Research Output 1979 2020

2016
35 Citations (Scopus)

To wake up cancer stem cells, or to let them sleep, that is the question

Takeishi, S. & Nakayama, K. I., Jul 1 2016, In : Cancer Science. 107, 7, p. 875-881 7 p.

Research output: Contribution to journalReview article

Neoplastic Stem Cells
Sleep
Cell Cycle
Stem Cell Niche
Therapeutics
73 Citations (Scopus)

Trans-Omics: How To Reconstruct Biochemical Networks Across Multiple 'Omic' Layers

Yugi, K., Kubota, H., Hatano, A. & Kuroda, S., Apr 1 2016, In : Trends in biotechnology. 34, 4, p. 276-290 15 p.

Research output: Contribution to journalReview article

Data integration
Metabolism
Life Style
Technology
Phenotype
19 Citations (Scopus)

Trisaccharide containing α2,3-linked sialic acid is a receptor for mumps virus

Kubota, M., Takeuchi, K., Watanabe, S., Ohno, S., Matsuoka, R., Kohda, D., Nakakita, S. I., Hiramatsu, H., Suzuki, Y., Nakayama, T., Terada, T., Shimizu, K., Shimizu, N., Shiroishi, M., Yanagi, Y. & Hashiguchi, T., Oct 11 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 41, p. 11579-11584 6 p.

Research output: Contribution to journalArticle

Mumps virus
Trisaccharides
N-Acetylneuraminic Acid
Mumps
Polysaccharides
21 Citations (Scopus)

Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels

Inoue, D., Matsumoto, M., Nagase, R., Saika, M., Fujino, T., Nakayama, K. & Kitamura, T., Mar 1 2016, In : Experimental Hematology. 44, 3, p. 172-176.e1

Research output: Contribution to journalArticle

Mutation
Neoplasms
Proteins
Myelodysplastic Syndromes
Hematologic Neoplasms
2 Citations (Scopus)

Two isoforms of TALDO1 generated by alternative translational initiation show differential nucleocytoplasmic distribution to regulate the global metabolic network

Moriyama, T., Tanaka, S., Nakayama, Y., Fukumoto, M., Tsujimura, K., Yamada, K., Bamba, T., Yoneda, Y., Fukusaki, E. & Oka, M., Oct 5 2016, In : Scientific reports. 6, 34648.

Research output: Contribution to journalArticle

Transaldolase
Metabolic Networks and Pathways
Protein Isoforms
Karyopherins
Pentose Phosphate Pathway
7 Citations (Scopus)

Two types of interleukin 17A-producing γδ T cells in protection against pulmonary infection with klebsiella pneumoniae

Murakami, T., Hatano, S., Yamada, H., Iwakura, Y. & Yoshikai, Y., Jan 1 2016, In : Journal of Infectious Diseases. 214, 11, p. 1752-1761 10 p.

Research output: Contribution to journalArticle

Cytoprotection
Interleukin-17
Klebsiella pneumoniae
T-Lymphocytes
Lung
11 Citations (Scopus)

UV damage-induced phosphorylation of HBO1 triggers CRL4DDB2-mediated degradation to regulate cell proliferation

Matsunuma, R., Niida, H., Ohhata, T., Kitagawa, K., Sakai, S., Uchida, C., Shiotani, B., Matsumoto, M., Nakayama, K. I., Ogura, H., Shiiya, N. & Kitagawa, M., Jan 1 2016, In : Molecular and cellular biology. 36, 3, p. 394-406 13 p.

Research output: Contribution to journalArticle

Histone Acetyltransferases
Phosphorylation
Cell Proliferation
Replication Origin
DNA Damage
2015
11 Citations (Scopus)

3-O-sulfo-β-d-galactose moiety of endogenous sulfoglycolipids is a potential ligand for immunoglobulin-like receptor LMIR5

Phongsisay, V., Iizasa, E., Hara, H. & Yamasaki, S., Feb 1 2015, In : Molecular Immunology. 63, 2, p. 595-599 5 p.

Research output: Contribution to journalArticle

Glycolipids
Galactose
C-Type Lectins
Immunoglobulins
Basophils
25 Citations (Scopus)

A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation

Tomita, S., Abdalla, M. O. A., Fujiwara, S., Matsumori, H., Maehara, K., Ohkawa, Y., Iwase, H., Saitoh, N. & Nakao, M., Apr 29 2015, In : Nature communications. 6, 6966.

