Research Output 1976 2020

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2016
1 Citation (Scopus)

Population pharmacodynamic analysis of hemoglobin A1c-lowering effects by adding treatment of DPP-4 inhibitors (sitagliptin) in type 2 diabetes mellitus patients based on electronic medical records

Kakara, M., Nomura, H., Ezaki, M., Fukae, M., Hirota, T., Matsubayashi, S., Hirakawa, M. & Ieiri, I., Sep 1 2016, In : Journal of Diabetes and Its Complications. 30, 7, p. 1282-1286 5 p.

Research output: Contribution to journalArticle

Electronic Health Records
pioglitazone
Type 2 Diabetes Mellitus
Hemoglobins
Population
9 Citations (Scopus)

Population pharmacokinetic–pharmacodynamic modeling and model-based prediction of docetaxel-induced neutropenia in Japanese patients with non-small cell lung cancer

Fukae, M., Shiraishi, Y., Hirota, T., Sasaki, Y., Yamahashi, M., Takayama, K., Nakanishi, Y. & Ieiri, I., Nov 1 2016, In : Cancer chemotherapy and pharmacology. 78, 5, p. 1013-1023 11 p.

Research output: Contribution to journalArticle

docetaxel
Neutropenia
Non-Small Cell Lung Carcinoma
Cells
Population
1 Citation (Scopus)

Prediction of intracellular localization of fluorescent dyes using QSAR Models

Uchinomiya, S., Horobin, R. W., Alvarado-Martínez, E., Peña-Cabrera, E. & Chang, Y. T., Jun 1 2016, In : Combinatorial Chemistry and High Throughput Screening. 19, 5, p. 378-383 6 p.

Research output: Contribution to journalArticle

Fluorescent Dyes
Coloring Agents
Dyes
Optical Imaging
Lysosomes
7 Citations (Scopus)

Preparation and application of a monoclonal antibody against the isoflavone glycoside daidzin using a mannich reaction-derived hapten conjugate

Yusakul, G., Sakamoto, S., Juengwatanatrakul, T., Putalun, W., Tanaka, H. & Morimoto, S., Jan 1 2016, In : Phytochemical Analysis. 27, 1, p. 81-88 8 p.

Research output: Contribution to journalArticle

daidzin
haptens
Isoflavones
Haptens
isoflavones
7 Citations (Scopus)

Prescription factors associated with medication non-adherence in Japan assessed from leftover drugs in the SETSUYAKU-BAG campaign: Focus on oral antidiabetic drugs

Koyanagi, K., Kubota, T., Kobayashi, D., Kihara, T., Yoshida, T., Miisho, T., Miura, T., Sakamoto, Y., Takaki, J., Seo, T. & Shimazoe, T., Jul 20 2016, In : Frontiers in Pharmacology. 7, JUL, 212.

Research output: Contribution to journalArticle

Medication Adherence
Hypoglycemic Agents
Prescriptions
Japan
Pharmaceutical Preparations
8 Citations (Scopus)

Professional behaviours and factors contributing to nursing professionalism among nurse managers

Tanaka, M., Taketomi, K., Yonemitsu, Y. & Kawamoto, R., Jan 1 2016, In : Journal of Nursing Management. 24, 1, p. 12-20 9 p.

Research output: Contribution to journalArticle

Nurse Administrators
Nursing
Japan
Professionalism
Nursing Education
31 Citations (Scopus)

Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension

Nishimura, A., Sunggip, C., Tozaki-Saitoh, H., Shimauchi, T., Numaga-Tomita, T., Hirano, K., Ide, T., Boeynaems, J. M., Kurose, H., Tsuda, M., Robaye, B., Inoue, K. & Nishida, M., Jan 19 2016, In : Science Signaling. 9, 411, aac9187.

Research output: Contribution to journalArticle

Purinergic Receptors
Angiotensin Type 1 Receptor
Angiotensin II
Hypertension
Arrestin
1 Citation (Scopus)
Origin Recognition Complex
Saccharomyces cerevisiae
Yeasts
Genetic Phenomena
Saccharomycetales
20 Citations (Scopus)

Rational Design and Synthesis of [5]Helicene-Derived Phosphine Ligands and Their Application in Pd-Catalyzed Asymmetric Reactions

Yamamoto, K., Shimizu, T., Igawa, K., Tomooka, K., Hirai, G., Suemune, H. & Usui, K., Nov 8 2016, In : Scientific reports. 6, 36211.

