Research Output 1979 2019

2019
Islands of Calleja
Neurogenesis
Dentate Gyrus
Phenotype
Lateral Ventricles
1 Citation (Scopus)

A 23 gene–based molecular prognostic score precisely predicts overall survival of breast cancer patients

Shimizu, H. & Nakayama, K., Aug 1 2019, In : EBioMedicine. 46, p. 150-159 10 p.

Research output: Contribution to journalArticle

Open Access
Genes
Breast Neoplasms
Survival
RNA Sequence Analysis
Organized Financing
5 Citations (Scopus)

A chromatin integration labelling method enables epigenomic profiling with lower input

Harada, A., Maehara, K., Handa, T., Arimura, Y., Nogami, J., Hayashi-Takanaka, Y., Shirahige, K., Kurumizaka, H., Kimura, H. & Ohkawa, Y., Feb 1 2019, In : Nature Cell Biology. 21, 2, p. 287-296 10 p.

Research output: Contribution to journalArticle

Epigenomics
Chromatin
Chromatin Immunoprecipitation
Histone Code
Immunoprecipitation

Aging of spermatogonial stem cells by Jnk-mediated glycolysis activation

Kanatsu-Shinohara, M., Yamamoto, T., Toh, H., Kazuki, Y., Kazuki, K., Imoto, J., Ikeo, K., Oshima, M., Shirahige, K., Iwama, A., Nabeshima, Y., Sasaki, H. & Shinohara, T., Aug 13 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 33, p. 16404-16409 6 p.

Research output: Contribution to journalArticle

Open Access
Glycolysis
Stem Cells
JNK Mitogen-Activated Protein Kinases
Cell Aging
Telomere Shortening

A highly sensitive determination method for acrylamide in beverages, grains, and confectioneries by supercritical fluid chromatography tandem mass spectrometry

Yoshioka, T., Izumi, Y., Nagatomi, Y., Miyamoto, Y., Suzuki, K. & Bamba, T., Oct 1 2019, In : Food Chemistry. 294, p. 486-492 7 p.

Research output: Contribution to journalArticle

supercritical fluid chromatography
Supercritical Fluid Chromatography
Beverages
Acrylamide
acrylamides

Anti-tumour effects of antimicrobial peptides, components of the innate immune system, against haematopoietic tumours in Drosophila mxc mutants

Araki, M., Kurihara, M., Kinoshita, S., Awane, R., Sato, T., Ohkawa, Y. & Inoue, Y. H., Jan 1 2019, In : DMM Disease Models and Mechanisms. 12, 6, dmm037721.

Research output: Contribution to journalArticle

Open Access
Immune system
Drosophila
Tumors
Immune System
Peptides

Biochemical analysis of nucleosome targeting by Tn5 transposase

Sato, S., Arimura, Y., Kujirai, T., Harada, A., Maehara, K., Nogami, J., Ohkawa, Y. & Kurumizaka, H., Aug 1 2019, In : Open Biology. 9, 8, 190116.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome

Unoki, M., Funabiki, H., Velasco, G., Francastel, C. & Sasaki, H., Jan 2 2019, In : Journal of Clinical Investigation. 129, 1, CI99751.

Research output: Contribution to journalArticle

Chromosome Segregation
Mutation
HEK293 Cells
Chromatin
Apoptosis
1 Citation (Scopus)

Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires HeS1 to bind diverse DNA sites

Noguchi, Y. T., Nakamura, M., Hino, N., Nogami, J., Tsuji, S., Sato, T., Zhang, L., Tsujikawa, K., Tanaka, T., Izawa, K., Okada, Y., Doi, T., Kokubo, H., Harada, A., Uezumi, A., Gessler, M., Ohkawa, Y. & Fukada, S. I., Feb 1 2019, In : Development (Cambridge). 146, 4, dev163618.

Research output: Contribution to journalArticle

Open Access
Muscle Cells
Stem Cells
DNA
Myogenin
Chromatin

CLEC3A, MMP7, and LCN2 as novel markers for predicting recurrence in resected G1 and G2 pancreatic neuroendocrine tumors

Miki, M., ono, T., Fujimori, N., Takaoka, T., Kawabe, K., Miyasaka, Y., Takao, O., Saito, D., Nakamura, M., Ohkawa, Y., Oda, Y., Suyama, M., Ito, T. & Ogawa, Y., Jul 1 2019, In : Cancer Medicine. 8, 8, p. 3748-3760 13 p.

