., Hiraoka, W., Yamasaki, T., Yamada, K. I. & Inanami, O., Aug 1 2018, In : Applied Magnetic Resonance. 49, 8, p. 837-851 15 p.

Research output: Contribution to journalArticle

oxygen consumption
electron paramagnetic resonance
respiration
tumors
mitochondria
6 Citations (Scopus)

Gliotransmitters and cytokines in the control of blood-brain barrier permeability

Osipova, E. D., Semyachkina-Glushkovskaya, O. V., Morgun, A. V., Pisareva, N. V., Malinovskaya, N. A., Boitsova, E. B., Pozhilenkova, E. A., Belova, O. A., Salmin, V. V., Taranushenko, T. E., Noda, M. & Salmina, A. B., Jul 26 2018, In : Reviews in the Neurosciences. 29, 5, p. 567-591 25 p.

Research output: Contribution to journalArticle

Blood-Brain Barrier
Permeability
Cytokines
Neuroglia
Amino Acid Transport System X-AG

Growth suppression of human colorectal cancer cells with mutated KRAS by 3-deaza-cytarabine in 3d floating culture

Luo, H., Nishi, K., Ishikura, S., Swain, A., Morishige, N., Yazaki, R., Ohshima, T., Shirasawa, S. & Tsunoda, T., Jul 2018, In : Anticancer research. 38, 7, p. 4247-4256 10 p.

Research output: Contribution to journalArticle

Cytarabine
Colorectal Neoplasms
Uridine
Growth
gemcitabine
3 Citations (Scopus)

GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system

Watanabe, S., Fujiyama, H., Takafuji, T., Kayama, K., Matsumoto, M., Nakayama, K. I., Yoshida, K., Sugimoto, N. & Fujita, M., Aug 1 2018, In : Journal of Cell Science. 131, 15

Research output: Contribution to journalArticle

Ribosomal Proteins
Proteasome Endopeptidase Complex
Ubiquitin
Glutamic Acid
Down-Regulation
3 Citations (Scopus)

Gut microbiota-derived D-serine protects against acute kidney injury

Nakade, Y., Iwata, Y., Furuichi, K., Mita, M., Hamase, K., Konno, R., Miyake, T., Sakai, N., Kitajima, S., Toyama, T., Shinozaki, Y., Sagara, A., Miyagawa, T., Hara, A., Shimizu, M., Kamikawa, Y., Sato, K., Oshima, M., Yoneda-Nakagawa, S., Yamamura, Y. & 8 others, Kaneko, S., Miyamoto, T., Katane, M., Homma, H., Morita, H., Suda, W., Hattori, M. & Wada, T., Oct 18 2018, In : JCI Insight. 3, 20

Research output: Contribution to journalArticle

Open Access
Acute Kidney Injury
Serine
Kidney
Amino Acids
Dysbiosis
2 Citations (Scopus)

12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration

Kim, T. H., Yang, Y. M., Han, C. Y., Koo, J. H., Oh, H., Kim, S. S., You, B. H., Choi, Y. H., Park, T. S., Lee, C. H., Kurose, H., Noureddin, M., Seki, E., Wan, Y. J. Y., Choi, C. S. & Kim, S. G., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5587-5602 16 p.

Research output: Contribution to journalArticle

Sirtuin 1
Fatty Liver
Ubiquitin
GTP-Binding Proteins
Respiration
10 Citations (Scopus)

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence

Nishimura, A., Shimauchi, T., Tanaka, T., Shimoda, K., Toyama, T., Kitajima, N., Ishikawa, T., Shindo, N., Numaga-Tomita, T., Yasuda, S., Sato, Y., Kuwahara, K., Kumagai, Y., Akaike, T., Ide, T., Ojida, A., Mori, Y. & Nishida, M., Nov 13 2018, In : Science Signaling. 11, 556, eaat5185.

Research output: Contribution to journalArticle

Filamins
Dynamins
Actins
Mitochondrial Dynamics
Proteins

Imaging Doxorubicin Free Radical in Mice with Overhauser Enhanced MRI and its Tumor Suppression Effect in Mice

Kato, N., Sato, S., Yamada, K-I. & Ichikawa, K., Aug 1 2018, In : Applied Magnetic Resonance. 49, 8, p. 869-879 11 p.

Research output: Contribution to journalArticle

free radicals
mice
tumors
retarding
magnetic resonance
2 Citations (Scopus)
Antigens
Paclitaxel
Antibodies
Immunoglobulin G
Light

Inhibition of amyloid fibril formation in the variable domain of λ6 light chain mutant Wil caused by the interaction between its unfolded state and epigallocatechin-3-O-gallate

Abe, Y., Odawara, N., Aeimhirunkailas, N., Shibata, H., Fujisaki, N., Tachibana, H. & Ueda, T., Dec 1 2018, In : Biochimica et Biophysica Acta - General Subjects. 1862, 12, p. 2570-2578 9 p.

Research output: Contribution to journalArticle

Amyloid
Light
Amyloidosis
epigallocatechin gallate
Oxidation
Amyloid
Light
Amyloidosis
epigallocatechin gallate
Oxidation
5 Citations (Scopus)
CpG Islands
Human Activities
Methylation
Skin
Messenger RNA
1 Citation (Scopus)

Interleukin-27 controls basal pain threshold in physiological and pathological conditions

Sasaguri, T., Taguchi, T., Murata, Y., Kobayashi, K., Iizasa, S., Iizasa, E., Tsuda, M., Hirakawa, N., Hara, H., Yoshida, H. & Yasaka, T., Dec 1 2018, In : Scientific reports. 8, 1, 11022.

