Research Output 1979 2019

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Review article
2009
8 Citations (Scopus)

Functional similarities and uniqueness of p27 and p57: Insight from a knock-in mouse model

Susaki, E. & Nakayama, K., Aug 15 2009, In : Cell Cycle. 8, 16, p. 2497-2501 5 p.

Research output: Contribution to journalReview article

Cyclin-Dependent Kinases
Cyclin-Dependent Kinase Inhibitor p57
Cyclin-Dependent Kinase Inhibitor p27
Genes
Phenotype
2008
249 Citations (Scopus)

Calcium signaling in lymphocytes

Ohora, M. & Rao, A., Jun 1 2008, In : Current Opinion in Immunology. 20, 3, p. 250-258 9 p.

Research output: Contribution to journalReview article

Calcium Signaling
Lymphocytes
T-Lymphocytes
Mast Cells
Antigen-Presenting Cells
28 Citations (Scopus)

Fbxw7 in cell cycle exit and stem cell maintenance: Insight from gene-targeted mice

Onoyama, I. & Nakayama, K., Nov 1 2008, In : Cell Cycle. 7, 21, p. 3307-3313 7 p.

Research output: Contribution to journalReview article

Cell Cycle
Stem Cells
Maintenance
Genes
SKP Cullin F-Box Protein Ligases
55 Citations (Scopus)

Oncogenesis by retroviruses: Old and new paradigms

Maeda, N., Fan, H. & Yoshikai, Y., Nov 1 2008, In : Reviews in Medical Virology. 18, 6, p. 387-405 19 p.

Research output: Contribution to journalReview article

Retroviridae
Carcinogenesis
Oncogenes
Proto-Oncogenes
Neoplasms
2 Citations (Scopus)
F-Box Proteins
Proto-Oncogene Proteins c-myc
Tumor Suppressor Protein p53
Cell Cycle Resting Phase
Cell Cycle Proteins

Regulation of cell proliferation and tumorigenesis by ubiquitin-proteasome pathway

Matsumoto, A. & Nakayama, K., Nov 2008, In : Biotherapy. 22, 6, p. 363-370 8 p.

Research output: Contribution to journalReview article

Proteasome Endopeptidase Complex
Ubiquitin
Cell Cycle
Carcinogenesis
Cell Proliferation

Soft interaction for the recognition of mitochondrial targeting signal

Kohda, D., 2008, In : Seikagaku. The Journal of Japanese Biochemical Society. 80, 10, p. 888-896 9 p.

Research output: Contribution to journalReview article

Saccharomyces cerevisiae Proteins
Signal transduction
Mitochondria
Protein Precursors
Mitochondrial Proteins
2007
37 Citations (Scopus)

Multiple mechanisms for p27Kip1 translocation and degradation

Susaki, E. & Nakayama, K., Dec 15 2007, In : Cell Cycle. 6, 24, p. 3015-3020 6 p.

Research output: Contribution to journalReview article

Cyclin D2
Cell Nucleus Active Transport
Cyclin-Dependent Kinases
Growth
Cell Cycle
1 Citation (Scopus)

New molecular mechanisms of virus-mediated carcinogenesis: oncogenic transformation of cells by retroviral structural protein Envelope

Maeda, N. & Yoshikai, Y., Jan 1 2007, In : Uirusu. Journal of virology. 57, 2, p. 159-170 12 p.

Research output: Contribution to journalReview article

Retroviridae
Carcinogenesis
Viruses
Proteins
Oncogenes
158 Citations (Scopus)

Oxidative damage in nucleic acids and Parkinson's disease

Nakabeppu, Y., Tsuchimoto, D., yamaguchi, H. & Kunihiko, S., Apr 1 2007, In : Journal of Neuroscience Research. 85, 5, p. 919-934 16 p.

Research output: Contribution to journalReview article

Mitochondrial DNA
Nucleic Acids
DNA Glycosylases
Parkinson Disease
Dopaminergic Neurons
20 Citations (Scopus)

Regeneration-based therapies for spinal cord injuries

Okano, H., Kaneko, S., Okada, S., Iwanami, A., Nakamura, M. & Toyama, Y., Jul 1 2007, In : Neurochemistry International. 51, 2-4 SPEC. ISS., p. 68-73 6 p.

Research output: Contribution to journalReview article

Spinal Cord Injuries
Regeneration
Central Nervous System
Developmental Biology
Regenerative Medicine

Roles of natural memory lymphocytes in host defense mechanisms

Yoshikai, Y., Jan 1 2007, In : Nippon rinsho. Japanese journal of clinical medicine. 65 Suppl 2 Pt. 1, p. 109-112 4 p.