Research output: Contribution to journalArticle

Untranslated RNA
loci
breast
estrogens
cancer
17 Citations (Scopus)

Activation of an innate immune receptor, Nod1, accelerates atherogenesis in Apoe2/2 mice

Kanno, S., Nishio, H., Tanaka, T., Motomura, Y., Murata, K., Ihara, K., Onimaru, M., Yamasaki, S., Kono, H., Sueishi, K. & Hara, T., Jan 15 2015, In : Journal of Immunology. 194, 2, p. 773-780 8 p.

Research output: Contribution to journalArticle

Apolipoprotein E2
Atherosclerosis
Apolipoproteins E
Knockout Mice
Blood Vessels
12 Citations (Scopus)

A genome-wide analysis identifies a Notch-RBP-Jk-IL-7Ra axis that controls IL-17-Producing γδ T cell homeostasis in mice

Nakamura, M., Shibata, K., Hatano, S., Sato, T., Ohkawa, Y., Yamada, H., Ikuta, K. & Yoshikai, Y., Jan 1 2015, In : Journal of Immunology. 194, 1, p. 243-251 9 p.

Research output: Contribution to journalArticle

Interleukin-17
Homeostasis
Genome
T-Lymphocytes
Interleukin-7
7 Citations (Scopus)

Agplus: A rapid and flexible tool for aggregation plots

Maehara, K. & Ohkawa, Y., Jul 31 2015, In : Bioinformatics. 31, 18, p. 3046-3047 2 p.

Research output: Contribution to journalArticle

Nucleic Acid Regulatory Sequences
Transcription Initiation Site
Aggregation
Agglomeration
Transcription
18 Citations (Scopus)

A metabolomics-based strategy for identification of gene targets for phenotype improvement and its application to 1-butanol tolerance in Saccharomyces cerevisiae

Teoh, S. T., Putri, S., Mukai, Y., Bamba, T. & Fukusaki, E., Sep 15 2015, In : Biotechnology for Biofuels. 8, 1, 330.

Research output: Contribution to journalArticle

1-Butanol
Metabolomics
Metabolites
Butenes
Yeast
4 Citations (Scopus)

An Enhancer of the IL-7 receptor α-chain locus controls IL-7 receptor expression and maintenance of peripheral T cells

Abe, A., Tani-ichi, S., Shitara, S., Cui, G., Yamada, H., Miyachi, H., Kitano, S., Hara, T., Abe, R., Yoshikai, Y. & Ikuta, K., Oct 1 2015, In : Journal of Immunology. 195, 7, p. 3129-3138 10 p.

Research output: Contribution to journalArticle

Interleukin-7 Receptors
Internal-External Control
Maintenance
T-Lymphocytes
Interleukin-7
2 Citations (Scopus)

A new Xist allele driven by a constitutively active promoter is dominated by Xist locus environment and exhibits the parent-oforigin effects

Amakawa, Y., Sakata, Y., Hoki, Y., Arata, S., Shioda, S., Fukagawa, T., Sasaki, H. & Sado, T., Dec 15 2015, In : Development (Cambridge). 142, 24, p. 4299-4308 10 p.

Research output: Contribution to journalArticle

Alleles
Mothers
X Chromosome Inactivation
Blastocyst
X-Linked Genes
24 Citations (Scopus)

An optogenetic system for interrogating the temporal dynamics of Akt

Katsura, Y., Kubota, H., Kunida, K., Kanno, A., Kuroda, S. & Ozawa, T., Oct 1 2015, In : Scientific reports. 5, 14589.

Research output: Contribution to journalArticle

Optogenetics
Light
Muscular Atrophy
Protein-Serine-Threonine Kinases
Lighting
3 Citations (Scopus)

A novel missense mutation of RYR1 in familial idiopathic hyper CK-emia

Sano, K., Miura, S., Fujiwara, T., Fujioka, R., Yorita, A., Noda, K., Kida, H., Azuma, K., Kaieda, S., Yamamoto, K., Taniwaki, T., Fukumaki, Y. & Shibata, H., Sep 15 2015, In : Journal of the Neurological Sciences. 356, 1-2, p. 142-147 6 p., 13864.

Research output: Contribution to journalArticle

Missense Mutation
Creatine Kinase
Pedigree
Nucleotides
Genes
36 Citations (Scopus)

Axl phosphorylates Elmo scaffold proteins to promote rac activation and cell invasion

Abu-Thuraia, A., Gauthier, R., Chidiac, R., Fukui, Y., Screaton, R. A., Gratton, J. P. & Côté, J. F., Jan 1 2015, In : Molecular and cellular biology. 35, 1, p. 76-87 12 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Cell Proliferation
Proteins
Guanine Nucleotide Exchange Factors
Mutagenesis
5 Citations (Scopus)

Biochemical characterization of three BLT receptors in zebrafish

Okuno, T., Ishitani, T. & Yokomizo, T., Mar 4 2015, In : PloS one. 10, 3, e0117888.