Research output: Contribution to journalArticle

phosphine
Ligands
Indoles
Acetates
Alcohols
10 Citations (Scopus)

Rational syntheses of helical π-conjugated oligopyrrins with a bipyrrole linkage: Geometry control of bis-copper(II) coordination

Zhang, K., Savage, M., Li, X., Jiang, Y., Ishida, M., Mitsuno, K., Karasawa, S., Kato, T., Zhu, W., Yang, S., Furuta, H. & Xie, Y., Jan 1 2016, In : Chemical Communications. 52, 29, p. 5148-5151 4 p.

Research output: Contribution to journalArticle

Copper
Geometry
2 Citations (Scopus)
Fluorescent Dyes
Adenosine
RNA
DNA
Deoxyadenosines
7 Citations (Scopus)

Regioselective Photocyclizations of Di(quinolinyl)arylamines and Tri(quinolinyl)amine with Emission Color Changes and Photoreaction-Induced Self-Assemblies

Karasawa, S., Todo, J. I., Usui, K., Harada, N., Yoza, K., Suemune, H. & Koga, N., Jun 1 2016, In : Chemistry - A European Journal. 22, 23, p. 7771-7781 11 p.

Research output: Contribution to journalArticle

Self assembly
Amines
Color
Derivatives
Fluorophores
2 Citations (Scopus)

Relationship between the magnitude of IgE production in mice and conformational stability of the house dust mite allergen, Der p 2

Nakamura, H., Ohkuri, T., So, T. & Ueda, T., Oct 1 2016, In : Biochimica et Biophysica Acta - General Subjects. 1860, 10, p. 2279-2284 6 p.

Research output: Contribution to journalArticle

Dermatophagoides Antigens
Immunoglobulin E
Antigens
Denaturation
Proteins
5 Citations (Scopus)

RhoA mediates the expression of acidic extracellular pH-induced matrix metalloproteinase-9 mRNA through phospholipase D1 in mouse metastatic B16-BL6 melanoma cells

Maeda, T., Yuzawa, S., Suzuki, A., Baba, Y., Nishimura, Y. & Kato, Y., Mar 2016, In : International journal of oncology. 48, 3, p. 1251-1257 7 p.

Research output: Contribution to journalArticle

Experimental Melanomas
Matrix Metalloproteinase 9
Messenger RNA
Phospholipase D
Small Interfering RNA

Role of IRF transcription factor family in regulating reactive phenotype of microglia

Masuda, T., Tsuda, M. & Inoue, K., Jan 1 2016, In : Seikagaku. 88, 1, p. 124-127 4 p.

Research output: Contribution to journalArticle

Interferon Regulatory Factors
Animals
Transcription Factors
Microglia
5 Citations (Scopus)

Site-Specific Turn-On Fluorescent Labeling of DNA-Interacting Protein Using Oligodeoxynucleotides That Modify Lysines to Produce 5,6-Dimethoxy 3-Methyleneisoindolin-1-one

Gatanaga, C., Yang, B., Inadomi, Y., Usui, K., Ota, C., Katayama, T., Suemune, H. & Aso, M., Aug 19 2016, In : ACS Chemical Biology. 11, 8, p. 2216-2221 6 p.

Research output: Contribution to journalArticle

Oligodeoxyribonucleotides
Labeling
Lysine
DNA
Proteins
19 Citations (Scopus)

Structural basis for broad neutralization of HIV-1 through the molecular recognition of 10E8 helical epitope at the membrane interface.

Rujas, E., Caaveiro, J. M. M., Partida-Hanon, A., Gulzar, N., Morante, K., Apellaniz, B., García-Porras, M., Bruix, M., Tsumoto, K., Scott, J. K., Jimenez, M. A. & Nieva, J. L., 2016, In : Scientific Reports. 6, 13 p., 38177.

