Research Output 1979 2020

1990
22 Citations (Scopus)

Nuclear‐magnetic‐resonance studies of human epidermal growth factor

COOKE, R. M., TAPPIN, M. J., CAMPBELL, I. D., KOHDA, D., MIYAKE, T., FUWA, T., MIYAZAWA, T. & INAGAKI, F., Nov 1990, In : European Journal of Biochemistry. 193, 3, p. 807-815 9 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor
Population Groups
Transforming Growth Factors
Conformations
Rats
34 Citations (Scopus)

Positive and negative regulation of transcription by a cleavage product of Ada protein

Akimaru, H., Sakumi, K., Yoshikai, T., Anai, M. & Sekiguchi, M., Nov 20 1990, In : Journal of Molecular Biology. 216, 2, p. 261-273 13 p.

Research output: Contribution to journalArticle

Proteins
DNA-Directed RNA Polymerases
Genes
Escherichia coli Proteins
Methyltransferases
13 Citations (Scopus)

'Radioresistant' CD4-CD8- intrathymic T cell precursors differentiate into mature CD4+CD8- and CD4-CD8+ T cells. Development of 'radioresistant' CD4-CD8- intrathymic T cell precursors

Ayukawa, K., Tomooka, S., Asano, T., Taniguchi, K., Yoshikai, Y. & Nomoto, K., Jan 1 1990, In : Thymus. 15, 2, p. 65-78 14 p.

Research output: Contribution to journalArticle

T-Lymphoid Precursor Cells
T-Lymphocytes
Thymocytes
Interleukin-1
Thymus Gland
14 Citations (Scopus)

Sequential appearance of host-derived T cell subsets during differentiation in nude mice grafted with rat fetal thymus

Iwasaki, A., Yoshikai, Y., Sakumoto, M., Himeno, K., Yuuki, H., Kumamoto, M., Sueishi, K. & Nomoto, K., Jan 1 1990, In : Journal of Immunology. 145, 1, p. 28-35 8 p.

Research output: Contribution to journalArticle

T-Lymphocyte Subsets
Nude Mice
Thymus Gland
T-Lymphocytes
Autoimmune Diseases
125 Citations (Scopus)

Sequential appearance of γ/δ‐ and α/β‐bearing T cells in the peritoneal cavity during an i.p. infection with Listeria monocytogenes

Ohga, S., Yoshikai, Y., Takeda, Y., Hiromatsu, K. & Nomoto, K., Jan 1 1990, In : European Journal of Immunology. 20, 3, p. 533-538 6 p.

Research output: Contribution to journalArticle

Peritoneal Cavity
Listeria monocytogenes
T-Lymphocytes
Exudates and Transudates
Infection
63 Citations (Scopus)

Sequential mechanisms of cyclophosphamide-induced skin allograft tolerance including the intrathymic clonal deletion followed by late breakdown of the clonal deletion

Eto, M., Mayumi, H., Tomita, Y., Yoshikai, Y., Nishimura, Y. & Nomoto, K., Jan 1 1990, In : Journal of Immunology. 145, 5, p. 1303-1310 8 p.

Research output: Contribution to journalArticle

Clonal Deletion
Transplantation Tolerance
Cyclophosphamide
T-Lymphocytes
Skin
68 Citations (Scopus)

Stimulation of all T cells bearing Vβ1, Vβ3, Vβ11 and Vβ12 by staphylococcal enterotoxin A

Takimoto, H., Yoshikai, Y., Kishihara, K., Matsuzaki, G., Kuga, H., Otani, T. & Nomoto, K., Jan 1 1990, In : European Journal of Immunology. 20, 3, p. 617-621 5 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Clonal Deletion
Staphylococcal enterotoxin A
Inbred C57BL Mouse
Inbred AKR Mouse
4 Citations (Scopus)

