Research Output 1979 2020

Article
3 Citations (Scopus)

Alterations in Docosahexaenoic Acid-Related Lipid Cascades in Inflammatory Bowel Disease Model Mice

Nishiumi, S., Izumi, Y. & Yoshida, M., Jun 1 2018, In : Digestive Diseases and Sciences. 63, 6, p. 1485-1496 12 p.

Research output: Contribution to journalArticle

Docosahexaenoic Acids
Inflammatory Bowel Diseases
Knockout Mice
Interleukin-10
Lipids
11 Citations (Scopus)

Alterations in Fetal Leydig Cell Gene Expression during Fetal and Adult Development

Miyabayashi, K., Shima, Y., Inoue, M., Sato, T., Baba, T., Ohkawa, Y., Suyama, M. & Morohashi, K. I., May 1 2017, In : Sexual Development. 11, 2, p. 53-63 11 p.

Research output: Contribution to journalArticle

Leydig Cells
Fetal Development
Gene Expression
Testis
Mitochondrial Genes
116 Citations (Scopus)

Altered expression of diabetes-related genes in Alzheimer's disease brains: The Hisayama study

Hokama, M., Oka, S., Leon, J., Ninomiya, T., Honda, H., Sasaki, K., Iwaki, T., Ohara, T., Sasaki, T., LaFerla, F. M., Kiyohara, Y. & Nakabeppu, Y., Sep 2014, In : Cerebral Cortex. 24, 9, p. 2476-2488 13 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Brain
Genes
Diabetes Mellitus
Brain Diseases
25 Citations (Scopus)

Altered expression of MUTYH and an increase in 8-hydroxydeoxyguanosine are early events in ulcerative colitis-associated carcinogenesis

Gushima, M., Hirahashi, M., Matsumoto, T., Fujita, K., Fujisawa, R., Mizumoto, K., Nakabeppu, Y., Iida, M., Yao, T. & Tsuneyoshi, M., Sep 1 2009, In : Journal of Pathology. 219, 1, p. 77-86 10 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
Carcinogenesis
Mutation
Neoplasms
Mucous Membrane
5 Citations (Scopus)

Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus

Dan, Y., Ohta, Y., Tsuchimoto, D., Mizuki, O., Ide, Y., Sami, M., Kanda, T., Kunihiko, S. & Nakabeppu, Y., Sep 1 2008, In : DNA Repair. 7, 9, p. 1437-1454 18 p.

Research output: Contribution to journalArticle

Thymus
DNA Breaks
Thymocytes
Transcriptome
Gene expression

Alternative mRNA splicing in three venom families underlying a possible production of divergent venom proteins of the habu snake, protobothrops flavoviridis

Ogawa, T., Oda-Ueda, N., Hisata, K., Nakamura, H., Chijiwa, T., Hattori, S., Isomoto, A., Yugeta, H., Yamasaki, S., Fukumaki, Y., Ohno, M., Satoh, N. & Shibata, H., Oct 9 2019, In : Toxins. 11, 10, 581.

Research output: Contribution to journalArticle

Open Access
Trimeresurus
Snakes
Venoms
Alternative Splicing
Genes
44 Citations (Scopus)

A Lysosomal Protein Negatively Regulates Surface T Cell Antigen Receptor Expression by Promoting CD3ζ-Chain Degradation

Ouchida, R., Yamasaki, S., Hikida, M., Masuda, K., Kawamura, K., Wada, A., Mochizuki, S., Tagawa, M., Sakamoto, A., Hatano, M., Tokuhisa, T., Koseki, H., Saito, T., Kurosaki, T. & Wang, J. Y., Jul 18 2008, In : Immunity. 29, 1, p. 33-43 11 p.

