Innovation Center for Medical Redox Navigation

Research Output

2017

Design of a 15 N Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State

Nonaka, H., Hirano, M., Imakura, Y., Takakusagi, Y., Ichikawa, K. & Sando, S., Jan 9 2017, In : Scientific reports. 7, 40104.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Extra-pancreatic invasion induces lipolytic and fibrotic changes in the adipose microenvironment, with released fatty acids enhancing the invasiveness of pancreatic cancer cells

Okumura, T., Ohuchida, K., Sada, M., Abe, T., Endo, S., Koikawa, K., Iwamoto, C., Miura, D., Mizuuchi, Y., Moriyama, T., Nakata, K., Miyasaka, Y., Manabe, T., Ohtsuka, T., Nagai, E., Mizumoto, K., Oda, Y., Hashizume, M. & Nakamura, M., Jan 1 2017, In : Oncotarget. 8, 11, p. 18280-18295 16 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Lipid radicals cause light-induced retinal degeneration

Enoki, M., Shinto, S., Matsuoka, Y., Otsuka, A., Kaidzu, S., Tanito, M., Shibata, T., Uchida, K., Ohira, A., Yamato, M. & Yamada, K-I., Sep 20 2017, In : Chemical Communications.

Research output: Contribution to journalArticle

Non-invasive evaluation of atopic dermatitis based on redox status using in vivo dynamic nuclear polarization magnetic resonance imaging

Eto, H., Tsuji, G., Chiba, T., Furue, M. & Hyodo, F., Feb 1 2017, In : Free Radical Biology and Medicine. 103, p. 209-215 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Oligomer formation of a tea polyphenol, EGCG, on its sensing molecule 67 kDa laminin receptor

Huang, Y., Sumida, M., Kumazoe, M., Sugihara, K., Suemasu, Y., Yamada, S., Yamashita, S., Miyakawa, J., Takahashi, T., Tanaka, H., Fujimura, Y. & Tachibana, H., Jan 1 2017, In : Chemical Communications. 53, 12, p. 1941-1944 4 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Pioglitazone improves whole-body aerobic capacity and skeletal muscle energy metabolism in patients with metabolic syndrome

Yokota, T., Kinugawa, S., Hirabayashi, K., Suga, T., Takada, S., Omokawa, M., Kadoguchi, T., Takahashi, M., Fukushima, A., Matsushima, S., Yamato, M., Okita, K. & Tsutsui, H., Jul 2017, In : Journal of Diabetes Investigation. 8, 4, p. 535-541 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Preference for and learning of amino acids in larval Drosophila

Kudow, N., Miura, D., Schleyer, M., Toshima, N., Gerber, B. & Tanimura, T., Mar 15 2017, In : Biology Open. 6, 3, p. 365-369 5 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Role of Ad4-binding protein/steroidogenic factor 1 in regulating NADPH production in adrenocortical Y-1 cells

Li, B., Baba, T., Miyabayashi, K., Sato, T., Shima, Y., Ichinose, T., Miura, D., Ohkawa, Y., Suyama, M. & Morohashi, K. I., Jan 1 2017, In : Endocrine Journal. 64, 3, p. 315-324 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Spatially resolved metabolic distribution for unraveling the physiological change and responses in tomato fruit using matrix-assisted laser desorption/ionization–mass spectrometry imaging (MALDI–MSI)

Nakamura, J., Morikawa-Ichinose, T., Fujimura, Y., Hayakawa, E., Takahashi, K., Ishii, T., Miura, D. & Wariishi, H., Jan 1 2017, In : Analytical and Bioanalytical Chemistry. 409, 6, p. 1697-1706 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2016

Anti-obesity and anti-inflammatory effects of macrophage-targeted interleukin-10-conjugated liposomes in obese mice

Toita, R., Kawano, T., Murata, M. & Kang, J. H., Dec 1 2016, In : Biomaterials. 110, p. 81-88 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

A profluorescent nitroxide probe for ascorbic acid detection and its application to quantitative analysis of diabetic rat plasma

Matsuoka, Y., Ohkubo, K., Yamasaki, T., Yamato, M., Ohtabu, H., Shirouzu, T., Fukuzumi, S. & Yamada, K. I., Jan 1 2016, In : RSC Advances. 6, 65, p. 60907-60915 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Bilirubin as an important physiological modulator of oxidative stress and chronic inflammation in metabolic syndrome and diabetes: a new aspect on old molecule

Inoguchi, T., Sonoda, N. & Maeda, Y., Dec 1 2016, In : Diabetology International. 7, 4, p. 338-341 4 p.