Research output: Contribution to journalArticle

Open Access
HIV-1
Epitopes
Membranes
Complementarity Determining Regions
Peptides
9 Citations (Scopus)

Studies of the Electronic Effects of Zinc Cluster Catalysts and Their Application to the Transesterification of β-Keto Esters

Agura, K., Hayashi, Y., Wada, M., Nakatake, D., Mashima, K. & Ohshima, T., May 20 2016, In : Chemistry - An Asian Journal. 11, 10, p. 1548-1554 7 p.

Research output: Contribution to journalArticle

Transesterification
Zinc
Esters
Catalysts
Alkalinity
13 Citations (Scopus)

Sustained βAR stimulation mediates cardiac insulin resistance in a PKA-dependent manner

Mangmool, S., Denkaew, T., Phosri, S., Pinthong, D., Parichatikanond, W., Shimauchi, T. & Nishida, M., Jan 1 2016, In : Molecular Endocrinology. 30, 1, p. 118-132 15 p.

Research output: Contribution to journalArticle

Adrenergic Receptors
Insulin Resistance
Cyclic AMP-Dependent Protein Kinases
Insulin
Cardiac Myocytes
14 Citations (Scopus)

Synergistic antiproliferative effects of zoledronic acid and fluvastatin on human pancreatic cancer cell lines: An in Vitro study

Elsayed, M., Kobayashi, D., Kubota, T., Matsunaga, N., Murata, R., Yoshizawa, Y., Watanabe, N., Matsuura, T., Tsurudome, Y., Ogino, T., Ohdo, S. & Shimazoe, T., Jan 1 2016, In : Biological and Pharmaceutical Bulletin. 39, 8, p. 1238-1246 9 p.

Research output: Contribution to journalArticle

zoledronic acid
fluvastatin
Pancreatic Neoplasms
Prenylation
Hydroxymethylglutaryl-CoA Reductase Inhibitors
1 Citation (Scopus)

Synthesis and Electron Paramagnetic Resonance Studies of Oligodeoxynucleotides Containing 2-N-tert-Butylaminoxyl-2′-deoxyadenosines

Kurita, M., Higuchi, Y., Mirc, J. W., Matsumoto, S., Usui, K., Suemune, H. & Aso, M., Dec 14 2016, In : ChemBioChem. 17, 24, p. 2346-2352 7 p.

Research output: Contribution to journalArticle

Oligodeoxyribonucleotides
Electron Spin Resonance Spectroscopy
Paramagnetic resonance
Monitoring
Adenine
3 Citations (Scopus)

Synthesis of radioiodinated probes to evaluate the biodistribution of a potent TRPC3 inhibitor

Hagimori, M., Murakami, T., Shimizu, K., Nishida, M., Ohshima, T. & Mukai, T., Jan 1 2016, In : MedChemComm. 7, 5, p. 1003-1006 4 p.

Research output: Contribution to journalArticle

Therapeutic Human Experimentation
HEK293 Cells
Treatment Failure
Heart Failure
Cell Membrane
3 Citations (Scopus)

Synthetic receptor molecules for selective fluorescence detection of 8-oxo-dGTP in aqueous media

Fuchi, Y., Fukuda, T. & Sasaki, S., Jan 1 2016, In : Organic and Biomolecular Chemistry. 14, 33, p. 7949-7955 7 p.

Research output: Contribution to journalArticle

Artificial Receptors
Fluorescence
fluorescence
Molecules
molecules
6 Citations (Scopus)

TEMPOL increases NAD+ and improves redox imbalance in obese mice

Yamato, M., Kawano, K., Yamanaka, Y., Saiga, M. & Yamada, K. I., Aug 1 2016, In : Redox Biology. 8, p. 316-322 7 p.

Research output: Contribution to journalArticle

Obese Mice
NAD
Oxidation
Nutrition
Diet
7 Citations (Scopus)
Prophages
Multigene Family
Escherichia coli
Hydroxyurea
Proteins
4 Citations (Scopus)

The relation between hepatotoxicity and the total coumarin intake from traditional Japanese medicines containing cinnamon bark

Iwata, N., Kainuma, M., Kobayashi, D., Kubota, T., Sugawara, N., Uchida, A., Ozono, S., Yamamuro, Y., Furusyo, N., Ueda, K., Tahara, E. & Shimazoe, T., Jun 20 2016, In : Frontiers in Pharmacology. 7, JUN, 174.