Research output: Contribution to journalArticle

Leukotriene B4 Receptors
Leukotriene B4
leukotrienes
Zebrafish
Danio rerio
2 Citations (Scopus)

Brief report: Successful in vitro culture of rheumatoid arthritis synovial tissue explants at the air-liquid interface

Sakuraba, K., Fujimura, K., Nakashima, Y., Okazaki, K., Fukushi, J-I., Ohishi, M., Oyamada, A., Esaki, Y., Miyahara, H., Iwamoto, Y., Yoshikai, Y. & Yamada, H., Jan 1 2015, In : Arthritis and Rheumatology. 67, 4, p. 887-892 6 p.

Research output: Contribution to journalArticle

Rheumatoid Arthritis
Air
Synovitis
SCID Mice
Cytokines
52 Citations (Scopus)

Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU

Shanmughapriya, S., Rajan, S., Hoffman, N. E., Zhang, X., Guo, S., Kolesar, J. E., Hines, K. J., Ragheb, J., Jog, N. R., Caricchio, R., Baba, Y., Zhou, Y., Kaufman, B. A., Cheung, J. Y., Kurosaki, T., Gill, D. L. & Madesh, M., Mar 3 2015, In : Science Signaling. 8, 366, p. ra23

Research output: Contribution to journalArticle

Metabolism
Endoplasmic Reticulum
Mitochondria
Lymphocytes
Genes

CD30 ligand could be a new therapeutic target for central nervous system autoimmunity

Shinoda, K. & Yoshikai, Y., May 1 2015, In : Clinical and Experimental Neuroimmunology. 6, 2, p. 111-112 2 p.

Research output: Contribution to journalComment/debate

CD30 Ligand
Autoimmunity
Central Nervous System
Therapeutics
9 Citations (Scopus)

CD30 ligand is a new therapeutic target for central nervous system autoimmunity

Shinoda, K., Sun, X., Oyamada, A., Yamada, H., Muta, H., Podack, E. R., Kira, J-I. & Yoshikai, Y., Feb 1 2015, In : Journal of Autoimmunity. 57, p. 14-23 10 p.

Research output: Contribution to journalArticle

CD30 Ligand
Autoimmunity
Central Nervous System
Th17 Cells
Th1 Cells
19 Citations (Scopus)

Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture

Sugimoto, N., Maehara, K., Yoshida, K., Yasukouchi, S., Osano, S., Watanabe, S., Aizawa, M., Yugawa, T., Kiyono, T., Kurumizaka, H., Ohkawa, Y. & Fujita, M., Jan 1 2015, In : Nucleic acids research. 43, 12, p. 5898-5911 14 p.

Research output: Contribution to journalArticle

Histones
Chromatin
Glutamic Acid
Carrier Proteins
Replication Origin
3 Citations (Scopus)

ChromContact: A web tool for analyzing spatial contact of chromosomes from Hi-C data

Sato, T. & Suyama, M., Dec 15 2015, In : BMC Genomics. 16, 1, 1060.

Research output: Contribution to journalArticle

Chromosomes, Human, 6-12 and X
Chromosomes
Genome-Wide Association Study
Genome
Genes
30 Citations (Scopus)

Corynomycolic acid-containing glycolipids signal through the pattern recognition receptor Mincle

Van Der Peet, P. L., Gunawan, C., Torigoe, S., Yamasaki, S. & Williams, S. J., Jan 1 2015, In : Chemical Communications. 51, 24, p. 5100-5103 4 p.

Research output: Contribution to journalArticle

Pattern Recognition Receptors
Trehalose
Glycolipids
Glycerol
Pattern recognition
33 Citations (Scopus)

Crossreactive αβ T Cell Receptors Are the Predominant Targets of Thymocyte Negative Selection

McDonald, B. D., Bunker, J. J., Erickson, S. A., Ohora, M. & Bendelac, A., Nov 17 2015, In : Immunity. 43, 5, p. 859-869 11 p.

Research output: Contribution to journalArticle

Thymocytes
T-Cell Antigen Receptor
Clonal Deletion
Lymphocytes
Process Assessment (Health Care)
50 Citations (Scopus)

C-type lectin receptor MCL facilitates mincle expression and signaling through complex formation

Miyake, Y., Ohora, M. & Yamasaki, S., Jun 1 2015, In : Journal of Immunology. 194, 11, p. 5366-5374 9 p.

