Research Output 1993 2019

2013
14 Citations (Scopus)

Exposure to transforming growth factor-β1 after basic fibroblast growth factor promotes the fibroblastic differentiation of human periodontal ligament stem/progenitor cell lines

Kono, K., Maeda, H., Fujii, S., Tomokiyo, A., Yamamoto, N., Wada, N., Monnouchi, S., Teramatsu, Y., Hamano, S., Koori, K. & Akamine, A., May 1 2013, In : Cell and tissue research. 352, 2, p. 249-263 15 p.

Research output: Contribution to journalArticle

Periodontal Ligament
Transforming Growth Factors
Fibroblast Growth Factor 2
Stem Cells
Cell Line
25 Citations (Scopus)

Immunohistochemical location of the p75 neurotrophin receptor (p75NTR) in oral leukoplakia and oral squamous cell carcinoma

Kiyosue, T., Kawano, S., Matsubara, R., Goto, Y., Hirano, M., Jinno, T., Toyoshima, T., Kitamura, R., Oobu, K. & Nakamura, S., Feb 1 2013, In : International Journal of Clinical Oncology. 18, 1, p. 154-163 10 p.

Research output: Contribution to journalArticle

Oral Leukoplakia
Nerve Growth Factor Receptor
Squamous Cell Carcinoma
Stem Cells
Keratin-5
40 Citations (Scopus)

Immunomodulatory effects of stem cells

Wada, N., Gronthos, S. & Bartold, P. M., Oct 1 2013, In : Periodontology 2000. 63, 1, p. 198-216 19 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Stem Cells
Periodontal Ligament
Tooth
Regeneration
7 Citations (Scopus)

Periodontal tissue engineering: Defining the triad

Maeda, H., Fujii, S., Tomokiyo, A., Wada, N. & Akamine, A., Jan 1 2013, In : International Journal of Oral and Maxillofacial Implants. 28, 6, p. e461-e471

Research output: Contribution to journalArticle

Periodontal Ligament
Tissue Engineering
Stem Cells
Cell Line
Phenotype
23 Citations (Scopus)

Prospective potency of TGF-β1 on maintenance and regeneration of periodontal tissue

Maeda, H., Wada, N., Tomokiyo, A., Monnouchi, S. & Akamine, A., Jan 1 2013, International Review of Cell and Molecular Biology. Elsevier Inc., p. 283-367 85 p. (International Review of Cell and Molecular Biology; vol. 304).

Research output: Chapter in Book/Report/Conference proceedingChapter

Periodontal Ligament
Ligaments
Regeneration
Maintenance
Tissue
9 Citations (Scopus)

Quantitative single-nucleotide polymorphism analysis in secondary-structured DNA by affinity capillary electrophoresis using a polyethylene glycol-peptide nucleic acid block copolymer

Tsukada, H., Kundu, L. M., Matsuoka, Y., Kanayama, N., Takarada, T. & Maeda, M., Feb 15 2013, In : Analytical Biochemistry. 433, 2, p. 150-152 3 p.

Research output: Contribution to journalArticle

Peptide Nucleic Acids
Capillary electrophoresis
Capillary Electrophoresis
Polymorphism
Block copolymers
28 Citations (Scopus)

Regeneration of periodontal tissues using allogeneic periodontal ligament stem cells in an ovine model

Mrozik, K. M., Wada, N., Marino, V., Richter, W., Shi, S., Wheeler, D. L., Gronthos, S. & Bartold, P. M., Nov 2013, In : Regenerative Medicine. 8, 6, p. 711-723 13 p.

Research output: Contribution to journalArticle

Absorbable Gelatin Sponge
Periodontal Ligament
Ligaments
Stem cells
Regeneration
2014

Effect of a rotation training system on the mental health status of postgraduate dental trainees at Kyushu University Hospital, Fukuoka, Japan

Takarada, T., Asada, T., Sumi, Y. & Higuchi, Y., Feb 1 2014, In : Journal of dental education. 78, 2, p. 243-249 7 p.

