Research Output 1976 2020

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2016
7 Citations (Scopus)

Diacylglycerol kinase ζ generates dipalmitoyl-phosphatidic acid species during neuroblastoma cell differentiation

Mizuno, S., Kado, S., Goto, K., Takahashi, D. & Sakane, F., Dec 2016, In : Biochemistry and Biophysics Reports. 8, p. 352-359 8 p.

Research output: Contribution to journalArticle

Diacylglycerol Kinase
Phosphatidic Acids
Neuroblastoma
Cell Differentiation
Tretinoin
8 Citations (Scopus)

Diethylenetriamine-Mediated Direct Cleavage of Unactivated Carbamates and Ureas

Noshita, M., Shimizu, Y., Morimoto, H. & Ohshima, T., Dec 2 2016, In : Organic Letters. 18, 23, p. 6062-6065 4 p.

Research output: Contribution to journalArticle

Carbamates
ureas
Urea
cleavage
Amides
11 Citations (Scopus)

Differential Effect of Membrane Composition on the Pore-Forming Ability of Four Different Sea Anemone Actinoporins

García-Linares, S., Rivera-De-Torre, E., Morante, K., Tsumoto, K., Caaveiro, J. M. M., Gavilanes, J. G., Slotte, J. P. & Martínez-Del-Pozo, Á., Dec 6 2016, In : Biochemistry. 55, 48, p. 6630-6641 12 p.

Research output: Contribution to journalArticle

Sea Anemones
Aptitude
Sphingomyelins
Membranes
Chemical analysis
9 Citations (Scopus)

Different roles of negative and positive components of the circadian clock in oncogene-induced neoplastic transformation

Katamune, C., Koyanagi, S., Shiromizu, S., Matsunaga, N., Shimba, S., Shibata, S. & Ohdo, S., May 13 2016, In : Journal of Biological Chemistry. 291, 20, p. 10541-10550 10 p.

Research output: Contribution to journalArticle

Circadian Clocks
Oncogenes
Clocks
Cell Aging
Fibroblasts
36 Citations (Scopus)
Amination
Amino acids
Derivatives
Catalysis
Amino Acids
8 Citations (Scopus)

DNA cleavage at the AP site via β-elimination mediated by the AP site-binding ligands

Abe, Y. S. & Sasaki, S., Feb 15 2016, In : Bioorganic and Medicinal Chemistry. 24, 4, p. 910-914 5 p.

Research output: Contribution to journalArticle

DNA Cleavage
Binding Sites
Ligands
DNA
Alkylating Agents
49 Citations (Scopus)

Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain

Masuda, T., Ozono, Y., Mikuriya, S., Kohro, Y., Tozaki-Saitoh, H., Iwatsuki, K., Uneyama, H., Ichikawa, R., Salter, M. W., Tsuda, M. & Inoue, K., Aug 12 2016, In : Nature communications. 7, 12529.

Research output: Contribution to journalArticle

Posterior Horn Cells
transporter
pain
adenosine triphosphate
nucleotides
19 Citations (Scopus)

Duloxetine inhibits microglial P2X4 receptor function and alleviates neuropathic pain after peripheral nerve injury

Yamashita, T., Yamamoto, S., Zhang, J., Kometani, M., Tomiyama, D., Kohno, K., Tozaki-Saitoh, H., Inoue, K. & Tsuda, M., Oct 2016, In : PloS one. 11, 10, e0165189.

Research output: Contribution to journalArticle

Purinergic P2X4 Receptors
Peripheral Nerve Injuries
peripheral nerves
Neuralgia
pain
9 Citations (Scopus)

Dysfunction of glutamate receptors in microglia may cause neurodegeneration

Noda, M., Apr 1 2016, In : Current Alzheimer Research. 13, 4, p. 381-386 6 p.

Research output: Contribution to journalArticle

Glutamate Receptors
Microglia
Isoxazoles
Propionates
Ionotropic Glutamate Receptors
6 Citations (Scopus)

Effect of linker length between variable domains of single chain variable fragment antibody against daidzin on its reactivity

Yusakul, G., Sakamoto, S., Pongkitwitoon, B., Tanaka, H. & Morimoto, S., Jan 1 2016, In : Bioscience, Biotechnology and Biochemistry. 80, 7, p. 1306-1312 7 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Bombyx
Nucleopolyhedrovirus
Immunosorbents
Peptides
3 Citations (Scopus)

Effect on catalysis by replacement of catalytic residue from hen egg white lysozyme to Venerupis philippinarum lysozyme*

Abe, Y., Kubota, M., Takazaki, S., Ito, Y., Yamamoto, H., Kang, D., Ueda, T. & Imoto, T., Sep 1 2016, In : Protein Science. p. 1637-1647 11 p.

