Research Output

Article

Thy-1 antigen mediates apoptosis of rat glomerular cells in vitro and in vivo

Morita, H., Isobe, K. I., Cai, Z., Miyazaki, T., Matsumoto, Y., Sliinzato, T., Yoshikai, Y., Kimata, K. & Maeda, K., Jan 1 1996, In : Nephron. 73, 2, p. 293-298 6 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
1 Citation (Scopus)

Thymic Selection Determines γδ T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon γ

Jensen, K. D. C., Su, X., Shin, S., Li, L., Youssef, S., Yamasaki, S., Steinman, L., Saito, T., Locksley, R. M., Davis, M. M., Baumgarth, N. & Chien, Y. H., Jul 18 2008, In : Immunity. 29, 1, p. 90-100 11 p.

Research output: Contribution to journalArticle

313 Citations (Scopus)

Thymine DNA glycosylase modulates DNA damage response and gene expression by base excision repair-dependent and independent mechanisms

Nakamura, T., Murakami, K., Tada, H., Uehara, Y., Nogami, J., Maehara, K., Ohkawa, Y., Saitoh, H., Nishitani, H., Ono, T., Nishi, R., Yokoi, M., Sakai, W. & Sugasawa, K., Apr 1 2017, In : Genes to Cells. 22, 4, p. 392-405 14 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Thymus-dependent modulation of Ly49 inhibitory receptor expression on NK1.1+ γ/δ T cells

Hara, T., Nishimura, H., Hasegawa, Y. & Yoshikai, Y., Feb 20 2001, In : Immunology. 102, 1, p. 24-30 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Thymus‐derived cytokine(s) including interleukin‐7 induce increase of T cell receptor α/β+ CD4CD8 T cells which are extrathymically differentiated in athymic nude mice

Kenai, H., Matsuzaki, G., Nakamura, T., Yoshikai, Y. & Nomoto, K., Jan 1 1993, In : European Journal of Immunology. 23, 8, p. 1818-1825 8 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Tissue regulatory T cells and neural repair

Ito, M., Komai, K., Nakamura, T., Srirat, T. & Yoshimura, A., Feb 19 2019, In : International immunology. 31, 6, p. 361-369 9 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
19 Citations (Scopus)

TLR7 ligand augments GM-CSF-initiated antitumor immunity through activation of plasmacytoid dendritic cells

Narusawa, M., Inoue, H., Sakamoto, C., Matsumura, Y., Takahashi, A., Inoue, T., Watanabe, A., Miyamoto, S., Miura, Y., Hijikata, Y., Tanaka, Y., Inoue, M., Takayama, K., Okazaki, T., Hasegawa, M., Nakanishi, Y. & Tani, K., Jun 2014, In : Cancer Immunology Research. 2, 6, p. 568-580 13 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

TLR signals posttranscriptionally regulate the cytokine trafficking mediator sortilin

Yabe-Wada, T., Matsuba, S., Takeda, K., Sato, T., Suyama, M., Ohkawa, Y., Takai, T., Shi, H., Philpott, C. C. & Nakamura, A., May 25 2016, In : Scientific reports. 6, 1 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

TMEM55B contributes to lysosomal homeostasis and amino acid–induced mTORC1 activation

Hashimoto, Y., Shirane, M. & Nakayama, K. I., Jun 2018, In : Genes to Cells. 23, 6, p. 418-434 17 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice

Shimizu, H., Matsuguchi, T., Fukuda, Y., Nakano, I., Hayakawa, T., Takeuchi, O., Akira, S., Umemura, M., Suda, T. & Yoshikai, Y., Jan 1 2002, In : Gastroenterology. 123, 4, p. 1265-1277 13 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Toll-like receptor 2 is at least partly involved in the antitumor activity of glycoprotein from Chlorella vulgaris

Hasegawa, T., Matsuguchi, T., Noda, K., Tanaka, K., Kumamoto, S., Shoyama, Y. & Yoshikai, Y., Mar 5 2002, In : International Immunopharmacology. 2, 4, p. 579-589 11 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Toll-like receptors 2 and 4 are differentially involved in Fas dependent apoptosis in Peyer's patch and the liver at an early stage after bile duct ligation in mice