Research output: Contribution to journalEditorial

8 Citations (Scopus)

Design of a Hyperpolarized Molecular Probe for Detection of Aminopeptidase N Activity

Hata, R., Nonaka, H., Takakusagi, Y., Ichikawa, K. & Sando, S., Jan 26 2016, In : Angewandte Chemie - International Edition. 55, 5, p. 1765-1768 4 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Development of a PET/OMRI combined system for simultaneous imaging of positron and free radical probes for small animals

Yamamoto, S., Watabe, T., Ikeda, H., Kanai, Y., Ichikawa, K., Nakao, M., Kato, K. & Hatazawa, J., Oct 1 2016, In : Medical physics. 43, 10, p. 5676-5684 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Development of a real-time imaging system for hypoxic cell apoptosis

Kagiya, G., Ogawa, R., Hyodo, F., Yamashita, K., Nakamura, M., Ishii, A., Sejimo, Y., Tominaga, S., Murata, M., Tanaka, Y. & Hatashita, M., Mar 16 2016, In : Molecular Therapy - Methods and Clinical Development. 3, 1 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Development of redox metabolic imaging using endogenous molecules

Hyodo, F., Ito, S., Eto, H., Nakaji, T., Yasukawa, K., Kobayashi, R. & Utsumi, H., Jan 1 2016, In : Yakugaku Zasshi. 136, 8, p. 1107-1114 8 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Direct Monitoring of γ-Glutamyl Transpeptidase Activity In Vivo Using a Hyperpolarized13C-Labeled Molecular Probe

Nishihara, T., Yoshihara, H. A. I., Nonaka, H., Takakusagi, Y., Hyodo, F., Ichikawa, K., Can, E., Bastiaansen, J. A. M., Takado, Y., Comment, A. & Sando, S., Jan 1 2016, In : Angewandte Chemie - International Edition. 55, 36, p. 10626-10629 4 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Dynamic nuclear polarization-magnetic resonance imaging at low ESR irradiation frequency for ascorbyl free radicals

Ito, S. & Hyodo, F., Feb 19 2016, In : Scientific reports. 6, 21407.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Effect of ionic interaction between a hyperpolarized magnetic resonance chemical probe and a gadolinium contrast agent for the hyperpolarized lifetime after dissolution

Takakusagi, Y., Inoue, K., Naganuma, T., Hyodo, F. & Ichikawa, K., Sep 1 2016, In : Journal of Magnetic Resonance. 270, p. 157-160 4 p.

Research output: Contribution to journalArticle

Evaluation of brain redox status and its association with cognitive dysfunction in diabetic animal models by redox molecular imaging (ReMI)

Sonoda, N., Inoguchi, T., Minami, Y., Hyodo, F., Ichikawa, K., Yamato, M., Utsumi, H. & Takayanagi, R., Jan 1 2016, In : Yakugaku Zasshi. 136, 8, p. 1081-1086 6 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Fluorescence probe for the convenient and sensitive detection of ascorbic acid

Matsuoka, Y., Yamato, M. & Yamada, K. I., Jan 2016, In : Journal of Clinical Biochemistry and Nutrition. 58, 1, p. 16-22 7 p.

Research output: Contribution to journalReview article

13 Citations (Scopus)

Fluorescence probes to detect lipid-derived radicals

Yamada, K. I., Mito, F., Matsuoka, Y., Ide, S., Shikimachi, K., Fujiki, A., Kusakabe, D., Ishida, Y., Enoki, M., Tada, A., Ariyoshi, M., Yamasaki, T. & Yamato, M., Aug 1 2016, In : Nature Chemical Biology. 12, 8, p. 608-613 6 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Förster Resonance Energy Transfer-Based Self-Assembled Nanoprobe for Rapid and Sensitive Detection of Postoperative Pancreatic Fistula

Hamano, N., Murata, M., Kawano, T., Piao, J. S., Narahara, S., Nakata, R., Akahoshi, T., Ikeda, T. & Hashizume, M., Mar 2 2016, In : ACS Applied Materials and Interfaces. 8, 8, p. 5114-5123 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Hyperinsulinemia and sulfonylurea use are independently associated with left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus with suboptimal blood glucose control

Inoue, T., Maeda, Y., Sonoda, N., Sasaki, S., Kabemura, T., Kobayashi, K. & Inoguchi, T., Aug 1 2016, In : BMJ Open Diabetes Research and Care. 4, 1, e000223.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Integrated endoscopic system based on optical imaging and hyperspectral data analysis for colorectal cancer detection

Kumashiro, R., Konishi, K., Chiba, T., Akahoshi, T., Nakamura, S., Murata, M., Tomikawa, M., Matsumoto, T., Maehara, Y. & Hashizume, M., Aug 2016, In : Anticancer research. 36, 8, p. 3925-3932 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Liver cell-targeted delivery of therapeutic molecules

Kang, J. H., Toita, R. & Murata, M., Jan 2 2016, In : Critical Reviews in Biotechnology. 36, 1, p. 132-143 12 p.