Research output: Contribution to journalArticle

Kampo Medicine
Cinnamomum zeylanicum
Traditional Medicine
No-Observed-Adverse-Effect Level
coumarin
6 Citations (Scopus)

Thermal- and pH-Dependent Size Variable Radical Nanoparticles and Its Water Proton Relaxivity for Metal-Free MRI Functional Contrast Agents

Morishita, K., Murayama, S., Araki, T., Aoki, I. & Karasawa, S., Sep 16 2016, In : Journal of Organic Chemistry. 81, 18, p. 8351-8362 12 p.

Research output: Contribution to journalArticle

Contrast Media
Protons
Metals
Magnetic resonance imaging
Nanoparticles
2 Citations (Scopus)

Total synthesis of natural derivatives and artificial analogs of 13-oxyingenol and their biological evaluation

Ohyoshi, T., Tamura, Y., Hayakawa, I., Hirai, G., Miyazawa, Y., Funakubo, S., Sodeoka, M. & Kigoshi, H., Jan 1 2016, In : Organic and Biomolecular Chemistry. 14, 48, p. 11426-11437 12 p.

Research output: Contribution to journalArticle

Protein Kinase C
analogs
Derivatives
proteins
evaluation
12 Citations (Scopus)

Transesterification Reactions Catalyzed by a Recyclable Heterogeneous Zinc/Imidazole Catalyst

Nakatake, D., Yazaki, R., Matsushima, Y. & Ohshima, T., Jan 1 2016, In : Advanced Synthesis and Catalysis. 358, 15, p. 2569-2574 6 p.

Research output: Contribution to journalArticle

Transesterification
Zinc
Catalysts
Catalysis
Catalyst activity
3 Citations (Scopus)

Trifasciatosides A-J, steroidal saponins from Sansevieria trifasciata

Teponno, R. B., Tanaka, C., Jie, B., Tapondjou, L. A. & Miyamoto, T., Jan 1 2016, In : Chemical and Pharmaceutical Bulletin. 64, 9, p. 1347-1355 9 p.

Research output: Contribution to journalArticle

Sansevieria
Saponins
Spectrum Analysis
Spectroscopy
Nuclear magnetic resonance
22 Citations (Scopus)

Trisaccharide containing α2,3-linked sialic acid is a receptor for mumps virus

Kubota, M., Takeuchi, K., Watanabe, S., Ohno, S., Matsuoka, R., Kohda, D., Nakakita, S. I., Hiramatsu, H., Suzuki, Y., Nakayama, T., Terada, T., Shimizu, K., Shimizu, N., Shiroishi, M., Yanagi, Y. & Hashiguchi, T., Oct 11 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 41, p. 11579-11584 6 p.

Research output: Contribution to journalArticle

Mumps virus
Trisaccharides
N-Acetylneuraminic Acid
Mumps
Polysaccharides
2 Citations (Scopus)

TRPC3 amplifies B-cell receptor-induced ERK signalling via protein kinase D-dependent Rap1 activation

Numaga-Tomita, T., Nishida, M., Putney, J. W. & Mori, Y., Jan 15 2016, In : Biochemical Journal. 473, 2, p. 201-210 10 p.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
B-Lymphocytes
Chemical activation
Cells
Lymphocytes
20 Citations (Scopus)

TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis

Numaga-Tomita, T., Kitajima, N., Kuroda, T., Nishimura, A., Miyano, K., Yasuda, S., Kuwahara, K., Sato, Y., Ide, T., Birnbaumer, L., Sumimoto, H., Mori, Y. & Nishida, M., Dec 19 2016, In : Scientific reports. 6, 39383.

Research output: Contribution to journalArticle

Cardiac Myocytes
Fibrosis
Microtubules
Pressure
Fibroblasts
33 Citations (Scopus)

TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling

Kitajima, N., Numaga-Tomita, T., Watanabe, M., Kuroda, T., Nishimura, A., Miyano, K., Yasuda, S., Kuwahara, K., Sato, Y., Ide, T., Birnbaumer, L., Sumimoto, H., Mori, Y. & Nishida, M., Nov 11 2016, In : Scientific reports. 6, 37001.