Research output: Contribution to journalArticle

Surface Antigens
T-Cell Antigen Receptor
T-Lymphocytes
Thymocytes
Ubiquitin
32 Citations (Scopus)

A major lipid raft protein raftlin modulates T cell receptor signaling and enhances Th17-mediated autoimmune responses

Saeki, K., Fukuyama, S., Ayada, T., Nakaya, M., Aki, D., Takaesu, G., Hanada, T., Matsumura, Y., Kobayashi, T., Nakagawa, R. & Yoshimura, A., May 15 2009, In : Journal of Immunology. 182, 10, p. 5929-5937 9 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Autoimmunity
Lipids
Proteins
T-Lymphocytes
42 Citations (Scopus)

A massively parallel sequencing approach uncovers ancient origins and high genetic variability of endangered Przewalski's horses

Goto, H., Ryder, O. A., Fisher, A. R., Schultz, B., Pond, S. L. K., Nekrutenko, A. & Makova, K. D., Dec 1 2011, In : Genome Biology and Evolution. 3, 1, p. 1096-1106 11 p.

Research output: Contribution to journalArticle

Equus przewalskii
High-Throughput Nucleotide Sequencing
horse
Horses
genetic variation
7 Citations (Scopus)

A mechanism of transcriptional regulation of the CSF-1 gene by interferon-gamma

Tsuchimoto, D., Tojo, A. & Asano, S., Dec 15 2004, In : Immunological Investigations. 33, 4, p. 397-405 9 p.

Research output: Contribution to journalArticle

Macrophage Colony-Stimulating Factor
Interferon-gamma
Genes
5' Flanking Region
Transcription Initiation Site
3 Citations (Scopus)

Ameliorating effects of D-47, a newly developed compound, on lipid metabolism in an animal model of familial hypercholesterolemia (WHHLMI rabbits)

Tamura, S., Koike, Y., Takeda, H., Koike, T., Izumi, Y., Nagasaka, R., Tsunoda, T., Tori, M., Ogawa, K., Bamba, T. & Shiomi, M., Mar 5 2018, In : European Journal of Pharmacology. 822, p. 147-153 7 p.

Research output: Contribution to journalArticle

Hyperlipoproteinemia Type II
Lipid Metabolism
Animal Models
Rabbits
Fats

A metabolite of dietary glucosylceramide from pineapples improves the skin barrier function in hairless mice

Kuwata, T., Hashimoto, T., Ohto, N., Kuwahara, H., Lee, J. W., Bamba, T. & Mizuno, M., Mar 1 2017, In : Journal of Functional Foods. 30, p. 228-236 9 p.

Research output: Contribution to journalArticle

Ananas
Glucosylceramides
Hairless Mouse
pineapples
interleukins
33 Citations (Scopus)

A methylation imprint mark in the mouse imprinted gene Grf1/Cdc25Mm locus shares a common feature with the U2afbp-rs gene: An association with a short tandem repeat and a hypermethylated region

Shibata, H., Yoda, Y., Kato, R., Ueda, T., Kamiya, M., Hiraiwa, N., Yoshiki, A., Plass, C., Pearsall, R. S., Held, W. A., Muramatsu, M., Sasaki, H., Kusakabe, M. & Hayashizaki, Y., Apr 1 1998, In : Genomics. 49, 1, p. 30-37 8 p.

Research output: Contribution to journalArticle

ras-GRF1
Microsatellite Repeats
Methylation
Germ Cells
Genes

AML1/ETO oncoprotein is directed to AML1 binding regions and co-localizes with AML1 and HEB on its targets

Gardini, A., Cesaroni, M., Luzi, L., Okumura, A. J., Biggs, J. R., Minardi, S. P., Venturini, E., Zhang, D. E., Pelicci, P. G. & Alcalay, M., Nov 1 2008, In : PLoS genetics. 4, 11, e1000275.

Research output: Contribution to journalArticle

Open Access
Oncogene Proteins
protein
Proteins
proteins
DNA
62 Citations (Scopus)

A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1

Sakai, Y., Furuichi, M., Takahashi, M., Mishima, M., Iwai, S., Shirakawa, M. & Nakabeppu, Y., Mar 8 2002, In : Journal of Biological Chemistry. 277, 10, p. 8579-8587 9 p.

Research output: Contribution to journalArticle

Substrate Specificity
Purine Nucleosides
Substrates
DNA Replication
Phosphoric Monoester Hydrolases
15 Citations (Scopus)

A molecular roadmap for the emergence of early-embryonic-like cells in culture

Rodriguez-Terrones, D., Gaume, X., Ishiuchi, T., Weiss, A., Kopp, A., Kruse, K., Penning, A., Vaquerizas, J. M., Brino, L. & Torres-Padilla, M. E., Jan 1 2018, In : Nature genetics. 50, 1, p. 106-119 14 p.

