Research Output 1976 2020

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2018
1 Citation (Scopus)

Molecular basis for governing the morphology of type-I collagen fibrils by Osteomodulin

Tashima, T., Nagatoishi, S., Caaveiro, J. M. M., Nakakido, M., Sagara, H., Kusano-Arai, O., Iwanari, H., Mimuro, H., Hamakubo, T., Ohnuma, S. I. & Tsumoto, K., Dec 1 2018, In : Communications Biology. 1, 1, 33.

Research output: Contribution to journalArticle

Open Access
Collagen Type I
collagen
Collagen
Proteoglycans
Static Electricity

Natural antibody against neuroblastoma of TH-MYCN transgenic mice does not correlate with spontaneous regression

Kawakubo, N., Harada, Y., Ishii, M., Souzaki, R., Kinoshita, Y., Tajiri, T., Taguchi, T. & Yonemitsu, Y., Sep 10 2018, In : Biochemical and Biophysical Research Communications. 503, 3, p. 1666-1673 8 p.

Research output: Contribution to journalArticle

Neuroblastoma
Transgenic Mice
Antibodies
Tumors
Cytotoxicity
1 Citation (Scopus)

Neuropathic pain inhibitor, RAP-103, is a potent inhibitor of microglial CCL1/CCR8

Noda, M., Tomonaga, D., Kitazono, K., Yoshioka, Y., Liu, J., Rousseau, J. P., Kinkead, R., Ruff, M. R. & Pert, C. B., Oct 1 2018, In : Neurochemistry International. 119, p. 184-189 6 p.

Research output: Contribution to journalArticle

Neuralgia
Ligands
Hyperalgesia
Chemokine Receptors
Inhibitory Concentration 50

New strategies for exercise-mimetic medication

Oda, S., Numaga-Tomita, T. & Nishida, M., Jan 1 2018, In : Yakugaku Zasshi. 138, 10, p. 1257-1262 6 p.

Research output: Contribution to journalArticle

Exercise Therapy
Exercise
Reactive Oxygen Species
NADP
Vascular Smooth Muscle
Protein Phosphatase 2
Dextran Sulfate
Toll-Like Receptor 4
Protein Tyrosine Phosphatases
Colitis
2 Citations (Scopus)

Nucleosome positioning and gene regulation of the SGLT2 gene in the renal proximal tubular epithelial cells

Takesue, H., Hirota, T., Tachimura, M., Tokashiki, A. & Ieiri, I., Sep 1 2018, In : Molecular Pharmacology. 94, 3, p. 953-962 10 p.

Research output: Contribution to journalArticle

Sodium-Glucose Transport Proteins
Nucleosomes
Epithelial Cells
Kidney
Genes
1 Citation (Scopus)

Oleanane-type glycosides from the roots of Weigela florida “rumba” and evaluation of their antibody recognition

Champy-Tixier, A. S., Mitaine-Offer, A. C., Real Fernández, F., Miyamoto, T., Tanaka, C., Papini, A. M. & Lacaille-Dubois, M. A., Jul 1 2018, In : Fitoterapia. 128, p. 198-203 6 p.

Research output: Contribution to journalArticle

Glycosides
Acids
Antibodies
Triterpenes
Multiple Sclerosis
8 Citations (Scopus)

Optimized dosing schedule based on circadian dynamics of mouse breast cancer stem cells improves the antitumor effects of aldehyde dehydrogenase inhibitor

Naoya, M., Ogino, T., Hara, Y., Tanaka, T., Satoru, K. & Ohdo, S., Jul 1 2018, In : Cancer Research. 78, 13, p. 3698-3708 11 p.

Research output: Contribution to journalArticle

Aldehyde Dehydrogenase
Neoplastic Stem Cells
Appointments and Schedules
Breast Neoplasms
Triple Negative Breast Neoplasms
4 Citations (Scopus)

Optimizing the dosing schedule of L-asparaginase improves its anti-tumor activity in breast tumor-bearing mice

Shiromizu, S., Kusunose, N., Matsunaga, N., Koyanagi, S. & Ohdo, S., Apr 2018, In : Journal of Pharmacological Sciences. 136, 4, p. 228-233 6 p.

