Research Output 1979 2020

[Mitochondrial quality control and regulation of neuronal function].

Shirane, M., 2014, In : Seikagaku. The Journal of Japanese Biochemical Society. 86, 4, p. 479-482 4 p.

Research output: Contribution to journalReview article

Tacrolimus Binding Proteins
Mitochondria
Molecular Chaperones
Neurons
Quality control

[Studies of T cells for better understanding of immunity and allergy].

Yoshikai, Y., Jan 1 2011, In : Nihon Jibiinkoka Gakkai kaiho. 114, 6, p. 539-546 8 p.

Research output: Contribution to journalReview article

Immunity
Hypersensitivity
T-Lymphocytes
88 Citations (Scopus)

1H nuclear magnetic resonance study of the solution conformation of an antibacterial protein, sapecin

Hanzawa, H., Shimada, I., Kuzuhara, T., Komano, H., Kohda, D., Inagaki, F., Natori, S. & Arata, Y., Sep 3 1990, In : FEBS Letters. 269, 2, p. 413-420 8 p.

Research output: Contribution to journalArticle

Defensins
Protein Conformation
Conformations
Amino Acid Sequence
Neutrophils

2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway

Asada, S., Ohta, E., Akimoto, Y., Abolhassani, N., Tsuchimoto, D. & Nakabeppu, Y., Dec 1 2017, In : Scientific Reports. 7, 1, 6528.

Research output: Contribution to journalArticle

Open Access
Adenosine Kinase
p38 Mitogen-Activated Protein Kinases
Adenosine Triphosphate
Cell Death
Nucleoside-Triphosphatase
2 Citations (Scopus)

3D structures of EGF and TGF-alpha determined by NMR

Kohda, D. & Inagaki, F., Jan 1 1991, In : analytical sciences. 7, p. 853-856 4 p.

Research output: Contribution to journalArticle

Transforming Growth Factor alpha
Epidermal Growth Factor
Nuclear magnetic resonance
Micelles
Transforming Growth Factors
11 Citations (Scopus)

3-O-sulfo-β-d-galactose moiety of endogenous sulfoglycolipids is a potential ligand for immunoglobulin-like receptor LMIR5

Phongsisay, V., Iizasa, E., Hara, H. & Yamasaki, S., Feb 1 2015, In : Molecular Immunology. 63, 2, p. 595-599 5 p.

Research output: Contribution to journalArticle

Glycolipids
Galactose
C-Type Lectins
Immunoglobulins
Basophils
16 Citations (Scopus)

8-Chloro-dGTP, a hypochlorous acid-modified nucleotide, is hydrolyzed by hMTH1, the human MutT homolog

Fujikawa, K., Yakushiji, H., Nakabeppu, Y., Suzuki, T., Masuda, M., Ohshima, H. & Kasai, H., Feb 13 2002, In : FEBS Letters. 512, 1-3, p. 149-151 3 p.

Research output: Contribution to journalArticle

Hypochlorous Acid
Nucleotides
Pyrophosphatases
Purine Nucleotides
Adenosinetriphosphate
Islands of Calleja
Neurogenesis
Dentate Gyrus
Phenotype
Lateral Ventricles
23 Citations (Scopus)
Mitochondrial DNA
Neurons
Antioxidants
Neurodegenerative Diseases
Cytosine
66 Citations (Scopus)

8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair

Sheng, Z., Oka, S., Tsuchimoto, D., Abolhassani, N., Nomaru, H., Sakumi, K., Yamada, H. & Nakabeppu, Y., Dec 3 2012, In : Journal of Clinical Investigation. 122, 12, p. 4344-4361 18 p.

Research output: Contribution to journalArticle

Microglia
DNA Repair
Carcinogenesis
Oxidative Stress
Apoptosis Inducing Factor
63 Citations (Scopus)

8-Oxoguanine causes spontaneous de novo germline mutations in mice

Ohno, M., Sakumi, K., Fukumura, R., Furuichi, M., Iwasaki, Y., Hokama, M., Ikemura, T., Tsuzuki, T., Gondo, Y. & Nakabeppu, Y., Apr 1 2014, In : Scientific reports. 4, 4689.