Research output: Contribution to journalReview article

Immunologic Memory
Defense Mechanisms
Communicable Diseases
B-Lymphocytes
Lymphocytes
71 Citations (Scopus)

Significance of error-avoiding mechanisms for oxidative DNA damage in carcinogenesis

Tsuzuki, T., Nakatsu, Y. & Nakabeppu, Y., Apr 1 2007, In : Cancer Science. 98, 4, p. 465-470 6 p.

Research output: Contribution to journalReview article

Mutagenesis
DNA Damage
Carcinogenesis
Adenine
Escherichia coli
2006
4 Citations (Scopus)

Crosstalk between innate and adaptive immunity

Yoshikai, Y., Jan 1 2006, In : Nippon rinsho. Japanese journal of clinical medicine. 64, 7, p. 1223-1228 6 p.

Research output: Contribution to journalReview article

Adaptive Immunity
Innate Immunity
Interferon-gamma
Interferon-beta
Immunity

Immune response against HSV

Kagimoto, Y. & Yoshikai, Y., Jan 1 2006, In : Nippon rinsho. Japanese journal of clinical medicine. 64 Suppl 3, p. 178-183 6 p.

Research output: Contribution to journalReview article

Herpes Simplex
Simplexvirus
Phagocytes
Innate Immunity
B-Lymphocytes
21 Citations (Scopus)

Immunological protection against Mycobacterium tuberculosis infection

Yoshikai, Y., 2006, In : Critical Reviews in Immunology. 26, 6, p. 515-526 12 p.

Research output: Contribution to journalReview article

Mycobacterium Infections
Mycobacterium tuberculosis
T-Lymphocytes
Adaptive Immunity
Infection
61 Citations (Scopus)
Nucleoside-Triphosphatase
Purine Nucleosides
Purine Nucleotides
Cytotoxicity
Brain
886 Citations (Scopus)

Ubiquitin ligases: Cell-cycle control and cancer

Nakayama, K. & Nakayama, K., May 1 2006, In : Nature Reviews Cancer. 6, 5, p. 369-381 13 p.

Research output: Contribution to journalReview article

Ubiquitination
Ligases
Ubiquitin
Cell Cycle Checkpoints
Cell Cycle
2 Citations (Scopus)

Ubiquitin system regulating G1 and S phases of cell cycle

Nakayama, K. & Nakayama, K., Aug 2006, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 51, 10 Suppl, p. 1362-1369 8 p.

Research output: Contribution to journalReview article

Ubiquitin-Protein Ligase Complexes
Cyclin-Dependent Kinase Inhibitor Proteins
Cell Cycle Proteins
Cyclin-Dependent Kinases
G1 Phase
2005

Development of vaccine and its immunological mechanism

Nishimura, H. & Yoshikai, Y., Jan 1 2005, In : Nippon rinsho. Japanese journal of clinical medicine. 63 Suppl 5, p. 585-589 5 p.

Research output: Contribution to journalReview article

Toxoids
Attenuated Vaccines
Inactivated Vaccines
DNA Vaccines
Drug Design

Gamma-delta T cells

Tagawa, T. & Yoshikai, Y., Jan 1 2005, In : Nippon rinsho. Japanese journal of clinical medicine. 63 Suppl 4, p. 149-153 5 p.

Research output: Contribution to journalReview article

delta-Chain T-Cell Antigen Receptor Gene Rearrangement
gamma-Chain T-Cell Antigen Receptor Gene Rearrangement
Antigen Receptors, T-Cell, gamma-delta
CC Chemokines
Somatostatin-Secreting Cells
8 Citations (Scopus)

Mapping of ubiquitination sites on target proteins

Hatakeyama, S., Matsumoto, M. & Nakayama, K., Jan 1 2005, In : Methods in enzymology. 399, p. 277-286 10 p., 19.

Research output: Contribution to journalReview article

Ubiquitinated Proteins
Ubiquitination
Lysine
Mass Spectrometry
Polyubiquitin
102 Citations (Scopus)

Negative regulation of cytokine signaling and immune responses by SOCS proteins

Yoshimura, A., Nishinakamura, H., Matsumura, Y. & Hanada, T., Jun 1 2005, In : Arthritis Research and Therapy. 7, 3, p. 100-110 11 p.

Research output: Contribution to journalReview article

Suppressor of Cytokine Signaling Proteins
Cytokines
Janus Kinases
Interleukins
Adaptive Immunity
253 Citations (Scopus)

Regulation of the cell cycle by SCF-type ubiquitin ligases

Nakayama, K. & Nakayama, K., Jan 1 2005, In : Seminars in Cell and Developmental Biology. 16, 3, p. 323-333 11 p.

Research output: Contribution to journalReview article

SKP Cullin F-Box Protein Ligases
Cell Cycle
F-Box Proteins
Ubiquitin
Proteolysis
17 Citations (Scopus)

Regulation of the neuronal fate by ΔFosB and its downstream target, galectin-1

Miura, T., Ohnishi, Y., Kurushima, H., Horie, H., Kadoya, T. & Nakabeppu, Y., Jun 1 2005, In : Current Drug Targets. 6, 4, p. 437-444 8 p.