Research output: Contribution to journalArticle

C-Type Lectins
Macrophages
Cord Factors
Dendritic Cells
Bone Marrow
28 Citations (Scopus)

Dectin-2 deficiency promotes Th2 response and mucin production in the lungs after pulmonary infection with Cryptococcus neoformans

Nakamura, Y., Sato, K., Yamamoto, H., Matsumura, K., Matsumoto, I., Nomura, T., Miyasaka, T., Ishii, K., Kanno, E., Tachi, M., Yamasaki, S., Saijo, S., Iwakura, Y. & Kawakami, K., Jan 1 2015, In : Infection and Immunity. 83, 2, p. 671-681 11 p.

Research output: Contribution to journalArticle

Cryptococcus neoformans
Mucins
Lung
Infection
Cytokines
16 Citations (Scopus)

Dedicator of cytokinesis 2, a novel regulator for smooth muscle phenotypic modulation and vascular remodeling

Guo, X., Shi, N., Cui, X. B., Wang, J. N., Fukui, Y. & Chen, S. Y., May 8 2015, In : Circulation research. 116, 10, p. e71-e80

Research output: Contribution to journalArticle

Cytokinesis
Smooth Muscle
Smooth Muscle Myocytes
Serum Response Factor
Neointima
12 Citations (Scopus)

Dermal Vγ4+ γδ T Cells Possess a Migratory Potency to the Draining Lymph Nodes and Modulate CD8+ T-Cell Activity through TNF-α Production

Nakamizo, S., Egawa, G., Tomura, M., Sakai, S., Tsuchiya, S., Kitoh, A., Honda, T., Otsuka, A., Nakajima, S., Dainichi, T., Tanizaki, H., Mitsuyama, M., Sugimoto, Y., Kawai, K., Yoshikai, Y., Miyachi, Y. & Kabashima, K., Apr 20 2015, In : Journal of Investigative Dermatology. 135, 4, p. 1007-1015 9 p.

Research output: Contribution to journalArticle

T-cells
Lymph Nodes
T-Lymphocytes
Skin
Dendritic Cells

Development of μtas for high-throughput screening of nad(p)-dependent oxidoreductases

Shimokihara, S., Shitara, S., Oyobiki, R., Watanabe, T., Einaga, Y., Matsumoto, Y., Fujiwara, K., Horisawa, K. & Doi, N., Jan 1 2015, MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, p. 1302-1304 3 p. (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Screening
Throughput
Microfluidics
Biological fuel cells
Sorting
9 Citations (Scopus)

Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo

Kubokura, N., Takahashi, F., arioka, M., Yoshihara, T., Igawa, K., Tomooka, K., Morimoto, S., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., Matsumoto, T., Kitazono, T. & Sasaguri, T., Jan 1 2015, In : Journal of Pharmacological Sciences. 127, 4, p. 446-455 10 p.

Research output: Contribution to journalArticle

Growth
Neoplasms
Intestinal Neoplasms
Catenins
Dictyostelium
2 Citations (Scopus)
Thermoplasma
Multicarrier modulation
Archaea
Proteins
Eukaryota
20 Citations (Scopus)

Distribution of histone H4 modifications as revealed by a panel of specific monoclonal antibodies

Hayashi-Takanaka, Y., Maehara, K., Harada, A., Umehara, T., Yokoyama, S., Obuse, C., Ohkawa, Y., Nozaki, N. & Kimura, H., Dec 1 2015, In : Chromosome Research. 23, 4, p. 753-766 14 p.

Research output: Contribution to journalArticle

Histone Code
Acetylation
Histones
Monoclonal Antibodies
Epigenomics
47 Citations (Scopus)

DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis

Kubo, N., Toh, H., Shirane, K., Shirakawa, T., Kobayashi, H., Sato, T., Sone, H., Sato, Y., Tomizawa, S. I., Tsurusaki, Y., Shibata, H., Saitsu, H., Suzuki, Y., Matsumoto, N., Suyama, M., Kono, T., Ohbo, K. & Sasaki, H., Aug 20 2015, In : BMC Genomics. 16, 1, 624.

Research output: Contribution to journalArticle

DNA Methylation
Methylation
Testis
Cell Differentiation
Germ Cells
23 Citations (Scopus)

Dynamic three-dimensional morphogenesis of intrahepatic bile ducts in mouse liver development

Takashima, Y., Terada, M., Kawabata, M. & Suzuki, A., Mar 1 2015, In : Hepatology. 61, 3, p. 1003-1011 9 p.