Research output: Contribution to journalArticle

trainee
Health Status
health status
Tooth
Mental Health
4 Citations (Scopus)

Effects of Activin A on the phenotypic properties of human periodontal ligament cells

Sugii, H., Maeda, H., Tomokiyo, A., Yamamoto, N., Wada, N., Koori, K., Hasegawa, D., Hamano, S., Yuda, A., Monnouchi, S. & Akamine, A., Jan 1 2014, In : Bone. 66, p. 62-71 10 p.

Research output: Contribution to journalArticle

Periodontal Ligament
Cell Differentiation
Interleukin-1
Tooth Root
activin A
7 Citations (Scopus)

Expression and effects of epidermal growth factor on human periodontal ligament cells

Teramatsu, Y., Maeda, H., Sugii, H., Tomokiyo, A., Hamano, S., Wada, N., Yuda, A., Yamamoto, N., Koori, K. & Akamine, A., Sep 1 2014, In : Cell and tissue research. 357, 3, p. 633-643 11 p.

Research output: Contribution to journalArticle

Periodontal Ligament
Epidermal Growth Factor
Interleukin-1
Epidermal Growth Factor Receptor
Bone Morphogenetic Protein 2
7 Citations (Scopus)

Inhibition of JNK in HaCaT cells induced tight junction formation with decreased expression of cytokeratin 5, cytokeratin 17 and desmoglein 3

Kitagawa, N., Inai, Y., Higuchi, Y., Iida, H. & Inai, T., Jan 1 2014, In : Histochemistry and Cell Biology. 142, 4, p. 389-399 11 p.

Research output: Contribution to journalArticle

Keratin-17
Keratin-3
Desmoglein 3
Keratin-5
JNK Mitogen-Activated Protein Kinases
50 Citations (Scopus)

Periodontal-ligament-derived stem cells exhibit the capacity for long-term survival, self-renewal, and regeneration of multiple tissue types in vivo

Menicanin, D., Mrozik, K. M., Wada, N., Marino, V., Shi, S., Bartold, P. M. & Gronthos, S., May 1 2014, In : Stem Cells and Development. 23, 9, p. 1001-1011 11 p.

Research output: Contribution to journalArticle

Periodontal Ligament
Regeneration
Stem Cells
Deoxyuridine
Transplants
45 Citations (Scopus)

PH-responsive release of proteins from biocompatible and biodegradable reverse polymer micelles

Koyamatsu, Y., Hirano, T., Kakizawa, Y., Okano, F., Takarada, T. & Maeda, M., Jan 1 2014, In : Journal of Controlled Release. 173, 1, p. 89-95 7 p.

Research output: Contribution to journalArticle

Micelles
Polymers
glycolic acid
Proteins
Drug Carriers
12 Citations (Scopus)

Porphyromonas gingivalis gingipain is involved in the detachment and aggregation of Aggregatibacter actinomycetemcomitans biofilm

Haraguchi, A., Miura, M., Fujise, O., Hamachi, T. & Nishimura, F., Jan 1 2014, In : Molecular Oral Microbiology. 29, 3, p. 131-143 13 p.

Research output: Contribution to journalArticle

Aggregatibacter actinomycetemcomitans
Porphyromonas gingivalis
Biofilms
Peptide Hydrolases
Cysteine Proteases
5 Citations (Scopus)

Possible involvement of ΔNp63 downregulation in the invasion and metastasis of oral squamous cell carcinoma via induction of a mesenchymal phenotype

Goto, Y., Kawano, S., Matsubara, R., Kiyosue, T., Hirano, M., Jinno, T., Maruse, Y., Toyoshima, T., Kitamura, R., Tanaka, H., Oobu, K. & Nakamura, S., Mar 2014, In : Clinical and Experimental Metastasis. 31, 3, p. 293-306 14 p.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Down-Regulation
Neoplasm Metastasis
Phenotype
Epithelial-Mesenchymal Transition
3 Citations (Scopus)

Regeneration of the periodontium for preservation of the damaged tooth

Maeda, H., Tomokiyo, A., Wada, N., Koori, K., Kawachi, G. & Akamine, A., Oct 1 2014, In : Histology and histopathology. 29, 10, p. 1249-1262 14 p.

