Research Output 1993 2019

2014
5 Citations (Scopus)

Possible involvement of ΔNp63 downregulation in the invasion and metastasis of oral squamous cell carcinoma via induction of a mesenchymal phenotype

Goto, Y., Kawano, S., Matsubara, R., Kiyosue, T., Hirano, M., Jinno, T., Maruse, Y., Toyoshima, T., kitamura, R., Tanaka, H., Oobu, K. & Nakamura, S., Jan 1 2014, In : Clinical and Experimental Metastasis. 31, 3, p. 293-306 14 p.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Down-Regulation
Neoplasm Metastasis
Phenotype
Epithelial-Mesenchymal Transition
3 Citations (Scopus)

Regeneration of the periodontium for preservation of the damaged tooth

Maeda, H., Tomokiyo, A., Wada, N., Koori, K., Kawachi, G. & Akamine, A., Oct 1 2014, In : Histology and histopathology. 29, 10, p. 1249-1262 14 p.

Research output: Contribution to journalReview article

Periodontium
Regeneration
Tooth Loss
Tooth
Periodontitis
15 Citations (Scopus)

Semaphorin 3A induces mesenchymal-stem-like properties in human periodontal ligament cells

Wada, N., Maeda, H., Hasegawa, D., Gronthos, S., Bartold, P. M., Menicanin, D., Fujii, S., Yoshida, S., Tomokiyo, A., Monnouchi, S. & Akamine, A., Sep 15 2014, In : Stem Cells and Development. 23, 18, p. 2225-2236 12 p.

Research output: Contribution to journalArticle

Semaphorin-3A
Periodontal Ligament
Stem Cells
Mesenchymal Stromal Cells
Tooth
20 Citations (Scopus)
Calcium-Sensing Receptors
Periodontal Ligament
Calcium Channels
Stem Cells
Calcium
2013
1 Citation (Scopus)

Adenosine blocks aminopterin-induced suppression of osteoclast differentiation

Teramachi, J., Kukita, A., Qu, P., Wada, N., Li, Y. J., Nakamura, S. & Kukita, T., Jan 1 2013, In : Journal of Bone and Mineral Metabolism. 31, 1, p. 64-70 7 p.

Research output: Contribution to journalArticle

Aminopterin
Osteoclasts
Osteogenesis
Adenosine
Hypoxanthine

A questionnaire survey for the systemic disease that general dentist should be dealing with

Takarada, T. & Higuchi, Y., 2013, In : Journal of Japanese Dental Society of Anesthesiology. 41, 3, p. 287-291 5 p.

Research output: Contribution to journalShort survey

Dentists
Surveys and Questionnaires
14 Citations (Scopus)

Exposure to transforming growth factor-β1 after basic fibroblast growth factor promotes the fibroblastic differentiation of human periodontal ligament stem/progenitor cell lines

Kono, K., Maeda, H., Fujii, S., Tomokiyo, A., Yamamoto, N., Wada, N., Monnouchi, S., Teramatsu, Y., Hamano, S., Koori, K. & Akamine, A., May 1 2013, In : Cell and tissue research. 352, 2, p. 249-263 15 p.

Research output: Contribution to journalArticle

Periodontal Ligament
Transforming Growth Factors
Fibroblast Growth Factor 2
Stem Cells
Cell Line
25 Citations (Scopus)

Immunohistochemical location of the p75 neurotrophin receptor (p75NTR) in oral leukoplakia and oral squamous cell carcinoma

Kiyosue, T., Kawano, S., Matsubara, R., Goto, Y., Hirano, M., Jinno, T., Toyoshima, T., Kitamura, R., Oobu, K. & Nakamura, S., Feb 1 2013, In : International Journal of Clinical Oncology. 18, 1, p. 154-163 10 p.