Research output: Contribution to journalArticle

Asparaginase
Appointments and Schedules
Breast Neoplasms
Asparagine
Neoplasms
8 Citations (Scopus)

Optogenetic activation of non-nociceptive aβ fibers induces neuropathic pain-like sensory and emotional behaviors after nerve injury in rats

Tashima, R., Koga, K., Sekine, M., Kanehisa, K., Kohro, Y., Tominaga, K., Matsushita, K., Tozaki-Saitoh, H., Fukazawa, Y., Inoue, K., Yawo, H., Furue, H. & Tsuda, M., Jan 1 2018, In : eNeuro. 5, 1, e0450-17.2018.

Research output: Contribution to journalArticle

Optogenetics
Peripheral Nerve Injuries
Neuralgia
Myelinated Nerve Fibers
Wounds and Injuries
2 Citations (Scopus)

Phytochemistry of weigela x “kosteriana variegata” (Caprifoliaceae)

Andriamisaina, N., Mitaine-Offer, A. C., Pruvot, B., Chluba, J., Miyamoto, T., Tanaka, C. & Lacaille-Dubois, M. A., Jan 1 2018, In : Natural product communications. 13, 4, p. 403-406 4 p.

Research output: Contribution to journalArticle

Caprifoliaceae
Weigela
plant biochemistry
Glycosides
glycosides

Population Pharmacodynamic Analysis of Uric Acid–Lowering Effects of Febuxostat Based on Electronic Medical Records in Two Hospitals

Muraki, S., Moriki, K., Shigematsu, S., Fukae, M., Kakara, M., Yamashita, D., Hirota, T., Takane, H., Shimada, M., Hirakawa, M. & Ieiri, I., Mar 2018, In : Journal of Clinical Pharmacology. 58, 3, p. 304-313 10 p.

Research output: Contribution to journalArticle

Electronic Health Records
Uric Acid
Population
Blood Urea Nitrogen
Urban Hospitals

Population Pharmacokinetics and Pharmacodynamics of Oral Propranolol in Pediatric Patients With Infantile Hemangioma

Takechi, T., Kumokawa, T., Kato, R., Higuchi, T., Kaneko, T. & Ieiri, I., Oct 2018, In : Journal of Clinical Pharmacology. 58, 10, p. 1361-1370 10 p.

Research output: Contribution to journalArticle

Hemangioma
Propranolol
Pharmacokinetics
Pediatrics
Population

Prolonged stimulation of β2-adrenergic receptor with β2-agonists impairs insulin actions in H9c2 cells

Parichatikanond, W., Nishimura, A., Nishida, M. & Mangmool, S., Nov 1 2018, In : Journal of Pharmacological Sciences. 138, 3, p. 184-191 8 p.

Research output: Contribution to journalArticle

Adrenergic Receptors
Insulin Resistance
Insulin
Glucose
Smooth Muscle Myocytes

Psychological assessment of acute schizophrenia patients who experienced seclusion either alone or in combination with restraint

Eguchi, R., Onozuka, D., Ikeda, K., Kuroda, K., Ieiri, I. & Hagihara, A., May 1 2018, In : International Journal of Psychiatry in Medicine. 53, 3, p. 171-188 18 p.

Research output: Contribution to journalArticle

Schizophrenia
Psychiatry
Psychology
Brief Psychiatric Rating Scale
Hostility
2 Citations (Scopus)
CpG Islands
DNA Methylation
Liver
Proteins
Messenger RNA
1 Citation (Scopus)
oxaliplatin
Riluzole
Hyperalgesia
Spinal Ganglia
Oxalates
3 Citations (Scopus)
Intravenous Administration
Nanoparticles
Pharmacokinetics
Placebos
Research Personnel
5 Citations (Scopus)

Sensitive detection of fluorescence in western blotting by merging images

Kondo, Y., Higa, S., Iwasaki, T., Matsumoto, T., Maehara, K., Harada, A., Baba, Y., Fujita, M. & Ohkawa, Y., Jan 2018, In : PloS one. 13, 1, e0191532.