Research output: Contribution to journalArticle

Egg White
Muramidase
Catalysis
Acetylglucosamine
Decomposition
4 Citations (Scopus)
Epidemiologic Effect Modifiers
Cell proliferation
DNA-Directed DNA Polymerase
Cell Proliferation
Halogens
3 Citations (Scopus)

Effects on deaf patients of medication education by pharmacists

Hyoguchi, N., Kobayashi, D., Kubota, T. & Shimazoe, T., Oct 1 2016, In : Journal of Deaf Studies and Deaf Education. 21, 4, p. 416-421 6 p.

Research output: Contribution to journalArticle

pharmacist
Patient Education
Pharmacists
Hearing
medication
5 Citations (Scopus)
Nucleopolyhedrovirus
Single-Chain Antibodies
Bombyx
Paclitaxel
docetaxel
2 Citations (Scopus)
Deoxyribose
Thioguanine
Crosslinking
Thymidine
Nucleic Acids

Emission characteristics of paliperidone from invega™ tablets in one-dose packages and the evaluation of patients

Kito, H., Ishida, Y., Kunimi, M., Morooka, Y., Hirowatari, T., Akamine, T., Hashimoto, H., Koyanagi, S., Ohdo, S. & Kamimura, H., Jan 1 2016, In : Japanese Pharmacology and Therapeutics. 44, 1, p. 65-69 5 p.

Research output: Contribution to journalArticle

Tablets
Delayed-Action Preparations
Medication Adherence
Paliperidone Palmitate
Osmotic Pressure
14 Citations (Scopus)

Enantioselective determination of citrulline and ornithine in the urine of D-amino acid oxidase deficient mice using a two-dimensional high-performance liquid chromatographic system

Koga, R., Miyoshi, Y., Sato, Y., Mita, M., Konno, R., Lindner, W. & Hamase, K., Oct 7 2016, In : Journal of Chromatography A. 1467, p. 312-317 6 p.

Research output: Contribution to journalArticle

D-Amino-Acid Oxidase
Citrulline
Ornithine
Enantiomers
Urine
3 Citations (Scopus)

Ephedrae herba stimulates hepatocyte growth factor-induced MET endocytosis and downregulation via early/late endocytic pathways in gefitinib-resistant human lung cancer cells

Nishimura, Y., Hyuga, S., Takiguchi, S., Hyuga, M., Itoh, K. & Hanawa, T., May 2016, In : International journal of oncology. 48, 5, p. 1895-1906 12 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Endocytosis
Lung Neoplasms
Down-Regulation
Endosomes
15 Citations (Scopus)

Fluorescence probes to detect lipid-derived radicals

Yamada, K. I., Mito, F., Matsuoka, Y., Ide, S., Shikimachi, K., Fujiki, A., Kusakabe, D., Ishida, Y., Enoki, M., Tada, A., Ariyoshi, M., Yamasaki, T. & Yamato, M., Aug 1 2016, In : Nature Chemical Biology. 12, 8, p. 608-613 6 p.

Research output: Contribution to journalArticle

Fluorescence
Lipids
Diethylnitrosamine
Apoptosis
Inflammation
31 Citations (Scopus)

Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia

Koyanagi, S., Kusunose, N., Taniguchi, M., Akamine, T., Kanado, Y., Ozono, Y., Masuda, T., Kohro, Y., Matsunaga, N., Tsuda, M., Salter, M. W., Inoue, K. & Ohdo, S., Oct 14 2016, In : Nature communications. 7, 13102.

Research output: Contribution to journalArticle

glucocorticoids
pain
adenosine triphosphate
Hyperalgesia
Astrocytes
13 Citations (Scopus)

Identification of a membrane-bound prepore species clarifies the lytic mechanism of actinoporins

Morante, K., Bellomio, A., Gil-Cartón, D., Redondo-Morata, L., Sot, J., Scheuring, S., Valle, M., González-Mañas, J. M., Tsumoto, K. & Caaveiro, J. M. M., Sep 9 2016, In : Journal of Biological Chemistry. 291, 37, p. 19210-19219 10 p.

