Research Output 1976 2019

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Review article
2019

Chronopharmacological strategies focused on chrono-drug discovery

Ohdo, S., Satoru, K. & Naoya, M., Oct 1 2019, In : Pharmacology and Therapeutics. 202, p. 72-90 19 p.

Research output: Contribution to journalReview article

Drug Discovery
Periodicity
Chronic Renal Insufficiency
Pharmaceutical Preparations
Neoplastic Stem Cells
1 Citation (Scopus)

Circulating messenger for neuroprotection induced by molecular hydrogen

Noda, M., Uemura, Y., Yoshii, Y., Horita, T., Takemi, S., Sakata, I. & Sakai, T., Jan 1 2019, In : Canadian journal of physiology and pharmacology. 97, 10, p. 909-915 7 p.

Research output: Contribution to journalReview article

Ghrelin
Hydrogen
Drinking Water
Oxidative Stress
Ghrelin Receptor
6 Citations (Scopus)

Clinical Pharmacokinetics of Anaplastic Lymphoma Kinase Inhibitors in Non-Small-Cell Lung Cancer

Hirota, T., Muraki, S. & Ieiri, I., Apr 4 2019, In : Clinical Pharmacokinetics. 58, 4, p. 403-420 18 p.

Research output: Contribution to journalReview article

Non-Small Cell Lung Carcinoma
Pharmacokinetics
Pharmaceutical Preparations
Cytochrome P-450 Enzyme System
Cytochrome P-450 CYP3A

Development of novel functional molecules targeting DNA and RNA

Sasaki, S., Jan 1 2019, In : Chemical and Pharmaceutical Bulletin. 67, 6, p. 505-518 14 p.

Research output: Contribution to journalReview article

Open Access
Nucleosides
Oligonucleotides
Artificial Receptors
RNA
Molecules
1 Citation (Scopus)

Marine natural products from Indonesian waters

Hanif, N., Murni, A., Tanaka, C. & Tanaka, J., Jun 19 2019, In : Marine Drugs. 17, 6, 364.

Research output: Contribution to journalReview article

Open Access
Biological Products
Biodiversity
Water
Organic Chemistry
Aquatic Organisms
1 Citation (Scopus)

Metabolic plasticity of astrocytes and aging of the brain

Morita, M., Ikeshima-Kataoka, H., Kreft, M., Vardjan, N., Zorec, R. & Noda, M., Feb 2 2019, In : International journal of molecular sciences. 20, 4, 941.

Research output: Contribution to journalReview article

Open Access
plastic properties
Astrocytes
brain
Plasticity
Brain

Microglia-mediated regulation of neuropathic pain: Molecular and cellular mechanisms

Tsuda, M., Jan 1 2019, In : Biological and Pharmaceutical Bulletin. 42, 12, p. 1959-1968 10 p.

Research output: Contribution to journalReview article

Open Access
Microglia
Neuralgia
Nervous System
Drug Delivery Systems
Chronic Pain
1 Citation (Scopus)

Microglia-neuron interactions in the models of neuropathic pain

Saitoh, H. & Makoto, T., Nov 1 2019, In : Biochemical Pharmacology. 169, 113614.

Research output: Contribution to journalReview article

Microglia
Neuralgia
Neurons
Chronic Pain
Chemical activation
1 Citation (Scopus)

Mitochondrial dynamics in exercise physiology

Tanaka, T., Nishimura, A., Nishiyama, K., Goto, T., Numaga-Tomita, T. & Nishida, M., Jan 1 2019, In : Pflugers Archiv European Journal of Physiology.

Research output: Contribution to journalReview article

Mitochondrial Dynamics
Physiology
Organelle Biogenesis
Post Translational Protein Processing
Homeostasis

New applications of high-resolution analytical methods to study trace organic compounds in extraterrestrial materials

Naraoka, H., Hashiguchi, M., Sato, Y. & Hamase, K., Sep 2019, In : Life. 9, 3, 62.

Research output: Contribution to journalReview article

Open Access
Meteoroids
organic compounds
Organic compounds
analytical methods
organic compound
3 Citations (Scopus)

Oncogenic Y-box binding protein-1 as an effective therapeutic target in drug-resistant cancer

Kuwano, M., Shibata, T., Watari, K. & Ono, M., May 2019, In : Cancer Science. 110, 5, p. 1536-1543 8 p.

Research output: Contribution to journalReview article

Open Access
Y-Box-Binding Protein 1
Drug Resistance
Pharmaceutical Preparations
Neoplasms
Therapeutics

Recent strategic advances for the activation of benzylic C–H bonds for the formation of C–C bonds

Yazaki, R. & Ohshima, T., Nov 7 2019, In : Tetrahedron Letters. 60, 45, 151225.