Research output: Contribution to journalArticle

Oral Leukoplakia
Nerve Growth Factor Receptor
Squamous Cell Carcinoma
Stem Cells
Keratin-5
40 Citations (Scopus)

Immunomodulatory effects of stem cells

Wada, N., Gronthos, S. & Bartold, P. M., Oct 1 2013, In : Periodontology 2000. 63, 1, p. 198-216 19 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Stem Cells
Periodontal Ligament
Tooth
Regeneration
7 Citations (Scopus)

Periodontal tissue engineering: Defining the triad

Maeda, H., Fujii, S., Tomokiyo, A., Wada, N. & Akamine, A., Jan 1 2013, In : International Journal of Oral and Maxillofacial Implants. 28, 6, p. e461-e471

Research output: Contribution to journalArticle

Periodontal Ligament
Tissue Engineering
Stem Cells
Cell Line
Phenotype
23 Citations (Scopus)

Prospective potency of TGF-β1 on maintenance and regeneration of periodontal tissue

Maeda, H., Wada, N., Tomokiyo, A., Monnouchi, S. & Akamine, A., Jan 1 2013, International Review of Cell and Molecular Biology. Elsevier Inc., p. 283-367 85 p. (International Review of Cell and Molecular Biology; vol. 304).

Research output: Chapter in Book/Report/Conference proceedingChapter

Periodontal Ligament
Ligaments
Regeneration
Maintenance
Tissue
9 Citations (Scopus)

Quantitative single-nucleotide polymorphism analysis in secondary-structured DNA by affinity capillary electrophoresis using a polyethylene glycol-peptide nucleic acid block copolymer

Tsukada, H., Kundu, L. M., Matsuoka, Y., Kanayama, N., Takarada, T. & Maeda, M., Feb 15 2013, In : Analytical Biochemistry. 433, 2, p. 150-152 3 p.

Research output: Contribution to journalArticle

Peptide Nucleic Acids
Capillary electrophoresis
Capillary Electrophoresis
Polymorphism
Block copolymers
28 Citations (Scopus)

Regeneration of periodontal tissues using allogeneic periodontal ligament stem cells in an ovine model

Mrozik, K. M., Wada, N., Marino, V., Richter, W., Shi, S., Wheeler, D. L., Gronthos, S. & Bartold, P. M., Nov 2013, In : Regenerative Medicine. 8, 6, p. 711-723 13 p.

Research output: Contribution to journalArticle

Absorbable Gelatin Sponge
Periodontal Ligament
Ligaments
Stem cells
Regeneration
2012
10 Citations (Scopus)

Alternation of extracellular matrix remodeling and apoptosis by activation of the aryl hydrocarbon receptor pathway in human periodontal ligament cells

Tomokiyo, A., Maeda, H., Fujii, S., Monnouchi, S., Wada, N., Hori, K., Koori, K., Yamamoto, N., Teramatsu, Y. & Akamine, A., Jan 1 2012, In : Journal of Cellular Biochemistry. 113, 10, p. 3093-3103 11 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Periodontal Ligament
Ligaments
Extracellular Matrix
Chemical activation
24 Citations (Scopus)

A multipotent clonal human periodontal ligament cell line with neural crest cell phenotypes promotes neurocytic differentiation, migration, and survival

Tomokiyo, A., Maeda, H., Fujii, S., Monnouchi, S., Wada, N., Kono, K., Yamamoto, N., Koori, K., Teramatsu, Y. & Akamine, A., May 1 2012, In : Journal of Cellular Physiology. 227, 5, p. 2040-2050 11 p.

Research output: Contribution to journalArticle

Periodontal Ligament
Neural Crest
Ligaments
Cells
Phenotype
28 Citations (Scopus)
Fluorodeoxyglucose F18
Positron-Emission Tomography
Area Under Curve
Squamous Cell Carcinoma
Lymph Nodes
1 Citation (Scopus)

Differentiation of periodontal ligament stem/progenitor cells: Roles of TGF-β1

Maeda, H., Fujii, S., Monnouchi, S., Wada, N. & Akamine, A., Jan 1 2012, Stem Cells and Cancer Stem Cells, Volume 4: Therapeutic Applications in Disease and Injury. Springer Netherlands, p. 51-58 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Periodontal Ligament
Periodontium
Stem Cells
Tooth Loss
Regenerative Medicine

Differentiation of Periodontal Stem/Progenitor Cells: Roles of TGF-beta1.