Research output: Contribution to journalArticle

NADPH Oxidase
Reactive Oxygen Species
Physiological Adaptation
Proteasome Endopeptidase Complex
Cardiac Myocytes
4 Citations (Scopus)

Ultrasensitive time-resolved fluoroimmunoassay for saikosaponin a in Chaihu (Bupleuri Radix)

Chao, Z., Cui, Q., Tian, E., Zeng, W., Cai, X., Li, X., Tanaka, H., Shoyama, Y. & Wu, Y., Mar 2016, In : PloS one. 11, 3, e0151032.

Research output: Contribution to journalArticle

Fluoroimmunoassay
Assays
assays
drugs
mice
12 Citations (Scopus)

Up-Regulation of Oligodendrocyte Lineage Markers in the Cerebellum of Autistic Patients: Evidence from Network Analysis of Gene Expression

Zeidán-Chuliá, F., de Oliveira, B. H. N., Casanova, M. F., Casanova, E. L., Noda, M., Salmina, A. B. & Verkhratsky, A., Aug 1 2016, In : Molecular Neurobiology. 53, 6, p. 4019-4025 7 p.

Research output: Contribution to journalArticle

Oligodendroglia
Cerebellum
Up-Regulation
Autistic Disorder
Gene Expression
11 Citations (Scopus)
Amino alcohols
Amino Alcohols
Acylation
Transesterification
Alcohols
2015

10,10'-dimethoxy-9,9'-biazuleno[2,1-c]phenanthrene

Yamamoto, K., Nakamae, R., Suemune, H. & Usui, K., Jan 1 2015, In : MolBank. 2015, 1, p. 1-4 4 p.

Research output: Contribution to journalArticle

phenanthrene
Electrochemical properties
Crystal structure
Nuclear magnetic resonance
nuclear magnetic resonance
5 Citations (Scopus)

A new aromatic compound from the stem bark of Terminalia catappa

Pertuit, D., Mitaine-Offer, A. C., Miyamoto, T., Tanaka, C., Delemasure, S., Dutartre, P. & Lacaille-Dubois, M. A., Jan 1 2015, In : Natural Product Communications. 10, 6, p. 1005-1007 3 p.

Research output: Contribution to journalArticle

Terminalia catappa
Terminalia
triterpene acids
Triterpenes
sitosterols
28 Citations (Scopus)

A new minimally-invasive method for microinjection into the mouse spinal dorsal horn

Kohro, Y., Sakaguchi, E., Tashima, R., Tozaki-Saitoh, H., Okano, H., Inoue, K. & Tsuda, M., Sep 21 2015, In : Scientific reports. 5, 14306.

Research output: Contribution to journalArticle

Microinjections
Laminectomy
Inflammation
Gene Expression
Peripheral Nerve Injuries
4 Citations (Scopus)

A novel anti-microtubule agent with carbazole and benzohydrazide structures suppresses tumor cell growth in vivo

Ohira, M., Iwasaki, Y., Tanaka, C., Kuroki, M., Matsuo, N., Kitamura, T., Yukuhiro, M., Morimoto, H., Pang, N., Liu, B., Kiyono, T., Amemiya, M., Tanaka, K., Yoshida, K., Sugimoto, N., Ohshima, T. & Fujita, M., May 19 2015, In : Biochimica et Biophysica Acta - General Subjects. 1850, 9, p. 1676-1684 9 p.

Research output: Contribution to journalArticle

Cell growth
Microtubules
Tumors
Cells
Growth
7 Citations (Scopus)

Basic and aromatic residues in the C-terminal domain of PriC are involved in ssDNA and SSB binding

Aramaki, T., Abe, Y., Furutani, K., Katayama, T. & Ueda, T., Jan 1 2015, In : Journal of Biochemistry. 157, 6, p. 529-537 9 p.