Research output: Contribution to journalReview article

Galectin 1
Cell death
Cell Death
Cells
Transcription Factor AP-1

Signaling pathway through T cell receptor

Yamasaki, S. & Saito, T., Jan 1 2005, In : Nippon rinsho. Japanese journal of clinical medicine. 63 Suppl 4, p. 335-340 6 p.

Research output: Contribution to journalReview article

Signal Transducing Adaptor Proteins
ZAP-70 Protein-Tyrosine Kinase
CD3 Antigens
NF-kappa B
Phosphoproteins
1 Citation (Scopus)

Structural basis of mitochondrial import

Kohda, D., 2005, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 50, 10 Suppl, p. 1303-1310 8 p.

Research output: Contribution to journalReview article

Mitochondrial Membrane Transport Proteins
Intracellular Signaling Peptides and Proteins
Saccharomyces cerevisiae Proteins
Tumor Suppressor Proteins
Multiprotein Complexes
3 Citations (Scopus)

The degradation of p27 and cancer

Kotoshiba, S. & Nakayama, K., Jan 1 2005, In : Nippon rinsho. Japanese journal of clinical medicine. 63, 11, p. 2047-2056 10 p.

Research output: Contribution to journalReview article

Cyclin-Dependent Kinases
Cell Cycle
Cell Cycle Resting Phase
Cyclins
Ubiquitination
2004
5 Citations (Scopus)
Immunophilins
Mitochondria
Apoptosis
Tacrolimus Binding Protein 1A
Apoptosis Regulatory Proteins
75 Citations (Scopus)
Mutagenesis
Cell death
Nucleic Acids
DNA Glycosylases
Cell Death
2003

Deregulated Proteolysis of the Cell Cycle Regulator p27Kip1 and Cancers

Susaki, E. & Nakayama, K., Nov 2003, In : Biotherapy. 17, 6, p. 546-555 10 p.

Research output: Contribution to journalReview article

Proteolysis
Cell Cycle
Neoplasms
Ubiquitin
S-Phase Kinase-Associated Proteins
6 Citations (Scopus)

Glutamate receptor genes as candidates for schizophrenia susceptibility

Fukumaki, Y. & Shibata, H., Oct 1 2003, In : Drug Development Research. 60, 2, p. 137-151 15 p.

Research output: Contribution to journalReview article

Glutamate Receptors
Schizophrenia
Genes
Endophenotypes
Haplotypes
215 Citations (Scopus)

Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis

Shirane, M. & Nakayama, K., Jan 1 2003, In : Nature Cell Biology. 5, 1, p. 28-37 10 p.

Research output: Contribution to journalReview article

Tacrolimus Binding Proteins
Mitochondria
Apoptosis
Tacrolimus Binding Protein 1A
Calcineurin
21 Citations (Scopus)

NKT cells are dispensable in the induction of oral tolerance but are indispensable in the abrogation of oral tolerance by prostaglandin E

Ishimitsu, R., Yajima, T., Nishimura, H., Kawauchi, H. & Yoshikai, Y., Jan 1 2003, In : European Journal of Immunology. 33, 1, p. 183-193 11 p.

Research output: Contribution to journalReview article

Prostaglandins E
Alprostadil
Interleukin-4
T-Lymphocytes
Th1-Th2 Balance
33 Citations (Scopus)

Thymic generation and selection of CD25+CD4+ regulatory T cells: Implications of their broad repertoire and high self-reactivity for the maintenance of immunological self-tolerance

Sakaguchi, S., Hori, S., Fukui, Y., Sasazuki, T., Sakaguchi, N., Takahashi, T. & Bach, Dec 1 2003, In : Novartis Foundation Symposium. 252, p. 6-23 18 p.

Research output: Contribution to journalReview article

Self Tolerance
Regulatory T-Lymphocytes
Thymus Gland
T-Lymphocytes
Ligands
42 Citations (Scopus)

Ubiquitylation as a quality control system for intracellular proteins

Hatakeyama, S. & Nakayama, K., Jul 1 2003, In : Journal of Biochemistry. 134, 1, p. 1-8 8 p.

Research output: Contribution to journalReview article

Ubiquitination
Quality Control
Quality control
Control systems
Ubiquitin
147 Citations (Scopus)

U-box proteins as a new family of ubiquitin ligases

Hatakeyama, S. & Nakayama, K., Mar 21 2003, In : Biochemical and Biophysical Research Communications. 302, 4, p. 635-645 11 p.

Research output: Contribution to journalReview article

Ligases
Ubiquitin
Fungal Proteins
Fingers
Proteins
2002

A critical role of the CDM family molecule DOCK2 in lymphocyte migration

Fukui, Y., 2002, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 47, 16 Suppl, p. 2194-2199 6 p.