Research output: Contribution to journalReview article

Periodontium
Regeneration
Tooth Loss
Tooth
Periodontitis
15 Citations (Scopus)

Semaphorin 3A induces mesenchymal-stem-like properties in human periodontal ligament cells

Wada, N., Maeda, H., Hasegawa, D., Gronthos, S., Bartold, P. M., Menicanin, D., Fujii, S., Yoshida, S., Tomokiyo, A., Monnouchi, S. & Akamine, A., Sep 15 2014, In : Stem Cells and Development. 23, 18, p. 2225-2236 12 p.

Research output: Contribution to journalArticle

Semaphorin-3A
Periodontal Ligament
Stem Cells
Mesenchymal Stromal Cells
Tooth
21 Citations (Scopus)
Calcium-Sensing Receptors
Periodontal Ligament
Calcium Channels
Stem Cells
Calcium
2015
12 Citations (Scopus)

Effect of CTGF/CCN2 on osteo/ cementoblastic and fibroblastic differentiation of a human periodontal ligament stem/progenitor cell line

Yuda, A., Maeda, H., Fujii, S., Monnouchi, S., Yamamoto, N., Wada, N., Koori, K., Tomokiyo, A., Hamano, S., Hasegawa, D. & Akamine, A., Jan 1 2015, In : Journal of cellular physiology. 230, 1, p. 150-159 10 p.

Research output: Contribution to journalArticle

Periodontal Ligament
Ligaments
Stem cells
Stem Cells
Cell Line
43 Citations (Scopus)

Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma

Jinno, T., Kawano, S., Maruse, Y., Matsubara, R., Goto, Y., Sakamoto, T., Hashiguchi, Y., Kaneko, N., Tanaka, H., Kitamura, R., Toyoshima, T., Jinno, A., Moriyama, M., Oobu, K., Kiyoshima, T. & Nakamura, S., May 1 2015, In : Oncology reports. 33, 5, p. 2161-2168 8 p.

Research output: Contribution to journalArticle

Chemoradiotherapy
Squamous Cell Carcinoma
Interleukin-6
Interleukin-6 Receptors
Neoplasms
13 Citations (Scopus)

Mechanical induction of interleukin-11 regulates osteoblastic/cementoblastic differentiation of human periodontal ligament stem/progenitor cells

Monnouchi, S., Maeda, H., Yuda, A., Hamano, S., Wada, N., Tomokiyo, A., Koori, K., Sugii, H., Serita, S. & Akamine, A., Apr 1 2015, In : Journal of Periodontal Research. 50, 2, p. 231-239 9 p.

Research output: Contribution to journalArticle

Interleukin-11
Periodontal Ligament
Stem Cells
Angiotensin II
Cell Line
12 Citations (Scopus)

Microbial community in persistent apical periodontitis: A 16S rRNA gene clone library analysis

Zakaria, M. N., Takeshita, T., Shibata, Y., Maeda, H., Wada, N., Akamine, A. & Yamashita, Y., Jan 1 2015, In : International Endodontic Journal. 48, 8, p. 717-728 12 p.

Research output: Contribution to journalArticle

Periapical Periodontitis
Porphyromonas gingivalis
Gene Library
rRNA Genes
Clone Cells
19 Citations (Scopus)

Modulation of Interparticle Distance in Discrete Gold Nanoparticle Dimers and Trimers by DNA Single-Base Pairing

Akiyama, Y., Shikagawa, H., Kanayama, N., Takarada, T. & Maeda, M., Jul 1 2015, In : Small. 11, 26, p. 3153-3161 9 p.

