Research Output 1979 2020

Article
193 Citations (Scopus)
S-Phase Kinase-Associated Proteins
Proteolysis
Stomach
Carcinoma
Phenotype
4 Citations (Scopus)

Clinical and Immunological Characterization of ICF Syndrome in Japan

Kamae, C., Imai, K., Kato, T., Okano, T., Honma, K., Nakagawa, N., Yeh, T. W., Noguchi, E., Ohara, A., Shigemura, T., Takahashi, H., Takakura, S., Hayashi, M., Honma, A., Watanabe, S., Shigemori, T., Ohara, O., Sasaki, H., Kubota, T., Morio, T. & 2 others, Kanegane, H. & Nonoyama, S., Nov 1 2018, In : Journal of Clinical Immunology. 38, 8, p. 927-937 11 p.

Research output: Contribution to journalArticle

Japan
Passive Immunization
Virus Diseases
B-Lymphocytes
T-Lymphocytes
2 Citations (Scopus)

Clinical effectiveness of ezetimibe for a non-obese patient with nonalcoholic fatty liver disease

Enjoji, M., Tanaka, M., Miyazaki, M., Higuchi, N., Kato, M., Kotoh, K., Matsunaga, K., Nishinakagawa, T., Machida, K., Nakashima, M. & Nakamuta, M., Dec 1 2009, In : American Journal of Case Reports. 10, p. 145-148 4 p.

Research output: Contribution to journalArticle

alpha-Tocopherol
Cholesterol
Anticholesteremic Agents
Dietary Cholesterol
Ursodeoxycholic Acid
Heavy Ion Radiotherapy
Sarcoma
Spine
Spinal Cord Compression
Compression Fractures
27 Citations (Scopus)

Clonal anergy in self‐reactive α/β T cells is abrogated by heat‐shock protein‐reactive γ/δ T cells in aged athymic nude mice

Yuuki, H., Yoshikai, Y., Kishihara, K., Iwasaki, A., Matsuzaki, G., Takimoto, H. & Nomoto, K., Jan 1 1990, In : European Journal of Immunology. 20, 7, p. 1475-1482 8 p.

Research output: Contribution to journalArticle

Clonal Anergy
Nude Mice
T-Lymphocytes
Interleukin-2
Clonal Deletion
2 Citations (Scopus)

Clonal deletion of self-Mls-reactive thymocytes at the early stage in H-2-compatible but Mls-disparate radiation chimeras

Ogimoto, M., Yoshikai, Y., Matsuzaki, G., Ohga, S., Matsumoto, K. & Nomoto, K., Jan 1 1990, In : Immunology. 69, 3, p. 482-486 5 p.

Research output: Contribution to journalArticle

Radiation Chimera
Clonal Deletion
Thymocytes
T-Lymphocytes
Thymus Gland
17 Citations (Scopus)

Clonal deletion of self-reactive T cells at the early stage of T cell development in thymus of radiation bone marrow chimeras

Matsuzaki, G., Yoshikai, Y., Ogimoto, M., Kishihara, K. & Nomoto, K., Jan 1 1990, In : Journal of Immunology. 145, 1, p. 46-51 6 p.

Research output: Contribution to journalArticle

Clonal Deletion
Thymocytes
Thymus Gland
Bone Marrow
Radiation
17 Citations (Scopus)

Clonal expansion but lack of subsequent clonal deletion of bacterial superantigen-reactive T cells in murine retroviral infection

Aoki, Y., Hiromatsu, K., Usami, J., Makino, M., Igarashi, H., Ogasawara, J., Nagata, S. & Yoshikai, Y., Oct 15 1994, In : Journal of Immunology. 153, 8, p. 3611-3621 11 p.

Research output: Contribution to journalArticle

Clonal Deletion
Superantigens
T-Lymphocytes
Infection
Murine Leukemia Viruses
3 Citations (Scopus)

Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS

Yoshikai, Y., Kidokoro, H., Kimura, K., Aoki, Y., Makino, M. & Hiromatsu, K., Jan 1 1997, In : Journal of Virology. 71, 1, p. 746-749 4 p.

