Molecular and Biochemical Systems Engineering

Research Output 1980 2019

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2019

Analysis of sulfated glycosaminoglycans in ECM scaffolds for tissue engineering applications: Modified alcian blue method development and validation

Iimaa, T., Ikegami, Y., Bual, R., Shirakigawa, N. & Ijima, H., Jan 1 2019, In : Journal of Functional Biomaterials. 10, 2, 19.

Research output: Contribution to journalArticle

Open Access
A73025
Alcian Blue
Scaffolds (biology)
Tissue engineering
Heparin

A novel evaluation system for whole-organ-engineered liver graft by ex vivo application to a highly reproducible hepatic failure rat model

Sakamoto, H., Shirakigawa, N., Bual, R. P., Fukuda, Y., Nakamura, S., Miyata, T., Yamao, T., Yamashita, Y. I., Baba, H. & Ijima, H., Jan 1 2019, In : Journal of Artificial Organs.

Research output: Contribution to journalArticle

Liver Failure
Grafts
Liver
Rats
Transplants

Correlation of phase equilibria by new activity coefficient model

Iwai, Y., Seki, R. & Tanaka, Y., Jun 1 2019, In : Fluid Phase Equilibria. 488, p. 62-71 10 p.

Research output: Contribution to journalArticle

Activity coefficients
Phase equilibria
liquid-vapor equilibrium
Gibbs free energy
coefficients

Design of Synthetic Polymer Nanoparticles Specifically Capturing Indole, a Small Toxic Molecule

Okishima, A., Koide, H., Hoshino, Y., Egami, H., Hamashima, Y., Oku, N. & Asai, T., Apr 8 2019, In : Biomacromolecules. 20, 4, p. 1644-1654 11 p.

Research output: Contribution to journalArticle

Poisons
Polymers
Nanoparticles
Molecules
Biomolecules
Induced Pluripotent Stem Cells
Stem cells
Sorting
Cell culture
Cells

Fabricating Muscle-Neuron Constructs with Improved Contractile Force Generation

Arifuzzaman, M., Ito, A., Ikeda, K., Yoshinori, K. & Kamihira, M., Apr 1 2019, In : Tissue Engineering - Part A. 25, 7-8, p. 563-574 12 p.

Research output: Contribution to journalArticle

Neurons
Muscle
Skeletal Muscle
Skeletal Muscle Fibers
Tissue
Neuraminic Acids
G(M1) Ganglioside
Cholera Toxin
Galactose
Polymers
4 Citations (Scopus)

High-throughput label-free molecular fingerprinting flow cytometry

Hiramatsu, K., Ideguchi, T., Yonamine, Y., Lee, S. W., Luo, Y., Hashimoto, K., Ito, T., Hase, M., Park, J. W., Kasai, Y., Sakuma, S., Hayakawa, T., Arai, F., Hoshino, Y. & Goda, K., Jan 16 2019, In : Science Advances. 5, 1, eaau0241.

Research output: Contribution to journalArticle

Flow cytometry
Labels
Throughput
Vibrational spectra
Microfluidics
Hydrogel
Hydrogels
Liver
Extracellular Matrix
Hepatocytes

Magnetically triggered transgene expression in mammalian cells by localized cellular heating of magnetic nanoparticles

Ito, A., Teranishi, R., Kamei, K., Yamaguchi, M., Ono, A., Masumoto, S., Sonoda, Y., Horie, M., Yoshinori, K. & Kamihira, M., Jan 1 2019, In : Journal of Bioscience and Bioengineering.

Research output: Contribution to journalArticle

Transgenes
Nanoparticles
Heating
Cells
Magnetic fields

Neural differentiation of mouse induced pluripotent stem cells using cadherin gene-engineered PA6 feeder cells

Paerhati, P., Ito, A., Yoshioka, K., Iwamoto, K., Fujiwara, S., Horie, M., Yoshinori, K. & Kamihira, M., May 1 2019, In : Journal of Bioscience and Bioengineering. 127, 5, p. 633-640 8 p.