Maeda, H., Fujii, S., Monnouch, S., Wada, N. & Akamine, A., 2012, Stem Cells and Cancer Stem Cells : Therapeutic Applications in Disease and Injury. Springer Science + Business Media, Vol. 4. p. 51-58 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Citations (Scopus)

Estimation of binding constants of peptide nucleic acid and secondary-structured DNA by affinity capillary electrophoresis

Kundu, L. M., Tsukada, H., Matsuoka, Y., Kanayama, N., Takarada, T. & Maeda, M., Jun 19 2012, In : Analytical chemistry. 84, 12, p. 5204-5209 6 p.

Research output: Contribution to journalArticle

Peptide Nucleic Acids
Capillary electrophoresis
DNA
Nucleic Acid Probes
Single-Stranded DNA
9 Citations (Scopus)

Expression and effects of glial cell line-derived neurotrophic factor on periodontal ligament cells

Yamamoto, N., Maeda, H., Tomokiyo, A., Fujii, S., Wada, N., Monnouchi, S., Kono, K., Koori, K., Teramatsu, Y. & Akamine, A., Jun 2012, In : Journal of Clinical Periodontology. 39, 6, p. 556-564 9 p.

Research output: Contribution to journalArticle

Glial Cell Line-Derived Neurotrophic Factor
Periodontal Ligament
Glial Cell Line-Derived Neurotrophic Factor Receptors
Integrin-Binding Sialoprotein
Interleukin-1beta

Induction of BMP-2 in periodontal ligament cells by calcium-based biomaterial

Maeda, H., Tomokiyo, A., Wada, N. & Akamine, A., Feb 1 2012, Bone Morphogenetic Proteins: New Research. Nova Science Publishers, Inc., p. 187-202 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Periodontal Ligament
Ligaments
Periodontium
Biocompatible Materials
Tissue
2 Citations (Scopus)

Serotype-dependent expression patterns of stabilized lipopolysaccharide aggregates in aggregatibacter actinomycetemcomitans strains

Kikuchi, H., Fujise, O., Miura, M., Tanaka, A., Hisano, K., Haraguchi, A., Hamachi, T. & Maeda, K., Oct 1 2012, In : MICROBIOLOGY and IMMUNOLOGY. 56, 10, p. 680-691 12 p.

Research output: Contribution to journalArticle

Aggregatibacter actinomycetemcomitans
Lipopolysaccharides
Detergents
Divalent Cations
Serogroup
15 Citations (Scopus)

Structural characterization of nanoparticles from thermoresponsive poly(N-isopropylacrylamide)-DNA conjugate

Ooi, W. Y., Fujita, M., Pan, P., Tang, H. Y., Sudesh, K., Ito, K., Kanayama, N., Takarada, T. & Maeda, M., May 15 2012, In : Journal of Colloid And Interface Science. 374, 1, p. 315-320 6 p.

Research output: Contribution to journalArticle

DNA
Nanoparticles
Single-Stranded DNA
Turbidity
X ray scattering
2011

[An epidemiologic examination on the prevalence of the periodontal diseases and oral pigmentation in Yusho patients in 2010].

Hashiguchi, I., Yoshimine, Y., Maeda, H., Gotou, Y., Wada, N., Fujii, S., Tomokiyo, A., Saito, K., Monnouchi, S., Kouno, K., Okumura, H. & Akamine, A., Apr 1 2011, In : Fukuoka igaku zasshi = Hukuoka acta medica. 102, 4, p. 75-80 6 p.