Research output: Contribution to journalArticle

superantigens
Superantigens
Tacrolimus
Murine Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
312 Citations (Scopus)

Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver

Suzuki, A., Zheng, Y. W., Kaneko, S., Onodera, M., Fukao, K., Nakauchi, H. & Taniguchi, H., Jan 7 2002, In : Journal of Cell Biology. 156, 1, p. 173-184 12 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Hepatocytes
Liver
Stem Cells
Digestive System Diseases
72 Citations (Scopus)

Cloning and characterization of the alkA gene of Escherichia coli that encodes 3-methyladenine DNA glycosylase II

Nakabeppu, Y., Kondo, H. & Sekiguchi, M., Dec 1 1984, In : Journal of Biological Chemistry. 259, 22, p. 13723-13729 7 p.

Research output: Contribution to journalArticle

Cloning
Escherichia coli
Organism Cloning
Genes
Plasmids
354 Citations (Scopus)

Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo- dGTP, a mutagenic substrate for DNA synthesis

Kunihiko, S., Furuichi, M., Tsuzuki, T., Kakuma, T., Kawabata, S-I., Maki, H. & Sekiguchi, M., 1993, In : Journal of Biological Chemistry. 268, 31, p. 23524-23530 7 p.

Research output: Contribution to journalArticle

Cloning
Organism Cloning
Complementary DNA
Nucleotides
DNA
26 Citations (Scopus)

Cloning and expression of cDNA for rat O6-methylguanine-DNA methyltransferse

Sakumi, K., Shiraishi, A., Hayakawa, H. & Sekiguchi, M., Oct 25 1991, In : Nucleic acids research. 19, 20, p. 5597-5601 5 p.

Research output: Contribution to journalArticle

Cloning
Methyltransferases
CDNA
Rats
Organism Cloning
21 Citations (Scopus)

Cloning and expression of the Bacillus subtilis methyltransferase gene in Escherichia coli ada- cells

Kodama, K. I., Nakabeppu, Y. & Sekiguchi, M., Sep 1989, In : Mutation Research-DNA Repair. 218, 2, p. 153-163 11 p.

Research output: Contribution to journalArticle

Cloning
Methyltransferases
Bacilli
Bacillus subtilis
Escherichia coli
40 Citations (Scopus)

Cloning and sequence analysis of cDNA for Trimeresurus flavoviridis phospholipase A2, and consequent revision of the amino acid sequence

Oda, N., Ogawa, T., Ohno, M., Sasaki, H., Sakaki, Y. & Kihara, H., Jan 1 1990, In : Journal of Biochemistry. 108, 5, p. 816-821 6 p.

Research output: Contribution to journalArticle

Trimeresurus
Cloning
Phospholipases A2
Sequence Analysis
Organism Cloning
20 Citations (Scopus)

Cloning and sequence of the gene encoding the major structural component of mannose-resistant fimbriae of Serratia marcescens

Mizunoe, Y., Nakabeppu, Y., Sekiguchi, M., Kawabata, S. I., Moriya, T. & Amako, K., Jan 1 1988, In : Journal of bacteriology. 170, 8, p. 3567-3574 8 p.

Research output: Contribution to journalArticle

Serratia marcescens
Mannose
Organism Cloning
Genes
Escherichia coli
9 Citations (Scopus)

Cloning of B cell-specific membrane tetraspanning molecule BTS possessing B cell proliferation-inhibitory function

Suenaga, T., Arase, H., Yamasaki, S., Kohno, M., Yokosuka, T., Takeuchi, A., Hattori, T. & Saito, T., Nov 1 2007, In : European Journal of Immunology. 37, 11, p. 3197-3207 11 p.

Research output: Contribution to journalArticle

Organism Cloning
B-Lymphocytes
Cell Proliferation
Cell Membrane
B-Lymphoid Precursor Cells
25 Citations (Scopus)

Clozapine-, but not haloperidol-, induced increases in ΔFosB-like immunoreactivity are completely blocked in the striatum of mice lacking D3 dopamine receptors

Robertson, G. S., Lee, C. J., Sridhar, K., Nakabeppu, Y., Cheng, M., Wang, Y. M. & Caron, M. G., Dec 1 2004, In : European Journal of Neuroscience. 20, 11, p. 3189-3194 6 p.