Research output: Contribution to journalReview article

Hydrocarbons
Anions
Chemical activation
Feedstocks
2 Citations (Scopus)

TRPC channels in exercise-mimetic therapy

Numaga-Tomita, T., Oda, S., Nishiyama, K., Tanaka, T., Nishimura, A. & Nishida, M., Mar 7 2019, In : Pflugers Archiv European Journal of Physiology. 471, 3, p. 507-517 11 p.

Research output: Contribution to journalReview article

Exercise Therapy
Muscle
Mechanical Stress
Proteins
Oxidative stress
2018
6 Citations (Scopus)

Astrocytes in the spinal dorsal horn and chronic itch

Makoto, T., Jan 1 2018, In : Neuroscience Research. 126, p. 9-14 6 p.

Research output: Contribution to journalReview article

Atopic Dermatitis
Astrocytes
Peripheral Nervous System
Central Nervous System
Skin
1 Citation (Scopus)

Biophysical analysis of the protein-small molecule interactions to develop small molecule drug discovery

Nagatoishi, S., Caaveiro, J. M. M. & Tsumoto, K., Jan 1 2018, In : Yakugaku Zasshi. 138, 8, p. 1033-1041 9 p.

Research output: Contribution to journalReview article

Drug Discovery
Small Molecule Libraries
Thermodynamics
Proteins
Research Personnel
6 Citations (Scopus)

D-Amino acids in molecular evolution in space – Absolute asymmetric photolysis and synthesis of amino acids by circularly polarized light

Sugahara, H., Meinert, C., Nahon, L., Jones, N. C., Hoffmann, S. V., Hamase, K., Takano, Y. & Meierhenrich, U. J., Jul 1 2018, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1866, 7, p. 743-758 16 p.

Research output: Contribution to journalReview article

Molecular Evolution
Photolysis
Light polarization
Light
Amino Acids
9 Citations (Scopus)

DNA replication stress and cancer chemotherapy

Kitao, H., Iimori, M., Kataoka, Y., Wakasa, T., Tokunaga, E., Saeki, H., Oki, E. & Maehara, Y., Feb 1 2018, In : Cancer Science. 109, 2, p. 264-271 8 p.

Research output: Contribution to journalReview article

DNA Replication
Drug Therapy
Neoplasms
Biological Phenomena
Genomic Instability
22 Citations (Scopus)

Enzyme-linked immunosorbent assay for the quantitative/qualitative analysis of plant secondary metabolites

Sakamoto, S., Putalun, W., Vimolmangkang, S., Phoolcharoen, W., Shoyama, Y., Tanaka, H. & Morimoto, S., Jan 1 2018, In : Journal of Natural Medicines. 72, 1, p. 32-42 11 p.

Research output: Contribution to journalReview article

Immunosorbents
Metabolites
Immunoassay
Assays
Enzyme-Linked Immunosorbent Assay

Epigenetic regulation of pharmacokinetic-related genes in human tissues

Hirota, T., Jan 1 2018, In : Yakugaku Zasshi. 138, 11, p. 1391-1396 6 p.

Research output: Contribution to journalReview article

Epigenomics
Pharmacokinetics
Breast Neoplasms
Pharmaceutical Preparations
Genes

Green Pharma: A new strategy for drug discovery in academia by targeting glial cells and ATP receptors

Yamashita, T., Makoto, T., Saitoh, H. & Inoue, K., Jan 1 2018, In : Yakugaku Zasshi. 138, 8, p. 1027-1031 5 p.

Research output: Contribution to journalReview article

Purinergic P2 Receptors
Drug Discovery
Neuroglia
Hyperalgesia
Neuralgia
50 Citations (Scopus)

Microglia in neuropathic pain: Cellular and molecular mechanisms and therapeutic potential

Inoue, K. & Tsuda, M., Feb 16 2018, In : Nature Reviews Neuroscience. 19, 3, p. 138-152 15 p.

Research output: Contribution to journalReview article

Microglia
Neuralgia
Chronic Pain
Nociceptive Pain
Peripheral Nerve Injuries
14 Citations (Scopus)

Modulation of Pain and Itch by Spinal Glia

Makoto, T., Feb 1 2018, In : Neuroscience Bulletin. 34, 1, p. 178-185 8 p.

Research output: Contribution to journalReview article

Neuroglia
Chronic Pain
Pain
Spinal Cord
Posterior Horn Cells
3 Citations (Scopus)

Therapeutic targets for treatment of heart failure: Focus on GRKs and β-arrestins affecting βaR signaling

Mangmool, S., Parichatikanond, W. & Kurose, H., Nov 27 2018, In : Frontiers in Pharmacology. 9, NOV, 01336.