Research output: Contribution to journalArticle

Base Pairing
Gold
Dimers
Nanoparticles
DNA
1 Citation (Scopus)

Noncontact monitoring of respiration by dynamic air-pressure sensor

Takarada, T., Asada, T., Sumi, Y. & Higuchi, Y., Sep 1 2015, In : Anesthesia progress. 62, 3, p. 100-105 6 p.

Research output: Contribution to journalArticle

Air Pressure
Respiration
Clothing
Tidal Volume
Tooth
18 Citations (Scopus)

Saliva as a potential tool for diagnosis of dry mouth including Sjögren's syndrome

Ohyama, K., Moriyama, M., Hayashida, J. N., Tanaka, A., Maehara, T., Ieda, S., Furukawa, S., Ohta, M., Imabayashi, Y. & Nakamura, S., Mar 1 2015, In : Oral Diseases. 21, 2, p. 224-231 8 p.

Research output: Contribution to journalArticle

Saliva
Mouth
Xerostomia
Chromogranin A
Secretory Immunoglobulin A
14 Citations (Scopus)
Periodontal Ligament
Ligaments
Up-Regulation
Collagen
Tissue
2016

Antibiotic effects against periodontal bacteria in organ cultured tissue

Takeshita, M., Haraguchi, A., Miura, M., Hamachi, T., Fukuda, T., Sanui, T., Takano, A. & Nishimura, F., Nov 2016, (Accepted/In press) In : Clinical and Experimental Dental Research.

Research output: Contribution to journalArticle

8 Citations (Scopus)
Aryl Hydrocarbon Receptors
Periodontal Ligament
Benzo(a)pyrene
Collagen
Cyclic Hydrocarbons
3 Citations (Scopus)

Clinicopathological evaluation of pre-operative chemoradiotherapy with S-1 as a treatment for locally advanced oral squamous cell carcinoma

Kawano, S., Zheng, Y., Oobu, K., Matsubara, R., Goto, Y., Chikui, T., Yoshitake, T., Kiyoshima, T., Jinno, T., Maruse, Y., Mitate, E., Kitamura, R., Tanaka, H., Toyoshima, T., Sugiura, T. & Nakamura, S., May 2016, In : Oncology Letters. 11, 5, p. 3369-3376 8 p.

Research output: Contribution to journalArticle

Chemoradiotherapy
Squamous Cell Carcinoma
Therapeutics
Radiotherapy
Survival Rate

Contribution of Stem Cells to Dental Tissue Regeneration: Isolation, Function, and Application.

Tomokiyo, A., Wada, N. & Maeda, H., 2016, Frontiers in Stem Cell and Regenerative Medicine Research. Bentham Science Publishers, Vol. 2. p. 3-38 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Parathyroid Hormone-Related Protein
Organized Financing
Granulocyte Colony-Stimulating Factor
Tongue
Sports
5 Citations (Scopus)

Facioscapulohumeral muscular dystrophy (FSHD) region gene 1 (FRG1) expression and possible function in mouse tooth germ development

Hasegawa, K., Wada, H., Nagata, K., Fujiwara, H., Wada, N., Someya, H., Mikami, Y., Sakai, H. & Kiyoshima, T., Aug 1 2016, In : Journal of Molecular Histology. 47, 4, p. 375-387 13 p.

Research output: Contribution to journalArticle

Facioscapulohumeral Muscular Dystrophy
Tooth Germ
Gene Expression
Genes
Cytoplasm
8 Citations (Scopus)

Rapid Naked-Eye Discrimination of Cytochrome P450 Genetic Polymorphism through Non-Crosslinking Aggregation of DNA-Functionalized Gold Nanoparticles

Akiyama, Y., Wang, G., Shiraishi, S., Kanayama, N., Takarada, T. & Maeda, M., Dec 1 2016, In : ChemistryOpen. 5, 6, p. 508-512 5 p.