Research output: Contribution to journalArticle

Pigmentation
Periodontal Diseases
Periodontal Pocket
Tooth
Tooth Diseases
15 Citations (Scopus)

Adenosine abolishes MTX-induced suppression of osteoclastogenesis and inflammatory bone destruction in adjuvant-induced arthritis

Teramachi, J., Kukita, A., Li, Y. J., Ushijima, Y., Ohkuma, H., Wada, N., Watanabe, T., Nakamura, S. & Kukita, T., May 1 2011, In : Laboratory Investigation. 91, 5, p. 719-731 13 p.

Research output: Contribution to journalArticle

Experimental Arthritis
Osteogenesis
Methotrexate
Adenosine
Bone and Bones
6 Citations (Scopus)

An in vitro evaluation of two resin-based sealers on proliferation and differentiation of human periodontal ligament cells

Maeda, H., Tomokiyo, A., Koori, K., Monnouchi, S., Fujii, S., Wada, N., Kono, K., Yamamoto, N., Saito, T. & Akamine, A., May 1 2011, In : International Endodontic Journal. 44, 5, p. 425-431 7 p.

Research output: Contribution to journalArticle

Periodontal Ligament
Osteopontin
Osteocalcin
Electron Scanning Microscopy
In Vitro Techniques
37 Citations (Scopus)

DNA-functionalized thermoresponsive bioconjugates synthesized via ATRP and click chemistry

Pan, P., Fujita, M., Ooi, W. Y., Sudesh, K., Takarada, T., Goto, A. & Maeda, M., Feb 17 2011, In : Polymer. 52, 4, p. 895-900 6 p.

Research output: Contribution to journalArticle

Atom transfer radical polymerization
DNA
Copolymers
Single-Stranded DNA
Micelles
17 Citations (Scopus)

Increased ΔNp63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma

Matsubara, R., Kawano, S., Kiyosue, T., Goto, Y., Hirano, M., Jinno, T., Toyoshima, T., kitamura, R., Oobu, K. & Nakamura, S., Dec 1 2011, In : International journal of oncology. 39, 6, p. 1391-1399 9 p.

Research output: Contribution to journalArticle

Oral Leukoplakia
Squamous Cell Carcinoma
Keratin-14
Keratinocytes
Stem Cells

Periodontal ligament stem cells

Maeda, H., Wada, N., Fujii, S., Tomokiyo, A. & Akamine, A., 2011, Stem Cells. Croatia: InTech, p. 619-636 38 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

24 Citations (Scopus)

Promise of periodontal ligament stem cells in regeneration of periodontium

Maeda, H., Tomokiyo, A., Fujii, S., Wada, N. & Akamine, A., Sep 12 2011, In : Stem Cell Research and Therapy. 2, 4, 33.

Research output: Contribution to journalReview article

Periodontium
Periodontal Ligament
Ligaments
Stem cells
Regeneration
2010
45 Citations (Scopus)
Periodontal Ligament
Transforming Growth Factors
Stem Cells
Cell Line
Messenger RNA
64 Citations (Scopus)

Mineral Trioxide Aggregate Induces Bone Morphogenetic Protein-2 Expression and Calcification in Human Periodontal Ligament Cells

Maeda, H., Nakano, T., Tomokiyo, A., Fujii, S., Wada, N., Monnouchi, S., Hori, K. & Akamine, A., Apr 1 2010, In : Journal of Endodontics. 36, 4, p. 647-652 6 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 2
Periodontal Ligament
Calcium-Sensing Receptors
Bone Morphogenetic Protein Receptors
Calcium
2008
72 Citations (Scopus)

Development of a multipotent clonal human periodontal ligament cell line

Tomokiyo, A., Maeda, H., Fujii, S., Wada, N., Shima, K. & Akamine, A., Apr 2008, In : Differentiation. 76, 4, p. 337-347 11 p.