Research output: Contribution to journalReview article

Arrestins
G-Protein-Coupled Receptor Kinases
Treatment Failure
Heart Failure
Adrenergic Receptors
15 Citations (Scopus)
Diacylglycerol Kinase
Phosphatidic Acids
Diglycerides
Phosphatidylinositols
Isoenzymes
2017
6 Citations (Scopus)

Activation of the FA pathway mediated by phosphorylation and ubiquitination

Ishiai, M., Sato, K., Tomida, J., Kitao, H., Kurumizaka, H. & Takata, M., Oct 2017, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 803-805, p. 89-95 7 p.

Research output: Contribution to journalReview article

Fanconi Anemia
Ubiquitination
Phosphorylation
Fanconi Anemia Complementation Group D2 Protein
Bone Marrow Cells
14 Citations (Scopus)

DNA replication origins and fork progression at mammalian telomeres

Higa, M., Fujita, M. & Yoshida, K., Apr 2017, In : Genes. 8, 4, 112.

Research output: Contribution to journalReview article

Replication Origin
Telomere
DNA Replication
Chromosomal Instability
Proteins
4 Citations (Scopus)

Epigenetic regulation of drug transporter expression in human tissues

Hirota, T., Tanaka, T., Takesue, H. & Ieiri, I., Jan 2 2017, In : Expert Opinion on Drug Metabolism and Toxicology. 13, 1, p. 19-30 12 p.

Research output: Contribution to journalReview article

Drug and Narcotic Control
Epigenomics
Tissue
Pharmaceutical Preparations
Genes
9 Citations (Scopus)

Fluorescence Sensing of Inorganic Phosphate and Pyrophosphate Using Small Molecular Sensors and Their Applications

Wongkongkatep, J., Ojida, A. & Hamachi, I., Apr 1 2017, In : Topics in Current Chemistry. 375, 2, 30.

Research output: Contribution to journalReview article

Fluorescence
Phosphates
Sensors
Chemical reactions
Quenching
9 Citations (Scopus)

Glycosylation of IgG-Fc: A molecular perspective

Kiyoshi, M., Tsumoto, K., Ishii-Watabe, A. & Martinez Caaveiro, J. M., Jul 1 2017, In : International Immunology. 29, 7, p. 311-317 7 p.

Research output: Contribution to journalReview article

Glycosylation
Polysaccharides
Immunoglobulin G
Antibodies
Immunoglobulin Isotypes
4 Citations (Scopus)

GRWD1, a new player among oncogenesis-related ribosomal/nucleolar proteins

Takafuji, T., Kayama, K., Sugimoto, N. & Fujita, M., Aug 3 2017, In : Cell Cycle. 16, 15, p. 1397-1403 7 p.

Research output: Contribution to journalReview article

Ribosomal Proteins
Nuclear Proteins
Carcinogenesis
Neoplasms
Protein Biosynthesis

Microglia and its phagocytic abilities.

Noda, M., 2017, In : Clinical Pathophysiology. 23, 1, p. 11-18 8 p., 22(1).

Research output: Contribution to journalReview article

Microglia
Phagocytosis
Ficus
Cytophagocytosis
Nerve Tissue
1 Citation (Scopus)

Molecular mechanism whereby maternal exposure to dioxin suppresses sexual maturation of the offspring after growing up

Takeda, T., Jan 1 2017, In : Yakugaku Zasshi. 137, 11, p. 1373-1379 7 p.

Research output: Contribution to journalReview article

Maternal Exposure
Sexual Maturation
Dioxins
Luteinizing Hormone
Histone Deacetylases
10 Citations (Scopus)

Mouse D-amino-acid oxidase: Distribution and physiological substrates

Koga, R., Miyoshi, Y., Sakaue, H., Hamase, K. & Konno, R., Dec 4 2017, In : Frontiers in Molecular Biosciences. 4, DEC, 82.

Research output: Contribution to journalReview article

D-Amino-Acid Oxidase
Substrates
Serine
Amino Acids
Alanine
37 Citations (Scopus)

Neuronal and microglial mechanisms for neuropathic pain in the spinal dorsal horn and anterior cingulate cortex

Makoto, T., Koga, K., Chen, T. & Zhuo, M., May 1 2017, In : Journal of Neurochemistry. 141, 4, p. 486-498 13 p.

Research output: Contribution to journalReview article

Gyrus Cinguli
Neurology
Neuralgia
Chronic Pain
Pain
26 Citations (Scopus)

P2 receptors, microglial cytokines and chemokines, and neuropathic pain

Makoto, T., Jun 1 2017, In : Journal of Neuroscience Research. 95, 6, p. 1319-1329 11 p.

Research output: Contribution to journalReview article

Cytokine Receptors
Chemokine Receptors
Neuralgia
Microglia
Peripheral Nerve Injuries
6 Citations (Scopus)

Purinergic P2Y6 receptors: A new therapeutic target of age-dependent hypertension

Sunggip, C., Nishimura, A., Shimoda, K., Numaga-Tomita, T., Makoto, T. & Nishida, M., Jun 1 2017, In : Pharmacological Research. 120, p. 51-59 9 p.