Research output: Contribution to journalArticle

Polymorphism
Gold
Cytochrome P-450 Enzyme System
Assays
Agglomeration
14 Citations (Scopus)

Semaphorin 3A induces odontoblastic phenotype in dental pulp stem cells

Yoshida, S., Wada, N., Hasegawa, D., Miyaji, H., Mitarai, H., Tomokiyo, A., Hamano, S. & Maeda, H., Oct 1 2016, In : Journal of Dental Research. 95, 11, p. 1282-1290 9 p.

Research output: Contribution to journalArticle

Semaphorin-3A
Dental Pulp
Stem Cells
Dentin
Phenotype
3 Citations (Scopus)

Tongue squamous cell carcinoma producing both parathyroid hormone-related protein and granulocyte colony-stimulating factor: A case report and literature review

Kaneko, N., Kawano, S., Matsubara, R., Goto, Y., Jinno, T., Maruse, Y., Sakamoto, T., Hashiguchi, Y., Iida, M. & Nakamura, S., Jun 17 2016, In : World Journal of Surgical Oncology. 14, 1, 161.

Research output: Contribution to journalArticle

Parathyroid Hormone-Related Protein
Hypercalcemia
Granulocyte Colony-Stimulating Factor
Tongue
Squamous Cell Carcinoma
2017

Antibiotic effects against periodontal bacteria in organ cultured tissue

Takeshita, M., Haraguchi, A., Miura, M., Hamachi, T., Fukuda, T., Sanui, T., Takano, A. & Nishimura, F., Feb 1 2017, In : Clinical and Experimental Dental Research. 3, 1, p. 5-12 8 p.

Research output: Contribution to journalArticle

Epithelium
Anti-Bacterial Agents
Bacteria
cefdinir
Periodontitis
1 Citation (Scopus)
Anti-Idiotypic Antibodies
Neutrophils
Toll-Like Receptor 4
Superoxides
Lipids
12 Citations (Scopus)

Calcium-sensing receptor-ERK signaling promotes odontoblastic differentiation of human dental pulp cells

Mizumachi, H., Yoshida, S., Tomokiyo, A., Hasegawa, D., Hamano, S., Yuda, A., Sugii, H., Serita, S., Mitarai, H., Koori, K., Wada, N. & Maeda, H., Aug 1 2017, In : Bone. 101, p. 191-201 11 p.

Research output: Contribution to journalArticle

Calcium-Sensing Receptors
Dental Pulp
Strontium
Calcium
L-Type Calcium Channels
30 Citations (Scopus)

CD163+CD204+ tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma

Kubota, K., Moriyama, M., Furukawa, S., Rafiul, H. A. S. M., Maruse, Y., Jinno, T., Tanaka, A., Ohta, M., Ishiguro, N., Yamauchi, M., Sakamoto, M., Maehara, T., Hayashida, J. N., Kawano, S., Kiyoshima, T. & Nakamura, S., Dec 1 2017, In : Scientific reports. 7, 1, 1755.

Research output: Contribution to journalArticle

Interleukin-10
Squamous Cell Carcinoma
Macrophages
T-Lymphocytes
Neoplasms
5 Citations (Scopus)

Critical roles of Wnt5a–Ror2 signaling in aggressiveness of tongue squamous cell carcinoma and production of matrix metalloproteinase-2 via ΔNp63β-mediated epithelial–mesenchymal transition

Sakamoto, T., Kawano, S., Matsubara, R., Goto, Y., Jinno, T., Maruse, Y., Kaneko, N., Hashiguchi, Y., Hattori, T., Tanaka, S., Kitamura, R., Kiyoshima, T. & Nakamura, S., Jun 1 2017, In : Oral Oncology. 69, p. 15-25 11 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 2
Tongue
Squamous Cell Carcinoma
Cell Movement
B-Lymphocytes
16 Citations (Scopus)

Cross-linking versus non-cross-linking aggregation of gold nanoparticles induced by DNA hybridization: A comparison of the rapidity of solution color change

Wang, G., Akiyama, Y., Shiraishi, S., Kanayama, N., Takarada, T. & Maeda, M., Jan 1 2017, In : Bioconjugate Chemistry. 28, 1, p. 270-277 8 p.

