Research Output 1992 2019

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2019
1 Citation (Scopus)

2-Oxo-histidine-containing dipeptides are functional oxidation products

Ihara, H., Kakihana, Y., Yamakage, A., Kai, K., Shibata, T., Nishida, M., Yamada, K-I. & Uchida, K., Jan 1 2019, In : Journal of Biological Chemistry. 294, 4, p. 1279-1289 11 p.

Research output: Contribution to journalArticle

Carnosine
Dipeptides
Histidine
Oxidation
Antioxidants

A deletion in the Ctns gene causes renal tubular dysfunction and cystine accumulation in LEA/Tohm rats

Shimizu, Y., Yanobu-Takanashi, R., Nakano, K., Hamase, K., Shimizu, T. & Okamura, T., Feb 13 2019, In : Mammalian Genome. 30, 1-2, p. 23-33 11 p.

Research output: Contribution to journalArticle

Cystine
Kidney
Glucose
Cystinosis
Genes

D -Serine reflects kidney function and diseases

Hesaka, A., Sakai, S., Hamase, K., Ikeda, T., Matsui, R., Mita, M., Horio, M., Isaka, Y. & Kimura, T., Dec 1 2019, In : Scientific reports. 9, 1, 5104.

Research output: Contribution to journalArticle

Open Access
Kidney Diseases
Serine
Chronic Renal Insufficiency
Kidney
Amino Acids
2 Citations (Scopus)

In Vivo Imaging of the Intra-and Extracellular Redox Status in Rat Stomach with Indomethacin-Induced Gastric Ulcers Using Overhauser-Enhanced Magnetic Resonance Imaging

Yasukawa, K., Shigemi, R., Kanbe, T., Mutsumoto, Y., Oda, F., Ichikawa, K., Yamada, K-I., Tun, X. & Utsumi, H., Jan 1 2019, In : Antioxidants and Redox Signaling. 30, 9, p. 1147-1161 15 p.

Research output: Contribution to journalArticle

Stomach Ulcer
Indomethacin
Oxidation-Reduction
Rats
Stomach
1 Citation (Scopus)

Non-invasive mapping of glutathione levels in mouse brains by in vivo electron paramagnetic resonance (EPR) imaging: Applied to a kindling mouse model

Emoto, M. C., Sato-Akaba, H., Matsuoka, Y., Yamada, K-I. & Fujii, H. G., Jan 18 2019, In : Neuroscience Letters. 690, p. 6-10 5 p.

Research output: Contribution to journalArticle

Electron Spin Resonance Spectroscopy
Glutathione
Brain
Brain Mapping
Pentylenetetrazole
1 Citation (Scopus)

Optimized reaction pair of the Cyshis tag and Ni(II)-Nta probe for highly selective chemical labeling of membrane proteins

Zenmyo, N., Tokumaru, H., Uchinomiya, S., Fuchida, H., Tabata, S., Hamachi, I., Shigemoto, R. & Ojida, A., Jan 1 2019, In : Bulletin of the Chemical Society of Japan. 92, 5, p. 995-1000 6 p.

Research output: Contribution to journalArticle

Labeling
Membrane Proteins
Proteins
Cells
Molecular Probes

Radiation-induced redox alteration in the mouse brain

Nakamura, M., Yamasaki, T., Ueno, M., Shibata, S., Ozawa, Y., Kamada, T., Nakanishi, I., Yamada, K-I., Aoki, I. & Matsumoto, K. I., Nov 1 2019, In : Free Radical Biology and Medicine. 143, p. 412-421 10 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Brain
Carbon
Ion beams
Irradiation
7 Citations (Scopus)

Selective and reversible modification of kinase cysteines with chlorofluoroacetamides

Shindo, N., Fuchida, H., Sato, M., Watari, K., Shibata, T., Kuwata, K., Miura, C., Okamoto, K., Hatsuyama, Y., Tokunaga, K., Sakamoto, S., Morimoto, S., Abe, Y., Shiroishi, M., Caaveiro, J. M. M., Ueda, T., Tamura, T., Matsunaga, N., Nakao, T., Koyanagi, S. & 5 others, Ohdo, S., Yamaguchi, Y., Hamachi, I., Ono, M. & Ojida, A., Jan 14 2019, In : Nature Chemical Biology.