Research output: Contribution to journalArticle

Cell Culture Techniques
Embryonic Stem Cells
Epigenomics
Pluripotent Stem Cells
Small Interfering RNA
12 Citations (Scopus)

Amyloid β-protein gene duplication is not common in Alzheimer's disease: Analysis by polymorphic restriction fragments

Furuya, H., Sasaki, H., Goto, I., Wong, C. W., Glenner, G. G. & Sakaki, Y., Jan 15 1988, In : Biochemical and Biophysical Research Communications. 150, 1, p. 75-81 7 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Gene Duplication
Alzheimer Disease
Genes
Chromosomes, Human, Pair 21

An albino mutant of the Japanese rat snake (Elaphe climacophora) carries a nonsense mutation in the tyrosinase gene

Iwanishi, S., Zaitsu, S., Shibata, H. & Nitasaka, E., Jan 1 2018, In : Genes and Genetic Systems. 93, 4, p. 163-167 5 p.

Research output: Contribution to journalArticle

Monophenol Monooxygenase
Snakes
Nonsense Codon
Pets
Genes
41 Citations (Scopus)

Analysis of CDMA systems that are characterized by eigenvalue spectrum

Takeda, K., Uda, S. & Kabashima, Y., 2006, In : Europhysics Letters. 76, p. 1193-1199

Research output: Contribution to journalArticle

16 Citations (Scopus)

Analysis of effector T cells against the murine syngeneic tumor MethA in mice orally administered antitumor polysaccharide SPR-901

Takeda, Y., Tanaka, M., Miyazaki, H., Takeo, S., Nomoto, K. & Yoshikai, Y., May 1 1994, In : Cancer Immunology Immunotherapy. 38, 3, p. 143-148 6 p.

Research output: Contribution to journalArticle

Polysaccharides
T-Lymphocytes
Neoplasms
Oral Administration
Lymph Nodes
23 Citations (Scopus)

Analysis of long-chain polyprenols using supercritical fluid chromatography and matrix-assisted laser desorption ionization time-of-flight mass spectrometry

Bamba, T., Fukusaki, E., Nakazawa, Y., Sato, H., Ute, K., Kitayama, T. & Kobayashi, A., May 2 2003, In : Journal of Chromatography A. 995, 1-2, p. 203-207 5 p.

Research output: Contribution to journalArticle

Supercritical Fluid Chromatography
Ionization
Mass spectrometry
Desorption
Mass Spectrometry

Analysis of protective mechanisms. Relationship between activity of non-immune macrophages and immune responses

Yoshikai, Y., Dec 1 1981, In : Fukuoka Acta Medica. 72, 12, p. 647-666 20 p.

Research output: Contribution to journalArticle

Delayed Hypersensitivity
Listeria monocytogenes
Antibody Formation
Spleen
Macrophages

Analysis of the Molecular Recognition of L-lsoleucine by Isoleucyl-tRNA Synthetase

Yokoyama, S., Kohda, D. & Miyazawa, T., Jan 1 1987, In : NIPPON KAGAKU KAISHI. 1987, 3, p. 402-404 3 p.

Research output: Contribution to journalArticle

Isoleucine-tRNA Ligase
Molecular recognition
Isoleucine
Amino Acyl-tRNA Synthetases
Escherichia coli
4 Citations (Scopus)

An animal model manifesting neurodegeneration and obesity

Susaki, E. & Nakayama, K. I., Jul 2010, In : Aging. 2, 7, p. 453-456 4 p.

Research output: Contribution to journalArticle

Animal Models
Obesity
Ubiquitin
Neurodegenerative Diseases
Transgenic Mice
6 Citations (Scopus)

An approach to peak detection in GC-MS chromatograms and application of KNApSAcK database in prediction of candidate metabolites

Oishi, T., Tanaka, K. I., Hashimoto, T., Shinbo, Y., Jumtee, K., Bamba, T., Fukusaki, E., Suzuki, H., Shibata, D., Takahashi, H., Asahi, H., Kurokawa, K., Nakamura, Y., Hirai, A., Nakamura, K., Altaf-Ul-Amin, M. & Kanaya, S., 2009, In : Plant Biotechnology. 26, 1, p. 167-174 8 p.