Structure and expression of Alzheimer's amyloid β-protein precursor gene

Sasaki, H., Yoshikai, S. I., Izumi, R., Yamada, T., Furuya, H., Doh-Ura, K., Goto, I. & Sakaki, Y., Jan 1 1990, Molecular biology and genetics of Alzheimer's disease: proceedings of the International Symposium on Dementia: Molecular Biology and Genetics of Alzheimer's Disease. ICS884. Miyatake, T., Selkoe, D. J., Ihara, Y., Miyatake, T., Selkoe, D. J. & Ihara, Y. (eds.). Elsevier Science Publishers B.V., p. 105-112 8 p. (Molecular biology and genetics of Alzheimer's disease: proceedings of the International Symposium on Dementia: Molecular Biology and Genetics of Alzheimer's Disease. ICS884).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Amyloid beta-Protein Precursor
Amyloid beta-Peptides
Genes
99 Citations (Scopus)

Structures and functions of DNA glycosylases

Kunihiko, S. & Sekiguchi, M., Jan 1 1990, In : Mutation Research-DNA Repair. 236, 2-3, p. 161-172 12 p.

Research output: Contribution to journalArticle

Endodeoxyribonucleases
N-Glycosyl Hydrolases
Nucleic acid sequences
DNA Glycosylases
Escherichia coli
2 Citations (Scopus)

Subpopulations of CD4+ cells in lpr/lpr mice: differences in expression of T cell receptor/CD3 complex and proliferative responses

Asano, T., Yoshikai, Y., Matsumoto, K., Matuzaki, G. & Nomoto, K., Jan 1 1990, In : Clinical and Experimental Immunology. 81, 1, p. 90-96 7 p.

Research output: Contribution to journalArticle

CD3 Antigens
T-Cell Antigen Receptor
Monoclonal Antibodies
Messenger RNA
93 Citations (Scopus)

The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in Japanese

Todd, J. A., Fukui, Y., Kltagawa, T. & Sasazuki, T., Jan 1 1990, In : Proceedings of the National Academy of Sciences of the United States of America. 87, 3, p. 1094-1098 5 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Alleles
HLA-DQ Antigens
HLA-DR Antigens
Haplotypes
26 Citations (Scopus)

The requirement of intrathymic mixed chimerism and clonal deletion for a long‐lasting skin allograft tolerance in cyclophosphamide‐induced tolerance

Eto, M., Mayumi, H., Yoshikai, Y., Nishimura, Y. & Nomoto, K., Sep 1990, In : European Journal of Immunology. 20, 9, p. 2005-2013 9 p.

Research output: Contribution to journalArticle

Clonal Deletion
Transplantation Tolerance
Chimerism
T-Lymphocytes
Skin

The role of gamma delta T cells in infectious disease

Yoshikai, Y., Jan 1 1990, In : Human cell : official journal of Human Cell Research Society. 3, 3, p. 213-219 7 p.

Research output: Contribution to journalArticle

Somatostatin-Secreting Cells
Heat-Shock Proteins
Communicable Diseases
T-Lymphocytes
Phagocytes
76 Citations (Scopus)

Type I familial amyloid polyneuropathy: A pathological study of the peripheral nervous system

Sobue, G., Nakao, N., Murakami, K., Yasuda, T., Sahashi, K., Mitsuma, T., Sasaki, H., Sakaki, Y. & Takahashi, A., Aug 1 1990, In : Brain. 113, 4, p. 903-919 17 p.

Research output: Contribution to journalArticle

Familial Amyloid Neuropathies
Amyloid Plaques
Peripheral Nervous System
Peripheral Nerves
Sympathetic Ganglia
1989
1 Citation (Scopus)

Abnormal rearrangements of T-cell receptor genes occur in long-term cultured bone marrow cells of lpr/lpr mice

Ohga, S., Yoshikai, Y., Matsumoto, K., Kishihara, K., Matsuzaki, G. & Nomoto, K., 1989, In : Immunology. 67, 4, p. 543-546 4 p.

Research output: Contribution to journalArticle

T-Cell Receptor Genes
Bone Marrow Cells
Cultured Cells
T-Lymphoid Precursor Cells
Wasting Syndrome
7 Citations (Scopus)

Activity of a metallothionein-transthyretin fusion gene in transgenic mice. Possible effect of plasmid sequences on tissue-specific expression

Sasaki, H., Nakazato, M., Saraiva, M. J. M., Matsuo, H. & Sakaki, Y., Dec 1 1989, In : Molecular Biology and Medicine. 6, 4, p. 345-353 9 p.