Research output: Contribution to journalArticle

Germ-Line Mutation
Mutation
Germ Cells
Exome
DNA
10 Citations (Scopus)

8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle

Vartanian, V., Tumova, J., Dobrzyn, P., Dobrzyn, A., Nakabeppu, Y., Lloyd, R. S. & Sampath, H., Jul 1 2017, In : PloS one. 12, 7, e0181687.

Research output: Contribution to journalArticle

DNA Glycosylases
glycosylases
Lipid Metabolism
Metabolism
Muscle
57 Citations (Scopus)

8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction

Sampath, H., Vartanian, V., Rollins, M. R., Sakumi, K., Nakabeppu, Y. & Lloyd, R. S., Dec 17 2012, In : PloS one. 7, 12, e51697.

Research output: Contribution to journalArticle

DNA Glycosylases
glycosylases
obesity
Obesity
Fats
99 Citations (Scopus)

8-Oxoguanine formation induced by chronic UVB exposure makes Ogg1 knockout mice susceptible to skin carcinogenesis

Kunisada, M., Sakumi, K., Tominaga, Y., Budiyanto, A., Ueda, M., Ichihashi, M., Nakabeppu, Y. & Nishigori, C., Jul 15 2005, In : Cancer Research. 65, 14, p. 6006-6010 5 p.

Research output: Contribution to journalArticle

Knockout Mice
Carcinogenesis
Skin
Sarcoma
DNA Damage
14 Citations (Scopus)

A 210-kb segment of tandem repeats and retroelements located between imprinted subdomains of mouse distal chromosome 7

Shirohzu, H., Yokomine, T., Sato, C., Kato, R., Toyoda, A., Purbowasito, W., Suda, C., Mukai, T., Hattori, M., Okumura, K., Sakaki, Y. & Sasaki, H., Dec 1 2004, In : DNA Research. 11, 5, p. 325-334 10 p.

Research output: Contribution to journalArticle

Retroelements
Tandem Repeat Sequences
Chromosomes, Human, Pair 7
Genes
Beckwith-Wiedemann Syndrome
1 Citation (Scopus)

A 23 gene–based molecular prognostic score precisely predicts overall survival of breast cancer patients

Shimizu, H. & Nakayama, K., Aug 1 2019, In : EBioMedicine. 46, p. 150-159 10 p.

Research output: Contribution to journalArticle

Open Access
Genes
Breast Neoplasms
Survival
RNA Sequence Analysis
Organized Financing
16 Citations (Scopus)

A2-pancortins (Pancortin-3 and -4) are the dominant Pancortins during neocortical development

Nagano, T., Nakamura, A., Konno, D., Kurata, M., Yagi, H. & Sato, M., Jul 11 2000, In : Journal of Neurochemistry. 75, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

varespladib methyl
Messenger RNA
Genes
Neocortex
Proteins
42 Citations (Scopus)

A 40-kDa epidermal growth factor/transforming growth factor α-binding domain produced by limited proteolysis of the extracellular domain of the epidermal growth factor receptor

Kohda, D., Odaka, M., Lax, I., Kawasaki, H., Suzuki, K., Ullrich, A., Schlessinger, J. & Inagaki, F., Jan 1 1993, In : Journal of Biological Chemistry. 268, 3, p. 1976-1981 6 p.