Research output: Contribution to journalArticle

Quinazolines
Epidermal Growth Factor Receptor
Cysteine
Phosphotransferases
Hydrolysis
Acridines
Chemiluminescence
Choline
Hydrogen peroxide
Hydrogen Peroxide

Three-Dimensional High-Performance Liquid Chromatographic Determination of Asn, Ser, Ala, and Pro Enantiomers in the Plasma of Patients with Chronic Kidney Disease

Furusho, A., Koga, R., Akita, T., Mita, M., Kimura, T. & Hamase, K., Sep 17 2019, In : Analytical chemistry. 91, 18, p. 11569-11575 7 p.

Research output: Contribution to journalArticle

Enantiomers
High performance liquid chromatography
Plasmas
Amino Acids
Liquids
2018
1 Citation (Scopus)

Antioxidant nitroxides protect hepatic cells from oxidative stress-induced cell death

Shinto, S., Matsuoka, Y., Yamato, M. & Yamada, K-I., Mar 1 2018, In : Journal of Clinical Biochemistry and Nutrition. 62, 2, p. 132-138 7 p.

Research output: Contribution to journalArticle

Oxidative stress
Cell death
Hepatocytes
Oxidative Stress
Cell Death
5 Citations (Scopus)
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Connexins
varespladib methyl
Astrocytes
Parkinson Disease

Detection and inhibition of redox reaction and lipid derived radicals

Yamada, K-I., Jan 1 2018, In : Drug Delivery System. 33, 3, p. 197-203 7 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Lipids
Free Radicals
Animal Models
Carcinogenesis
6 Citations (Scopus)
Amino Acids
Fluids
Liquids
High Pressure Liquid Chromatography
L Forms
2 Citations (Scopus)
Plasma (human)
3-Hydroxybutyric Acid
High performance liquid chromatography
Lactic Acid
Enantiomers
2 Citations (Scopus)

Endogenous Membrane Receptor Labeling by Reactive Cytokines and Growth Factors to Chase Their Dynamics in Live Cells

Takaoka, Y., Uchinomiya, S., Kobayashi, D., Endo, M., Hayashi, T., Fukuyama, Y., Hayasaka, H., Miyasaka, M., Ueda, T., Shimada, I. & Hamachi, I., Jun 14 2018, In : Chem. 4, 6, p. 1451-1464 14 p.

Research output: Contribution to journalArticle

Labeling
Intercellular Signaling Peptides and Proteins
Cytokines
membrane
Membranes
1 Citation (Scopus)

Enhancement effect on the chemiluminescence of acridinium esters under neutral conditions

Nakazono, M. & Nanbu, S., Mar 1 2018, In : Luminescence. 33, 2, p. 345-348 4 p.

Research output: Contribution to journalArticle

Chemiluminescence
Luminescence
Esters
Acridines
Derivatives

Fluorescence tumor-imaging using a thermo-responsive molecule with an emissive aminoquinoline derivative

Araki, T., Fuchi, Y., Murayama, S., Shiraishi, R., Oyama, T., Aso, M., Aoki, I., Kobayashi, S., Yamada, K-I. & Karasawa, S., Oct 2 2018, In : Nanomaterials. 8, 10, 782.

Research output: Contribution to journalArticle

Aminoquinolines
Tumors
Fluorescence
Derivatives
Imaging techniques
3 Citations (Scopus)

Genotoxic Responses of Mitochondrial Oxygen Consumption Rate and Mitochondrial Semiquinone Radicals in Tumor Cells

Yamamoto, K., Yasui, H., Bo, T., Yamamori, T., Hiraoka, W., Yamasaki, T., Yamada, K-I. & Inanami, O., Aug 1 2018, In : Applied Magnetic Resonance. 49, 8, p. 837-851 15 p.

