Research Output 1977 2019

2019
1 Citation (Scopus)

Acetylsalicylic Acid Treatment and Suppressive Regulation of AKT Accelerate Odontogenic Differentiation of Stem Cells from the Apical Papilla

Tanaka, Y., Sonoda, S., Yamaza, H., Murata, S., Nishida, K., Kyumoto, Y., Uehara, N., Nonaka, K., Kukita, T. & Yamaza, T., May 1 2019, In : Journal of Endodontics. 45, 5, p. 591-598.e6

Research output: Contribution to journalArticle

Aspirin
Stem Cells
Tooth Root
NFI Transcription Factors
Small Interfering RNA

An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain

Ni, J., Wu, Z., Meng, J., Saito, T., Saido, T. C., Qing, H. & Nakanishi, H., Aug 30 2019, In : Journal of neuroinflammation. 16, 1, 173.

Research output: Contribution to journalArticle

Open Access
Amyloid beta-Protein Precursor
Microglia
Brain
Alzheimer Disease
Genes

Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis

Touyama, K., Khan, M., Aoki, K., Matsuda, M., Hiura, F., Takakura, N., Matsubara, T., Harada, Y., Hirohashi, Y., Tamura, Y., Gao, J., Mori, K., Kokabu, S., Yasuda, H., Fujita, Y., Watanabe, K., Takahashi, Y., Maki, K. & Jimi, E., Nov 1 2019, In : Journal of Cellular Biochemistry. 120, 11, p. 18793-18804 12 p.

Research output: Contribution to journalArticle

Bone
Homeostasis
Bone and Bones
Osteoclasts
Osteogenesis
1 Citation (Scopus)

Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis

Harada, Y., Zhang, J., Imari, K., Yamasaki, R., Ni, J., Take, H., Yamamoto, K., Kira, J-I., Nakanishi, H. & Hayashi, Y., Sep 1 2019, In : Pain. 160, 9, p. 2050-2062 13 p.

Research output: Contribution to journalArticle

Cathepsin E
Autoimmune Experimental Encephalomyelitis
Neuralgia
Neutrophils
Hyperalgesia

Ccr7 null mice are protected against diet-induced obesity via Ucp1 upregulation and enhanced energy expenditure

Sano, T., Sanada, T., Sotomaru, Y., Shinjo, T., Iwashita, M., Yamashita, A., Fukuda, T., Sanui, T., Asano, T., Kanematsu, T. & Nishimura, F., Jul 4 2019, In : Nutrition and Metabolism. 16, 1, 43.

Research output: Contribution to journalArticle

Open Access
Energy Metabolism
Up-Regulation
Obesity
Diet
White Adipose Tissue

Challenges in the clinical implementation of a biopsychosocial model for assessment and management of orofacial pain

Sharma, S., Breckons, M., Brönnimann Lambelet, B., Chung, J. W., List, T., Lobbezoo, F., Nixdorf, D. R., Oyarzo, J. F., Peck, C., Tsukiyama, Y. & Ohrbach, R., Jan 1 2019, (Accepted/In press) In : Journal of oral rehabilitation.

Research output: Contribution to journalReview article

Facial Pain
Temporomandibular Joint Disorders
Pain
Research Personnel
Health Literacy
1 Citation (Scopus)

Constitutive activation of the alternative NF-κB pathway disturbs endochondral ossification

Nakatomi, C., Nakatomi, M., Matsubara, T., Komori, T., Doi-Inoue, T., Ishimaru, N., Weih, F., Iwamoto, T., Matsuda, M., Kokabu, S. & Jimi, E., Apr 1 2019, In : Bone. 121, p. 29-41 13 p.

Research output: Contribution to journalArticle

Chondrocytes
Osteogenesis
Collagen Type X
Ankyrin Repeat
Matrix Metalloproteinase 13
1 Citation (Scopus)

Deficiency of stress-associated gene Nupr1 increases bone volume by attenuating differentiation of osteoclasts and enhancing differentiation of osteoblasts

Shiraki, M., Xu, X., Iovanna, J. L., Kukita, T., Hirata, H., Kamohara, A., Kubota, Y., Miyamoto, H., Mawatari, M. & Kukita, A., Aug 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 8, p. 8836-8852 17 p.