Research output: Contribution to journalArticle

Intrahepatic Bile Ducts
Morphogenesis
Liver
Portal Vein
Spatio-Temporal Analysis
28 Citations (Scopus)

Engrafted Neural Stem/Progenitor Cells Promote Functional Recovery through Synapse Reorganization with Spared Host Neurons after Spinal Cord Injury

Yokota, K., Kobayakawa, K., Kubota, K., Miyawaki, A., Okano, H., Ohkawa, Y., Iwamoto, Y. & Okada, S., Jan 1 2015, In : Stem Cell Reports. 5, 2, p. 264-277 14 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Stem cells
Spinal Cord Injuries
Synapses
Neurons
Genome
DNA
Research
Genes
2 Citations (Scopus)
DNA Glycosylases
Carcinogenesis
Cell Death
Neoplasms
4-iodo-2,5-dimethoxyphenylisopropylamine

Erratum: PSMC5, a 19S proteasomal ATPase, regulates cocaine action in the nucleus accumbens (PLoS ONE (2015) 10:5 (e0126710) DOI: 10.1371/journal.pone.0126710)

Ohnishi, Y. H., Ohnishi, Y. N., Nakamura, T., Ohno, M., Kennedy, P. J., Ohkawa, Y., Nishi, A., Neve, R., Tsuzuki, T. & Nestler, E. J., Jun 25 2015, In : PloS one. 10, 6, e0131263.

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Erratum: Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria (Nucleic Acids Res. (2000) 28 (1355-64))

Ohtsubo, T., Nishioka, K., Imaiso, Y., Iwai, S., Shimokawa, H., Oda, H., Fujiwara, T. & Nakabeppu, Y., Mar 23 2015, In : Nucleic acids research. 43, 7, p. 3870-3871 2 p.

Research output: Contribution to journalComment/debate

Forensic Anthropology
Nucleic Acids
Mitochondria
DNA
Enzymes

Erratum: Identification and Characterization of a Novel Small-Molecule Inhibitor of β-Catenin Signaling ((2014) 184 (2111-2122) DOI: 10.1016/j.ajpath.2014.04.002)

Delgado, E. R., Yang, J., So, J., Fanti, M., Leimgruber, S., Kahn, M., Ishitani, T., Shin, D., Wilson, G. M. & Monga, S. P., Jan 1 2015, In : American Journal of Pathology. 185, 10, 1 p., 2145.

Research output: Contribution to journalComment/debate

6 Citations (Scopus)
Hepatocytes
Liver
Cell Tracking
Cell Lineage
Tamoxifen
49 Citations (Scopus)

F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner

Yumimoto, K., Akiyoshi, S., Ueo, H., Sagara, Y., Onoyama, I., Ueo, H., Ohno, S., Mori, M., Mimori, K. & Nakayama, K., Feb 2 2015, In : Journal of Clinical Investigation. 125, 2, p. 621-635 15 p.

Research output: Contribution to journalArticle

F-Box Proteins
Neoplasm Metastasis
Neoplasms
Chemokine CCL2
Stromal Cells
6 Citations (Scopus)

FBXL12-mediated degradation of ALDH3 is essential for trophoblast differentiation during placental development

Nishiyama, M., Nita, A., Yumimoto, K. & Nakayama, K., Jan 1 2015, In : STEM CELLS. 33, 11, p. 3327-3340 14 p.

Research output: Contribution to journalArticle

Placentation
Trophoblasts
Stem Cells
Placenta
Aldehyde Dehydrogenase
6 Citations (Scopus)

FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1

Watanabe, K., Yumimoto, K. & Nakayama, K., Aug 1 2015, In : Genes to Cells. 20, 8, p. 667-674 8 p.

Research output: Contribution to journalArticle

F-Box Proteins
Ubiquitin-Protein Ligases
Ubiquitination
Clustered Regularly Interspaced Short Palindromic Repeats
Proteomics
4 Citations (Scopus)

Fbxw7 suppresses cancer metastasis by inhibiting niche formation

Yumimoto, K. & Nakayama, K., Aug 3 2015, In : OncoImmunology. 4, 8

Research output: Contribution to journalArticle

Neoplasm Metastasis
Chemokine CCL2
Mesenchymal Stromal Cells
Neoplasms
Macrophages
41 Citations (Scopus)

Foxl3 is a germ cell-intrinsic factor involved in sperm-egg fate decision in medaka

Nishimura, T., Sato, T., Yamamoto, Y., Watakabe, I., Ohkawa, Y., Suyama, M., Kobayashi, S. & Tanaka, M., Jul 17 2015, In : Science. 349, 6245, p. 328-331 4 p.

Research output: Contribution to journalArticle

Oryzias
Intrinsic Factor
Germ Cells
Ovum
Spermatozoa