Research output: Contribution to journalArticle

Feeder Cells
Induced Pluripotent Stem Cells
Cadherins
Stem cells
Genes
Bearings (structural)
Biopolymers
Acrylamide
Lectins
Block copolymers

Sequestering and inhibiting a vascular endothelial growth factor in vivo by systemic administration of a synthetic polymer nanoparticle

Koide, H., Yoshimatsu, K., Hoshino, Y., Ariizumi, S., Okishima, A., Ide, T., Egami, H., Hamashima, Y., Nishimura, Y., Kanazawa, H., Miura, Y., Asai, T., Oku, N. & Shea, K. J., Feb 10 2019, In : Journal of Controlled Release. 295, p. 13-20 8 p.

Research output: Contribution to journalArticle

Nanoparticles
Vascular Endothelial Growth Factor A
Polymers
Proteins
Neoplasms
1 Citation (Scopus)

Size-Controlled Preparation of Microsized Perfluorocarbon Emulsions as Oxygen Carriers via the Shirasu Porous Glass Membrane Emulsification Technique

Fu, X., Ohta, S., Kamihira, M., Sakai, Y. & Ito, T., Mar 19 2019, In : Langmuir. 35, 11, p. 4094-4100 7 p.

Research output: Contribution to journalArticle

Fluorocarbons
Emulsification
Emulsions
emulsions
Oxygen
2018
2 Citations (Scopus)
Activity coefficients
liquid-vapor equilibrium
Ternary systems
ternary systems
Phase equilibria
1 Citation (Scopus)

Bacterial Inhibition and Osteoblast Adhesion on Ti Alloy Surfaces Modified by Poly(PEGMA- r-Phosmer) Coating

Cui, X., Murakami, T., Tamura, Y., Aoki, K., Hoshino, Y. & Miura, Y., Jul 18 2018, In : ACS Applied Materials and Interfaces. 10, 28, p. 23674-23681 8 p.

Research output: Contribution to journalArticle

Osteoblasts
Adhesion
Coatings
Bacteria
Brushes
Transcription factors
Liver
Hepatocellular Carcinoma
Transcription Factors
CCAAT-Enhancer-Binding Proteins

Cre-Mediated Transgene Integration in Chinese Hamster Ovary Cells Using Minicircle DNA Vectors

Wang, X., Yoshinori, K., Hada, T., Ito, A. & Kamihira, M., Jul 1 2018, In : Biotechnology Journal. 13, 7, 1800063.

Research output: Contribution to journalArticle

Cricetulus
Transgenes
Ovary
DNA
Plasmids
8 Citations (Scopus)

Decellularized Liver Matrix-Modified Cryogel Scaffolds as Potential Hepatocyte Carriers in Bioartificial Liver Support Systems and Implantable Liver Constructs

Damania, A., Kumar, A., Teotia, A. K., Kimura, H., Kamihira, M., Ijima, H., Sarin, S. K. & Kumar, A., Jan 10 2018, In : ACS Applied Materials and Interfaces. 10, 1, p. 114-126 13 p.

Research output: Contribution to journalArticle

Cryogels
Scaffolds (biology)
Liver
Bioreactors
Tissue engineering

Development of human-derived hemoglobin–albumin microspheres as oxygen carriers using Shirasu porous glass membrane emulsification

Ohta, S., Hashimoto, K., Fu, X., Kamihira, M., Sakai, Y. & Ito, T., Oct 1 2018, In : Journal of Bioscience and Bioengineering. 126, 4, p. 533-539 7 p.

Research output: Contribution to journalArticle

Emulsification
Human Development
Microspheres
Glass
Hemoglobin
1 Citation (Scopus)

Evaluation of hollow fiber culture for large-scale production of mouse embryonic stem cell-derived hematopoietic stem cells

Nakano, Y., Iwanaga, S., Mizumoto, H. & Kajiwara, T., Mar 3 2018, (Accepted/In press) In : Cytotechnology. p. 1-8 8 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
Cell culture
Organoids
Fibers

Excess heat evolution from nanocomposite samples under exposure to hydrogen isotope gases

Kitamura, A., Takahashi, A., Takahashi, K., Seto, R., Hatano, T., Iwamura, Y., Itoh, T., Kasagi, J., Nakamura, M., Uchimura, M., Takahashi, H., Sumitomo, S., Hioki, T., Motohiro, T., Furuyama, Y., Kishida, M. & Matsune, H., Aug 16 2018, In : International Journal of Hydrogen Energy. 43, 33, p. 16187-16200 14 p.