Research output: Contribution to journalArticle

Open Access
Sea Anemones
Cryoelectron Microscopy
Atomic Force Microscopy
Military operations
Cell membranes
13 Citations (Scopus)

Identification of a Potent and Selective GPR4 Antagonist as a Drug Lead for the Treatment of Myocardial Infarction

Fukuda, H., Ito, S., Watari, K., Mogi, C., Arisawa, M., Okajima, F., Kurose, H. & Shuto, S., May 12 2016, In : ACS Medicinal Chemistry Letters. 7, 5, p. 493-497 5 p.

Research output: Contribution to journalArticle

Lead compounds
Endothelial cells
G-Protein-Coupled Receptors
Myocardial Infarction
Tissue
3 Citations (Scopus)

Identification of immunoglobulin gene sequences from a small read number of mRNA-seq using hybridomas

Kuniyoshi, Y., Maehara, K., Iwasaki, T., Hayashi, M., Semba, Y., Fujita, M., Sato, Y., Kimura, H., Harada, A. & Ohkawa, Y., Oct 2016, In : PloS one. 11, 10, e0165473.

Research output: Contribution to journalArticle

immunoglobulin genes
Immunoglobulin Genes
hybridomas
Hybridomas
Immunoglobulins
2 Citations (Scopus)

Identification of novel secreted fatty acids that regulate nitrogen catabolite repression in fission yeast

Sun, X., Hirai, G., Ueki, M., Hirota, H., Wang, Q., Hongo, Y., Nakamura, T., Hitora, Y., Takahashi, H., Sodeoka, M., Osada, H., Hamamoto, M., Yoshida, M. & Yashiroda, Y., Feb 19 2016, In : Scientific reports. 6, 20856.

Research output: Contribution to journalArticle

Catabolite Repression
Schizosaccharomyces
Nitrogen
Fatty Acids
Amino Acids
7 Citations (Scopus)

Immunochromatographic strip assay for detection of bioactive Ganoderma triterpenoid, ganoderic acid A in Ganoderma lingzhi

Sakamoto, S., Kikkawa, N., Kohno, T., Shimizu, K., Tanaka, H. & Morimoto, S., Oct 1 2016, In : Fitoterapia. 114, p. 51-55 5 p.

Research output: Contribution to journalArticle

Ganoderma
Immunochromatography
Reishi
Agaricales
Gold Colloid
8 Citations (Scopus)

Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice

Watari, K., Shibata, T., Nabeshima, H., Shinoda, A., Fukunaga, Y., Kawahara, A., Karasuyama, K., Fukushi, J. I., Iwamoto, Y., Kuwano, M. & Ono, M., Jan 18 2016, In : Scientific reports. 6, 19470.

Research output: Contribution to journalArticle

Bone Remodeling
Macrophages
Knockout Mice
Genes
Osteoclasts
5 Citations (Scopus)

Improved quality of life in patients with no-option critical limb ischemia undergoing gene therapy with DVC1-0101

Matsumoto, T., Tanaka, M., Yoshiya, K., Yoshiga, R., Matsubara, Y., Horiuchi-Yoshida, K., Yonemitsu, Y. & Maehara, Y., Jul 15 2016, In : Scientific reports. 6, 30035.

Research output: Contribution to journalArticle

Genetic Therapy
Ischemia
Extremities
Quality of Life
Sendai virus
1 Citation (Scopus)

In-Cell Enzymology to Probe His-Heme Ligation in Heme Oxygenase Catalysis

Sigala, P. A., Morante, K., Tsumoto, K., Caaveiro, J. M. M. & Goldberg, D. E., Aug 30 2016, In : Biochemistry. 55, 34, p. 4836-4849 14 p.

Research output: Contribution to journalArticle

Heme Oxygenase (Decyclizing)
Catalysis
Heme
Ligation
Biliverdine
4 Citations (Scopus)

Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease

Matsunaga, N., Ikeda, E., Kakimoto, K., Watanabe, M., Shindo, N., Tsuruta, A., Ikeyama, H., Hamamura, K., Higashi, K., Yamashita, T., Kondo, H., Yoshida, Y., Matsuda, M., Ogino, T., Tokushige, K., Itcho, K., Furuichi, Y., Nakao, T., Yasuda, K., Doi, A. & 7 others, Amamoto, T., Aramaki, H., Tsuda, M., Inoue, K., Ojida, A., Koyanagi, S. & Ohdo, S., Nov 1 2016, In : EBioMedicine. 13, p. 262-273 12 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Switches
Inflammation
Kidney
Gene encoding
4 Citations (Scopus)
Derivatives
Antineoplastic Agents
Cell Survival
Cells
Substrates
31 Citations (Scopus)

Interplay between microbial d-amino acids and host d-amino acid oxidase modifies murine mucosal defence and gut microbiota

Sasabe, J., Miyoshi, Y., Rakoff-Nahoum, S., Zhang, T., Mita, M., Davis, B. M., Hamase, K. & Waldor, M. K., Jul 25 2016, In : Nature Microbiology. 1, 16125.