Research output: Contribution to journalArticle

Dopamine D3 Receptors
Clozapine
Nucleus Accumbens
Haloperidol
Putamen
14 Citations (Scopus)

Cold exposure down-regulates zebrafish hematopoiesis

Kulkeaw, K., Ishitani, T., Kanemaru, T., Fucharoen, S. & Sugiyama, D., Apr 16 2010, In : Biochemical and Biophysical Research Communications. 394, 4, p. 859-864 6 p.

Research output: Contribution to journalArticle

Erythropoiesis
Hematopoiesis
Zebrafish
Anemia
Down-Regulation
8 Citations (Scopus)

Cold exposure down-regulates zebrafish pigmentation

Kulkeaw, K., Ishitani, T., Kanemaru, T., Ivanovski, O., Nakagawa, M., Mizuochi, C., Horio, Y. & Sugiyama, D., Apr 1 2011, In : Genes to Cells. 16, 4, p. 358-367 10 p.

Research output: Contribution to journalArticle

Pigmentation
Zebrafish
Down-Regulation
Melanophores
Melanosomes
18 Citations (Scopus)

Collaboration of PSD-Zip70 with its binding partner, SPAR, in dendritic spine maturity

Maruoka, H., Konno, D., Hori, K. & Sobue, K., Feb 9 2005, In : Journal of Neuroscience. 25, 6, p. 1421-1430 10 p.

Research output: Contribution to journalArticle

Post-Synaptic Density
Dendritic Spines
Spine
Electroporation
11 Citations (Scopus)

Combined mutation of Apc, Kras, and Tgfbr2 effectively drives metastasis of intestinal cancer

Sakai, E., Nakayama, M., Oshima, H., Kouyama, Y., Niida, A., Fujii, S., Ochiai, A., Nakayama, K. I., Mimori, K., Suzuki, Y., Hong, C. P., Ock, C. Y., Kim, S. J. & Oshima, M., Mar 1 2018, In : Cancer Research. 78, 5, p. 1334-1346 13 p.

Research output: Contribution to journalArticle

Intestinal Neoplasms
Neoplasm Metastasis
Mutation
Colorectal Neoplasms
Organoids
39 Citations (Scopus)

Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model

Susaki, E., Nakayama, K., Yamasaki, L. & Nakayama, K. I., Mar 31 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 13, p. 5192-5197 6 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinases
E2F1 Transcription Factor
Genes
Apoptosis
60 Citations (Scopus)

Common pathway for the ubiquitination of IκBα, Iκbβ, and IκBε mediated by the F-box protein FWD1

Shirane, M., Hatakeyama, S., Hattori, K., Nakayama, K. & Nakayama, K., Oct 1 1999, In : Journal of Biological Chemistry. 274, 40, p. 28169-28174 6 p.

Research output: Contribution to journalArticle

F-Box Proteins
Ubiquitination
Proteins
SKP Cullin F-Box Protein Ligases
Proteolysis
18 Citations (Scopus)

Comparative analysis of archaeal lipid-linked oligosaccharides that serve as oligosaccharide donors for Asn glycosylation

Taguchi, Y., Fujinami, D. & Kohda, D., May 20 2016, In : Journal of Biological Chemistry. 291, 21, p. 11042-11054 13 p.

Research output: Contribution to journalArticle

Glycosylation
Oligosaccharides
Archaeoglobus fulgidus
Bearings (structural)
Euryarchaeota
14 Citations (Scopus)

Comparative analysis of human Src-family kinase substrate specificity in vitro

Takeda, H., Kawamura, Y., Miura, A., Mori, M., Wakamatsu, A., Yamamoto, J. I., Isogai, T., Matsumoto, M., Nakayama, K., Natsume, T., Nomura, N. & Goshima, N., Nov 5 2010, In : Journal of Proteome Research. 9, 11, p. 5982-5993 12 p.