Research output: Contribution to journalArticle

hydrogen isotopes
Isotopes
Nanocomposites
nanocomposites
heat
1 Citation (Scopus)

Fabrication of liver-derived extracellular matrix nanofibers and functional evaluation in in vitro culture using primary hepatocytes

Bual, R., Kimura, H., Ikegami, Y., Shirakigawa, N. & Ijima, H., Dec 1 2018, In : Materialia. 4, p. 518-528 11 p.

Research output: Contribution to journalArticle

Nanofibers
Liver
Military electronic countermeasures
Scaffolds (biology)
Fabrication

Highly Active Low Cobalt Content-Based Bulk MoS2 Hydrodesulfurization Catalysts with a Unique Impact of H2S

Farag, H., Embaby, A. A., Kishida, M., El-Hendawy, A. N. A. & Nasef, M. M., Jan 1 2018, In : Journal of Chemistry. 2018, 8076534.

Research output: Contribution to journalArticle

Hydrodesulfurization
Cobalt
Catalysts
Desulfurization
Hydrogenation
4 Citations (Scopus)

Improvement in the durability of carbon black-supported Pt cathode catalysts by silica-coating for use in PEFCs

Takenaka, S., Goto, M., Masuda, Y., Emura, S. & Kishida, M., Apr 12 2018, In : International Journal of Hydrogen Energy. 43, 15, p. 7473-7482 10 p.

Research output: Contribution to journalArticle

Carbon black
durability
Durability
Cathodes
cathodes
29 Citations (Scopus)

Intelligent Image-Activated Cell Sorting

Nitta, N., Sugimura, T., Isozaki, A., Mikami, H., Hiraki, K., Sakuma, S., Iino, T., Arai, F., Endo, T., Fujiwaki, Y., Fukuzawa, H., Hase, M., Hayakawa, T., Hiramatsu, K., Hoshino, Y., Inaba, M., Ito, T., Karakawa, H., Kasai, Y., Koizumi, K. & 31 othersLee, S. W., Lei, C., Li, M., Maeno, T., Matsusaka, S., Murakami, D., Nakagawa, A., Oguchi, Y., Oikawa, M., Ota, T., Shiba, K., Shintaku, H., Shirasaki, Y., Suga, K., Suzuki, Y., Suzuki, N., Tanaka, Y., Tezuka, H., Toyokawa, C., Yalikun, Y., Yamada, M., Yamagishi, M., Yamano, T., Yasumoto, A., Yatomi, Y., Yazawa, M., Di Carlo, D., Hosokawa, Y., Uemura, S., Ozeki, Y. & Goda, K., Sep 20 2018, In : Cell. 175, 1, p. 266-276.e13

Research output: Contribution to journalArticle

Sorting
Cells
Technology
Artificial Intelligence
Flow cytometry
2 Citations (Scopus)

In vitro and ex vivo Functional Evaluation of a Hollow Fiber-type Bioartificial Liver Module Containing ES Cell-derived Hepatocyte-like Cells

Mizumoto, H., Amimoto, N., Miyazawa, T., Tani, H., Ikeda, K. & Kajiwara, T., 2018, In : Advanced Biomedical Engineering. 7, 0, p. 18-27 10 p.

Research output: Contribution to journalArticle

Artificial Liver
Hepatocytes
Acute Liver Failure
Liver
Liver Transplantation
1 Citation (Scopus)

Reversible p Ka Modulation of Carboxylic Acids in Temperature-Responsive Nanoparticles through Imprinted Electrostatic Interactions

Hoshino, Y., Jibiki, T., Nakamoto, M. & Miura, Y., Sep 19 2018, In : ACS Applied Materials and Interfaces. 10, 37, p. 31096-31105 10 p.

Research output: Contribution to journalArticle

Carboxylic Acids
Coulomb interactions
Carboxylic acids
Modulation
Nanoparticles
5 Citations (Scopus)

Self-Assembly of a Double Hydrophilic Block Glycopolymer and the Investigation of Its Mechanism

Oh, T., Nagao, M., Hoshino, Y. & Miura, Y., Jul 24 2018, In : Langmuir. 34, 29, p. 8591-8598 8 p.