Research output: Contribution to journalArticle

Periodontal Ligament
Cell Line
Fibroblast Growth Factor 2
Stem Cells
Tooth Root
75 Citations (Scopus)

Investigating a clonal human periodontal ligament progenitor/stem cell line in vitro and in vivo

Fujii, S., Maeda, H., Wada, N., Tomokiyo, A., Saito, M. & Akamine, A., Jun 1 2008, In : Journal of cellular physiology. 215, 3, p. 743-749 7 p.

Research output: Contribution to journalArticle

Periodontal Ligament
Ligaments
Stem cells
Stem Cells
Cell Line
2007
17 Citations (Scopus)

MK-801 enhances gabaculine-induced loss of the righting reflex in mice, but not immobility

Irifune, M., Katayama, S., Takarada, T., Shimizu, Y., Endo, C., Takata, T., Morita, K., Dohi, T., Sato, T. & Kawahara, M., Dec 2007, In : Canadian Journal of Anesthesia. 54, 12, p. 998-1005 8 p.

Research output: Contribution to journalArticle

Righting Reflex
Dizocilpine Maleate
gamma-Aminobutyric Acid
Ketamine
N-Methylaspartate
20 Citations (Scopus)

Riluzole, a glutamate release inhibitor, induces loss of righting reflex, antinociception, and immobility in response to noxious stimulation in mice

Irifune, M., Kikuchi, N., Saida, T., Takarada, T., Shimizu, Y., Endo, C., Morita, K., Dohi, T., Sato, T. & Kawahara, M., Jun 1 2007, In : Anesthesia and Analgesia. 104, 6, p. 1415-1421 7 p.

Research output: Contribution to journalArticle

Riluzole
Righting Reflex
Glutamic Acid
General Anesthetics
Unconsciousness
36 Citations (Scopus)

Turbidimetric detection of ATP using polymeric micelles and DNA aptamers

Miyamoto, D., Tang, Z., Takarada, T. & Maeda, M., Nov 21 2007, In : Chemical Communications. 45, p. 4743-4745 3 p.

Research output: Contribution to journalArticle

Nucleotide Aptamers
Micelles
Adenosine
DNA
Molecular recognition
2006
74 Citations (Scopus)

Establishing and characterizing human periodontal ligament fibroblasts immortalized by SV40T-antigen and hTERT gene transfer

Fujii, S., Maeda, H., Wada, N., Kano, Y. & Akamine, A., Apr 1 2006, In : Cell and tissue research. 324, 1, p. 117-125 9 p.

Research output: Contribution to journalArticle

Gene transfer
Periodontal Ligament
Ligaments
Fibroblasts
Antigens
2005
6 Citations (Scopus)
Periapical Tissue
Granulation
Granulation Tissue
Rats
Bone
13 Citations (Scopus)

Identification of genes differentially expressed in osteoclast-like cells

Nomiyama, H., Egami, K., Wada, N., Tou, K., Horiuchi, M., Matsusaki, H., Miura, R., Yoshie, O. & Kukita, T., Apr 1 2005, In : Journal of Interferon and Cytokine Research. 25, 4, p. 227-231 5 p.

Research output: Contribution to journalArticle

Osteoclasts
Genes
Osteogenesis
Cathepsin K
Proton-Translocating ATPases
3 Citations (Scopus)

Immunocytochemical localization of the neurokinin 1 receptor in rat dental pulp

Kido, M. A., Ibuki, T., Danjo, A., Kondo, T., Zhang, J. Q., Yamaza, T., Yamashita, Y., Higuchi, Y. & Tanaka, T., Dec 1 2005, In : Archives of Histology and Cytology. 68, 4, p. 259-265 7 p.

Research output: Contribution to journalArticle

Neurokinin-1 Receptors
Dental Pulp
Substance P
Odontoblasts
Nerve Fibers
2004
84 Citations (Scopus)

Direct stimulation of osteoclastogenesis by MIP-1α: Evidence obtained from studies using RAW264 cell clone highly responsive to RANKL

Watanabe, T., Kukita, T., Kukita, A., Wada, N., Toh, K., Nagata, K., Nomiyama, H. & Iijima, T., Jan 1 2004, In : Journal of Endocrinology. 180, 1, p. 193-201 9 p.