Research output: Contribution to journalArticle

Proteolysis
Transforming Growth Factors
Epidermal Growth Factor Receptor
Epidermal Growth Factor
Molecular mass
408 Citations (Scopus)

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

Takai, H., Tominaga, K., Motoyama, N., Minamishima, Y. A., Nagahama, H., Tsukiyama, T., Ikeda, K., Nakayama, K., Nakanishi, M. & Nakayama, K., Jun 15 2000, In : Genes and Development. 14, 12, p. 1439-1447 9 p.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Mammals
Blastocyst
DNA Damage
Embryonic Structures
279 Citations (Scopus)

Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients

Kobayashi, H., Sato, A., Otsu, E., Hiura, H., Tomatsu, C., Utsunomiya, T., Sasaki, H., Yaegashi, N. & Arima, T., Nov 1 2007, In : Human Molecular Genetics. 16, 21, p. 2542-2551 10 p.

Research output: Contribution to journalArticle

Assisted Reproductive Techniques
DNA Methylation
Spermatozoa
Methylation
Oligospermia
31 Citations (Scopus)

Ability of various alkylating agents to induce adaptive and SOS responses: A study with lacZ fusion

Otsuka, M., Nakabeppu, Y. & Sekiguchi, M., Jan 1 1985, In : Mutation Research DNA Repair Reports. 146, 2, p. 149-154 6 p.

Research output: Contribution to journalArticle

Alkylating Agents
Galactosidases
Ethylnitrosourea
Methylnitronitrosoguanidine
Lac Operon
85 Citations (Scopus)

Ablation of Fbxw7 Eliminates Leukemia-Initiating Cells by Preventing Quiescence

Takeishi, S., Matsumoto, A., Onoyama, I., Naka, K., Hirao, A. & Nakayama, K., Mar 18 2013, In : Cancer Cell. 23, 3, p. 347-361 15 p.

Research output: Contribution to journalArticle

Leukemia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Hematopoietic Stem Cells
Stem Cells
Maintenance
6 Citations (Scopus)

Ablation of p27 enhance kainate-induced seizure and hippocampal degeneration

Ueyama, C., Akashiba, H., Nakayama, K., Nakayama, K., Nishiyama, N. & Matsuki, N., Nov 2007, In : NeuroReport. 18, 17, p. 1781-1785 5 p.

Research output: Contribution to journalArticle

Kainic Acid
Seizures
Cell Death
Retinoblastoma Protein
Cyclin-Dependent Kinases
14 Citations (Scopus)

Ablation of the microglial protein DOCK2 reduces amyloid burden in a mouse model of Alzheimer's disease

Cimino, P. J., Yang, Y., Li, X., Hemingway, J. F., Cherne, M. K., Khademi, S. B., Fukui, Y., Montine, K. S., Montine, T. J. & Keene, C. D., Apr 1 2013, In : Experimental and Molecular Pathology. 94, 2, p. 366-371 6 p.

Research output: Contribution to journalArticle

Cytokinesis
Ablation
Amyloid
Alzheimer Disease
Proteins
238 Citations (Scopus)

Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice

Furuyama, T., Kitayama, K., Shimoda, Y., Ogawa, M., Sone, K., Yoshida-Araki, K., Hisatsune, H., Nishikawa, S. I., Nakayama, K., Nakayama, K., Ikeda, K., Motoyama, N. & Mori, N., Aug 13 2004, In : Journal of Biological Chemistry. 279, 33, p. 34741-34749 9 p.

Research output: Contribution to journalArticle

Endothelial cells
Endothelial Cells
Vascular Endothelial Growth Factor A
Embryonic Stem Cells
Stem cells
47 Citations (Scopus)

Abnormal DNA methyltransferase expression in mouse germline stem cells results in spermatogenic defects

Takashima, S., Takehashi, M., Lee, J., Chuma, S., Okano, M., Hata, K., Suetake, I., Nakatsuji, N., Miyoshi, H., Tajima, S., Tanaka, Y., Toyokuni, S., Sasaki, H., Kanatsu-Shinohara, M. & Shinohara, T., Jul 1 2009, In : Biology of Reproduction. 81, 1, p. 155-164 10 p.

Research output: Contribution to journalArticle

Methyltransferases
Stem Cells
DNA
Spermatogenesis
Seminiferous Tubules

Abnormalities in cloned animals and epigenetics

Kawano, T., Sasaki, H. & Nakatsuji, N., Oct 2002, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 47, 13, p. 1785-1787 3 p.