Research output: Contribution to journalArticle

Self assembly
Polyethylene glycols
self assembly
Hydrogen bonds
Methacrylates
1 Citation (Scopus)

Size-tuned hydrogel network of palladium-confining polymer particles: a highly active and durable catalyst for Suzuki coupling reactions in water at ambient temperature

Matsumoto, H., Akiyoshi, T., Hoshino, Y., Seto, H. & Miura, Y., Dec 1 2018, In : Polymer Journal. 50, 12, p. 1179-1186 8 p.

Research output: Contribution to journalArticle

Hydrogel
Palladium
Hydrogels
Particles (particulate matter)
Polymers
6 Citations (Scopus)

Targeted knock-in of an scFv-Fc antibody gene into the hprt locus of Chinese hamster ovary cells using CRISPR/Cas9 and CRIS-PITCh systems

Yoshinori, K., Komatsu, S., Komatsu, S., Murakami, M., Ito, A., Sakuma, T., Nakamura, T., Yamamoto, T. & Kamihira, M., May 1 2018, In : Journal of Bioscience and Bioengineering. 125, 5, p. 599-605 7 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Single-Chain Antibodies
Chromosomes
Cricetulus
Antibodies
2017
6 Citations (Scopus)

Accumulative scFv-Fc antibody gene integration into the hprt chromosomal locus of Chinese hamster ovary cells

Wang, X., Yoshinori, K., Kato, R., Hada, T., Ito, A., Yamana, Y., Kondo, M. & Kamihira, M., Nov 1 2017, In : Journal of Bioscience and Bioengineering. 124, 5, p. 583-590 8 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Cricetulus
Antibodies
Ovary
Systems Integration
6 Citations (Scopus)

Alleviating liver failure conditions using an integrated hybrid cryogel based cellular bioreactor as a bioartificial liver support

Kumar, A., Damania, A., Hassan, M., Shirakigawa, N., Mizumoto, H., Kumar, A., Sarin, S. K., Ijima, H. & Kamihira, M., Jan 12 2017, In : Scientific reports. 7, 40323.

Research output: Contribution to journalArticle

Cryogels
Artificial Liver
Liver Failure
Bioreactors
Plasmapheresis
3 Citations (Scopus)

Anti-biofouling phosphorylated HEMA and PEGMA block copolymers show high affinity to hydroxyapatite

Cui, X., Murakami, T., Hoshino, Y. & Miura, Y., Dec 1 2017, In : Colloids and Surfaces B: Biointerfaces. 160, p. 289-296 8 p.

Research output: Contribution to journalArticle

Biofouling
Durapatite
block copolymers
Hydroxyapatite
Block copolymers
21 Citations (Scopus)

A polymer nanoparticle with engineered affinity for a vascular endothelial growth factor (VEGF 165 )

Koide, H., Yoshimatsu, K., Hoshino, Y., Lee, S. H., Okajima, A., Ariizumi, S., Narita, Y., Yonamine, Y., Weisman, A. C., Nishimura, Y., Oku, N., Miura, Y. & Shea, K. J., Jul 1 2017, In : Nature Chemistry. 9, 7, p. 715-722 8 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Polymers
Nanoparticles
Proteins
Vascular Endothelial Growth Factor Receptor-2
2 Citations (Scopus)
fuel cells
Fuel cells
Cathodes
cathodes
Electrolytes
4 Citations (Scopus)

Controlling the lectin recognition of glycopolymers: Via distance arrangement of sugar blocks

Jono, K., Nagao, M., Oh, T., Sonoda, S., Hoshino, Y. & Miura, Y., Jan 1 2017, In : Chemical Communications. 54, 1, p. 82-85 4 p.

Research output: Contribution to journalArticle

Methacrylates
Lectins
Sugars
Molecular recognition
Living polymerization
1 Citation (Scopus)
Alkanes
Paraffins
Methanol
Liquids
1 Citation (Scopus)

Design and preparation of thermo-responsive vinylamine-containing micro-gel particles for reversible absorption of carbon dioxide

Yue, M., Imai, K., Miura, Y. & Hoshino, Y., Aug 1 2017, In : Polymer Journal. 49, 8, p. 601-606 6 p.