Research output: Contribution to journalArticle

Merging
Western blotting
Fluorescence
Western Blotting
fluorescence
2 Citations (Scopus)
Glycosides
Immunosorbents
Monoclonal antibodies
Assays
Enzymes
1 Citation (Scopus)

Sequential actions of immune effector cells induced by viral activation of dendritic cells to eliminate murine neuroblastoma

Kawakubo, N., Tanaka, S., Kinoshita, Y., Tajiri, T., Yonemitsu, Y. & Taguchi, T., Aug 2018, In : Journal of Pediatric Surgery. 53, 8, p. 1615-1620 6 p.

Research output: Contribution to journalArticle

Virus Activation
Neuroblastoma
Dendritic Cells
Radiation
Natural Killer Cells
3 Citations (Scopus)
Leukemia
Derivatives
Cephalotaxus
Immunosorbents
Acute Promyelocytic Leukemia

Stable and selective antiparallel type triplex DNA formation by targeting a GC base pair with the TFO containing one N2-phenyl-2-deoxyguanosine

Taniguchi, Y., Miyazaki, M., Matsueda, N., Wang, L., Okamura, H. & Sasaki, S., Jan 1 2018, In : Chemical and Pharmaceutical Bulletin. 66, 6, p. 624-631 8 p.

Research output: Contribution to journalArticle

Deoxyguanosine
Oligonucleotides
Base Pairing
DNA
Gene expression
8 Citations (Scopus)

Strategy for Catalytic Chemoselective Cross-Enolate Coupling Reaction via a Transient Homocoupling Dimer

Tanaka, T., Tanaka, T., Tsuji, T., Yazaki, R. & Ohshima, T., Jun 15 2018, In : Organic Letters. 20, 12, p. 3541-3544 4 p.

Research output: Contribution to journalArticle

cross coupling
Catalysis
Dimers
catalysis
Bearings (structural)

Structural and enzymatic properties of mammalian D-glutamate cyclase

Katane, M., Ariyoshi, M., Tateishi, S., Koiwai, S., Takaku, K., Nagai, K., Nakayama, K., Saitoh, Y., Miyamoto, T., Sekine, M., Mita, M., Hamase, K., Matoba, S. & Homma, H., Sep 15 2018, In : Archives of Biochemistry and Biophysics. 654, p. 10-18 9 p.

Research output: Contribution to journalArticle

Proline
Glutamic Acid
Heart Failure
D-glutamate cyclase
Oligomerization
2 Citations (Scopus)

Structure–function analyses of a stereotypic rheumatoid factor unravel the structural basis for germline-encoded antibody autoreactivity

Shiroishi, M., Ito, Y., Shimokawa, K., Lee, J. M., Kusakabe, T. & Ueda, T., Jan 1 2018, In : Journal of Biological Chemistry. 293, 18, p. 7008-7016 9 p.

Research output: Contribution to journalArticle

Rheumatoid Factor
Antibodies
Complementarity Determining Regions
Hematologic Diseases
Immunoglobulin G
2 Citations (Scopus)

Synthesis of azaheterocycles and related molecules by Tf2NH-catalyzed cycloadditions

Shindo, N. & Takasu, K., Jan 1 2018, In : Heterocycles. 96, 2, p. 195-212 18 p.

Research output: Contribution to journalArticle

Cycloaddition
Cycloaddition Reaction
Nitrogen
Nitrogen Compounds
Molecules

Synthesis of dendritic bisphosphonates as bone targeting ligands

Shimoda, K., Mitsuoka, T., Ueda, K., Suemune, H., Hirai, G. & Aso, M., Dec 19 2018, In : Tetrahedron Letters. 59, 51, p. 4528-4531 4 p.