Research output: Contribution to journalArticle

Recombinant Fusion Proteins
Restriction Mapping
Inbred Strains Mice
Prealbumin
Metallothionein
44 Citations (Scopus)

A novel CD3 J11d+ subset of CD4+CD8 cells repopulating thymus in radiation bone marrow chimeras

Matsumoto, K., Yoshikai, Y., Matsuzaki, G., Asano, T. & Nomoto, K., Jan 1 1989, In : European Journal of Immunology. 19, 7, p. 1203-1207 5 p.

Research output: Contribution to journalArticle

Thymus Gland
Bone Marrow
Radiation
Thymocytes
Bone Marrow Transplantation
24 Citations (Scopus)

Augmentation of the resistance against Escherichia coli by oral administration of a hot water extract of Chlorella vulgaris in rats

Takashi Hasegawa, H., Kuniaki Tanaka, T., Kimiko Ueno, U., Sugi Ueno, U., Masao Okuda, O., Yoshikai, Y. & Kikuo Nomoto, N., Jan 1 1989, In : International Journal of Immunopharmacology. 11, 8, p. 971-976 6 p.

Research output: Contribution to journalArticle

Chlorella vulgaris
Peritoneal Cavity
Oral Administration
Escherichia coli Infections
Escherichia coli
3 Citations (Scopus)

Clinical features and diagnosis by recombinant DNA techniques of familial amyloid polyneuropathy in Japan

Harada, T., Kito, S., Ishizaki, F., Matsubayashi, H., Katayama, S., Sasaki, H., Furuya, H. & Sakaki, Y., Jan 1 1989, In : Research Communications in Chemical Pathology and Pharmacology. 65, 2, p. 237-244 8 p.

Research output: Contribution to journalArticle

Familial Amyloid Neuropathies
Recombinant DNA
Amyloid
Japan
Prealbumin
21 Citations (Scopus)

Cloning and expression of the Bacillus subtilis methyltransferase gene in Escherichia coli ada- cells

Kodama, K. I., Nakabeppu, Y. & Sekiguchi, M., Jan 1 1989, In : Mutation Research-DNA Repair. 218, 2, p. 153-163 11 p.

Research output: Contribution to journalArticle

Cloning
Methyltransferases
Bacilli
Bacillus subtilis
Escherichia coli
25 Citations (Scopus)

Complementary DNA for the mouse homolog of the small subunit of human cytochrome b558

Sumimoto, H., Nozaki, M., Sasaki, H., Takeshige, K., Sakaki, Y. & Minakami, S., Dec 15 1989, In : Biochemical and Biophysical Research Communications. 165, 2, p. 902-906 5 p.

Research output: Contribution to journalArticle

Complementary DNA
Kidney
Messenger RNA
Macrophages
Peritoneal Macrophages
7 Citations (Scopus)

Deletion of Mls‐reactive T cells in H‐2‐compatible but Mls‐incompatible bone marrow chimeras

Yoshikai, Y., Ogimoto, M., Matsumoto, K., Sakumoto, M., Matsuzaki, G. & Nomoto, K., Jan 1 1989, In : European Journal of Immunology. 19, 6, p. 1009-1013 5 p.

Research output: Contribution to journalArticle

Bone Marrow
T-Lymphocytes
T-Cell Receptor Genes
Spleen
Bone Marrow Cells
438 Citations (Scopus)

Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes.

Christy, R. J., Yang, V. W., Ntambi, J. M., Geiman, D. E., Landschulz, W. H., Friedman, A. D., Nakabeppu, Y., Kelly, T. J. & Lane, M. D., Sep 1989, In : Genes & development. 3, 9, p. 1323-1335 13 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
Adipocytes
Gene Expression
Stearoyl-CoA Desaturase
Genes
6 Citations (Scopus)

Expression and sequences of T cell receptor β-chain variable genes in the enlarged lymph nodes of C57BL/6-lpr/lpr mice

Ohga, S., Yoshikai, Y., Kishihara, K., Matsuzaki, G., Asano, T. & Nomoto, K., Jan 1 1989, In : Clinical and Experimental Immunology. 77, 1, p. 130-136 7 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Lymph Nodes
Genes
Autoimmunity
Autoimmune Diseases
6 Citations (Scopus)

Genetic analysis of familial amyloidotic polyneuropathy, an autosomal dominant disease

Sakaki, Y., Sasaki, H., Yoshioka, K. & Furuya, H., Dec 15 1989, In : Clinica Chimica Acta. 185, 3, p. 291-297 7 p.