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
Osteogenesis
Clone Cells
Osteoclasts
Stromal Cells
40 Citations (Scopus)

Human periapical granulation tissue contains osteogenic cells

Maeda, H., Wada, N., Nakamuta, H. & Akamine, A., Feb 1 2004, In : Cell and tissue research. 315, 2, p. 203-208 6 p.

Research output: Contribution to journalArticle

Periapical Tissue
Granulation
Granulation Tissue
Osteopontin
Tissue
98 Citations (Scopus)
Receptor Activator of Nuclear Factor-kappa B
Osteoprotegerin
Periodontal Ligament
Interleukin-1beta
Lipopolysaccharides
7 Citations (Scopus)

Periodontal management of an adolescent with Down's syndrome - A case report

Sasaki, Y., Sumi, Y., Miyazaki, Y., Hamachi, T. & Nakata, M., Jan 1 2004, In : International Journal of Paediatric Dentistry. 14, 2, p. 127-135 9 p.

Research output: Contribution to journalArticle

Periodontitis
Down Syndrome
Dental Care
Oral Hygiene
Periodontal Diseases
208 Citations (Scopus)

RANKL-induced DC-STAMP is essential for osteoclastogenesis

Kukita, T., Wada, N., Kukita, A., Kakimoto, T., Sandra, F., Toh, K., Nagata, K., Iijima, T., Horiuchi, M., Matsusaki, H., Hieshima, K., Yoshie, O. & Nomiyama, H., Oct 4 2004, In : Journal of Experimental Medicine. 200, 7, p. 941-946 6 p.

Research output: Contribution to journalArticle

Osteogenesis
Dendritic Cells
Osteoclasts
Proteins
Cell Fusion
2003
3 Citations (Scopus)

An epidemiologic examination on the prevalence of the periodontal diseases and oral pigmentation in Yusho patients in 2002.

Hashiguchi, I., Yoshito, Y., Gotou, Y., Maeda, H., Wada, N., Akamine, A., Fukuyama, H. & Okumura, H., Jan 1 2003, In : Fukuoka igaku zasshi = Hukuoka acta medica. 94, 5, p. 81-86 6 p.

Research output: Contribution to journalArticle

Pigmentation
Periodontal Diseases
Periodontal Pocket
Tooth
Polychlorinated Biphenyls
73 Citations (Scopus)

Propofol-induced anesthesia in mice is mediated by γ-aminobutyric acid-A and excitatory amino acid receptors

Irifune, M., Takarada, T., Shimizu, Y., Endo, C., Katayama, S., Dohi, T. & Kawahara, M., Aug 1 2003, In : Anesthesia and Analgesia. 97, 2, p. 424-429 6 p.

Research output: Contribution to journalArticle

Aminobutyrates
Glutamate Receptors
Propofol
Anesthesia
Righting Reflex
2001
76 Citations (Scopus)

Periodontal ligament cells secrete the factor that inhibits osteoclastic differentiation and function: The factor is osteoprotegerin/ osteoclastogenesis inhibitory factor

Wada, N., Maeda, H., Tanabe, K., Tsuda, E., Yano, K., Nakamuta, H. & Akamine, A., Jan 1 2001, In : Journal of Periodontal Research. 36, 1, p. 56-63 8 p.

Research output: Contribution to journalArticle

Osteoprotegerin
Periodontal Ligament
Osteoclasts
Bone Marrow
Conditioned Culture Medium

Regulation of aggregated structure of dye molecules by DNA hybridization.

Asanuma, H., Shirasuka, K., Takarada, T. & Komiyama, M., Jan 1 2001, In : Nucleic acids research. Supplement (2001). 1, p. 193-194 2 p.

Research output: Contribution to journalArticle

Coloring Agents
Single-Stranded DNA
DNA
Complementary DNA
methyl red