Research output: Contribution to journalArticle

Diphosphonates
Bone
Ligands
Bone and Bones
Durapatite
1 Citation (Scopus)

Synthetic Method for 2′-Amino-LNA Bearing Any of the Four Nucleobases via a Transglycosylation Reaction

Sawamoto, H., Arai, Y., Yamakoshi, S., Obika, S. & Kawanishi, E., Apr 6 2018, In : Organic Letters. 20, 7, p. 1928-1931 4 p.

Research output: Contribution to journalArticle

Bearings (structural)
5-Methylcytosine
Thymine
Guanine
nucleic acids
6 Citations (Scopus)

Temporal kinetics of microgliosis in the spinal dorsal horn after peripheral nerve injury in rodents

Kohno, K., Kitano, J., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., Jan 1 2018, In : Biological and Pharmaceutical Bulletin. 41, 7, p. 1096-1102 7 p.

Research output: Contribution to journalArticle

Peripheral Nerve Injuries
Rodentia
Microglia
Neuralgia
S Phase
3 Citations (Scopus)

Terpenoid glycosides from the root's barks of Eriocoelum microspermum Radlk. ex Engl.

Pertuit, D., Mitaine-Offer, A. C., Miyamoto, T., Tanaka, C., Delaude, C. & Lacaille-Dubois, M. A., Aug 1 2018, In : Phytochemistry. 152, p. 182-190 9 p.

Research output: Contribution to journalArticle

Terpenes
Glycosides
terpenoids
glycosides
bark

The aryl hydrocarbon receptor is indispensable for dioxin-induced defects in sexually-dimorphic behaviors due to the reduction in fetal steroidogenesis of the pituitary-gonadal axis in rats

Hattori, Y., Takeda, T., Nakamura, A., Nishida, K., Shioji, Y., Fukumitsu, H., Yamada, H. & Ishii, Y., Aug 1 2018, In : Biochemical Pharmacology. 154, p. 213-221 9 p.

Research output: Contribution to journalArticle

Multifetal Pregnancy Reduction
Aryl Hydrocarbon Receptors
Dioxins
Rats
Defects
3 Citations (Scopus)

The DnaA AAA+ Domain His136 residue directs DnaB replicative helicase to the unwound region of the replication origin, oriC

Sakiyama, Y., Nishimura, M., Hayashi, C., Akama, Y., Ozaki, S. & Katayama, T., Aug 31 2018, In : Frontiers in Microbiology. 9, AUG, 2017.

Research output: Contribution to journalArticle

DnaB Helicases
Replication Origin
Nucleoproteins
Single-Stranded DNA
Protein Subunits
3 Citations (Scopus)

The first multicenter, randomized, controlled trial of home telemonitoring for Japanese patients with heart failure: home telemonitoring study for patients with heart failure (HOMES-HF)

On Behalf Of The Homes-Hf Study Investigators, Aug 1 2018, In : Heart and Vessels. 33, 8, p. 866-876 11 p.

Research output: Contribution to journalArticle

Randomized Controlled Trials
Heart Failure
Home Care Services
Physiologic Monitoring
Registries
3 Citations (Scopus)

The MAPK Erk5 is necessary for proper skeletogenesis involving a smurf-smad-Sox9 molecular axis

Iezaki, T., Fukasawa, K., Horie, T., Park, G., Robinson, S., Nakaya, M., Fujita, H., Onishi, Y., Ozaki, K., Kanayama, T., Hiraiwa, M., Kitaguchi, Y., Kaneda, K., Yoneda, Y., Takarada, T., Guo, X. E., Kurose, H. & Hinoi, E., Jul 15 2018, In : Development (Cambridge). 145, 14, dev164004.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinases
Smad Proteins
Ubiquitin-Protein Ligases
Transcription Factors
Cell Count
1 Citation (Scopus)

The relationship between fine particulate matter (PM) and schizophrenia severity

Eguchi, R., Onozuka, D., Ikeda, K., Kuroda, K., Ieiri, I. & Hagihara, A., Apr 23 2018, In : International Archives of Occupational and Environmental Health.

