Kyushu University Beppu Hospital

Research Output 2003 2018

  • 31 Article
  • 4 Review article
  • 1 Conference contribution
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Article
2018
2 Citations (Scopus)

A variant of death-receptor 3 associated with rheumatoid arthritis interferes with apoptosis-induction of T cell

Hashiramoto, A., Konishi, Y., Murayama, K., Kawasaki, H., Yoshida, K., Tsumiyama, K., Tanaka, K., Mizuhara, M., Shiotsuki, T., Kitamura, H., Komai, K., Kimura, T., Yagita, H., Shiozawa, K. & Shiozawa, S., Jan 1 2018, In : Journal of Biological Chemistry. 293, 6, p. 1933-1943 11 p.

Research output: Contribution to journalArticle

Receptors, Tumor Necrosis Factor, Member 25
T-cells
Rheumatoid Arthritis
Apoptosis
T-Lymphocytes
2016

L'induction précoce de la surexpression de l'interféron-alpha 1 murin in vivo induit une expansion de lymphocytes T régulateurs hautement suppressifs qui protègent contre l'arthrite expérimentale

Matyja, K., Ribon, M., Hervé, R., Lemeiter, D., Tsumiyama, K., Shiozawa, S., Bessis, N., Boissier, M. C. & Decker, P., Nov 1 2016, In : Revue du Rhumatisme (Edition Francaise). 83, p. A301-A302

Research output: Contribution to journalArticle

Interferon-alpha
Lymphocytes
12 Citations (Scopus)

MMP-3 as a predictor for structural remission in RA patients treated with MTX monotherapy

Shiozawa, K., Yamane, T., Murata, M., Yoshihara, R., Tsumiyama, K., Imura, S. & Shiozawa, S., Feb 27 2016, In : Arthritis Research and Therapy. 18, 1, 55.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 3
Methotrexate
Rheumatoid Arthritis
Antirheumatic Agents
Serum
2015
3 Citations (Scopus)

Refractory dermatomyositis complicated with myelodysplastic syndrome

Nakanishi, T., Horikoshi, H., Kusanagi, Y., Yamamura, T., Takahashi, R., Kimura, F. & Itoh, K., Oct 1 2015, In : Internal Medicine. 54, 19, p. 2507-2511 5 p.

Research output: Contribution to journalArticle

Dermatomyositis
Myelodysplastic Syndromes
Interstitial Lung Diseases
Skin Ulcer
Myositis
2014

Clinical utility of an array comparative genomic hybridization analysis for Williams syndrome

Yagihashi, T., Torii, C., Takahashi, R., Omori, M., Kosaki, R., Yoshihashi, H., Ihara, M., Minagawa-Kawai, Y., Yamamoto, J., Takahashi, T. & Kosaki, K., Nov 1 2014, In : Congenital Anomalies. 54, 4, p. 225-227 3 p.

Research output: Contribution to journalArticle

Williams Syndrome
Comparative Genomic Hybridization
Intellectual Disability
Fluorescence In Situ Hybridization
1 Citation (Scopus)

Induction of de novo autoimmune disease in normal mice upon repeated immunization with antigen

Tsumiyama, K. & Shiozawa, S., Jan 1 2014, In : Methods in Molecular Biology. 1142, p. 85-90 6 p.

Research output: Contribution to journalArticle

Autoimmunity
Autoimmune Diseases
Immunization
Antigens
Systemic Lupus Erythematosus
2013
4 Citations (Scopus)

Expansion of PD-1-positive effector CD4 T cells in an experimental model of SLE: Contribution to the self-organized criticality theory

Miyazaki, Y., Tsumiyama, K., Yamane, T., Ito, M. & Shiozawa, S., Apr 25 2013, In : Kobe Journal of Medical Sciences. 59, 2

Research output: Contribution to journalArticle

Systemic Lupus Erythematosus
Theoretical Models
T-Lymphocytes
Autoantibodies
Antigens
4 Citations (Scopus)

IFN-γ-producing effector CD8 T lymphocytes cause immune glomerular injury by recognizing antigen presented as immune complex on target tissue

Tsumiyama, K., Hashiramoto, A., Takimoto, M., Tsuji-Kawahara, S., Miyazawa, M. & Shiozawa, S., Jul 1 2013, In : Journal of Immunology. 191, 1, p. 91-96 6 p.