Research output: Contribution to journalReview article

23 Citations (Scopus)

Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease

Sato, E., Mori, T., Mishima, E., Suzuki, A., Sugawara, S., Kurasawa, N., Saigusa, D., Miura, D., Morikawa-Ichinose, T., Saito, R., Oba-Yabana, I., Oe, Y., Kisu, K., Naganuma, E., Koizumi, K., Mokudai, T., Niwano, Y., Kudo, T., Suzuki, C., Takahashi, N. & 4 others, Sato, H., Abe, T., Niwa, T. & Ito, S., Nov 10 2016, In : Scientific reports. 6, 36618.

Research output: Contribution to journalArticle

41 Citations (Scopus)

MSIDV: A versatile tool to visualize biological indices from mass spectrometry imaging data

Hayakawa, E., Fujimura, Y. & Miura, D., Jan 1 2016, In : Bioinformatics. 32, 24, p. 3852-3854 3 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Noninvasive mapping of the redox status of dimethylnitrosamine-induced hepatic fibrosis using in vivo dynamic nuclear polarization-magnetic resonance imaging

Kawano, T., Murata, M., Hyodo, F., Eto, H., Kosem, N., Nakata, R., Hamano, N., Piao, J. S., Narahara, S., Akahoshi, T. & Hashizume, M., Sep 2 2016, In : Scientific reports. 6, 32604.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Nuclear expression of Y-box binding protein-1 is associated with poor prognosis in patients with pancreatic cancer and its knockdown inhibits tumor growth and metastasis in mice tumor models

Shinkai, K., Nakano, K., Cui, L., Mizuuchi, Y., Onishi, H., Oda, Y., Obika, S., Tanaka, M. & Katano, M., Jul 15 2016, In : International Journal of Cancer. 139, 2, p. 433-445 13 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Plasma metabolites predict severity of depression and suicidal ideation in psychiatric patients-a multicenter pilot analysis

Setoyama, D., Kato, T. A., Hashimoto, R., Kunugi, H., Hattori, K., Hayakawa, K., Sato-Kasai, M., Shimokawa, N., Kaneko, S., Yoshida, S., Goto, Y. I., Yasuda, Y., Yamamori, H., Ohgidani, M., Sagata, N., Miura, D., Kang, D. & Kanba, S., Dec 2016, In : PloS one. 11, 12, e0165267.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Pulmonary thromboembolism during pregnancy in a woman with β-thalassaemia who had undergone splenectomy

Shimada, Y., Hidaka, N., Maehara, K., Murata, M., Fujita, Y. & Kato, K., Oct 2 2016, In : Journal of Obstetrics and Gynaecology. 36, 7, p. 883-884 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Role of amino acid residues surrounding the phosphorylation site in peptide substrates of G protein-coupled receptor kinase 2 (GRK2)

Asai, D., Murata, M., Toita, R., Kawano, T., Nakashima, H. & Kang, J. H., Dec 1 2016, In : Amino Acids. 48, 12, p. 2875-2880 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Selective Imaging of Malignant Ascites in a Mouse Model of Peritoneal Metastasis Using in Vivo Dynamic Nuclear Polarization-Magnetic Resonance Imaging

Eto, H., Hyodo, F., Nakano, K. & Utsumi, H., Feb 16 2016, In : Analytical chemistry. 88, 4, p. 2021-2027 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Silent myocardial ischemia in asymptomatic patients with type 2 diabetes mellitus without previous histories of cardiovascular disease

Kawano, Y., Takemoto, M., Mito, T., Morisaki, H., Tanaka, A., Sakaki, Y., Matsuo, A., Abe, K., Hida, S., Mukae, K., Okazaki, T., Tayama, K. I., Inoguchi, T., Yoshitake, K. & Kosuga, K. I., Aug 1 2016, In : International Journal of Cardiology. 216, p. 151-155 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Splenectomy enhances the therapeutic effect of adipose tissue-derived mesenchymal stem cell infusion on cirrhosis rats