Research output: Contribution to journalReview article

Purinergic Receptors
Hypertension
Angiotensin Type 1 Receptor
clopidogrel
Purinergic P2Y12 Receptors
18 Citations (Scopus)

Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases

Nishimura, A., Sunggip, C., Oda, S., Numaga-Tomita, T., Makoto, T. & Nishida, M., Dec 1 2017, In : Pharmacology and Therapeutics. 180, p. 113-128 16 p.

Research output: Contribution to journalReview article

Purinergic P2Y Receptors
G-Protein-Coupled Receptors
Cardiovascular System
Cardiovascular Diseases
Uracil Nucleotides
7 Citations (Scopus)

Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells

Nishida, M., Nishimura, A., Matsunaga, T., Motohashi, H., Kasamatsu, S. & Akaike, T., Aug 1 2017, In : Free Radical Biology and Medicine. 109, p. 132-140 9 p.

Research output: Contribution to journalReview article

Metabolism
Oxidation-Reduction
Nitric Oxide
Cardiovascular Physiological Phenomena
Cell signaling

Roles and educational effects of clinical case studies in home medical care

Ohsawa, T. & Shimazoe, T., Jan 1 2017, In : Yakugaku Zasshi. 137, 8, p. 947-956 10 p.

Research output: Contribution to journalReview article

Home Care Services
Pharmacists
Students
Education
Diagnostic Self Evaluation
3 Citations (Scopus)

Spinal dorsal horn astrocytes: New players in chronic itch

Tsuda, M., Jan 1 2017, In : Allergology International. 66, 1, p. 31-35 5 p.

Research output: Contribution to journalReview article

Atopic Dermatitis
Astrocytes
Skin
Spinal Cord Dorsal Horn
Therapeutics
20 Citations (Scopus)

The DnaA cycle in Escherichia coli: Activation, function and inactivation of the initiator protein

Katayama, T., Kasho, K. & Kawakami, H., Dec 21 2017, In : Frontiers in Microbiology. 8, DEC, 2496.

Research output: Contribution to journalReview article

Adenosine Triphosphate
Integration Host Factors
Escherichia coli
Adenosine Diphosphate
Proteins
2016

Development of a functional contrast agent for targeting lipid-derived radicals

Yamada, K. I., Jan 1 2016, In : Yakugaku Zasshi. 136, 8, p. 1093-1100 8 p.

Research output: Contribution to journalReview article

Contrast Media
Lipids
Electrons
Oxidative Stress
Fluorescence

Development of fluorescence sensing mechanism for cell functional analysis

Ojida, A. & Takashima, I., Jan 1 2016, In : Yakugaku Zasshi. 136, 1, p. 3-7 5 p.

Research output: Contribution to journalReview article

Fluorescent Dyes
Fluorescence
Metals
Ions
Biological Phenomena
12 Citations (Scopus)
Zinc
Esters
Transesterification
Amines
Catalyst activity
10 Citations (Scopus)

Fluorescence probe for the convenient and sensitive detection of ascorbic acid

Matsuoka, Y., Yamato, M. & Yamada, K. I., Jan 2016, In : Journal of Clinical Biochemistry and Nutrition. 58, 1, p. 16-22 7 p.

Research output: Contribution to journalReview article

Ascorbic Acid
Fluorescence
Fluorescent Dyes
Oxidation-Reduction
Electrons
NADPH Oxidase
Nicotinic Receptors
Microglia
Nicotine
Protons

Memorial address for Dr. Hideyuki Yamada, distinguished professor

Ishii, Y., Oct 1 2016, In : Drug Metabolism Reviews. 48, 4, p. 471-472 2 p.

Research output: Contribution to journalReview article

18 Citations (Scopus)

Myofibroblasts and inflammatory cells as players of cardiac fibrosis

Kurose, H. & Mangmool, S., Aug 1 2016, In : Archives of Pharmacal Research. 39, 8, p. 1100-1113 14 p.

Research output: Contribution to journalReview article

Myofibroblasts
Fibrosis
Collagen
Fibroblasts
Cells
40 Citations (Scopus)

Neuron-microglia interaction by purinergic signaling in neuropathic pain following neurodegeneration

Tsuda, M. & Inoue, K., May 1 2016, In : Neuropharmacology. 104, p. 76-81 6 p.

Research output: Contribution to journalReview article

Microglia
Neuralgia
Neurons
Purinergic P2Y Receptors
Purinergic P2X Receptors

New mechanism for chronic itch in the nervous system

Makoto, T. & Shiratori, M., Jan 1 2016, In : Seikagaku. 88, 5, p. 654-656 3 p.

Research output: Contribution to journalReview article

Neurology
Animals
Astrocytes
Atopic Dermatitis