Research output: Contribution to journalArticle

Antigen-Antibody Complex
T-Lymphocytes
Antigens
Wounds and Injuries
Immunization

Self-organized criticality theory and the expansion of PD-1-positive effector CD4 T cells: Search for autoantibody-inducing CD4 T cells

Miyazaki, Y., Tsumiyama, K., Yamane, T., Ito, M. & Shiozawa, S., Sep 16 2013, In : Frontiers in Immunology. 4, APR, Article 87.

Research output: Contribution to journalArticle

Autoantibodies
T-Lymphocytes
2011
107 Citations (Scopus)

SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-γ and IL-17A production

Takahashi, R., Nishimoto, S., Muto, G., Sekiya, T., Tamiya, T., Kimura, A., Morita, R., Asakawa, M., Chinen, T. & Yoshimura, A., Sep 26 2011, In : Journal of Experimental Medicine. 208, 10, p. 2055-2067 13 p.

Research output: Contribution to journalArticle

Interleukin-17
Regulatory T-Lymphocytes
Cytokines
Antigen-Presenting Cells
Colitis
13 Citations (Scopus)

SOCS1 regulates type I/type II NKT cell balance by regulating IFNγ signaling

Hashimoto, M., Hiwatashi, K., Ichiyama, K., Morita, R., Sekiya, T., Kimura, A., Sugiyama, Y., Sibata, T., Kuroda, K., Takahashi, R. & Yoshimura, A., Mar 18 2011, In : International Immunology. 23, 3, p. 165-176 12 p.

Research output: Contribution to journalArticle

Natural Killer T-Cells
Cytokines
Knockout Mice
Interleukin-2
Sulfoglycosphingolipids
197 Citations (Scopus)

Suppressors of cytokine signaling (SOCS) proteins and JAK/STAT pathways: Regulation of T-cell inflammation by SOCS1 and SOCS3

Tamiya, T., Kashiwagi, I., Takahashi, R., Yasukawa, H. & Yoshimura, A., May 1 2011, In : Arteriosclerosis, thrombosis, and vascular biology. 31, 5, p. 980-985 6 p.

Research output: Contribution to journalArticle

Suppressor of Cytokine Signaling Proteins
Janus Kinases
Cytokines
Inflammation
T-Lymphocytes
85 Citations (Scopus)

Transcription Factor Smad-Independent T Helper 17 Cell Induction by Transforming-Growth Factor-β Is Mediated by Suppression of Eomesodermin

Ichiyama, K., Sekiya, T., Inoue, N., Tamiya, T., Kashiwagi, I., Kimura, A., Morita, R., Muto, G., Shichita, T., Takahashi, R. & Yoshimura, A., May 27 2011, In : Immunity. 34, 5, p. 741-754 14 p.

Research output: Contribution to journalArticle

Th17 Cells
Transforming Growth Factors
Transcription Factors
JNK Mitogen-Activated Protein Kinases
Cell Differentiation
2010
113 Citations (Scopus)

Mammalian clock gene Cryptochrome regulates arthritis via proinflammatory cytokine TNF-α

Hashiramoto, A., Yamane, T., Tsumiyama, K., Yoshida, K., Komai, K., Yamada, H., Yamazaki, F., Doi, M., Okamura, H. & Shiozawa, S., Feb 1 2010, In : Journal of Immunology. 184, 3, p. 1560-1565 6 p.

Research output: Contribution to journalArticle

Cryptochromes
Arthritis
Cytokines
Genes
Spleen
2009
5 Citations (Scopus)

Peripheral T cell lymphoma with a high titer of proteinase-3-antineutrophil cytoplasmic antibodies that resembled Wegener's granulomatosis

Shirai, T., Takahashi, R., Tajima, Y., Kohata, K., Yamamoto, J., Fujii, H., Takasawa, N., Ishizawa, K., Ichinohasama, R., Ishii, T. & Harigae, H., Dec 1 2009, In : Internal Medicine. 48, 23, p. 2041-2045 5 p.

Research output: Contribution to journalArticle

Myeloblastin
Peripheral T-Cell Lymphoma
Antineutrophil Cytoplasmic Antibodies
Granulomatosis with Polyangiitis
Biopsy
4 Citations (Scopus)

Prospective study of methotrexate treatment for rheumatoid arthritis treated legitimately according to the government recommended 8 mg/week dose

Hashiramoto, A., Shiozawa, K., Tanaka, Y., Yamane, T., Murata, M., Tanaka, C., Terashima, Y., Koyama, K., Nakagawa, N., Abe, S., Yoshihara, R., Saegusa, Y., Tsumiyama, K., Komai, K., Sakai, Y. & Shiozawa, S., Dec 1 2009, In : Modern Rheumatology. 19, 6, p. 637-642 6 p.