Tang, W. P., Akahoshi, T., Piao, J. S., Narahara, S., Murata, M., Kawano, T., Hamano, N., Ikeda, T. & Hashizume, M., Aug 1 2016, In : Liver International. 36, 8, p. 1151-1159 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

TEMPOL increases NAD+ and improves redox imbalance in obese mice

Yamato, M., Kawano, K., Yamanaka, Y., Saiga, M. & Yamada, K. I., Aug 1 2016, In : Redox Biology. 8, p. 316-322 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The feasibility of in vivo imaging of infiltrating blood cells for predicting the functional prognosis after spinal cord injury

Yokota, K., Saito, T., Kobayakawa, K., Kubota, K., Hara, M., Murata, M., Ohkawa, Y., Iwamoto, Y. & Okada, S., May 9 2016, In : Scientific reports. 6, 25673.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2015

Applications of human hepatitis B virus preS domain in bio- and nanotechnology

Toita, R., Kawano, T., Kang, J. H. & Murata, M., Jun 28 2015, In : World Journal of Gastroenterology. 21, 24, p. 7400-7411 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Bacterial metabolism in immediate response to nutritional perturbation with temporal and network view of metabolites

Yukihira, D., Fujimura, Y., Wariishi, H. & Miura, D., Jun 26 2015, In : Molecular BioSystems. 11, 9, p. 2473-2482 10 p.

Research output: Contribution to journalArticle

Basic fibroblast growth factor-treated adipose tissue-derived mesenchymal stem cell infusion to ameliorate liver cirrhosis via paracrine hepatocyte growth factor

Tang, W. P., Akahoshi, T., Piao, J. S., Narahara, S., Murata, M., Kawano, T., Hamano, N., Ikeda, T. & Hashizume, M., Jun 1 2015, In : Journal of Gastroenterology and Hepatology (Australia). 30, 6, p. 1065-1074 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)
10 Citations (Scopus)

Brain redox imaging in the pentylenetetrazole (PTZ)-induced kindling model of epilepsy by using in vivo electron paramagnetic resonance and a nitroxide imaging probe

Emoto, M. C., Yamato, M., Sato-Akaba, H., Yamada, K. I. & Fujii, H. G., Nov 3 2015, In : Neuroscience Letters. 608, p. 40-44 5 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Clinical significance of barriers to blood glucose control in type 2 diabetes patients with insufficient glycemic control

Suzuki, T., Takei, R., Inoguchi, T., Sonoda, N., Sasaki, S., Kaise, T. & Takayanagi, R., Jun 25 2015, In : Patient Preference and Adherence. 9, p. 837-845 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Design and function of engineered protein nanocages as a drug delivery system for targeting pancreatic cancer cells via neuropilin-1

Murata, M., Narahara, S., Kawano, T., Hamano, N., Piao, J. S., Kang, J. H., Ohuchida, K., Murakami, T. & Hashizume, M., May 4 2015, In : Molecular pharmaceutics. 12, 5, p. 1422-1430 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Design of a hyperpolarized 15N NMR probe that induces a large chemical-shift change upon binding of calcium ions

Hata, R., Nonaka, H., Takakusagi, Y., Ichikawa, K. & Sando, S., Aug 7 2015, In : Chemical Communications. 51, 61, p. 12290-12292 3 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Development of a new redox molecular imaging method

Naganuma, T., Nakao, M., Ichikawa, K. & Utsumi, H., Jan 1 2015, In : Yakugaku Zasshi. 135, 5, p. 733-738 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Diffusion studies of redox-sensitive nitroxyl spin probes through bilayer lipid membranes using 300 MHz electron spin resonance spectrometer

Benial, A. M. F., Dhas, M. K., Ichikawa, K., Yamada, K., Hyodo, F., Jawahar, A. & Utsumi, H., Jan 1 2015, In : Biofizika. 60, 1, p. 88-94 7 p.

Research output: Contribution to journalArticle

Expression and characterization of myristoylated preS1-conjugated nanocages for targeted cell delivery

Murata, M., Piao, J. S., Narahara, S., Kawano, T., Hamano, N., Kang, J. H., Asai, D., Ugawa, R. & Hashizume, M., Jun 2015, In : Protein Expression and Purification. 110, p. 52-56 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Feasibility of a subcutaneously administered block/homo-mixed polyplex micelle as a carrier for DNA vaccination in a mouse tumor model

Cui, L., Osada, K., Imaizumi, A., Kataoka, K. & Nakano, K., May 28 2015, In : Journal of Controlled Release. 206, p. 220-231 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)