Research output: Contribution to journalArticle

Metabolomics
Databases
metabolites
metabolomics
prediction
81 Citations (Scopus)

An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequence

Liu, Y., Toh, H., Sasaki, H., Zhang, X. & Cheng, X., Nov 1 2012, In : Genes and Development. 26, 21, p. 2374-2379 6 p.

Research output: Contribution to journalArticle

Methylation
Zinc Fingers
DNA
5-Methylcytosine
Guanine
39 Citations (Scopus)

Anchoring of the 26S proteasome to the organellar membrane by FKBP38

Nakagawa, T., Shirane, M., Lemura, S. I., Natsume, T. & Nakayama, K., Jun 1 2007, In : Genes to Cells. 12, 6, p. 709-719 11 p.

Research output: Contribution to journalArticle

Tacrolimus Binding Proteins
Membranes
Immunophilins
Tandem Repeat Sequences
ATP dependent 26S protease
8 Citations (Scopus)

Androgen regulates Mafb expression through its 3′UTR during mouse urethral masculinization

Matsushita, S., Suzuki, K., Ogino, Y., Hino, S., Sato, T., Suyama, M., Matsumoto, T., Omori, A., Inoue, S. & Yamada, G., Feb 2016, In : Endocrinology. 157, 2, p. 844-857 14 p.

Research output: Contribution to journalArticle

Androgens
Response Elements
Genitalia
Catenins
Sex Differentiation
15 Citations (Scopus)
Hybridomas
Spleen
Ligands
Peptides
Amino Acid Substitution
5 Citations (Scopus)

An Enhancer of the IL-7 receptor α-chain locus controls IL-7 receptor expression and maintenance of peripheral T cells

Abe, A., Tani-ichi, S., Shitara, S., Cui, G., Yamada, H., Miyachi, H., Kitano, S., Hara, T., Abe, R., Yoshikai, Y. & Ikuta, K., Oct 1 2015, In : Journal of Immunology. 195, 7, p. 3129-3138 10 p.

Research output: Contribution to journalArticle

Interleukin-7 Receptors
Internal-External Control
Maintenance
T-Lymphocytes
Interleukin-7
173 Citations (Scopus)

An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation

Chen, Z., Foster, M. W., Zhang, J., Mao, L., Rockman, H. A., Kawamoto, T., Kitagawa, K., Nakayama, K., Hess, D. T. & Stamler, J. S., Aug 23 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 34, p. 12159-12164 6 p.

Research output: Contribution to journalArticle

Nitroglycerin
Mitochondria
Blood Vessels
Nitric Oxide
Guanylate Cyclase
9 Citations (Scopus)

A network of conserved co-occurring motifs for the regulation of alternative splicing

Suyama, M., Harrington, E. D., Vinokourova, S., Von Knebel Doeberitz, M., Ohara, O. & Bork, P., Dec 1 2010, In : Nucleic acids research. 38, 22, p. 7916-7926 11 p.

Research output: Contribution to journalArticle

Alternative Splicing
Exons
Conserved Sequence
Genome
Databases
2 Citations (Scopus)

A new gene encoding the ligand for deletion of T cells bearing Tcrb-V6 and V8.1 (Mtv-50)

Niimi, N., Wajjwalku, W., Ando, Y., Tomida, S., Ueda, M. & Yoshikai, Y., Aug 1 1994, In : Immunogenetics. 40, 4, 1 p.