Research output: Contribution to journalArticle

Particulate Matter
Schizophrenia
Brief Psychiatric Rating Scale
Patient Admission
Air Pollution
6 Citations (Scopus)

Thienyl-Substituted α-Ketoamide: A Less Hydrophobic Reactive Group for Photo-Affinity Labeling

Ota, E., Usui, K., Oonuma, K., Koshino, H., Nishiyama, S., Hirai, G. & Sodeoka, M., Apr 20 2018, In : ACS Chemical Biology. 13, 4, p. 876-880 5 p.

Research output: Contribution to journalArticle

Mannose
Labeling
Photolysis
Concanavalin A
Hydrophobic and Hydrophilic Interactions
3 Citations (Scopus)

Thymidine kinase 1 loss confers trifluridine resistance without affecting 5-fluorouracil metabolism and cytotoxicity

Edahiro, K., Iimori, M., Kobunai, T., Morikawa-Ichinose, T., Miura, D., Kataoka, Y., Niimi, S., Wakasa, T., Saeki, H., Oki, E., Kitao, H. & Maehara, Y., Oct 2018, In : Molecular Cancer Research. 16, 10, p. 1483-1490 8 p.

Research output: Contribution to journalArticle

Trifluridine
Fluorouracil
Pyrimidine Nucleotides
Pharmaceutical Preparations
Cell Line
22 Citations (Scopus)

Top-down descending facilitation of spinal sensory excitatory transmission from the anterior cingulate cortex

Chen, T., Taniguchi, W., Chen, Q. Y., Tozaki-Saitoh, H., Song, Q., Liu, R. H., Koga, K., Matsuda, T., Kaito-Sugimura, Y., Wang, J., Li, Z. H., Lu, Y. C., Inoue, K., Tsuda, M., Li, Y. Q., Nakatsuka, T. & Zhuo, M., Dec 1 2018, In : Nature communications. 9, 1, 1886.

Research output: Contribution to journalArticle

cortexes
Gyrus Cinguli
pain
Modulation
Synaptic Transmission

Triterpene saponins of the root bark of Olax obtusifolia De Wild

Pertuit, D., Mitaine-Offer, A. C., Miyamoto, T., Tanaka, C., Delaude, C. & Lacaille-Dubois, M. A., Dec 1 2018, In : Phytochemistry Letters. 28, p. 174-178 5 p.

Research output: Contribution to journalArticle

Triterpenes
triterpenoid saponins
Saponins
bark
Acids
11 Citations (Scopus)

TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes

Yamaguchi, Y., Iribe, G., Kaneko, T., Takahashi, K., Numaga-Tomita, T., Nishida, M., Birnbaumer, L. & Naruse, K., Mar 1 2018, In : Journal of Physiological Sciences. 68, 2, p. 153-164 12 p.

Research output: Contribution to journalArticle

Angiotensin Type 1 Receptor
Cardiac Myocytes
Angiotensin II Type 1 Receptor Blockers
Type C Phospholipases
Knockout Mice
6 Citations (Scopus)

TRPC5-eNOS axis negatively regulates ATP-induced cardiomyocyte hypertrophy

Sunggip, C., Shimoda, K., Oda, S., Tanaka, T., Nishiyama, K., Mangmool, S., Nishimura, A., Numaga-Tomita, T. & Nishida, M., May 22 2018, In : Frontiers in Pharmacology. 9, MAY, 523.

Research output: Contribution to journalArticle

Cardiac Myocytes
Hypertrophy
Adenosine Triphosphate
NFATC Transcription Factors
Cyclic GMP-Dependent Protein Kinases
3 Citations (Scopus)

Tyrosine Sulfation Restricts the Conformational Ensemble of a Flexible Peptide, Strengthening the Binding Affinity for an Antibody

Miyanabe, K., Yamashita, T., Abe, Y., Akiba, H., Takamatsu, Y., Nakakido, M., Hamakubo, T., Ueda, T., Martinez Caaveiro, J. M. & Tsumoto, K., Jul 17 2018, In : Biochemistry. 57, 28, p. 4177-4185 9 p.