Ogawa, A., Tagawa, T., Nishimura, H., Yajima, T., Abe, T., Arai, T., Taniguchi, M., Takeda, K., Akira, S., Nimura, Y. & Yoshikai, Y., Jan 1 2006, In : Gut. 55, 1, p. 105-113 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Tom20 recognizes mitochondrial presequences through dynamic equilibrium among multiple bound states

Saitoh, T., Igura, M., Obita, T., Ose, T., Kojima, R., Maenaka, K., Endo, T. & Kohda, D., Nov 14 2007, In : EMBO Journal. 26, 22, p. 4777-4787 11 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)

Total synthesis of a cyclopropane-fatty acid α-glucosyl diglyceride from: Lactobacillus plantarum and identification of its ability to signal through Mincle

Shah, S., Nagata, M., Yamasaki, S. & Williams, S. J., Jan 1 2016, In : Chemical Communications. 52, 72, p. 10902-10905 4 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Tranexamic acid reduces heme cytotoxicity via the TLR4/TNF axis and ameliorates functional recovery after spinal cord injury

Yoshizaki, S., Kijima, K., Hara, M., Saito, T., Tamaru, T., Tanaka, M., Konno, D. J., Nakashima, Y. & Okada, S., Jul 29 2019, In : Journal of neuroinflammation. 16, 1, 160.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCδ-dependent pathway in murine lung

Shukla, A., Barrett, T. F., Nakayama, K., Nakayama, K., Mossman, B. T. & Lounsbury, K. M., May 2006, In : FASEB Journal. 20, 7

Research output: Contribution to journalArticle

34 Citations (Scopus)

Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding

Hosokawa, H., Ungerbäck, J., Wang, X., Matsumoto, M., Nakayama, K. I., Cohen, S. M., Tanaka, T. & Rothenberg, E. V., Jun 19 2018, In : Immunity. 48, 6, p. 1119-1134.e7

Research output: Contribution to journalArticle

19 Citations (Scopus)

Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles

Hikichi, T., Matoba, R., Ikeda, T., Watanabe, A., Yamamoto, T., Yoshitake, S., Tamura-Nakano, M., Kimura, T., Kamon, M., Shimura, M., Kawakami, K., Okuda, A., Okochi, H., Inoue, T., Suzuki, A. & Masui, S., Apr 16 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 16, p. 6412-6417 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Transcriptome profiling of refractory atopic keratoconjunctivitis by RNA sequencing

Matsuda, A., Asada, Y., Suita, N., Iwamoto, S., Hirakata, T., Yokoi, N., Ohkawa, Y., Okada, Y., Yokomizo, T. & Ebihara, N., Apr 2019, In : Journal of Allergy and Clinical Immunology. 143, 4, p. 1610-1614.e6

Research output: Contribution to journalArticle

1 Citation (Scopus)

Transfer of the E. coli O6-methyltransferase gene into repair-deficient human cells and restoration of cellular resistance to N-methyl-N′-nitro-N-nitrosoguanidine

Ishizaki, K., Tsujimura, T., Yawata, H., Fujio, C., Nakabeppu, Y., Sekiguchi, M. & Ikenaga, M., Sep 1986, In : Mutation Research DNA Repair Reports. 166, 2, p. 135-141 7 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

Translational efficiency is up-regulated by alternative exon in murine IL-15 mRNA

Nishimura, H., Washizu, J., Nakamura, N., Enomoto, A. & Yoshikai, Y., Jan 15 1998, In : Journal of Immunology. 160, 2, p. 936-942 7 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., 2018, In : iScience. 7, p. 212-229

Research output: Contribution to journalArticle

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Kubota, H., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K. I., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., Sep 28 2018, In : iScience. 7, p. 212-229 18 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells

Ohigashi, I., Tanaka, Y., Kondo, K., Fujimori, S., Kondo, H., Palin, A. C., Hoffmann, V., Kozai, M., Matsushita, Y., Uda, S., Motosugi, R., Hamazaki, J., Kubota, H., Murata, S., Tanaka, K., Katagiri, T., Kosako, H. & Takahama, Y., Nov 26 2019, In : Cell Reports. 29, 9, p. 2901-2916.e6