Research output: Contribution to journalArticle

Osteoblasts
Osteoclasts
Bone
Genes
Bone and Bones

Effects of insulin signaling on mouse taste cell proliferation

Takai, S., Watanabe, Y., Sanematsu, K., Yoshida, R., Margolskee, R. F., Jiang, P., Atsuta, I., Koyano, K., Ninomiya, Y. & Shigemura, N., Jan 1 2019, In : PloS one. 14, 11, e0225190.

Research output: Contribution to journalArticle

Open Access
Cell proliferation
Sirolimus
cell proliferation
insulin
Cell Proliferation

Effects of zinc gluconate carbon dots in cell imaging and inducing osteoblastic differentiation in vitro

Meng, Y., Yang, M., Wang, L., Liu, D., Yu, W., Wang, W. & Take, H., May 1 2019, In : Journal of Jilin University Medicine Edition. 45, 3, p. 504-510 7 p.

Research output: Contribution to journalArticle

Carbon
Fluorescence
Control Groups
Optical Imaging
Osteocalcin

Expression of Renin-Angiotensin System Components in the Taste Organ of Mice

Shigemura, N., Takai, S., Hirose, F., Yoshida, R., Sanematsu, K. & Ninomiya, Y., Sep 19 2019, In : Nutrients. 11, 9

Research output: Contribution to journalArticle

Open Access
renin-angiotensin system
Renin-Angiotensin System
angiotensin II
mice
Angiotensin II
1 Citation (Scopus)

Fatty acid taste quality information via GPR120 in the anterior tongue of mice

Yasumatsu, K., Iwata, S., Inoue, M. & Ninomiya, Y., May 1 2019, In : Acta Physiologica. 226, 1, e13215.

Research output: Contribution to journalArticle

Tongue
Fatty Acids
Linoleic Acid
Knockout Mice
Chorda Tympani Nerve
3 Citations (Scopus)

Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice

Ni, J., Wu, Z., Stoka, V., Meng, J., Hayashi, Y., Peters, C., Qing, H., Turk, V. & Nakanishi, H., Feb 1 2019, In : Aging cell. 18, 1, e12856.

Research output: Contribution to journalArticle

Cathepsin B
Microglia
Oxidative Stress
Reactive Oxygen Species
Mitochondria

Induction of bone repair in rat calvarial defects using a combination of hydroxyapatite with phosphatidylserine liposomes

Hatakeyama, J., Anan, H., Hatakeyama, Y., Matsumoto, N., Takayama, F., Wu, Z., Matsuzaki, E., Minakami, M., Izumi, T. & Nakanishi, H., Jan 1 2019, In : Journal of Oral Science. 61, 1, p. 111-118 8 p.

Research output: Contribution to journalArticle

Open Access
Phosphatidylserines
Durapatite
Liposomes
Bone and Bones
Bone Regeneration

Osteoblast lineage-specific cell-surface antigen (A7) regulates osteoclast recruitment and calcification during bone remodeling

Badawy, T., Kyumoto, Y., Uehara, N., Zhang, J., Sonoda, S., Hiura, H., Yamaza, T., Kukita, A. & Kukita, T., Jun 1 2019, In : Laboratory Investigation. 99, 6, p. 866-884 19 p.

Research output: Contribution to journalArticle

Bone Remodeling
Osteoclasts
Surface Antigens
Osteoblasts
Antigens

Phospholipase C-related catalytically inactive protein: A novel signaling molecule for modulating fat metabolism and energy expenditure

Kanematsu, T., Oue, K., Okumura, T., Harada, K., Yamawaki, Y., Asano, S., Mizokami, A., Irifune, M. & Hirata, M., Jun 1 2019, In : journal of oral biosciences. 61, 2, p. 65-72 8 p.

Research output: Contribution to journalReview article

Staphylococcal Protein A
Type C Phospholipases
Metabolism
Energy Metabolism
Fats

Phospholipase C-related catalytically inactive protein regulates cytokinesis by protecting phosphatidylinositol 4,5-bisphosphate from metabolism in the cleavage furrow

Asano, S., Ikura, Y., Nishimoto, M., Yamawaki, Y., Hamao, K., Kamijo, K., Hirata, M. & Kanematsu, T., Dec 1 2019, In : Scientific reports. 9, 1, 12729.

Research output: Contribution to journalArticle

Open Access
Cytokinesis
Type C Phospholipases
Phosphatidylinositols
Proteins
Oculocerebrorenal Syndrome

Phospholipase C-related catalytically inactive protein regulates lipopolysaccharide-induced hypothalamic inflammation-mediated anorexia in mice

Yamawaki, Y., Shirawachi, S., Mizokami, A., Nozaki, K., Ito, H., Asano, S., Oue, K., Aizawa, H., Yamawaki, S., Hirata, M. & Kanematsu, T., Dec 2019, In : Neurochemistry International. 131, 104563.