Research output: Contribution to journalEditorial

20th Century History
Genomic Imprinting
DNA Methylation
Epigenomics
Organism Cloning
13 Citations (Scopus)

Abnormality in Wnt signaling is causatively associated with oxidative stress-induced intestinal tumorigenesis in MUTYH-null mice

Isoda, T., Nakatsu, Y., Yamauchi, K., Piao, J., Yao, T., Honda, H., Nakabeppu, Y. & Tsuzuki, T., Aug 23 2014, In : International journal of biological sciences. 10, 8, p. 940-947 8 p.

Research output: Contribution to journalArticle

abnormality
tumor
carcinogenesis
Carcinogenesis
Oxidative Stress
1 Citation (Scopus)

Abnormal rearrangements of T-cell receptor genes occur in long-term cultured bone marrow cells of lpr/lpr mice

Ohga, S., Yoshikai, Y., Matsumoto, K., Kishihara, K., Matsuzaki, G. & Nomoto, K., 1989, In : Immunology. 67, 4, p. 543-546 4 p.

Research output: Contribution to journalArticle

T-Cell Receptor Genes
Bone Marrow Cells
Cultured Cells
T-Lymphoid Precursor Cells
Wasting Syndrome
6 Citations (Scopus)

A BP-Based Algorithm for Performing Bayesian Inference in Large Perceptron-Type Networks

Kabashima, Y. & Uda, S., 2004, International Conference on Algorithmic Learning Theory. p. 479-493

Research output: Chapter in Book/Report/Conference proceedingConference contribution

14 Citations (Scopus)

Absence of LTB4/BLT1 axis facilitates generation of mouse GM-CSF-induced long-lasting antitumor immunologic memory by enhancing innate and adaptive immune systems

Yokota, Y., Inoue, H., Matsumura, Y., Nabeta, H., Narusawa, M., Watanabe, A., Sakamoto, C., Hijikata, Y., Iga-Murahashi, M., Takayama, K., Sasaki, F., Nakanishi, Y., Yokomizo, T. & Tani, K., Oct 25 2012, In : Blood. 120, 17, p. 3444-3454 11 p.

Research output: Contribution to journalArticle

Immunologic Memory
Leukotriene B4
Immune system
Granulocyte-Macrophage Colony-Stimulating Factor
Tumors
46 Citations (Scopus)

Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease

Agarwal, A., Bumm, T. G. P., Corbin, A. S., O'Hare, T., Loriaux, M., Van Dyke, J., Willis, S. G., Deininger, J., Nakayama, K. I., Druker, B. J. & Deininger, M. W., Sep 1 2008, In : Blood. 112, 5, p. 1960-1970 11 p.

Research output: Contribution to journalArticle

S-Phase Kinase-Associated Proteins
Bone Marrow
Cells
F-Box Proteins
Transformed Cell Line

A case of amebiasis with negative serologic markers that caused intra-abdominal abscess

Tanaka, R., Furusyo, N., Takeda, R., Yamasaki, S., Kusaga, A., Ogawa, E., Masayuki, M., Nakanishi, R. & Maehara, Y., Nov 1 2017, In : Journal of Infection and Chemotherapy. 23, 11, p. 778-781 4 p.

Research output: Contribution to journalArticle

Abdominal Abscess
Amebiasis
Abscess
Serology
Tomography

A case of breakthrough hepatitis caused by HBV-DNA mutations after 4 years combination therapy of Lamivudine and Adefovir dipivoxil

Miyazaki, M., Higuchi, N., Tanaka, M., Ueda, A., Kato, M., Tsuji, Y., Kotoh, K. & Takyanagi, R., Oct 14 2009, In : Acta Hepatologica Japonica. 50, 9, p. 514-519 6 p.