Research output: Contribution to journalArticle

Methotrexate
Rheumatoid Arthritis
Prospective Studies
Joints
Signs and Symptoms
31 Citations (Scopus)

Self-organized criticality theory of autoimmunity

Tsumiyama, K., Miyazaki, Y. & Shiozawa, S., Dec 1 2009, In : PloS one. 4, 12, e8382.

Research output: Contribution to journalArticle

autoimmunity
T-cells
Autoimmunity
T-lymphocytes
Autoantibodies
8 Citations (Scopus)

Sjögren's syndrome patients presenting with hypergammaglobulinemia are relatively unresponsive to cevimeline treatment 13474464

Komai, K., Shiozawa, K., Tanaka, Y., Yoshihara, R., Tanaka, C., Sakai, H., Yamane, T., Murata, M., Tsumiyama, K., Hashiramoto, A. & Shiozawa, S., May 19 2009, In : Modern Rheumatology. 19, 4, p. 416-419 4 p.

Research output: Contribution to journalArticle

Hypergammaglobulinemia
Saliva
Therapeutics
Mouth
cevimeline
2008
21 Citations (Scopus)

Easy and accurate diagnosis of rheumatoid arthritis using anti-cyclic citrullinated peptide 2 antibody, swollen joint count, and C-reactive protein/rheumatoid factor

Yamane, T., Hashiramoto, A., Tanaka, Y., Tsumiyama, K., Miura, Y., Shiozawa, K., Chihara, K. & Shiozawa, S., Mar 1 2008, In : Journal of Rheumatology. 35, 3, p. 414-420 7 p.

Research output: Contribution to journalArticle

Rheumatoid Factor
C-Reactive Protein
Rheumatoid Arthritis
Joints
Antibodies
23 Citations (Scopus)

Reversible bone marrow dysplasia in patients with systemic lupus erythematosus

Oka, Y., Kameoka, J., Hirabayashi, Y., Takahashi, R., Ishii, T., Sasaki, T. & Harigae, H., Jul 11 2008, In : Internal Medicine. 47, 8, p. 737-742 6 p.

Research output: Contribution to journalArticle

Developmental Bone Disease
Systemic Lupus Erythematosus
Bone Marrow
Erythroid Cells
Megakaryocytes
2007
7 Citations (Scopus)

A monoclonal antibody against human homocysteine-induced endoplasmic reticulum protein (Herp): A useful tool for evaluating endoplasmic reticulum stress

Oka, Y., Hirabayashi, Y., Ishii, T., Takahashi, R. & Sasaki, T., Jul 27 2007, In : Tohoku Journal of Experimental Medicine. 212, 4, p. 431-437 7 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Staphylococcal Protein A
Homocysteine
Endoplasmic Reticulum
Monoclonal Antibodies
24 Citations (Scopus)

Angiopoietin 1 directly induces destruction of the rheumatoid joint by cooperative, but independent, signaling via ERK/MAPK and phosphatidylinositol 3-kinase/Akt

Hashiramoto, A., Sakai, C., Yoshida, K., Tsumiyama, K., Miura, Y., Shiozawa, K., Nose, M., Komai, K. & Shiozawa, S., Jul 1 2007, In : Arthritis and rheumatism. 56, 7, p. 2170-2179 10 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Angiopoietin-1
Joints
Synovial Membrane
Western Blotting
2006
11 Citations (Scopus)

Two cases of systemic lupus erythematosus complicated with colonic ulcers

Miyahara, S., Ito, S., Soeda, A., Chino, Y., Hayashi, T., Takahashi, R., Goto, D., Matsumoto, I., Tsutsumi, A. & Sumida, T., Jan 17 2006, In : Internal Medicine. 44, 12, p. 1298-1306 9 p.

Research output: Contribution to journalArticle

Systemic Lupus Erythematosus
Ulcer
Steroids
Mesalamine
Therapeutics
2005

A case of pulmonary hypertension associated with systemic lupus erythematosus without anti-ribonucleoprotein antibodies

Suzuki, E., Hayashi, T., Ito, S., Miyazaki, K., Yamazaki, H., Machino, T., Takahashi, R., Chino, Y., Goto, D., Matsumoto, I., Tsutsumi, A., Sato, Y. & Sumida, T., Sep 1 2005, In : Acta Medica et Biologica. 53, 3, p. 87-93 7 p.