Research output: Contribution to journalArticle

Open Access
Matrix Metalloproteinase 7
Neuroendocrine Tumors
Recurrence
Genes
Neoplasms
Heavy Ion Radiotherapy
Sarcoma
Spine
Spinal Cord Compression
Compression Fractures
Open Access
Supercritical Fluid Chromatography
supercritical fluids
liquid chromatography
High performance liquid chromatography
chromatography

Comparison of sequential derivatization with concurrent methods for GC/MS-based metabolomics

Miyagawa, H. & Bamba, T., Feb 1 2019, In : Journal of Bioscience and Bioengineering. 127, 2, p. 160-168 9 p.

Research output: Contribution to journalArticle

Metabolomics
Metabolites
Gas chromatography
Gas Chromatography-Mass Spectrometry
Mass spectrometry
1 Citation (Scopus)

Computational investigation of the conformational dynamics in Tom20-mitochondrial presequence tethered complexes

Srivastava, A., Tama, F., Kohda, D. & Miyashita, O., Jan 1 2019, In : Proteins: Structure, Function and Bioinformatics. 87, 1, p. 81-90 10 p.

Research output: Contribution to journalArticle

Disulfides
Molecular Dynamics Simulation
Membranes
Peptides
Molecular dynamics
3 Citations (Scopus)

Development of a practical online supercritical fluid extraction–supercritical fluid chromatography/mass spectrometry system with an integrated split-flow method

Sakai, M., Hayakawa, Y., Funada, Y., Ando, T., Fukusaki, E. & Bamba, T., May 10 2019, In : Journal of Chromatography A. 1592, p. 161-172 12 p.

Research output: Contribution to journalArticle

Supercritical Fluid Chromatography
Supercritical fluids
Chromatography
Mass spectrometry
Mass Spectrometry

Diabetes Mellitus, A risk factor for Alzheimer's Disease

Nakabeppu, Y. (ed.) & Ninomiya, T. (ed.), May 7 2019, Singapore: Springer. 248 p. (Advances in Experimental Medicine and Biology)

Research output: Book/ReportBook

Diabetes Mellitus
Alzheimer Disease
Insulin
Glucose
Vascular Dementia
1 Citation (Scopus)

Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis

Muto, Y., Moroishi, T., Ichihara, K., Nishiyama, M., Shimizu, H., Eguchi, H., Moriya, K., Koike, K., Mimori, K., Mori, M., Katayama, Y. & Nakayama, K., Apr 1 2019, In : Journal of Experimental Medicine. 216, 4, p. 950-965 16 p.

Research output: Contribution to journalArticle

Open Access
Carcinogenesis
Homeostasis
Iron
Iron Overload
Liver

Dmrt factors determine the positional information of cerebral cortical progenitors via differential suppression of homeobox genes

Konno, D., Kishida, C., Maehara, K., Ohkawa, Y., Kiyonari, H., Okada, S. & Matsuzaki, F., Aug 1 2019, In : Development (Cambridge). 146, 15, dev174243.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Elucidating functions of DP1 and DP2 subunits from the Thermococcus kodakarensis family D DNA polymerase

Takashima, N., Ishino, S., Oki, K., Takafuji, M., Yamagami, T., Matsuo, R., Mayanagi, K. & Ishino, Y., Jan 22 2019, In : Extremophiles. 23, 1, p. 161-172 12 p.

Research output: Contribution to journalArticle

Thermococcus
Transcription Factor DP1
Archaea
DNA-Directed DNA Polymerase
DNA

Gas chromatography-mass spectrometry metabolomics-based prediction of potato tuber sprouting during long-term storage

Fukuda, T., Takamatsu, K., Bamba, T. & Fukusaki, E., Aug 1 2019, In : Journal of Bioscience and Bioengineering. 128, 2, p. 249-254 6 p.

Research output: Contribution to journalArticle

Metabolomics
Biomarkers
Solanum tuberosum
Gas chromatography
Gas Chromatography-Mass Spectrometry

Generation of human oogonia from induced pluripotent stem cells in vitro

Yamashiro, C., Sasaki, K., Yabuta, Y., Kojima, Y., Nakamura, T., Okamoto, I., Yokobayashi, S., Murase, Y., Ishikura, Y., Shirane, K., Sasaki, H., Yamamoto, T. & Saitou, M., Mar 1 2019, In : Obstetrical and Gynecological Survey. 74, 3, p. 158-159 2 p.