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Tricarboxylic acid cycle activity suppresses acetylation of mitochondrial proteins during early embryonic development in Caenorhabditis elegans

Hada, K., Hirota, K., Inanobe, A., Kako, K., Miyata, M., Araoi, S., Matsumoto, M., Ohta, R., Arisawa, M., Daitoku, H., Hanada, T. & Fukamizu, A., Jan 1 2019, In : Journal of Biological Chemistry. 294, 9, p. 3091-3099 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Trim33 mediates the proinflammatory function of Th17 cells

Tanaka, S., Jiang, Y., Martinez, G. J., Tanaka, K., Yan, X., Kurosaki, T., Kaartinen, V., Feng, X. H., Tian, Q., Wang, X. & Dong, C., Jul 1 2018, In : Journal of Experimental Medicine. 215, 7, p. 1853-1868 16 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

TRIM8 modulates STAT3 activity through negative regulation of PIAS3

Okumura, F., Matsunaga, Y., Katayama, Y., Nakayama, K. I. & Hatakeyama, S., Jul 1 2010, In : Journal of Cell Science. 123, 13, p. 2238-2245 8 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

TRIM8 regulates Nanog via Hsp90β-mediated nuclear translocation of STAT3 in embryonic stem cells

Okumura, F., Okumura, A. J., Matsumoto, M., Nakayama, K. I. & Hatakeyama, S., Oct 1 2011, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 10, p. 1784-1792 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Trisaccharide containing α2,3-linked sialic acid is a receptor for mumps virus

Kubota, M., Takeuchi, K., Watanabe, S., Ohno, S., Matsuoka, R., Kohda, D., Nakakita, S. I., Hiramatsu, H., Suzuki, Y., Nakayama, T., Terada, T., Shimizu, K., Shimizu, N., Shiroishi, M., Yanagi, Y. & Hashiguchi, T., Oct 11 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 41, p. 11579-11584 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P2

Takahashi, N., Hamada-Nakahara, S., Itoh, Y., Takemura, K., Shimada, A., Ueda, Y., Kitamata, M., Matsuoka, R., Hanawa-Suetsugu, K., Senju, Y., Mori, M. X., Kiyonaka, S., Kohda, D., Kitao, A., Mori, Y. & Suetsugu, S., 2014, In : Nature communications. 5, 4994.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels

Inoue, D., Matsumoto, M., Nagase, R., Saika, M., Fujino, T., Nakayama, K. I. & Kitamura, T., Mar 1 2016, In : Experimental Hematology. 44, 3, p. 172-176.e1

Research output: Contribution to journalArticle

24 Citations (Scopus)

Trypanosoma brucei 14-3-3I and II proteins predominantly form a heterodimer structure that acts as a potent cell cycle regulator in vivo

Inoue, M., Yasuda, K., Uemura, H., Yasaka, N., Schnaufer, A., Yano, M., Kido, H., Kohda, D., Doi, H., Fukuma, T., Tsuji, A. & Horikoshi, N., May 1 2013, In : Journal of biochemistry. 153, 5, p. 431-439 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity

Shinozaki, Y., Wang, S., Miyazaki, Y., Miyazaki, K., Yamada, H., Yoshikai, Y., Hara, H. & Yoshida, H., Mar 15 2009, In : International Journal of Cancer. 124, 6, p. 1372-1378 7 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Two differential pathways from double-negative to double-positive thymocytes

Matsumoto, K., Yoshikai, Y., Moroi, Y., Asano, T., Ando, T. & Nomoto, K., Jan 1 1991, In : Immunology. 72, 1, p. 20-26 7 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Two distinct knockout approaches highlight a critical role for p53 in rat development

Kawamata, M. & Ochiya, T., Dec 1 2012, In : Scientific reports. 2, 945.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs

Oka, S., Ohno, M., Tsuchimoto, D., Sakumi, K., Furuichi, M. & Nakabeppu, Y., Jan 23 2008, In : EMBO Journal. 27, 2, p. 421-432 12 p.

Research output: Contribution to journalArticle

147 Citations (Scopus)

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis

Nishitani, H., Sugimoto, N., Roukos, V., Nakanishi, Y., Saijo, M., Obuse, C., Tsurimoto, T., Nakayama, K. I., Nakayama, K., Fujita, M., Lygerou, Z. & Nishimoto, T., Mar 8 2006, In : EMBO Journal. 25, 5, p. 1126-1136 11 p.