Research output: Contribution to journalArticle

Open Access
Anorexia
Type C Phospholipases
Lipopolysaccharides
NF-kappa B
Inflammation

Phospholipase C-related inactive protein type-1 deficiency affects anesthetic electroencephalogram activity induced by propofol and etomidate in mice

Furukawa, T., Nikaido, Y., Shimoyama, S., Ogata, Y., Kushikata, T., Hirota, K., Kanematsu, T., Hirata, M. & Ueno, S., Aug 20 2019, In : Journal of Anesthesia. 33, 4, p. 531-542 12 p.

Research output: Contribution to journalArticle

Etomidate
Protein Deficiency
Type C Phospholipases
Propofol
Anesthetics
8 Citations (Scopus)

Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion

Matsuda, T., Irie, T., Katsurabayashi, S., Hayashi, Y., Nagai, T., Hamazaki, N., Adefuin, A. M. D., Miura, F., Ito, T., Kimura, H., Shirahige, K., Takeda, T., Iwasaki, K., Imamura, T. & Nakashima, K., Feb 6 2019, In : Neuron. 101, 3, p. 472-485.e7

Research output: Contribution to journalArticle

Microglia
Epigenomics
Neurons
Transcription Factors
Genes
1 Citation (Scopus)

Prolyl Isomerase Pin1 Suppresses Thermogenic Programs in Adipocytes by Promoting Degradation of Transcriptional Co-activator PRDM16

Nakatsu, Y., Matsunaga, Y., Yamamotoya, T., Ueda, K., Inoue, M. K., Mizuno, Y., Nakanishi, M., Sano, T., Yamawaki, Y., Kushiyama, A., Sakoda, H., Fujishiro, M., Ryo, A., Ono, H., Minamino, T., Takahashi, S. I., Ohno, H., Yoneda, M., Takahashi, K., Ishihara, H. & 5 others, Katagiri, H., Nishimura, F., Kanematsu, T., Yamada, T. & Asano, T., Mar 19 2019, In : Cell Reports. 26, 12, p. 3221-3230.e3

Research output: Contribution to journalArticle

Open Access
Peptidylprolyl Isomerase
Nutrition
Adipocytes
Thermogenesis
Obesity
1 Citation (Scopus)

Regenerative medicine using stem cells from human exfoliated deciduous teeth (SHED): a promising new treatment in pediatric surgery

Taguchi, T., Yanagi, Y., Yoshimaru, K., Zhang, X. Y., Matsuura, T., Nakayama, K., Kobayashi, E., Yamaza, H., Nonaka, K., Ohga, S. & Yamaza, T., Apr 10 2019, In : Surgery today. 49, 4, p. 316-322 7 p.

Research output: Contribution to journalReview article

Biliary Atresia
Diaphragmatic Hernia
Regenerative Medicine
Deciduous Tooth
Three-Dimensional Imaging
1 Citation (Scopus)

Structural architecture of a dimeric class C GPCR based on co-trafficking of sweet taste receptor subunits

Park, J., Selvam, B., Sanematsu, K., Shigemura, N., Shukla, D. & Procko, E., Jan 1 2019, In : Journal of Biological Chemistry. 294, 13, p. 4759-4774 16 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Dimerization
Dimers
Cysteine
Cells
1 Citation (Scopus)
Open Access
Hepatolenticular Degeneration
Deciduous Tooth
Inbred LEC Rats
Hepatocytes
Stem Cells
Deciduous Tooth
Hemophilia A
Liver Cirrhosis
Stem Cells
Hepatocytes
2018
1 Citation (Scopus)

A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain

Fujii, T., Yamasaki, R., Iinuma, K., Tsuchimoto, D., Hayashi, Y., Saitoh, B. Y., Matsushita, T., Kido, M. A., Aishima, S., Nakanishi, H., Nakabeppu, Y. & Kira, J. I., Aug 2018, In : Annals of Neurology. 84, 2, p. 208-224 17 p.