Research output: Contribution to journalArticle

Lamivudine
Hepatitis
Mutation
DNA
Chronic Hepatitis B

A case of fatal intrahepatic cholestasis with primary AL amyloidosis: Is early diagnosis possible?

Takao, S., Tanaka, K., Miyazaki, M., Tanaka, M., Ohashi, T., Kato, M., Kotoh, K., Aishima, S. & Takayanagi, R., Oct 1 2013, In : Clinical Journal of Gastroenterology. 6, 5, p. 386-389 4 p.

Research output: Contribution to journalArticle

Amyloidosis
Early Diagnosis
Immunoglobulin Light Chains
Liver
Intrahepatic Cholestasis
67 Citations (Scopus)

A CCAAT/enhancer binding protein β isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes

Hata, K., Nishimura, R., Ueda, M., Ikeda, F., Matsubara, T., Ichida, F., Hisada, K., Nokubi, T., Yamaguchi, A. & Yoneda, T., Mar 1 2005, In : Molecular and cellular biology. 25, 5, p. 1971-1979 9 p.

Research output: Contribution to journalArticle

Open Access
CCAAT-Enhancer-Binding Proteins
Osteoblasts
Adipocytes
Protein Isoforms
Liver
7 Citations (Scopus)

Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage

Jalland, C. M. O., Benestad, S. L., Ersdal, C., Scheffler, K., Suganthan, R., Nakabeppu, Y., Eide, L., Bjørås, M. & Tranulis, M. A., Jan 1 2014, In : Free Radical Biology and Medicine. 68, p. 1-7 7 p.

Research output: Contribution to journalArticle

Prion Diseases
Prions
DNA Damage
Repair
DNA Repair
177 Citations (Scopus)

Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene

Hamasaki, A., Sendo, F., Nakayama, K., Ishida, N., Negishi, I., Nakayama, K. I. & Hatakeyama, S., Dec 7 1998, In : Journal of Experimental Medicine. 188, 11, p. 1985-1992 8 p.

Research output: Contribution to journalArticle

Neutrophils
Apoptosis
Genes
Transendothelial and Transepithelial Migration
Lipopolysaccharides
5 Citations (Scopus)

Accelerated progression of a murine retrovirus-induced immunodeficiency syndrome in fas mutant C57BL/6 lpr/lpr mice

Hiromatsu, K., Usami, J., Aoki, Y., Makino, M. & Yoshikai, Y., Jan 1 1997, In : MICROBIOLOGY and IMMUNOLOGY. 41, 3, p. 221-227 7 p.

Research output: Contribution to journalArticle

Retroviridae
Murine Acquired Immunodeficiency Syndrome
Murine Leukemia Viruses
T-Lymphocytes
CD95 Antigens
30 Citations (Scopus)
Chlorella vulgaris
Leukocyte Count
Cyclophosphamide
Water
Escherichia coli Infections
55 Citations (Scopus)

Accumulation and loss of asymmetric non-CpG methylation during male germ-cell development

Ichiyanagi, T., Ichiyanagi, K., Miyake, M. & Sasaki, H., Jan 1 2013, In : Nucleic acids research. 41, 2, p. 738-745 8 p.

Research output: Contribution to journalArticle

Germ Cells
Methylation
Cytosine
Retroelements
Spermatogonia
64 Citations (Scopus)

Accumulation of 8-oxo-2′-deoxyguanosine and increased expression of hMTH1 protein in brain tumors

Iida, T., Furuta, A., Kawashima, M., Nishida, J. I., Nakabeppu, Y. & Iwaki, T., Jan 1 2001, In : Neuro-Oncology. 3, 2, p. 73-81 9 p.

Research output: Contribution to journalArticle

Brain Neoplasms
Proteins
Oxidative Stress
Glioma
DNA Damage
22 Citations (Scopus)

Accumulation of 8-oxo-deoxyguanosine in cardiovascular tissues with the development of hypertension

Ohtsubo, T., Ohya, Y., Nakamura, Y., Kansui, Y., Furuichi, M., Matsumura, K., Fujii, K., Iida, M. & Nakabeppu, Y., Jun 1 2007, In : DNA Repair. 6, 6, p. 760-769 10 p.