Research output: Contribution to journalArticle

Prealbumin
Polyneuropathies
Substitution reactions
Polymerase chain reaction
Amyloid
9 Citations (Scopus)

Genetic and clinical studies of japanese patients with familial amyloid polyneuropathy

Harada, T., Kito, S., Shimoyama, M., Katayama, S., Sasaki, H., Furuya, H., Yoshioka, K. & Sakaki, Y., Jan 1 1989, In : European Neurology. 29, 1, p. 48-52 5 p.

Research output: Contribution to journalArticle

Familial Amyloid Neuropathies
Prealbumin
Recombinant DNA
DNA
Valine
11 Citations (Scopus)

GLYCOSURIA AND INSULITIS IN NOD MICE EXPRESSING THE HLA‐DQw6 MOLECULE

Fukui, Y., Nishimura, Y., Iwanga, T., Kimura, A., Inamitsu, T., Hanaoka, Y., Kitigawa, T. & Sasazuki, T., Jan 1 1989, In : International Journal of Immunogenetics. 16, 6, p. 445-453 9 p.

Research output: Contribution to journalArticle

Glycosuria
Inbred NOD Mouse
Type 1 Diabetes Mellitus
Linkage Disequilibrium
Oligonucleotides
68 Citations (Scopus)

Haplotype analysis of familial amyloidotic polyneuropathy - Evidence for multiple origins of the Val→Met mutation most common to the disease

Yoshioka, K., Furuya, H., Sasaki, H., Saraiva, M. J. M., Costa, P. P. & Sakaki, Y., Apr 1 1989, In : Human Genetics. 82, 1, p. 9-13 5 p.

Research output: Contribution to journalArticle

Polyneuropathies
Haplotypes
Mutation
Prealbumin
Inborn Genetic Diseases
26 Citations (Scopus)

Human transthyretin (prealbumin) gene and molecular genetics of familial amyloidotic polyneuropthy

Sakaki, Y., Yoshioka, K., Tanahashi, H., Furuya, H. & Sasaki, H., Dec 1 1989, In : Molecular Biology and Medicine. 6, 2, p. 161-168 8 p.

Research output: Contribution to journalReview article

Prealbumin
Amyloidosis
Nervous System Diseases
Molecular Biology
Gene Expression
17 Citations (Scopus)

Isolation and characterization of the mouse CD8 β-chain (Ly-3) genes. Absenced of an intervening sequence between V- and J-like gene segments

Nakayama, K., Shinkai, Y. I., Okumura, K. & Nakauchi, H., Jan 1 1989, In : Journal of Immunology. 142, 7, p. 2540-2546 7 p.

Research output: Contribution to journalArticle

Introns
Exons
Genes
5' Flanking Region
Hinge Exons
40 Citations (Scopus)

Isolation and sequencing of a cDNA clone encoding 107 kDa sialoglycoprotein in rat liver lysosomal membranes

Himeno, M., Noguchi, Y., Sasaki, H., Tanaka, Y., Furuno, K., Kono, A., Sakaki, Y. & Kato, K., Feb 27 1989, In : FEBS Letters. 244, 2, p. 351-356 6 p.

Research output: Contribution to journalArticle

Sialoglycoproteins
Liver
Rats
Pancreas
Glycoproteins
20 Citations (Scopus)

Isolation and sequencing of a cDNA clone encoding 96 kDa sialoglycoprotein in rat liver lysosomal membranes

Noguchi, Y., Himeno, M., Sasaki, H., Tanaka, Y., Kono, A., Sakaki, Y. & Kato, K., Nov 15 1989, In : Biochemical and Biophysical Research Communications. 164, 3, p. 1113-1120 8 p.