Research output: Contribution to journalArticle

Ribonucleoproteins
Pulmonary Hypertension
Systemic Lupus Erythematosus
Anti-Idiotypic Antibodies
Steroids
73 Citations (Scopus)

Association of mannose binding lectin (MBL) gene polymorphism and serum MBL concentration with characteristics and progression of systemic lupus erythematosus

Takahashi, R., Tsutsumi, A., Ohtani, K., Muraki, Y., Goto, D., Matsumoto, I., Wakamiya, N. & Sumida, T., Feb 1 2005, In : Annals of the Rheumatic Diseases. 64, 2, p. 311-314 4 p.

Research output: Contribution to journalArticle

Mannose-Binding Lectin
Polymorphism
Systemic Lupus Erythematosus
Genes
Serum
7 Citations (Scopus)

Clinical characteristics of anti-glucose-6-phosphate isomerase antibody-positive Japanese patients with rheumatoid arthritis

Hayashi, T., Matsumoto, I., Muraki, Y., Takahashi, R., Chino, Y., Goto, D., Ito, S., Tsutsumi, A. & Sumida, T., Aug 1 2005, In : Modern Rheumatology. 15, 4, p. 258-263 6 p.

Research output: Contribution to journalArticle

Glucose-6-Phosphate Isomerase
Rheumatoid Arthritis
Antibodies
Arthritis
Systemic Lupus Erythematosus
2004
31 Citations (Scopus)

Anti-mannose binding lectin antibodies in sera of Japanese patients with systemic lupus erythematosus

Takahashi, R., Tsutsumi, A., Ohtani, K., Goto, D., Matsumoto, I., Ito, S., Wakamiya, N. & Sumida, T., Jun 1 2004, In : Clinical and Experimental Immunology. 136, 3, p. 585-590 6 p.

Research output: Contribution to journalArticle

Mannose-Binding Lectin
Systemic Lupus Erythematosus
Antibodies
Serum
Complement C1q
36 Citations (Scopus)

Polymorphisms of IL-1β Gene in Japanese Patients with Sjögren's Syndrome and Systemic Lupus Erythematosus

Muraki, Y., Tsutsumi, A., Takahashi, R., Suzuki, E., Hayashi, T., Chino, Y., Goto, D., Matsumoto, I., Murata, H., Noguchi, E. & Sumida, T., Apr 1 2004, In : Journal of Rheumatology. 31, 4, p. 720-725 6 p.

Research output: Contribution to journalArticle

Interleukin-1
Systemic Lupus Erythematosus
Genes
Genotype
Lacrimal Apparatus
8 Citations (Scopus)

Reiter's syndrome following intravesical bacille bilié de Calmette-Guérin treatment for superficial bladder carcinoma: Report of six cases

Murata, H., Adachi, Y., Ebitsuka, T., Chino, Y., Takahashi, R., Hayashi, T., Goto, D., Matsumoto, I., Tsutsumi, A., Akaza, H. & Sumida, T., Mar 1 2004, In : Modern Rheumatology. 14, 1, p. 82-86 5 p.

Research output: Contribution to journalArticle

Reactive Arthritis
Urinary Bladder
Arthritis
Carcinoma
Intravesical Administration
2003
7 Citations (Scopus)

Behçet's disease accompanied by myelodysplastic syndrome with trisomy 8: Two case reports and a review of 15 Japanese cases

Adachi, Y., Tsutsumi, A., Murata, H., Takemura, H., Chino, Y., Takahashi, R., Ebitsuka, T. & Sumida, T., Aug 11 2003, In : Modern Rheumatology. 13, 1, p. 90-94 5 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Cecum
Chromosome Aberrations
Trisomy Chromosome 8
20 Citations (Scopus)

Mannose binding lectin gene polymorphism in patients with type I diabetes

Tsutsumi, A., Ikegami, H., Takahashi, R., Murata, H., Goto, D., Matsumoto, I., Fujisawa, T. & Sumida, T., Jun 1 2003, In : Human Immunology. 64, 6, p. 621-624 4 p.

Research output: Contribution to journalArticle

Mannose-Binding Lectin
Type 1 Diabetes Mellitus
Alleles
Genes
Gene Frequency