Research output: Contribution to journalArticle

Deoxyguanosine
Tissue
Endothelial cells
Hypertension
Aorta
74 Citations (Scopus)

Accumulation of 8-oxoguanine in the cellular DNA and the alteration of the OGG1 expression during ischemia-reperfusion injury in the rat kidney

Tsuruya, K., Furuichi, M., Tominaga, Y., Shinozaki, M., Tokumoto, M., Yoshimitsu, T., Fukuda, K., Kanai, H., Hirakata, H., Iida, M. & Nakabeppu, Y., Feb 3 2003, In : DNA Repair. 2, 2, p. 211-229 19 p.

Research output: Contribution to journalArticle

Reperfusion Injury
Rats
Kidney
DNA
Reperfusion
8 Citations (Scopus)

Accumulation of adenine DNA glycosylase-sensitive sites in human mitochondrial DNA

Miyako, K., Takamatsu, C., Umeda, S., Tajiri, T., Furuichi, M., Nakabeppu, Y., Sekiguchi, M., Hamasaki, N., Takeshige, K. & Kang, D., Apr 21 2000, In : Journal of Biological Chemistry. 275, 16, p. 12326-12330 5 p.

Research output: Contribution to journalArticle

DNA Glycosylases
Adenine
Mitochondrial DNA
Electron Transport
Guanine
4 Citations (Scopus)

Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA

Matsuda, S., Yasukawa, T., Sakaguchi, Y., Ichiyanagi, K., Unoki, M., Gotou, K., Fukuda, K., Sasaki, H., Suzuki, T. & Kang, D., 2018, In : Scientific Reports. 8, 1

Research output: Contribution to journalArticle

Open Access
116 Citations (Scopus)

A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress

Nombela-Arrieta, C., Mempel, T. R., Soriano, S. F., Mazo, I., Wymann, M. P., Hirsch, E., Martínez-A., C., Fukui, Y., Von Andrian, U. H. & Stein, J. V., Mar 19 2007, In : Journal of Experimental Medicine. 204, 3, p. 497-510 14 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Lymphocytes
T-Lymphocytes
Lymph Nodes
B-Lymphocytes

Acetaldehyde administrationinduces salsolinol formation in vivo in the dorsal striatum of Aldh2-knockout and C57BL/6N mice

Ito, A., Jamal, M., Ameno, K., Tanaka, N., Takakura, A., Kawamoto, T., Kitagawa, K., Nakayama, K., Matsumoto, A., Miki, T. & Kinoshita, H., Oct 15 2018, In : Neuroscience Letters. 685, p. 50-54 5 p.

Research output: Contribution to journalArticle

Acetaldehyde
Inbred C57BL Mouse
Knockout Mice
Dopamine
Serotonin
12 Citations (Scopus)

A chromatin integration labelling method enables epigenomic profiling with lower input

Harada, A., Maehara, K., Handa, T., Arimura, Y., Nogami, J., Hayashi-Takanaka, Y., Shirahige, K., Kurumizaka, H., Kimura, H. & Ohkawa, Y., Feb 1 2019, In : Nature Cell Biology. 21, 2, p. 287-296 10 p.

Research output: Contribution to journalArticle

Epigenomics
Chromatin
Chromatin Immunoprecipitation
Histone Code
Immunoprecipitation
90 Citations (Scopus)

A chromosome 14 inversion in a T-cell lymphoma is caused by site-specific recombination between immunoglobulin and T-cell receptor loci

Denny, C. T., Yoshikai, Y., Mak, T. W., Smith, S. D., Hollis, G. F. & Kirsch, I. R., Dec 1 1986, In : Nature. 320, 6062, p. 549-551 3 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 14
T-Cell Lymphoma
T-Cell Antigen Receptor
Genetic Recombination
Immunoglobulins