Research output: Contribution to journalArticle

Sialoglycoproteins
Liver
Rats
Complementary DNA
Clone Cells
40 Citations (Scopus)

Polypeptide Chain Fold of Human Transforming Growth Factor α Analogous to Those of Mouse and Human Epidermal Growth Factors As Studied by Two-Dimensional 1H NMR

Kohda, D., Shimada, I., Miyake, T., Fuwa, T. & Inagaki, F., Jan 1 1989, In : Biochemistry. 28, 3, p. 953-958 6 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Nuclear magnetic resonance
Peptides
Epidermal Growth Factor
Protons
223 Citations (Scopus)

Pro→Leu change at position 102 of prinon protein is the most common but not the sole mutation related to Gerstmann-Sträussler syndrome

Doh-ura, K., Tateishi, J., Sasaki, H., Kitamoto, T. & Sakaki, Y., Sep 15 1989, In : Biochemical and Biophysical Research Communications. 163, 2, p. 974-979 6 p.

Research output: Contribution to journalArticle

Gerstmann Syndrome
Valine
Mutation
Amyloid
Proline
1 Citation (Scopus)

Rearrangements of T-cell antigen receptor γ and δ chain genes are detected in the long-term cultured bone marrow cells of athymic nude mice but not in those of euthymic mice

Yoshikai, Y., Takeda, Y., Ohga, S., Kishihara, K., Matsuzaki, G. & Nomoto, K., Jan 1 1989, In : Immunology. 66, 4, p. 512-516 5 p.

Research output: Contribution to journalArticle

T-Lymphocyte Gene Rearrangement
T-Cell Receptor Genes
Nude Mice
Bone Marrow Cells
Cultured Cells
34 Citations (Scopus)
Gene Expression Regulation
DNA-Directed RNA Polymerases
Proteins
Cysteine
Sigma Factor
46 Citations (Scopus)

Relayed HOHAHA, a useful method for extracting subspectra of individual components of sugar chains

Inagaki, F., Shimada, I., Kohda, D., Suzuki, A. & Bax, A., Jan 1 1989, In : Journal of Magnetic Resonance (1969). 81, 1, p. 186-190 5 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Tetramer formation of a variant type human transthyretin (prealbumin) produced by Escherichia coli expression system

Furuya, H., Nakazato, M., Saraiva, M. J. M., Costa, P. P., Sasaki, H., Matsuo, H., Goto, I. & Sakaki, Y., Sep 15 1989, In : Biochemical and Biophysical Research Communications. 163, 2, p. 851-859 9 p.

Research output: Contribution to journalArticle

Prealbumin
Polyneuropathies
Protein Sorting Signals
Escherichia coli
Inborn Genetic Diseases
91 Citations (Scopus)

The basic region of Fos mediates specific DNA binding

Nakabeppu, Y. & Nathans, D., Dec 1 1989, In : EMBO Journal. 8, 12, p. 3833-3841 9 p.

Research output: Contribution to journalArticle

Transcription Factor AP-1
Leucine
DNA
Proteins
DNA sequences
6 Citations (Scopus)

The expression and sequences of T cell antigen receptor β-chain genes in the thymus at an early stage after sublethal irradiation

Yuuki, H., Yoshikai, Y., Kishihara, K., Matsuzaki, G., Ayukawa, K. & Nomoto, K., Jan 1 1989, In : Journal of Immunology. 142, 10, p. 3683-3691 9 p.

Research output: Contribution to journalArticle

Thymocytes
T-Cell Antigen Receptor
Thymus Gland
Genes
Complementary DNA

Three-dimensional structure and function of epidermal growth factor

Kohda, D. & Inagaki, F., Aug 1 1989, In : Seikagaku. The Journal of Japanese Biochemical Society. 61, 8, p. 698-704 7 p.

Research output: Contribution to journalArticle

Molecular Sequence Data
Physical Chemistry
Magnetic resonance spectroscopy
Physical chemistry
Protein Conformation
1988
3 Citations (Scopus)

A comparative 1H NMR study of mouse alpha(1-53) and beta(2-53) epidermal growth factors.