Research output: Contribution to journalArticle

src-Family Kinases
Substrate Specificity
Phosphorylation
Substrates
Signal transduction
Oligosaccharides
Glycosylation
Asparagine
Archaea
Eukaryota
21 Citations (Scopus)

Comparative genomics and evolution of the alpha-defensin Multigene family in primates

Das, S., Nikolaidis, N., Goto, H., McCallister, C., Li, J., Hirano, M. & Cooper, M. D., Oct 1 2010, In : Molecular Biology and Evolution. 27, 10, p. 2333-2343 11 p.

Research output: Contribution to journalArticle

alpha-Defensins
Defensins
Multigene Family
Genomics
multigene family
19 Citations (Scopus)

Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

Castillo, E., Leon, J., Mazzei, G., Abolhassani, N., Haruyama, N., Saito, T., Saido, T., Hokama, M., Iwaki, T., Ohara, T., Ninomiya, T., Kiyohara, Y., Sakumi, K., Laferla, F. M. & Nakabeppu, Y., Dec 1 2017, In : Scientific reports. 7, 1, 17762.

Research output: Contribution to journalArticle

Gene Expression Profiling
Amyloidosis
Alzheimer Disease
Genes
Neurofibrillary Tangles
71 Citations (Scopus)

Comparative structural biology of eubacterial and archaeal oligosaccharyltransferases

Maita, N., Nyirenda, J., Igura, M., Kamishikiryo, J. & Kohda, D., Feb 12 2010, In : Journal of Biological Chemistry. 285, 7, p. 4941-4950 10 p.

Research output: Contribution to journalArticle

Archaea
Eukaryota
Catalytic Domain
Bacteria
Pyrococcus
Open Access
Supercritical Fluid Chromatography
supercritical fluids
liquid chromatography
High performance liquid chromatography
chromatography

Comparison of sequential derivatization with concurrent methods for GC/MS-based metabolomics

Miyagawa, H. & Bamba, T., Feb 1 2019, In : Journal of Bioscience and Bioengineering. 127, 2, p. 160-168 9 p.

Research output: Contribution to journalArticle

Metabolomics
Metabolites
Gas chromatography
Gas Chromatography-Mass Spectrometry
Mass spectrometry
15 Citations (Scopus)

Comparison of the microbial community structure between inflamed and non-inflamed sites in patients with ulcerative colitis

Hirano, A., Umeno, J., Okamoto, Y., Shibata, H., Ogura, Y., Moriyama, T., Torisu, T., Fujioka, S., Fuyuno, Y., Kawarabayasi, Y., Matsumoto, T., Kitazono, T. & Esaki, M., Sep 2018, In : Journal of Gastroenterology and Hepatology (Australia). 33, 9, p. 1590-1597 8 p.

Research output: Contribution to journalArticle

Ulcerative Colitis
Prevotella
Neisseria
Bilophila
Leptotrichia
112 Citations (Scopus)

Complementary DNA for the mouse homolog of the human amyloid beta protein precursor

Yamada, T., Sasaki, H., Furuya, H., Miyata, T., Goto, I. & Sakaki, Y., Dec 16 1987, In : Biochemical and Biophysical Research Communications. 149, 2, p. 665-671 7 p.

Research output: Contribution to journalArticle

Protein Precursors
Amyloid beta-Protein Precursor
Brain
Complementary DNA
Amino Acids
25 Citations (Scopus)

Complementary DNA for the mouse homolog of the small subunit of human cytochrome b558

Sumimoto, H., Nozaki, M., Sasaki, H., Takeshige, K., Sakaki, Y. & Minakami, S., Dec 15 1989, In : Biochemical and Biophysical Research Communications. 165, 2, p. 902-906 5 p.