Research output: Contribution to journalArticle

Gold
Nanoparticles
DNA
Agglomeration
Color
2 Citations (Scopus)

Cytokeratin 17 mRNA as a prognostic marker of oral squamous cell carcinoma

Kitamura, R., Toyoshima, T., Tanaka, H., Kawano, S., Matsubara, R., Goto, Y., Jinno, T., Maruse, Y., Oobu, K. & Nakamura, S., Dec 2017, In : Oncology Letters. 14, 6, p. 6735-6743 9 p.

Research output: Contribution to journalArticle

Keratin-17
Squamous Cell Carcinoma
Messenger RNA
Blood Cells
Survival Rate
1 Citation (Scopus)

Differential roles of kallikrein-related peptidase 6 in malignant transformation and ΔNp63β-mediated epithelial-mesenchymal transition of oral squamous cell carcinoma

Kaneko, N., Kawano, S., Yasuda, K., Hashiguchi, Y., Sakamoto, T., Matsubara, R., Goto, Y., Jinno, T., Maruse, Y., Morioka, M., Hattori, T., Tanaka, S., Tanaka, H., Kiyoshima, T. & Nakamura, S., Dec 2017, In : Oral Oncology. 75, p. 148-157 10 p.

Research output: Contribution to journalArticle

Kallikreins
Epithelial-Mesenchymal Transition
Squamous Cell Carcinoma
Peptide Hydrolases
Epithelium
Glial Cell Line-Derived Neurotrophic Factor
Periodontal Ligament
PC12 Cells
Ligaments
Interleukin-1beta
4 Citations (Scopus)
Porphyromonas gingivalis
Neutrophils
Toll-Like Receptor 4
Respiratory Burst
Interleukin-1
24 Citations (Scopus)

Iodine-mediated etching of triangular gold nanoplates for colorimetric sensing of copper ion and aptasensing of chloramphenicol

Chang, C. C., Wang, G., Takarada, T. & Maeda, M., Jan 1 2017, In : ACS Applied Materials and Interfaces. 9, 39, p. 34518-34525 8 p.

Research output: Contribution to journalArticle

Chloramphenicol
Iodine
Gold
Copper
Etching
2 Citations (Scopus)

Transforming growth factor-β-induced gene product-h3 inhibits odontoblastic differentiation of dental pulp cells

Serita, S., Tomokiyo, A., Hasegawa, D., Hamano, S., Sugii, H., Yoshida, S., Mizumachi, H., Mitarai, H., Monnouchi, S., Wada, N. & Maeda, H., Jun 1 2017, In : Archives of Oral Biology. 78, p. 135-143 9 p.

Research output: Contribution to journalArticle

Dental Pulp
Transforming Growth Factors
Odontoblasts
Genes
Dental Pulp Capping
3 Citations (Scopus)

Transgelin mediates transforming growth factor-β1-induced proliferation of human periodontal ligament cells

Mitarai, H., Wada, N., Hasegawa, D., Yoshida, S., Sonoda, M., Tomokiyo, A., Hamano, S., Serita, S., Mizumachi, H. & Maeda, H., Dec 1 2017, In : Journal of Periodontal Research. 52, 6, p. 984-993 10 p.

Research output: Contribution to journalArticle

Periodontal Ligament
Transforming Growth Factors
Small Interfering RNA
Fluorescent Antibody Technique
transgelin