Research output: Contribution to journalArticle

Oxidoreductases
Amino Acids
Microbiota
Small Intestine
Gastrointestinal Microbiome
8 Citations (Scopus)

Intracellular delivery of chemical probes using a glutathione-responsive traceless tag

Aoyama, E., Fuchida, H., Oshikawa, Y., Uchinomiya, S. & Ojida, A., Jan 1 2016, In : Chemical Communications. 52, 49, p. 7715-7718 4 p.

Research output: Contribution to journalArticle

Glutathione
Molecules
2 Citations (Scopus)

Introduction of an N-glycosylation site into UDP-glucuronosyltransferase 2B3 alters its sensitivity to cytochrome P450 3A1-dependent modulation

Nakamura, T., Yamaguchi, N., Miyauchi, Y., Takeda, T., Yamazoe, Y., Nagata, K., Mackenzie, P. I., Yamada, H. & Ishii, Y., Nov 14 2016, In : Frontiers in Pharmacology. 7, NOV, 427.

Research output: Contribution to journalArticle

Glucuronosyltransferase
Glycosylation
Cytochrome P-450 Enzyme System
Cytochrome P-450 CYP3A
Hymecromone
5 Citations (Scopus)

Isomeric iodinated analogs of nimesulide: Synthesis, physicochemical characterization, cyclooxygenase-2 inhibitory activity, and transport across Caco-2 cells

Yamamoto, Y., Arai, J., Hisa, T., Saito, Y., Mukai, T., Ohshima, T., Maeda, M. & Yamamoto, F., Jan 1 2016, In : Bioorganic and Medicinal Chemistry. 24, 16, p. 3727-3733 7 p.

Research output: Contribution to journalArticle

nimesulide
Caco-2 Cells
Cyclooxygenase 2
Brain
Celecoxib
6 Citations (Scopus)

Long inverted repeat transiently stalls DNA replication by forming hairpin structures on both leading and lagging strands

Lai, P. J., Lim, C. T., Le, H. P., Katayama, T., Leach, D. R. F., Furukohri, A. & Maki, H., Feb 1 2016, In : Genes to Cells. 21, 2, p. 136-145 10 p.

Research output: Contribution to journalArticle

DNA Replication
Cruciform DNA
Plasmids
DNA
Exonucleases
4 Citations (Scopus)

Lung adenocarcinoma may be a more susceptive subtype to a dendritic cell-based cancer vaccine than other subtypes of non-small cell lung cancers: a multicenter retrospective analysis

Takahashi, H., Shimodaira, S., Ogasawara, M., Ota, S., Kobayashi, M., Abe, H., Morita, Y., Nagai, K., Tsujitani, S., Okamoto, M., Suzuki, Y., Nakanishi, Y., Yonemitsu, Y. & for the DC Vaccine Study Group at the Japanese Society of Immunotherapy, T. DC. V. S. G. A. T. J. S. O. I., Sep 1 2016, In : Cancer Immunology, Immunotherapy. 65, 9, p. 1099-1111 13 p.

Research output: Contribution to journalArticle

Cancer Vaccines
Non-Small Cell Lung Carcinoma
Dendritic Cells
Vaccines
Erythema
30 Citations (Scopus)
Rhodium
Substrates
Alkynes
Acetic acid
Acetic Acid
20 Citations (Scopus)

Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells

Unoki, T., Abiko, Y., Toyama, T., Uehara, T., Tsuboi, K., Nishida, M., Kaji, T. & Kumagai, Y., Jun 30 2016, In : Scientific reports. 6, 28944.

Research output: Contribution to journalArticle

Signal Transduction
Cell Survival
Apoptosis Regulatory Proteins
Neuroblastoma
Phosphatidylinositol 3-Kinases
55 Citations (Scopus)

Microglia in the spinal cord and neuropathic pain

Tsuda, M., Jan 1 2016, In : Journal of Diabetes Investigation. 7, 1, p. 17-26 10 p.

Research output: Contribution to journalArticle

Microglia
Neuralgia
Spinal Cord
Purinergic P2X4 Receptors
Pain
2 Citations (Scopus)

Micro-scale and rapid expression screening of highly expressed and/or stable membrane protein variants in Saccharomyces cerevisiae

Shiroishi, M., Moriya, M. & Ueda, T., Oct 1 2016, In : Protein Science. p. 1863-1872 10 p.