Research output: Contribution to journalArticle

oxygen consumption
electron paramagnetic resonance
respiration
tumors
mitochondria
1 Citation (Scopus)

Gut microbiota-derived D-serine protects against acute kidney injury

Nakade, Y., Iwata, Y., Furuichi, K., Mita, M., Hamase, K., Konno, R., Miyake, T., Sakai, N., Kitajima, S., Toyama, T., Shinozaki, Y., Sagara, A., Miyagawa, T., Hara, A., Shimizu, M., Kamikawa, Y., Sato, K., Oshima, M., Yoneda-Nakagawa, S., Yamamura, Y. & 8 others, Kaneko, S., Miyamoto, T., Katane, M., Homma, H., Morita, H., Suda, W., Hattori, M. & Wada, T., Oct 18 2018, In : JCI insight. 3, 20

Research output: Contribution to journalArticle

Open Access
Acute Kidney Injury
Serine
Kidney
Amino Acids
Dysbiosis
9 Citations (Scopus)

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence

Nishimura, A., Shimauchi, T., Tanaka, T., Shimoda, K., Toyama, T., Kitajima, N., Ishikawa, T., Shindo, N., Numaga-Tomita, T., Yasuda, S., Sato, Y., Kuwahara, K., Kumagai, Y., Akaike, T., Ide, T., Ojida, A., Mori, Y. & Nishida, M., Nov 13 2018, In : Science Signaling. 11, 556, eaat5185.

Research output: Contribution to journalArticle

Filamins
Dynamins
Actins
Mitochondrial Dynamics
Proteins

Imaging Doxorubicin Free Radical in Mice with Overhauser Enhanced MRI and its Tumor Suppression Effect in Mice

Kato, N., Sato, S., Yamada, K-I. & Ichikawa, K., Aug 1 2018, In : Applied Magnetic Resonance. 49, 8, p. 869-879 11 p.

Research output: Contribution to journalArticle

free radicals
mice
tumors
retarding
magnetic resonance
2 Citations (Scopus)

Internal-Edge-Substituted Coumarin-Fused [6]Helicenes: Asymmetric Synthesis, Structural Features, and Control of Self-Assembly

Usui, K., Yamamoto, K., Ueno, Y., Igawa, K., Hagihara, R., Masuda, T., Ojida, A., Karasawa, S., Tomooka, K., Hirai, G. & Suemune, H., Oct 1 2018, In : Chemistry - A European Journal. 24, 55, p. 14617-14621 5 p.

Research output: Contribution to journalArticle

Self assembly
X ray crystallography
Quantum yield
Electronic structure
Physical properties
1 Citation (Scopus)

Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury

Homma, T., Shirato, T., Akihara, R., Kobayashi, S., Lee, J., Yamada, K-I., Miyata, S., Takahashi, M. & Fujii, J., Sep 15 2018, In : Toxicology Letters. 294, p. 37-43 7 p.

Research output: Contribution to journalArticle

Thioacetamide
Liver
Wounds and Injuries
Metabolites
Cytochrome P-450 CYP2E1
Protein Phosphatase 2
Dextran Sulfate
Toll-Like Receptor 4
Protein Tyrosine Phosphatases
Colitis

Structural and enzymatic properties of mammalian D-glutamate cyclase

Katane, M., Ariyoshi, M., Tateishi, S., Koiwai, S., Takaku, K., Nagai, K., Nakayama, K., Saitoh, Y., Miyamoto, T., Sekine, M., Mita, M., Hamase, K., Matoba, S. & Homma, H., Sep 15 2018, In : Archives of Biochemistry and Biophysics. 654, p. 10-18 9 p.

Research output: Contribution to journalArticle

Proline
Glutamic Acid
Heart Failure
D-glutamate cyclase
Oligomerization
1 Citation (Scopus)

The first multicenter, randomized, controlled trial of home telemonitoring for Japanese patients with heart failure: home telemonitoring study for patients with heart failure (HOMES-HF)

On Behalf Of The Homes-Hf Study Investigators, Aug 1 2018, In : Heart and Vessels. 33, 8, p. 866-876 11 p.