Research output: Contribution to journalReview article

rac1 GTP-Binding Protein
rac GTP-Binding Proteins
GTPase-Activating Proteins
Cytoskeleton
Cell Movement

From the structure to the function of the PX domain

Kohda, D., Jan 1 2002, In : Seikagaku. The Journal of Japanese Biochemical Society. 74, 10, p. 1244-1250 7 p.

Research output: Contribution to journalReview article

Secondary Protein Structure
Homeodomain Proteins
Phosphatidylinositol Phosphates
Protein Conformation
src Homology Domains
98 Citations (Scopus)

Functions of outer membrane receptors in mitochondrial protein import

Endo, T. & Kohda, D., Sep 2 2002, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1592, 1, p. 3-14 12 p.

Research output: Contribution to journalReview article

Protein Precursors
Mitochondrial Proteins
Membranes
Mitochondria
Mitochondrial Membranes
2001
94 Citations (Scopus)

Molecular genetics and structural biology of human MutT homolog, MTH1

Nakabeppu, Y., Jun 2 2001, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 477, 1-2, p. 59-70 12 p.

Research output: Contribution to journalReview article

Single Nucleotide Polymorphism
Molecular Biology
Exons
Messenger RNA
Nucleoside-Triphosphatase
189 Citations (Scopus)

Regulation of the cell cycle at the G1-S transition by proteolysis of cyclin E and p27Kip1

Nakayama, K., Hatakeyama, S. & Nakayama, K., Jan 1 2001, In : Biochemical and Biophysical Research Communications. 282, 4, p. 853-860 8 p.

Research output: Contribution to journalReview article

Proteolysis
Cyclin E
Cell Cycle
Cells
Ubiquitin
44 Citations (Scopus)

Roles of prostaglandins and leukotrienes in acute inflammation caused by bacterial infection

Yoshikai, Y., Jan 1 2001, In : Current Opinion in Infectious Diseases. 14, 3, p. 257-263 7 p.

Research output: Contribution to journalReview article

Leukotrienes
Bacterial Infections
Prostaglandins
Inflammation
Arachidonate 5-Lipoxygenase
2000
37 Citations (Scopus)

The role of interleukin 15 in mounting an immune response against microbial infections

Yoshikai, Y. & Nishimura, H., Jan 1 2000, In : Microbes and Infection. 2, 4, p. 381-389 9 p.

Research output: Contribution to journalReview article

Interleukin-15
Infection
Cytokines
T-Lymphocytes
Adaptive Immunity
1999
45 Citations (Scopus)

The interaction of intestinal epithelial cells and intraepithelial lymphocytes in host defense

Yoshikai, Y., Dec 1 1999, In : Immunologic Research. 20, 3, p. 219-235 17 p.

Research output: Contribution to journalReview article

Epithelial Cells
Lymphocytes
T-Lymphocytes
Listeria monocytogenes
T-Cell Antigen Receptor
1998
169 Citations (Scopus)

Cip/Kip cyclin-dependent kinase inhibitors: Brakes of the cell cycle engine during development

Nakayama, K. & Nakayama, K., Jan 1 1998, In : BioEssays. 20, 12, p. 1020-1029 10 p.

Research output: Contribution to journalReview article

Cyclin-Dependent Kinases
Brakes
Cell Cycle
Cells
Engines

Genomic imprinting and functional chromosome domain

Sasaki, H., Jan 1 1998, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 43, 14, p. 2101-2108 8 p.

Research output: Contribution to journalReview article

Angelman Syndrome
Genomic Imprinting
Prader-Willi Syndrome
Histone Deacetylases
Gene Expression Regulation

Genomic imprinting and mammalian development

Hatano, N. & Sasaki, H., Jan 1 1998, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 43, 4, p. 541-548 8 p.

Research output: Contribution to journalReview article

Genomic Imprinting
Mammals
Alleles
4 Citations (Scopus)

The roles of heat shock proteins in host defense against bacterial infection

Yoshikai, Y., Jan 1 1998, In : Rinsho byori. The Japanese journal of clinical pathology. 46, 6, p. 564-573 10 p.

Research output: Contribution to journalReview article

Cytoprotection
Heat-Shock Proteins
Bacterial Infections
Inflammation
Bacteria
1996
46 Citations (Scopus)

DNA-repair methyltransferase as a molecular device for preventing mutation and cancer

Sekiguchi, M., Nakabeppu, Y., Kunihiko, S. & Tuzuki, T., Jan 1 1996, In : Journal of Cancer Research and Clinical Oncology. 122, 4, p. 199-206 8 p.

Research output: Contribution to journalReview article

Methyltransferases
DNA Repair
Equipment and Supplies
Mutation
DNA