Research output: Contribution to journalArticle

Yeast
Saccharomyces cerevisiae
Screening
Membrane Proteins
Gel Chromatography
15 Citations (Scopus)

Near-atomic structural model for bacterial DNA replication initiation complex and its functional insights

Shimizu, M., Noguchi, Y., Sakiyama, Y., Kawakami, H., Katayama, T. & Takada, S., Dec 13 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. E8021-E8030

Research output: Contribution to journalArticle

Bacterial DNA
Structural Models
DNA Replication
DNA
DnaB Helicases
5 Citations (Scopus)

New pregnane and phenolic glycosides from Solenostemma argel

Ounaissia, K., Pertuit, D., Mitaine-Offer, A. C., Miyamoto, T., Tanaka, C., Delemasure, S., Dutartre, P., Smati, D. & Lacaille-Dubois, M. A., Oct 1 2016, In : Fitoterapia. 114, p. 98-104 7 p.

Research output: Contribution to journalArticle

Poisons
Glycosides
Tumor Cell Line
Antioxidants
pregnane glycoside
4 Citations (Scopus)
Nucleosomes
Carrier Proteins
Replication Origin
Histones
Chromatin
6 Citations (Scopus)

Oleanolic acid and hederagenin glycosides from Weigela stelzneri

Rezgui, A., Mitaine-Offer, A. C., Miyamoto, T., Tanaka, C., Delemasure, S., Dutartre, P. & Lacaille-Dubois, M. A., Mar 1 2016, In : Phytochemistry. 123, p. 40-47 8 p.

Research output: Contribution to journalArticle

Weigela
Oleanolic Acid
oleanolic acid
Glycosides
glycosides
17 Citations (Scopus)
Metal ions
metal ions
pyridines
Magnetic properties
Crystal structure
3 Citations (Scopus)

Participation of D-serine in the development and reproduction of the silkworm Bombyx mori

Tanigawa, M., Suzuki, C., Niwano, K., Kanekatsu, R., Tanaka, H., Horiike, K., Hamase, K. & Nagata, Y., Apr 1 2016, In : Journal of insect physiology. 87, p. 20-29 10 p.

Research output: Contribution to journalArticle

Bombyx
Bombyx mori
silkworms
serine
Serine
12 Citations (Scopus)

Peritoneal dissemination requires an Sp1-dependent CXCR4/CXCL12 signaling axis and extracellular matrix-directed spheroid formation

Kasagi, Y., Harada, Y., Morodomi, Y., Iwai, T., Saito, S., Yoshida, K., Oki, E., Saeki, H., Ohgaki, K., Sugiyama, M., Onimaru, M., Maehara, Y. & Yonemitsu, Y., Jan 15 2016, In : Cancer Research. 76, 2, p. 347-357 11 p.

Research output: Contribution to journalArticle

Extracellular Matrix
Peritoneal Cavity
Neoplasms
Peritoneal Lavage
Gastrointestinal Neoplasms
4 Citations (Scopus)

Phosphorylation of mTOR Ser2481 is a key target limiting the efficacy of rapalogs for treating hepatocellular carcinoma

Watari, K., Nishitani, A., Shibata, T., Noda, M., Kawahara, A., Akiba, J., Murakami, Y., Yano, H., Kuwano, M. & Ono, M., Jan 1 2016, In : Oncotarget. 7, 30, p. 47403-47417 15 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Phosphorylation
Sirolimus
Neoplasms
Biomarkers
8 Citations (Scopus)

Photodecomposition of tetrabromobisphenol A in aqueous humic acid suspension by irradiation with light of various wavelengths

Han, S. K., Yamasaki, T. & Yamada, K. I., Mar 1 2016, In : Chemosphere. 147, p. 124-130 7 p.

Research output: Contribution to journalArticle

Humic Substances
humic acid
Suspensions
irradiation
Irradiation
3 Citations (Scopus)

Polaprezinc reduces paclitaxel-induced peripheral neuropathy in rats without affecting anti-tumor activity

Tsutsumi, K., Kaname, T., Shiraishi, H., Kawashiri, T. & Egashira, N., Jun 1 2016, In : Journal of Pharmacological Sciences. 131, 2, p. 146-149 4 p.

Research output: Contribution to journalArticle

polaprezinc
Peripheral Nervous System Diseases
Paclitaxel
Neoplasms
Hyperalgesia