Research output: Contribution to journalArticle

Minor Lymphocyte Stimulatory Antigens
Molecular Sequence Data
Lymphocyte Depletion
Viral Envelope Proteins
Antigen Receptors, T-Cell, alpha-beta
12 Citations (Scopus)

A new subpopulation of intestinal intraepithelial lymphocytes expressing high level of T cell receptor γδ

Tauchi, Y., Matsuzaki, G., Takimoto, H., Yoshikai, Y. & Nomoto, K., Jan 1 1992, In : European Journal of Immunology. 22, 9, p. 2465-2468 4 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Lymphocytes
Haplotypes
Fluorescence
T-Lymphocytes

A new targeted capture method using bacterial artificial chromosome (BAC) libraries as baits for sequencing relatively large genes

Koganebuchi, K., Gakuhari, T., Takeshima, H., Sato, K., Fujii, K., Kumabe, T., Kasagi, S., Sato, T., Tajima, A., Shibata, H., Ogawa, M. & Oota, H., Jul 2018, In : PloS one. 13, 7, e0200170.

Research output: Contribution to journalArticle

Bacterial Artificial Chromosomes
bacterial artificial chromosomes
Chromosomes
baits
Genes
2 Citations (Scopus)

A new Xist allele driven by a constitutively active promoter is dominated by Xist locus environment and exhibits the parent-oforigin effects

Amakawa, Y., Sakata, Y., Hoki, Y., Arata, S., Shioda, S., Fukagawa, T., Sasaki, H. & Sado, T., Dec 15 2015, In : Development (Cambridge). 142, 24, p. 4299-4308 10 p.

Research output: Contribution to journalArticle

Alleles
Mothers
X Chromosome Inactivation
Blastocyst
X-Linked Genes
445 Citations (Scopus)

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin

Kitagawa, M., Hatakeyama, S., Shirane, M., Matsumoto, M., Ishida, N., Hattori, K., Nakamichi, I., Kikuchi, A., Nakayama, K. & Nakayama, K., May 4 1999, In : EMBO Journal. 18, 9, p. 2401-2410 10 p.

Research output: Contribution to journalArticle

F-Box Proteins
Proteolysis
Catenins
Ubiquitin
Ubiquitination
6 Citations (Scopus)

Angiotensin I-converting enzyme gene polymorphism modifies the smoking-cancer association: The Hisayama Study

Arima, H., Kiyohara, Y., Tanizaki, Y., Nakabeppu, Y., Kubo, M., Kato, I., Sueishi, K., Tsuneyoshi, M., Fujishima, M. & Iida, M., Jun 1 2006, In : European Journal of Cancer Prevention. 15, 3, p. 196-201 6 p.

Research output: Contribution to journalArticle

Peptidyl-Dipeptidase A
Smoking
Genotype
Genes
Neoplasms
19 Citations (Scopus)

An important role of Tyk2 in APC function of dendritic cells for priming CD8+ T cells producing IFN-γ

Aizu, K., Li, W., Yajima, T., Arai, T., Shimoda, K., Nimura, Y. & Yoshikai, Y., Nov 1 2006, In : European Journal of Immunology. 36, 11, p. 3060-3070 11 p.

Research output: Contribution to journalArticle

TYK2 Kinase
Dendritic Cells
Listeria monocytogenes
T-Lymphocytes
Adoptive Transfer
12 Citations (Scopus)

An improved method to make sequential deletion mutants for DNA sequencing.

Nakayama, K. & Nakauchi, H., Oct 1989, In : Trends in genetics : TIG. 5, 10, 1 p.

Research output: Contribution to journalArticle

Chromosome Deletion
DNA Sequence Analysis
Mutation
23 Citations (Scopus)

An improved scoring scheme for predicting glycan structures from gene expression data.

Suga, A., Yamanishi, Y., Hashimoto, K., Goto, S. & Kanehisa, M., Jan 1 2007, In : Genome informatics. International Conference on Genome Informatics. 18, p. 237-246 10 p.

Research output: Contribution to journalArticle

Polysaccharides
Gene Expression
Glycosyltransferases
Computational Biology
Precursor Cell Lymphoblastic Leukemia-Lymphoma
15 Citations (Scopus)

An increase in number of T-cell receptor γ/δ-bearing T cells in athymic nude mice treated with complete Freund's adjuvants

Yoshikai, Y., Matsuzaki, G., Inoue, T. & Nomoto, K., Jan 1 1990, In : Immunology. 70, 1, p. 61-65 5 p.