Research output: Contribution to journalArticle

Randomized Controlled Trials
Heart Failure
Home Care Services
Physiologic Monitoring
Registries
2017
3 Citations (Scopus)

A host-guest system based on collagen-like triple-helix hybridization

Delsuc, N., Uchinomiya, S., Ojida, A. & Hamachi, I., Jan 1 2017, In : Chemical Communications. 53, 51, p. 6856-6859 4 p.

Research output: Contribution to journalArticle

Collagen
Proteins
3 Citations (Scopus)

Detection and inhibition of lipid-derived radicals in low-density lipoprotein

Ishida, Y., Okamoto, Y., Matsuoka, Y., Tada, A., Janprasit, J., Yamato, M., Morales, N. P. & Yamada, K-I., Dec 1 2017, In : Free Radical Biology and Medicine. 113, p. 487-493 7 p.

Research output: Contribution to journalArticle

LDL Lipoproteins
Lipids
Iron
Deferoxamine
Oxidative stress
19 Citations (Scopus)

D -Glutamate is metabolized in the heart mitochondria

Ariyoshi, M., Katane, M., Hamase, K., Miyoshi, Y., Nakane, M., Hoshino, A., Okawa, Y., Mita, Y., Kaimoto, S., Uchihashi, M., Fukai, K., Ono, K., Tateishi, S., Hato, D., Yamanaka, R., Honda, S., Fushimura, Y., Iwai-Kanai, E., Ishihara, N., Mita, M. & 2 others, Homma, H. & Matoba, S., Mar 7 2017, In : Scientific reports. 7, 43911.

Research output: Contribution to journalArticle

Heart Mitochondria
Glutamic Acid
glutamate racemase
Amino Acids
Proline
1 Citation (Scopus)

Discovery of highly reactive peptide tag by ELISA-type screening for specific cysteine conjugation

Kurashige, N., Fuchida, H., Tabata, S., Uchinomiya, S. & Ojida, A., Apr 18 2017, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

Cysteine
Screening
Enzyme-Linked Immunosorbent Assay
Peptides
Labeling
1 Citation (Scopus)

Feasibility of magnetic resonance redox imaging at low magnetic field: Comparison at 1 T and 7 T

Nakamura, M., Shibata, S., Yamasaki, T., Ueno, M., Nakanishi, I., Matsumoto, K. I., Kamada, T., Yamada, K-I. & Aoki, I., Jan 1 2017, In : American Journal of Translational Research. 9, 10, p. 4481-4491 11 p., AJTR0054131.

Research output: Contribution to journalArticle

Magnetic resonance
Magnetic Fields
Oxidation-Reduction
Magnetic Resonance Imaging
Magnetic fields

Heightened aggressive behavior in mice deficient in aldo-keto reductase 1a (Akr1a)

Homma, T., Akihara, R., Okano, S., Shichiri, M., Yoshida, Y., Yamada, K-I., Miyata, S., Nakajima, O. & Fujii, J., Feb 15 2017, In : Behavioural Brain Research. 319, p. 219-224 6 p.

Research output: Contribution to journalArticle

Ascorbic Acid
Aggression
Aldehyde Reductase
carbonyl reductase (NADPH)
Social Behavior
11 Citations (Scopus)

Heterogeneity of D-serine distribution in the human central nervous system

Suzuki, M., Imanishi, N., Mita, M., Hamase, K., Aiso, S. & Sasabe, J., May 1 2017, In : ASN Neuro. 9, 3

Research output: Contribution to journalArticle

Serine
Central Nervous System
Cerebrum
4 alpha-glucanotransferase
Neurophysiology

Lipid radicals cause light-induced retinal degeneration

Enoki, M., Shinto, S., Matsuoka, Y., Otsuka, A., Kaidzu, S., Tanito, M., Shibata, T., Uchida, K., Ohira, A., Yamato, M. & Yamada, K-I., Sep 20 2017, In : Chemical Communications.