Research output: Contribution to journalArticle

Carbon Dioxide
Particles (particulate matter)
Carbon dioxide
Gels
Amines
8 Citations (Scopus)

Design of Glycopolymers Carrying Sialyl Oligosaccharides for Controlling the Interaction with the Influenza Virus

Nagao, M., Fujiwara, Y., Matsubara, T., Hoshino, Y., Sato, T. & Miura, Y., Dec 11 2017, In : Biomacromolecules. 18, 12, p. 4385-4392 8 p.

Research output: Contribution to journalArticle

Oligosaccharides
Viruses
Polymers
Sugars
Hydrophilicity
2 Citations (Scopus)

Development of an in situ evaluation system for neural cells using extracellular matrix-modeled gel culture

Nagai, T., Ikegami, Y., Mizumachi, H., Shirakigawa, N. & Ijima, H., Oct 1 2017, In : Journal of Bioscience and Bioengineering. 124, 4, p. 430-438 9 p.

Research output: Contribution to journalArticle

Cell culture
Extracellular Matrix
Gels
Hydrogel
Collagen
6 Citations (Scopus)
Ascorbic acid
Muscle
Skeletal Muscle
Phosphates
Hot Temperature
3 Citations (Scopus)
Hydrogels
Amines
copolymers
Polyvinyls
Copolymers
1 Citation (Scopus)

Effects of processing parameters in the sonic assisted water extraction (SAWE) of 6-gingerol

Syed Jaapar, S. Z., Morad, N. A., Iwai, Y. & Nordin, M. F. M., Sep 1 2017, In : Ultrasonics Sonochemistry. 38, p. 62-74 13 p.

Research output: Contribution to journalArticle

Sonication
Water
Ginger
Processing
water
2 Citations (Scopus)

Enhanced Hepatic Functions of Genetically Modified Mouse Hepatoma Cells by Spheroid Culture for Drug Toxicity Screening

Sarkar, J., Kumari, J., Tonello, J. M., Kamihira, M. & Kumar, A., Oct 1 2017, In : Biotechnology Journal. 12, 10, 1700274.

Research output: Contribution to journalArticle

Preclinical Drug Evaluations
Drug-Related Side Effects and Adverse Reactions
Hepatocellular Carcinoma
Cell Culture Techniques
Doxycycline
2 Citations (Scopus)

Fabrication of a fiber-type hepatic tissue by bottom-up method using multilayer spheroids

Okudaira, T., Yabuta, R., Mizumoto, H. & Kajiwara, T., Jun 1 2017, In : Journal of Bioscience and Bioengineering. 123, 6, p. 739-747 9 p.

Research output: Contribution to journalArticle

Multilayers
Tissue
Fabrication
Fibers
Liver
4 Citations (Scopus)

Glycopolymer monoliths for affinity bioseparation of proteins in a continuous-flow system: glycomonoliths

Seto, H., Shibuya, M., Matsumoto, H., Hoshino, Y. & Miura, Y., Jan 1 2017, In : Journal of Materials Chemistry B. 5, 6, p. 1148-1154 7 p.

Research output: Contribution to journalArticle

Concanavalin A
Proteins
Adsorption
Polyacrylates
Permeation
2 Citations (Scopus)

Hypoxia-responsive transgene expression system using RTP801 promoter and synthetic transactivator fused with oxygen-dependent degradation domain

Ono, A., Ito, A., Sato, T., Yamaguchi, M., Suzuki, T., Yoshinori, K. & Kamihira, M., Jul 1 2017, In : Journal of Bioscience and Bioengineering. 124, 1, p. 115-124 10 p.

Research output: Contribution to journalArticle

Trans-Activators
Transgenes
Oxygen
Degradation
Genes
8 Citations (Scopus)
Cricetulus
Transgenes
Antibodies
Antibody Formation
Ovary
5 Citations (Scopus)

In vitro drug testing based on contractile activity of C2C12 cells in an epigenetic drug model

Ikeda, K., Ito, A., Imada, R., Sato, M., Yoshinori, K. & Kamihira, M., Mar 16 2017, In : Scientific reports. 7, 44570.

Research output: Contribution to journalArticle

Epigenomics
Skeletal Muscle
trichostatin A
Cell Culture Techniques
Follistatin