Research output: Contribution to journalArticle

Antibody Affinity
Tyrosine
Peptides
Antibodies
Proteins
1 Citation (Scopus)

Y-box binding protein YBX1 and its correlated genes as biomarkers for poor outcomes in patients with breast cancer

Shibata, T., Tokunaga, E., Hattori, S., Watari, K., Murakami, Y., Yamashita, N., Oki, E., Itou, J., Toi, M., Maehara, Y., Kuwano, M. & Ono, M., Dec 1 2018, In : Oncotarget. 9, 98, p. 37216-37228 13 p.

Research output: Contribution to journalArticle

Carrier Proteins
Biomarkers
Breast Neoplasms
Genes
Databases

フェニルビスオキサゾリンロジウム(III)錯体を用いたα-ケトエステルおよびα-ケチミノエステルに対する直接的触媒的不斉アルキニル化反応の開発

Translated title of the contribution: Development of Direct Enantioselective Alkynylation of α-Ketoester and α-Ketiminoesters Catalyzed by Phenylbis(oxazoline)Rh(III) Complexes森崎一宏, 森本浩之, 真島和志 & 大嶋孝志, 2018, In : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 76, 3, p. 226-240 15 p.

Research output: Contribution to journalArticle

Carbonyl compounds
Rhodium
Catalysts
Proton transfer
Thalidomide

黄色ブドウ球菌の鉄取り込み機構:ISD

Translated title of the contribution: Heme-acquisition in Staphylococcus aureus by the iron-regulated surface determinant (Isd) systemMartinez Caaveiro, J. M. & Tsumoto, K., Jan 1 2018, In : Seikagaku. 90, 3, p. 279-289 11 p.

Research output: Contribution to journalArticle

Heme
Staphylococcus aureus
Iron
2017
1 Citation (Scopus)

7-Hydroxy-3-methyleneisoindolin-1-one as a New ESIPT-Fluorescent Probe to Monitor Aqueous Environments

Kimuro, Y., Usui, K., Karasawa, S., Hirai, G. & Aso, M., 2017, In : Chemical and Pharmaceutical Bulletin. 65, 8, p. 796-800 5 p.

Research output: Contribution to journalArticle

Proton transfer
Fluorescent Dyes
Excited states
Protons
Density functional theory
1 Citation (Scopus)

A dihydrochalcone derivative and further steroidal saponins from Sansevieria trifasciata Prain

Tchegnitegni, B. T., Teponno, R. B., Jenett-Siems, K., Melzig, M. F., Miyamoto, T. & Tapondjou, L. A., Oct 26 2017, In : Zeitschrift fur Naturforschung - Section C Journal of Biosciences. 72, 11-12, p. 477-482 6 p.

Research output: Contribution to journalArticle

Sansevieria
Aconitic Acid
Saponins
Derivatives
Spectroscopic analysis
8 Citations (Scopus)

Administering xCT inhibitors based on circadian clock improves antitumor effects

Okazaki, F., Naoya, M., Hamamura, K., Suzuki, K., Nakao, T., Okazaki, H., Kutsukake, M., Fukumori, S., Tsuji, Y. & To, H., Dec 1 2017, In : Cancer Research. 77, 23, p. 6603-6613 11 p.

Research output: Contribution to journalArticle

Sulfasalazine
Circadian Clocks
Circadian Rhythm
Drug Therapy
Cystine
3 Citations (Scopus)

A host-guest system based on collagen-like triple-helix hybridization

Delsuc, N., Uchinomiya, S., Ojida, A. & Hamachi, I., Jan 1 2017, In : Chemical Communications. 53, 51, p. 6856-6859 4 p.

Research output: Contribution to journalArticle

Collagen
Proteins