Research output: Contribution to journalArticle

279 Citations (Scopus)

Two inhibitory systems and CKIs regulate cell cycle exit of mammalian cardiomyocytes after birth

Tane, S., Okayama, H., Ikenishi, A., Amemiya, Y., Nakayama, K. & Takeuchi, T., Oct 16 2015, In : Biochemical and Biophysical Research Communications. 466, 2, p. 147-154 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D

Takada, A., Yoshida, S., Kajikawa, M., Miyatake, Y., Tomaru, U., Sakai, M., Chiba, H., Maenaka, K., Kohda, D., Fugo, K. & Kasahara, M., Feb 1 2008, In : Journal of Immunology. 180, 3, p. 1678-1685 8 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Two types of interleukin 17A-producing γδ T cells in protection against pulmonary infection with klebsiella pneumoniae

Murakami, T., Hatano, S., Yamada, H., Iwakura, Y. & Yoshikai, Y., Jan 1 2016, In : Journal of Infectious Diseases. 214, 11, p. 1752-1761 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Tyk2-dependent bystander activation of conventional and nonconventional Th1 cell subsets contributes to innate host defense against listeria monocytogenes infection

Hashiguchi, T., Oyamada, A., Sakuraba, K., Shimoda, K., Nakayama, K. I., Iwamoto, Y., Yoshikai, Y. & Yamada, H., May 15 2014, In : Journal of Immunology. 192, 10, p. 4739-4747 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Tyk2 is essential for IFN-α-induced gene expression in mast cells

Mori, Y., Hirose, K., Suzuki, K., Nakajima, H., Seto, Y., Ikeda, K., Shimoda, K., Nakayama, K. I., Saito, Y. & Iwamoto, I., Jun 15 2004, In : International Archives of Allergy and Immunology. 134, SUPPL. 1, p. 25-29 5 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Tyk2 plays a restricted role in IFNα signaling, although it is required for IL-12-mediated T cell function

Shimoda, K., Kato, K., Aoki, K., Matsuda, T., Miyamoto, A., Shibamori, M., Yamashita, M., Numata, A., Takase, K., Kobayashi, S., Shibata, S., Asano, Y., Gondo, H., Sekiguchi, K., Nakayama, K., Nakayama, T., Okamura, T., Okamura, S., Niho, Y. & Nakayama, K. I., Jan 1 2000, In : Immunity. 13, 4, p. 561-571 11 p.

Research output: Contribution to journalArticle

238 Citations (Scopus)

Tyk2 signaling in host environment plays an important role in contraction of antigen-specific CD8+ T cells following a microbial infection

Li, W., Yamada, H., Yajima, T., Nakagawa, R., Shimoda, K., Nakayama, K. & Yoshikai, Y., Apr 1 2007, In : Journal of Immunology. 178, 7, p. 4482-4488 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by γδ T cells

Nakamura, R., Shibata, K., Yamada, H., Shimoda, K., Nakayama, K. & Yoshikai, Y., Aug 1 2008, In : Journal of Immunology. 181, 3, p. 2071-2075 5 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Type I familial amyloid polyneuropathy: A pathological study of the peripheral nervous system

Sobue, G., Nakao, N., Murakami, K., Yasuda, T., Sahashi, K., Mitsuma, T., Sasaki, H., Sakaki, Y. & Takahashi, A., Aug 1 1990, In : Brain. 113, 4, p. 903-919 17 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)

Type I interferon limits influenza virus-induced acute lung injury by regulation of excessive inflammation in mice

Arimori, Y., Nakamura, R., Yamada, H., Shibata, K., Maeda, N., Kase, T. & Yoshikai, Y., Sep 1 2013, In : Antiviral Research. 99, 3, p. 230-237 8 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Type i interferon plays opposing roles in cytotoxicity and interferon-γ production by natural killer and CD8 T cells after influenza a virus infection in mice

Arimori, Y., Nakamura, R., Yamada, H., Shibata, K., Maeda, N., Kase, T. & Yoshikai, Y., Jun 2014, In : Journal of Innate Immunity. 6, 4, p. 456-466 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)