Research output: Contribution to journalArticle

Single-Stranded DNA
DNA-Binding Proteins
Protein Binding
Basic Amino Acids
Aromatic Amino Acids
18 Citations (Scopus)

Behavioral and pharmacological characteristics of bortezomib-induced peripheral neuropathy in rats

Yamamoto, S., Kawashiri, T., Higuchi, H., Tsutsumi, K., Ushio, S., Kaname, T., Shirahama, M. & Egashira, N., Oct 9 2015, In : Journal of Pharmacological Sciences. 129, 1, p. 43-50 8 p.

Research output: Contribution to journalArticle

Peripheral Nervous System Diseases
Pharmacology
Hyperalgesia
Sciatic Nerve
Analgesics
7 Citations (Scopus)

Bioconjugation of Oligodeoxynucleotides Carrying 1,4-Dicarbonyl Groups via Reductive Amination with Lysine Residues

Yang, B., Jinnouchi, A., Usui, K., Katayama, T., Fujii, M., Suemune, H. & Aso, M., Aug 19 2015, In : Bioconjugate Chemistry. 26, 8, p. 1830-1838 9 p.

Research output: Contribution to journalArticle

Amination
Oligodeoxyribonucleotides
Lysine
Aldehydes
Amines
25 Citations (Scopus)

Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB0,+, LAT1 and LAT2

Wongthai, P., Hagiwara, K., Miyoshi, Y., Wiriyasermkul, P., Wei, L., Ohgaki, R., Kato, I., Hamase, K., Nagamori, S. & Kanai, Y., Mar 1 2015, In : Cancer Science. 106, 3, p. 279-286 8 p.

Research output: Contribution to journalArticle

Neutron Capture Therapy
Amino Acid Transport Systems
Aromatic Amino Acids
Boron
Large Neutral Amino Acid-Transporter 1
10 Citations (Scopus)
Methamphetamine
Electron Spin Resonance Spectroscopy
Gadolinium
Magnetic resonance
Blood-Brain Barrier
7 Citations (Scopus)

Brain redox imaging in the pentylenetetrazole (PTZ)-induced kindling model of epilepsy by using in vivo electron paramagnetic resonance and a nitroxide imaging probe

Emoto, M. C., Yamato, M., Sato-Akaba, H., Yamada, K. I. & Fujii, H. G., Nov 3 2015, In : Neuroscience Letters. 608, p. 40-44 5 p.

Research output: Contribution to journalArticle

Pentylenetetrazole
Electron Spin Resonance Spectroscopy
Neuroimaging
Oxidation-Reduction
Epilepsy
9 Citations (Scopus)

BubR1 insufficiency inhibits neointimal hyperplasia through impaired vascular smooth muscle cell proliferation in mice

Kyuragi, R., Matsumoto, T., Harada, Y., Saito, S., Onimaru, M., Nakatsu, Y., Tsuzuki, T., Nomura, M., Yonemitsu, Y. & Maehara, Y., Feb 2 2015, In : Arteriosclerosis, thrombosis, and vascular biology. 35, 2, p. 341-347 7 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Smooth Muscle Myocytes
Hyperplasia
Cell Proliferation
Bone Marrow Transplantation
22 Citations (Scopus)

Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture

Sugimoto, N., Maehara, K., Yoshida, K., Yasukouchi, S., Osano, S., Watanabe, S., Aizawa, M., Yugawa, T., Kiyono, T., Kurumizaka, H., Ohkawa, Y. & Fujita, M., Jan 1 2015, In : Nucleic acids research. 43, 12, p. 5898-5911 14 p.

Research output: Contribution to journalArticle

Histones
Chromatin
Glutamic Acid
Carrier Proteins
Replication Origin
23 Citations (Scopus)

Changes in d-aspartic acid and d-glutamic acid levels in the tissues and physiological fluids of mice with various d-aspartate oxidase activities

Han, H., Miyoshi, Y., Koga, R., Mita, M., Konno, R. & Hamase, K., Dec 10 2015, In : Journal of Pharmaceutical and Biomedical Analysis. 116, p. 47-52 6 p.

Research output: Contribution to journalArticle

Aspartic Acid
Glutamic Acid
Oxidoreductases
Tissue
Fluids