Research output: Contribution to journalArticle

Lipids
Animals
Imaging techniques
Molecules
4 Citations (Scopus)

Lipid radicals cause light-induced retinal degeneration

Enoki, M., Shinto, S., Matsuoka, Y., Otsuka, A., Kaidzu, S., Tanito, M., Shibata, T., Uchida, K., Ohira, A., Yamato, M. & Yamada, K-I., Jan 1 2017, In : Chemical Communications. 53, 79, p. 10922-10925 4 p.

Research output: Contribution to journalArticle

Lipids
Animals
Imaging techniques
Molecules
6 Citations (Scopus)

Lipophilic triphenylphosphonium derivatives enhance radiation-induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells

Yasui, H., Yamamoto, K., Suzuki, M., Sakai, Y., Bo, T., Nagane, M., Nishimura, E., Yamamori, T., Inanami, O., Yamada, K-I. & Yamasaki, T., Apr 1 2017, In : Cancer Letters. 390, p. 160-167 8 p.

Research output: Contribution to journalArticle

Energy Metabolism
Radiation
Neoplasms
Adenosine Triphosphate
Cations
8 Citations (Scopus)
Electron Spin Resonance Spectroscopy
Oxidation-Reduction
Glutathione
Paramagnetic resonance
Brain
36 Citations (Scopus)

Reversible ratiometric detection of highly reactive hydropersulfides using a FRET-based dual emission fluorescent probe

Kawagoe, R., Takashima, I., Uchinomiya, S. & Ojida, A., Jan 1 2017, In : Chemical Science. 8, 2, p. 1134-1140 7 p.

Research output: Contribution to journalArticle

Fluorescent Dyes
Pyronine
Cells
Cell signaling
Mammals
6 Citations (Scopus)

Strongly Chemiluminescent Acridinium Esters under Neutral Conditions: Synthesis, Properties, Determination, and Theoretical Study

Nakazono, M., Oshikawa, Y., Nakamura, M., Kubota, H. & Nanbu, S., Mar 3 2017, In : Journal of Organic Chemistry. 82, 5, p. 2450-2461 12 p.

Research output: Contribution to journalArticle

Acridines
Chemiluminescence
Esters
Salts
Hydrogen Peroxide
2016
6 Citations (Scopus)

Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress

Akihara, R., Homma, T., Lee, J., Yamada, K-I., Miyata, S. & Fujii, J., Sep 16 2016, In : Biochemical and Biophysical Research Communications. 478, 2, p. 765-771 7 p.

Research output: Contribution to journalArticle

Aldehyde Reductase
Endoplasmic Reticulum Stress
Oxidative stress
Carbon Tetrachloride
Ablation
20 Citations (Scopus)

A novel DPP-4 inhibitor teneligliptin scavenges hydroxyl radicals: In vitro study evaluated by electron spin resonance spectroscopy and in vivo study using DPP-4 deficient rats

Kimura, S., Inoguchi, T., Yamasaki, T., Yamato, M., Ide, M., Sonoda, N., Yamada, K-I. & Takayanagi, R., Mar 1 2016, In : Metabolism: Clinical and Experimental. 65, 3, p. 138-145 8 p.

Research output: Contribution to journalArticle

Dipeptidyl-Peptidase IV Inhibitors
Electron Spin Resonance Spectroscopy
Hydroxyl Radical
Dipeptidyl Peptidase 4
Experimental Diabetes Mellitus
5 Citations (Scopus)

A profluorescent nitroxide probe for ascorbic acid detection and its application to quantitative analysis of diabetic rat plasma

Matsuoka, Y., Ohkubo, K., Yamasaki, T., Yamato, M., Ohtabu, H., Shirouzu, T., Fukuzumi, S. & Yamada, K-I., Jan 1 2016, In : RSC Advances. 6, 65, p. 60907-60915 9 p.