Research output: Contribution to journalArticle

Complementary DNA
Kidney
Messenger RNA
Macrophages
Peritoneal Macrophages
76 Citations (Scopus)

Complementation of placental defects and embryonic lethality by trophoblast-specific lentiviral gene transfer

Okada, Y., Ueshin, Y., Isotani, A., Saito-Fujita, T., Nakashima, H., Kimura, K., Mizoguchi, A., Ohora, M., Mori, Y., Ogata, M., Oshima, R. G., Okabe, M. & Ikawa, M., Feb 1 2007, In : Nature Biotechnology. 25, 2, p. 233-237 5 p.

Research output: Contribution to journalArticle

Gene transfer
Trophoblasts
Placenta
Genes
Placentation
6 Citations (Scopus)

Complete covalent structure of nisin Q, new natural nisin variant, containing post-translationally modified amino acids

Fukao, M., Obita, T., Yoneyama, F., Kohda, D., Zendo, T., Nakayama, J. & Sonomoto, K., Jul 30 2008, In : Bioscience, Biotechnology and Biochemistry. 72, 7, p. 1750-1755 6 p.

Research output: Contribution to journalArticle

Nisin
nisin
Amino acids
Amino Acids
amino acids
5 Citations (Scopus)

Complexity of Stomach–Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice

Yoshii, Y., Inoue, T., Uemura, Y., Iwasaki, Y., Yada, T., Nakabeppu, Y. & Noda, M., Sep 1 2017, In : Neurochemical Research. 42, 9, p. 2658-2665 8 p.

Research output: Contribution to journalArticle

Ghrelin
Parkinson Disease
Hydrogen
Water
Knockout Mice
12 Citations (Scopus)

Complex regulation of cell-cycle inhibitors by Fbxw7 in mouse embryonic fibroblasts

Masuda, K., Ishikawa, Y., Onoyama, I., Unno, M., De Alborán, I. M., Nakayama, K. I. & Nakayama, K., Mar 1 2010, In : Oncogene. 29, 12, p. 1798-1809 12 p.

Research output: Contribution to journalArticle

Cell Cycle
Fibroblasts
Cell Cycle Checkpoints
F-Box Proteins
Ubiquitination
59 Citations (Scopus)

Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing

Boscacci, R. T., Pfeiffer, F., Gollmer, K., Sevilla, A. I. C., Martin, A. M., Soriano, S. F., Natale, D., Henrickson, S., Von Andrian, U. H., Fukui, Y., Mellado, M., Deutsch, U., Engelhardt, B. & Stein, J. V., Aug 12 2010, In : Blood. 116, 6, p. 915-925 11 p.

Research output: Contribution to journalArticle

Lymphocytes
Vascular Cell Adhesion Molecule-1
Intercellular Adhesion Molecule-1
Lymph Nodes
Transendothelial and Transepithelial Migration
24 Citations (Scopus)

Comprehensive identification of substrates for f-box proteins by differential proteomics analysis

Yumimoto, K., Matsumoto, M., Oyamada, K., Moroishi, T. & Nakayama, K. I., Jun 1 2012, In : Journal of Proteome Research. 11, 6, p. 3175-3185 11 p.

Research output: Contribution to journalArticle

Ubiquitination
Ligases
Ubiquitin
Proteomics
Substrates
3 Citations (Scopus)

Computational investigation of the conformational dynamics in Tom20-mitochondrial presequence tethered complexes

Srivastava, A., Tama, F., Kohda, D. & Miyashita, O., Jan 2019, In : Proteins: Structure, Function and Bioinformatics. 87, 1, p. 81-90 10 p.

Research output: Contribution to journalArticle

Disulfides
Molecular Dynamics Simulation
Membranes
Peptides
Molecular dynamics
10 Citations (Scopus)

Concomitant infection with exogenous mouse mammary tumor virus encoding I- E-dependent superantigen in I-E-negative mouse strain

Ando, Y., Wajjwalku, W., Niimi, N., Hiromatsu, K., Morishima, T. & Yoshikai, Y., Jun 20 1995, In : Journal of Immunology. 154, 12, p. 6219-6226 8 p.