Research output: Contribution to journalComment/debate

Oogonia
Induced Pluripotent Stem Cells
In Vitro Techniques
6 Citations (Scopus)

Genomic Imprinting and Physiological Processes in Mammals

the Erice Imprinting Group, Feb 21 2019, In : Cell. 176, 5, p. 952-965 14 p.

Research output: Contribution to journalReview article

Physiological Phenomena
Genomic Imprinting
Mammals
Physiology
Genes

Germline mutation: De novo mutation in reproductive lineage cells

Kunihiko, S., Jan 1 2019, In : Genes and Genetic Systems. 94, 1, p. 3-12 10 p.

Research output: Contribution to journalArticle

Open Access
Germ-Line Mutation
Mutation Rate
Genome
Mutation
Cell Division

Histone H3K9 Methyltransferase G9a in Oocytes Is Essential for Preimplantation Development but Dispensable for CG Methylation Protection

Au Yeung, W. K., Brind'Amour, J., Hatano, Y., Yamagata, K., Feil, R., Lorincz, M. C., Tachibana, M., Shinkai, Y. & Sasaki, H., Apr 2 2019, In : Cell Reports. 27, 1, p. 282-293.e4

Research output: Contribution to journalArticle

Open Access
Methylation
Oocytes
Chromatin
Chromosome Segregation
Chromosomes

Identification of genomic alterations acquired during treatment with EGFR-TKIs in non-small cell lung cancer

Kubo, N., Harada, T., Shiraishi, Y., Nosaki, K., Nakagaki, N., Takeshita, M., Ouchi, H., Iwama, E., Tanaka, K., Okamoto, I., Sasaki, H. & Nakanishi, Y., Feb 1 2019, In : Anticancer research. 39, 2, p. 671-677 7 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Therapeutics
Exome
1 Citation (Scopus)

Identification of metabolites associated with onset of CAD in diabetic patients using ce-ms analysis: A pilot study

Omori, K., Katakami, N., Yamamoto, Y., Ninomiya, H., Takahara, M., Matsuoka, T. A., Bamba, T., Fukusaki, E. & Shimomura, I., Jan 1 2019, In : Journal of atherosclerosis and thrombosis. 26, 3, p. 233-245 13 p.

Research output: Contribution to journalArticle

Open Access
Metabolites
Coronary Artery Disease
Medical problems
Arteries
Galactosamine

Identification of novel serum markers for the progression of coronary atherosclerosis in WHHLMI rabbits, an animal model of familial hypercholesterolemia

Shiomi, M., Takeda, H., Irino, Y., Kimura, N., Yamada, S., Kuniyoshi, N., Kikumori, A., Koike, Y., Koike, T., Yoshida, M., Izumi, Y., Shinohara, M., Bamba, T. & Ishida, T., May 1 2019, In : Atherosclerosis. 284, p. 18-23 6 p.

Research output: Contribution to journalArticle

Hyperlipoproteinemia Type II
Coronary Artery Disease
Animal Models
Biomarkers
Rabbits

Improved quantitation of lipid classes using supercritical fluid chromatography with a charged aerosol detector

Takeda, H., Takahashi, M., Hara, T., Izumi, Y. & Bamba, T., Jan 1 2019, In : Journal of Lipid Research. 60, 8, p. 1465-1474 10 p.

Research output: Contribution to journalArticle

Open Access
Supercritical Fluid Chromatography
Sphingomyelins
Diglycerides
Aerosols
Phospholipids

Intragenic antagonistic roles of protein and circRNA in tumorigenesis

Guarnerio, J., Zhang, Y., Cheloni, G., Panella, R., Mae Katon, J., Simpson, M., Matsumoto, A., Papa, A., Loretelli, C., Petri, A., Kauppinen, S., Garbutt, C., Petur Nielsen, G., Deshpande, V., Castillo-Martin, M., Cordon-Cardo, C., Dimitrios, S., Clohessy, J. G., Batish, M. & Pandolfi, P. P., Aug 1 2019, In : Cell Research. 29, 8, p. 628-640 13 p.

Research output: Contribution to journalArticle

Carcinogenesis
Neoplasms
Proteins
Angiogenesis Inducing Agents
Transcription Factors

Locomotor Training Increases Synaptic Structure With High NGL-2 Expression After Spinal Cord Hemisection

Kobayakawa, K., DePetro, K. A., Zhong, H., Pham, B., Hara, M., Harada, A., Nogami, J., Ohkawa, Y. & Edgerton, V. R., Jan 1 2019, In : Neurorehabilitation and Neural Repair.