Research output: Contribution to journalArticle

Ascorbic acid
Ascorbic Acid
Rats
Plasmas
Chemical analysis
14 Citations (Scopus)

Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy

Kurahashi, T., Lee, J., Nabeshima, A., Homma, T., Kang, E. S., Saito, Y., Yamada, S., Nakayama, T., Yamada, K-I., Miyata, S. & Fujii, J., Aug 15 2016, In : Archives of Biochemistry and Biophysics. 604, p. 36-46 11 p.

Research output: Contribution to journalArticle

Autophagy
Acetaminophen
Ascorbic Acid
Glutathione
Recovery
3 Citations (Scopus)

Brain contrasting ability of blood-brain-barrier–permeable nitroxyl contrast agents for magnetic resonance redox imaging

Matsumoto, K. I., Yamasaki, T., Nakamura, M., Ishikawa, J., Ueno, M., Nakanishi, I., Sekita, A., Ozawa, Y., Kamada, T., Aoki, I. & Yamada, K-I., Sep 1 2016, In : Magnetic Resonance in Medicine. 76, 3, p. 935-945 11 p.

Research output: Contribution to journalArticle

Contrast Media
Oxidation-Reduction
Magnetic Resonance Imaging
Brain
Pharmacokinetics
8 Citations (Scopus)

Cell Surface-Anchored Fluorescent Probe Capable of Real-Time Imaging of Single Mast Cell Degranulation Based on Histamine-Induced Coordination Displacement

Oshikawa, Y., Furuta, K., Tanaka, S. & Ojida, A., Feb 2 2016, In : Analytical chemistry. 88, 3, p. 1526-1529 4 p.

Research output: Contribution to journalArticle

Fluorescent Dyes
Histamine
Imaging techniques
Fluorescence
Coloring Agents
43 Citations (Scopus)

Chiral amino acid metabolomics for novel biomarker screening in the prognosis of chronic kidney disease

Kimura, T., Hamase, K., Miyoshi, Y., Yamamoto, R., Yasuda, K., Mita, M., Rakugi, H., Hayashi, T. & Isaka, Y., May 18 2016, In : Scientific reports. 6, 26137.

Research output: Contribution to journalArticle

Metabolomics
Chronic Renal Insufficiency
Biomarkers
Amino Acids
Kidney Diseases
9 Citations (Scopus)

Development of pH-Responsive BODIPY Probes for Staining Late Endosome in Live Cells

Miao, F., Uchinomiya, S., Ni, Y., Chang, Y. T. & Wu, J., Nov 1 2016, In : ChemPlusChem. 81, 11, p. 1209-1215 7 p.

Research output: Contribution to journalArticle

Coloring Agents
Fluorescent Dyes
Fusion reactions
Cells
Infrared radiation
13 Citations (Scopus)

Enantioselective determination of citrulline and ornithine in the urine of D-amino acid oxidase deficient mice using a two-dimensional high-performance liquid chromatographic system

Koga, R., Miyoshi, Y., Sato, Y., Mita, M., Konno, R., Lindner, W. & Hamase, K., Oct 7 2016, In : Journal of Chromatography A. 1467, p. 312-317 6 p.

Research output: Contribution to journalArticle

D-Amino-Acid Oxidase
Citrulline
Ornithine
Enantiomers
Urine
4 Citations (Scopus)

Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease

Naoya, M., Ikeda, E., Kakimoto, K., Watanabe, M., Shindo, N., Tsuruta, A., Ikeyama, H., Hamamura, K., Higashi, K., Yamashita, T., Kondo, H., Yoshida, Y., Matsuda, M., Ogino, T., Tokushige, K., Itcho, K., Furuichi, Y., Nakao, T., Yasuda, K., Doi, A. & 7 others, Amamoto, T., Aramaki, H., Makoto, T., Inoue, K., Ojida, A., Satoru, K. & Ohdo, S., Nov 1 2016, In : EBioMedicine. 13, p. 262-273 12 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Switches
Inflammation
Kidney
Gene encoding