Kohda, D., Kodama, C., Kase, R., Nomoto, H., Hayashi, K. & Inagaki, F., Jan 1 1988, In : Biochemistry international. 16, 4, p. 647-654 8 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor
Nuclear magnetic resonance
Chemical shift
Protons
Molecules
26 Citations (Scopus)

Activation of Ada protein as a transcriptional regulator by direct alkylation with methylating agents

Takahashi, K., Kawazoe, Y., Kunihiko, S., Nakabeppu, Y. & Sekiguchi, M., Jan 1 1988, In : Journal of Biological Chemistry. 263, 27, p. 13490-13492 3 p.

Research output: Contribution to journalArticle

Alkylation
Chemical activation
Proteins
Methylation
Genes
6 Citations (Scopus)

Age-associated increase in the expression of T-cell antigen receptor γ-chain gene in conventional and germfree mice

Yoshikai, Y., Matsuzaki, G., Kishihara, K., Nomoto, K., Yokokura, T. & Nomoto, K., Jan 1 1988, In : Infection and Immunity. 56, 8, p. 2069-2074 6 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Lymphoid Tissue
Thymus Gland
Genes
Lymph Nodes
11 Citations (Scopus)

Age‐associated increase in the expression of T cell antigen receptor γ chain genes in mice

Matsuzaki, G., Yoshikai, Y., Kishihara, K., Nomoto, K., Yokokura, T. & Nomoto, K., Jan 1 1988, In : European Journal of Immunology. 18, 11, p. 1779-1784 6 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Mixed Lymphocyte Culture Test
Genes
Lymphoid Tissue
Lymphocytes
12 Citations (Scopus)

Amyloid β-protein gene duplication is not common in Alzheimer's disease: Analysis by polymorphic restriction fragments

Furuya, H., Sasaki, H., Goto, I., Wong, C. W., Glenner, G. G. & Sakaki, Y., Jan 15 1988, In : Biochemical and Biophysical Research Communications. 150, 1, p. 75-81 7 p.

Research output: Contribution to journalArticle

Amyloidogenic Proteins
Gene Duplication
Alzheimer Disease
Genes
Chromosomes, Human, Pair 21
20 Citations (Scopus)

Cloning and sequence of the gene encoding the major structural component of mannose-resistant fimbriae of Serratia marcescens

Mizunoe, Y., Nakabeppu, Y., Sekiguchi, M., Kawabata, S. I., Moriya, T. & Amako, K., Jan 1 1988, In : Journal of bacteriology. 170, 8, p. 3567-3574 8 p.

Research output: Contribution to journalArticle

Serratia marcescens
Mannose
Organism Cloning
Genes
Escherichia coli
20 Citations (Scopus)

Complete sequence-specific 1H nuclear magnetic resonance assignments for mouse epidermal growth factor

Kohda, D. & Inagaki, F., Jan 1 1988, In : Journal of biochemistry. 103, 3, p. 554-571 18 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor
Identification (control systems)
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Proline
7 Citations (Scopus)

Crystallization and preliminary X-ray diffraction studies of 3-methyladenine-DNA glycosylase II from Escherichia coli

Yamagata, Y., Odawara, K., Tomita, K. I., Nakabeppu, Y. & Sekiguchi, M., Dec 20 1988, In : Journal of Molecular Biology. 204, 4, p. 1055-1056 2 p.

Research output: Contribution to journalArticle

Crystallization
X-Ray Diffraction
Escherichia coli
Genes
DNA-3-methyladenine glycosidase II
12 Citations (Scopus)

Expression of T cell antigen receptor genes in the thymus of irradiated mice after bone marrow transplantation

Matsuzaki, G., Yoshikai, Y., Kishihara, K. & Nomoto, K., Jan 1 1988, In : Journal of Immunology. 140, 2, p. 385-387 3 p.

Research output: Contribution to journalArticle

T-Cell Receptor Genes
Thymocytes
T-Cell Antigen Receptor
Bone Marrow Transplantation
Thymus Gland