Research output: Contribution to journalArticle

Freund's Adjuvant
T-Cell Antigen Receptor
Nude Mice
T-Lymphocytes
Groin
2 Citations (Scopus)

An intronic single nucleotide polymorphism in the MUTYH gene is associated with increased risk for HCV-induced hepatocellular carcinoma

Sakurada, A., Miyanishi, K., Tanaka, S., Sato, M., Sakamoto, H., Kawano, Y., Takada, K., Nakabeppu, Y., Kobune, M. & Kato, J., Dec 1 2018, In : Free Radical Biology and Medicine. 129, p. 88-96 9 p.

Research output: Contribution to journalArticle

Polymorphism
Single Nucleotide Polymorphism
Hepatocellular Carcinoma
Nucleotides
Genes
64 Citations (Scopus)

An isoleucine zipper peptide forms a native-like triple stranded coiled coil in solution

Suzuki, K., Hiroaki, H., Kohda, D. & Tanaka, T., Nov 1 1998, In : Protein Engineering. 11, 11, p. 1051-1055 5 p.

Research output: Contribution to journalArticle

Isoleucine
Fasteners
Peptides
Amides
Protons
18 Citations (Scopus)
Flavonoids
Methylation
Liquid chromatography
Liquid Chromatography
Isotopes
37 Citations (Scopus)

An ITAM-Syk-CARD9 signalling axis triggers contact hypersensitivity by stimulating il-1 production in dendritic cells

Yasukawa, S., Miyazaki, Y., Yoshii, C., Nakaya, M., Ozaki, N., Toda, S., Kuroda, E., Ishibashi, K. I., Yasuda, T., Natsuaki, Y., Mi-Ichi, F., Iizasa, E., Nakahara, T., Yamazaki, M., Kabashima, K., Iwakura, Y., Takai, T., Saito, T., Kurosaki, T., Malissen, B. & 4 others, Ohno, N., Furue, M., Yoshida, H. & Hara, H., May 7 2014, In : Nature communications. 5, 3755.

Research output: Contribution to journalArticle

spleen
Haptens
tyrosine
Contact Dermatitis
interleukins
64 Citations (Scopus)

Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse

Floc'h, A. L., Tanaka, Y., Bantilan, N. S., Voisinne, G., Altan-Bonnet, G., Fukui, Y. & Huse, M., Nov 2013, In : Journal of Experimental Medicine. 210, 12, p. 2721-2737 17 p.

Research output: Contribution to journalArticle

Immunological Synapses
Actins
T-Lymphocytes
Synaptic Membranes
rho GTP-Binding Proteins
25 Citations (Scopus)

An optogenetic system for interrogating the temporal dynamics of Akt

Katsura, Y., Kubota, H., Kunida, K., Kanno, A., Kuroda, S. & Ozawa, T., Oct 1 2015, In : Scientific reports. 5, 14589.

Research output: Contribution to journalArticle

Optogenetics
Light
Muscular Atrophy
Protein-Serine-Threonine Kinases
Lighting
9 Citations (Scopus)

A novel, polymer-coated oncolytic measles virus overcomes immune suppression and induces robust antitumor activity

Nosaki, K., Hamada, K., Takashima, Y., Sagara, M., Matsumura, Y., Miyamoto, S., Hijikata, Y., Okazaki, T., Nakanishi, Y. & Tani, K., Nov 2 2016, In : Molecular Therapy - Oncolytics. 3, 1 p., 16022.

Research output: Contribution to journalArticle

Oncolytic Viruses
Measles virus
Polymers
Viruses
Oncolytic Virotherapy
2 Citations (Scopus)

A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain

Fujii, T., Yamasaki, R., Iinuma, K., Tsuchimoto, D., Hayashi, Y., Saitoh, B. Y., Matsushita, T., Kido, M. A., Aishima, S., Nakanishi, H., Nakabeppu, Y. & Kira, J. I., Aug 2018, In : Annals of Neurology. 84, 2, p. 208-224 17 p.

Research output: Contribution to journalArticle

Neuralgia
Autoantibodies
Spinal Ganglia
Neurons
Unmyelinated Nerve Fibers