Research output: Contribution to journalArticle

Interleukin-27
Pain Threshold
Pain
Chronic Pain
Hypersensitivity
3 Citations (Scopus)

Internal-Edge-Substituted Coumarin-Fused [6]Helicenes: Asymmetric Synthesis, Structural Features, and Control of Self-Assembly

Usui, K., Yamamoto, K., Ueno, Y., Igawa, K., Hagihara, R., Masuda, T., Ojida, A., Karasawa, S., Tomooka, K., Hirai, G. & Suemune, H., Oct 1 2018, In : Chemistry - A European Journal. 24, 55, p. 14617-14621 5 p.

Research output: Contribution to journalArticle

Self assembly
X ray crystallography
Quantum yield
Electronic structure
Physical properties
2 Citations (Scopus)

Intramolecular H-bonds govern the recognition of a flexible peptide by an antibody

Miyanabe, K., Akiba, H., Kuroda, D., Nakakido, M., Kusano-Arai, O., Iwanari, H., Hamakubo, T., Caaveiro, J. M. M. & Tsumoto, K., Jul 1 2018, In : Journal of biochemistry. 164, 1, p. 65-76 12 p.

Research output: Contribution to journalArticle

Biological Phenomena
Molecular recognition
Peptides
Antibodies
Free energy
3 Citations (Scopus)

Introduction of a glycosylation site in the constant region decreases the aggregation of adalimumab Fab

Nakamura, H., Oda-Ueda, N., Ueda, T. & Ohkuri, T., Sep 5 2018, In : Biochemical and Biophysical Research Communications. 503, 2, p. 752-756 5 p.

Research output: Contribution to journalArticle

Glycosylation
Agglomeration
Density (optical)
Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase
Pichia
3 Citations (Scopus)

Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons

Masuda, K., Tsutsuki, H., Kasamatsu, S., Ida, T., Takata, T., Sugiura, K., Nishida, M., Watanabe, Y., Sawa, T., Akaike, T. & Ihara, H., Jan 15 2018, In : Biochemical and Biophysical Research Communications. 495, 3, p. 2165-2170 6 p.

Research output: Contribution to journalArticle

1-Methyl-4-phenylpyridinium
PC12 Cells
Neurons
Rats
Reactive Oxygen Species
8 Citations (Scopus)

Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection

Imai, T., Matsumura, T., Mayer-Lambertz, S., Wells, C. A., Ishikawa, E., Butcher, S. K., Barnett, T. C., Walker, M. J., Imamura, A., Ishida, H., Ikebe, T., Miyamoto, T., Ato, M., Ohga, S., Lepenies, B., Van Sorge, N. M. & Yamasaki, S., Nov 6 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 45, p. E10662-E10671

Research output: Contribution to journalArticle

C-Type Lectins
Streptococcus
Immunity
Macrophages
Infection
5 Citations (Scopus)

Luminescent europium sensors for specific detection of 8-oxo-dGTP by time-gated fluorescence

Fuchi, Y., Fukuda, T. & Sasaki, S., Jul 23 2018, In : Bioorganic and Medicinal Chemistry. 26, 12, p. 3254-3260 7 p.

Research output: Contribution to journalArticle

Europium
Fluorescence
Sensors
Assays
Ions
9 Citations (Scopus)

Lycodine-type alkaloids and their glycosides from Lycopodiastrum casuarinoides

Wang, L. L., Hao, L. J., Zhou, Z. B., Zhu, X. L., Shi, Z. H., Miyamoto, T. & Pan, K., Oct 1 2018, In : Phytochemistry. 154, p. 63-72 10 p.

Research output: Contribution to journalArticle

Lycopodium alkaloids
Lycopodium
Glycosides
Alkaloids
glycosides
4 Citations (Scopus)

MDC1 methylation mediated by lysine methyltransferases EHMT1 and EHMT2 regulates active ATM accumulation flanking DNA damage sites

Watanabe, S., Iimori, M., Chan, D. V., Hara, E., Kitao, H. & Maehara, Y., Dec 1 2018, In : Scientific reports. 8, 1, 10888.

Research output: Contribution to journalArticle

Histone-Lysine N-Methyltransferase
Methyltransferases
Methylation
Lysine
DNA Damage
1 Citation (Scopus)

Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury

Homma, T., Shirato, T., Akihara, R., Kobayashi, S., Lee, J., Yamada, K. I., Miyata, S., Takahashi, M. & Fujii, J., Sep 15 2018, In : Toxicology Letters. 294, p. 37-43 7 p.

Research output: Contribution to journalArticle

Thioacetamide
Liver
Wounds and Injuries
Metabolites
Cytochrome P-450 CYP2E1
2 Citations (Scopus)

miR-3148 is a novel onco-microRNA that potentiates tumor growth in vivo

Akamine, T., Morodomi, Y., Harada, Y., Teraishi, K., Tagawa, T., Okamoto, T., Maehara, Y. & Yonemitsu, Y., Oct 2018, In : Anticancer research. 38, 10, p. 5693-5701 9 p.

Research output: Contribution to journalArticle

MicroRNAs
HCT116 Cells
Growth
Neoplasms
Extracellular Signal-Regulated MAP Kinases
2 Citations (Scopus)
Aminopyridines
Base Pairing
DNA
Nucleosides
Nucleotides