Research output: Contribution to journalArticle

Mouse mammary tumor virus
Superantigens
Infection
T-Lymphocytes
Milk
566 Citations (Scopus)

Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury

Okada, S., Nakamura, M., Katoh, H., Miyao, T., Shimazaki, T., Ishii, K., Yamane, J., Yoshimura, A., Iwamoto, Y., Toyama, Y. & Okano, H., Jul 1 2006, In : Nature medicine. 12, 7, p. 829-834 6 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Ablation
Spinal Cord Injuries
Astrocytes
Cytokines
131 Citations (Scopus)

Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis

Onoyama, I., Tsunematsu, R., Matsumoto, A., Kimura, T., De Alborán, I. M., Nakayama, K. & Nakayama, K. I., Nov 26 2007, In : Journal of Experimental Medicine. 204, 12, p. 2875-2888 14 p.

Research output: Contribution to journalArticle

Cell Differentiation
Cell Cycle
T-Lymphocytes
SKP Cullin F-Box Protein Ligases
Thymus Hyperplasia
92 Citations (Scopus)

Conditional knockdown of Nanog induces apoptotic cell death in mouse migrating primordial germ cells

Yamaguchi, S., Kurimoto, K., Yabuta, Y., Sasaki, H., Nakatsuji, N., Saitou, M. & Tada, T., Sep 25 2009, In : Development. 136, 23, p. 4011-4020 10 p.

Research output: Contribution to journalArticle

Germ Cells
Cell Death
Small Interfering RNA
Embryonic Structures
Tissue Array Analysis

Conformational ensemble of an intrinsically flexible loop in mitochondrial import protein Tim21 studied by modeling and molecular dynamics simulations

Srivastava, A., Bala, S., Motomura, H., Kohda, D., Tama, F. & Miyashita, O., Jan 1 2019, (Accepted/In press) In : Biochimica et Biophysica Acta - General Subjects. 1864, 2, 129417.

Research output: Contribution to journalArticle

Mitochondrial Proteins
Molecular Dynamics Simulation
Molecular dynamics
Crystals
Computer simulation
68 Citations (Scopus)

Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells

Hijikata, A., Kitamura, H., Kimura, Y., Yokoyama, R., Aiba, Y., Bao, Y., Fujita, S., Hase, K., Hori, S., Ishii, Y., Kanagawa, O., Kawamoto, H., Kawano, K., Koseki, H., Kubo, M., Kurita-Miki, A., Kurosaki, T., Masuda, K., Nakata, M., Oboki, K. & 20 others, Ohno, H., Okamoto, M., Okayama, Y., O-Wang, J., Saito, H., Saito, T., Sakuma, M., Sato, K., Sato, K., Seino, K. I., Setoguchi, R., Tamura, Y., Tanaka, M., Taniguchi, M., Taniuchi, I., Teng, A., Watanabe, T., Watarai, H., Yamasaki, S. & Ohara, O., Nov 1 2007, In : Bioinformatics. 23, 21, p. 2934-2941 8 p.

Research output: Contribution to journalArticle

Proteome
Transcriptome
Integrate
Genomics
Databases
9 Citations (Scopus)

Consumption of milk from cows immunized with intestinal bacteria influences age-related changes in immune competence in mice

Ishida, A., Yoshikai, Y., Murosaki, S., Kubo, C., Hidaka, Y. & Nomoto, K., Jan 1 1992, In : Journal of Nutrition. 122, 9, p. 1875-1883 9 p.

Research output: Contribution to journalArticle

Mental Competency
Milk
Enterobacteriaceae
Bacteria
Sheep
3 Citations (Scopus)

Contrast-enhanced ultrasonography using Sonazoid to evaluate changes in hepatic hemodynamics in acute liver injury

Miyazaki, M., Kato, M., Tanaka, M., Tanaka, K., Takao, S., Kohjima, M., Ito, T., Enjoji, M., Nakamuta, M., Kotoh, K. & Takayanagi, R., Jan 1 2011, In : Journal of Gastroenterology and Hepatology (Australia). 26, 12, p. 1749-1756 8 p.

Research output: Contribution to journalArticle

Ultrasonography
Hemodynamics
Hepatic Veins
Liver
Wounds and Injuries