Research output: Contribution to journalArticle

Spinal Cord
Synapses
RNA
Synaptophysin
Gene Ontology

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury

Kobayakawa, K., Ohkawa, Y., Yoshizaki, S., Tamaru, T., Saito, T., Kijima, K., Yokota, K., Hara, M., Kubota, K., Matsumoto, Y., Harimaya, K., Ozato, K., Masuda, T., Makoto, T., Tamura, T., Inoue, K., Reggie Edgerton, V., Iwamoto, Y., Nakashima, Y. & Okada, S., May 15 2019, In : Science Advances. 5, 5, eaav5086.

Research output: Contribution to journalArticle

Open Access
spinal cord injuries
macrophages
healing
interferon
lesions

miR-124 dosage regulates prefrontal cortex function by dopaminergic modulation

Kozuka, T., Omori, Y., Watanabe, S., Tarusawa, E., Yamamoto, H., Chaya, T., Furuhashi, M., Morita, M., Sato, T., Hirose, S., Ohkawa, Y., Yoshimura, Y., Hikida, T. & Furukawa, T., Dec 1 2019, In : Scientific reports. 9, 1, 3445.

Research output: Contribution to journalArticle

Prefrontal Cortex
MicroRNAs
Central Nervous System
Methamphetamine
Pyramidal Cells

Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer’s disease brain

Nakabeppu, Y., Jan 1 2019, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 27-44 18 p. (Advances in Experimental Medicine and Biology; vol. 1128).

Research output: Chapter in Book/Report/Conference proceedingChapter

Oxidative stress
Brain
Alzheimer Disease
Oxidative Stress
Medical problems

Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones

Katoh-Fukui, Y., Baba, T., Sato, T., Otake, H., Nagakui-Noguchi, Y., Shindo, M., Suyama, M., Ohkawa, Y., Tsumura, H., Morohashi, K-I. & Fukami, M., Mar 1 2019, In : Bone. 120, p. 219-231 13 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Bone and Bones
Cell Lineage
Genes
Polycomb-Group Proteins
1 Citation (Scopus)

Novel components of germline sex determination acting downstream of foxl3 in medaka

Kikuchi, M., Nishimura, T., Saito, D., Shigenobu, S., Takada, R., Gutierrez-Triana, J. A., Cerdán, J. L. M., Takada, S., Wittbrodt, J., Suyama, M. & Tanaka, M., Jan 1 2019, In : Developmental Biology. 445, 1, p. 80-89 10 p.

Research output: Contribution to journalArticle

Oryzias
Germ Cells
Sex Differentiation
Chromatids
Ubiquitin-Protein Ligases
1 Citation (Scopus)

Origins of brain insulin and its function

Nakabeppu, Y., Jan 1 2019, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 1-11 11 p. (Advances in Experimental Medicine and Biology; vol. 1128).

Research output: Chapter in Book/Report/Conference proceedingChapter

Brain
Insulin
Neurology
Glucose
Central Nervous System
1 Citation (Scopus)

Pathological changes of distal motor neurons after complete spinal cord injury

Yokota, K., Kubota, K., Kobayakawa, K., Saito, T., Hara, M., Kijima, K., Maeda, T., Katoh, H., Ohkawa, Y., Nakashima, Y. & Okada, S., Jan 9 2019, In : Molecular Brain. 12, 1, 4.

Research output: Contribution to journalArticle

Motor Neurons
Spinal Cord Injuries
Spinal Cord
Microdissection
Thoracic Injuries

Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. Science. 1993. 259: 822-825

Shinkai, Y., Koyasu, S., Nakayama, K., Murphy, K. M., Loh, D. Y., Reinherz, E. L. & Alt, F. W., Mar 1 2019, In : Journal of immunology (Baltimore, Md. : 1950). 202, 5, p. 1317-1320 4 p.

Research output: Contribution to journalArticle

Transgenes
T-Lymphocytes

Poorly controlled diabetes during pregnancy and lactation activates the Foxo1 pathway and causes glucose intolerance in adult offspring

Inoguchi, Y., Ichiyanagi, K., Ohishi, H., Maeda, Y., Sonoda, N., Ogawa, Y., Inoguchi, T. & Sasaki, H., Dec 1 2019, In : Scientific reports. 9, 1, 10181.

Research output: Contribution to journalArticle

Open Access
Glucose Intolerance
Streptozocin
Lactation
Pregnancy
Gluconeogenesis
Heavy Ion Radiotherapy
Spontaneous Fractures
Single-Photon Emission-Computed Tomography
Bone and Bones
Bone Remodeling

Potentials of C-C motif chemokine 2–C-C chemokine receptor type 2 blockers including propagermanium as anticancer agents

Yumimoto, K., Sugiyama, S., Mimori, K. & Nakayama, K., Jul 1 2019, In : Cancer Science. 110, 7, p. 2090-2099 10 p.

Research output: Contribution to journalReview article

Open Access
C Chemokines
CC Chemokines
Chemokine Receptors
Antineoplastic Agents
Inflammation
1 Citation (Scopus)

Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells

Shimizu, H., Takeishi, S., Nakatsumi, H. & Nakayama, K., Feb 21 2019, In : JCI insight. 4, 4

Research output: Contribution to journalArticle

Neoplasms
Breast Neoplasms
Drug Therapy
Paclitaxel
Heterografts
Arm Injuries
Ossification of Posterior Longitudinal Ligament
Pectoralis Muscles
Prone Position
Brachial Plexus

Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data

Kawata, K., Yugi, K., Hatano, A., Kokaji, T., Tomizawa, Y., Fujii, M., Uda, S., Kubota, H., Matsumoto, M., Nakayama, K. & Kuroda, S., Jan 1 2019, In : Genes to Cells. 24, 1, p. 82-93 12 p.

Research output: Contribution to journalArticle

Insulin
Phosphorylation
Proteins
Protein Kinases
Hepatocellular Carcinoma

Regulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1

Sorida, M., Hirauchi, T., Ishizaki, H., Kaito, W., Shimada, A., Mori, C., Chikashige, Y., Hiraoka, Y., Suzuki, Y., Ohkawa, Y., Kato, H., Takahata, S. & Murakami, Y., Jun 1 2019, In : PLoS genetics. 15, 6, e1008129.

Research output: Contribution to journalArticle

Open Access
Heterochromatin
methylation
heterochromatin
Epigenomics
epigenetics
9 Citations (Scopus)

Roles of ubiquitin in autophagy and cell death

Gómez-Díaz, C. & Ikeda, F., Sep 1 2019, In : Seminars in Cell and Developmental Biology. 93, p. 125-135 11 p.

Research output: Contribution to journalReview article

Open Access
Autophagy
Ubiquitin
Cell Death
Cell Survival
Garbage

SCF Fbxw7 ubiquitylates KLF7 for degradation in a manner dependent on GSK-3-mediated phosphorylation

Sugiyama, S., Yumimoto, K., Inoue, I. & Nakayama, K., May 1 2019, In : Genes to Cells. 24, 5, p. 354-365 12 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Ligases
Ubiquitin
SKP Cullin F-Box Protein Ligases
Maintenance
1 Citation (Scopus)

Spinocerebellar ataxia 27 with a novel nonsense variant (Lys177X) in FGF14

Miura, S., Kosaka, K., Fujioka, R., Uchiyama, Y., Shimojo, T., Morikawa, T., Irie, A., Taniwaki, T. & Shibata, H., Mar 1 2019, In : European Journal of Medical Genetics. 62, 3, p. 172-176 5 p.

Research output: Contribution to journalArticle

Dysarthria
Ataxia
Gait
Progressive Myoclonic Epilepsy
Genes

Structural visualization of key steps in nucleosome reorganization by human FACT

Mayanagi, K., Saikusa, K., Miyazaki, N., Akashi, S., Iwasaki, K., Nishimura, Y., Morikawa, K. & Tsunaka, Y., Dec 1 2019, In : Scientific reports. 9, 1, 10183.

Research output: Contribution to journalArticle

Open Access
Nucleosomes
Chromatin
Cryoelectron Microscopy
Histone Chaperones
DNA

Synthetic microbial consortium with specific roles designated by genetic circuits for cooperative chemical production

Honjo, H., Iwasaki, K., Soma, Y., Tsuruno, K., Hamada, H. & Hanai, T., Sep 1 2019, In : Metabolic Engineering. 55, p. 268-275 8 p.

Research output: Contribution to journalArticle

Microbial Consortia
Timing circuits
Saccharification
Metabolism
Escherichia coli