Research output: Contribution to journalArticle

Neuralgia
Autoantibodies
Spinal Ganglia
Neurons
Unmyelinated Nerve Fibers
6 Citations (Scopus)

A peptide that blocks the interaction of NF-κB p65 subunit with Smad4 enhances BMP2-induced osteogenesis

Urata, M., Kokabu, S., Matsubara, T., Sugiyama, G., Nakatomi, C., Takeuchi, H., Hirata-Tsuchiya, S., Aoki, K., Tamura, Y., Moriyama, Y., Ayukawa, Y., Matsuda, M., Zhang, M., Koyano, K., Kitamura, C. & Jimi, E., Sep 1 2018, In : Journal of cellular physiology. 233, 9, p. 7356-7366 11 p.

Research output: Contribution to journalArticle

Osteogenesis
Bone Morphogenetic Proteins
Bone
Peptides
Osteoblasts
2 Citations (Scopus)

Bilirubin reversibly affects cell death and odontogenic capacity in stem cells from human exfoliated deciduous teeth

Yamaza, H., Tomoda, E., Sonoda, S., Nonaka, K., Kukita, T. & Yamaza, T., Jul 1 2018, In : Oral Diseases. 24, 5, p. 809-819 11 p.

Research output: Contribution to journalArticle

Deciduous Tooth
Bilirubin
Cell Death
Stem Cells
Mitogen-Activated Protein Kinase 3
2 Citations (Scopus)

Bitter Taste Responses of Gustducin-positive Taste Cells in Mouse Fungiform and Circumvallate Papillae

Yoshida, R., Takai, S., Sanematsu, K., Margolskee, R. F., Shigemura, N. & Ninomiya, Y., Jan 15 2018, In : Neuroscience. 369, p. 29-39 11 p.

Research output: Contribution to journalArticle

Transient Receptor Potential Channels
Phospholipases
gustducin
Tongue
Phenylthiourea
1 Citation (Scopus)

Brazilian Green Propolis Prevents Cognitive Decline into Mild Cognitive Impairment in Elderly People Living at High Altitude

Zhu, A., Take, H., Zhong, X., Ni, J., Li, Y., Meng, J., Du, C., Zhao, X., Nakanishi, H. & Wu, S., Jan 1 2018, In : Journal of Alzheimer's Disease. 63, 2, p. 551-560 10 p.

Research output: Contribution to journalArticle

Propolis
Placebos
Inflammation
Serum
Interleukin-1

Cathepsin H deficiency in mice induces excess Th1 cell activation and early-onset of EAE though impairment of toll-like receptor 3 cascade

Okada, R., Zhang, X., Harada, Y., Take, H. & Nakanishi, H., May 1 2018, In : Inflammation Research. 67, 5, p. 371-374 4 p.

Research output: Contribution to journalArticle

Cathepsin H
Toll-Like Receptor 3
Th1 Cells
Autoimmune Experimental Encephalomyelitis
Interferon Regulatory Factor-3
PAR-2 Receptor
Porphyromonas gingivalis
Microglia
Cell Movement
Infection
2 Citations (Scopus)

Diurnal variation of sweet taste recognition thresholds is absent in overweight and obese humans

Sanematsu, K., Nakamura, Y., Nomura, M., Shigemura, N. & Ninomiya, Y., Mar 2 2018, In : Nutrients. 10, 3, 297.

Research output: Contribution to journalArticle

Taste Threshold
Leptin
leptin
diurnal variation
taste sensitivity

Enantioselective monoclonal antibodies for detecting ketamine to crack down on illicit use

Morita, I., Oyama, H., Kanda, Y., Yasuo, M., Ito, A., Toyota, M., Hayashi, Y., Yokoyama, T. & Kobayashi, N., Jan 1 2018, In : Biological and Pharmaceutical Bulletin. 41, 1, p. 123-131 9 p.

Research output: Contribution to journalArticle

Ketamine
Monoclonal Antibodies
Antibodies
Hybridomas
Anti-Idiotypic Antibodies
4 Citations (Scopus)

Exogenous nitric oxide stimulates the odontogenic differentiation of rat dental pulp stem cells

Sonoda, S., Mei, Y. F., Ikiru, A., Danjo, A., Yamaza, H., Hama, S., Nishida, K., Tang, R., Kyumoto, Y., Uehara, N., Kukita, T., Nishimura, F. & Yamaza, T., Dec 1 2018, In : Scientific reports. 8, 1, 3419.

Research output: Contribution to journalArticle

Dental Pulp
Nitric Oxide
Stem Cells
Odontoblasts
Dentin
6 Citations (Scopus)

IL-1β induces pathologically activated osteoclasts bearing extremely high levels of resorbing activity: A possible pathological subpopulation of osteoclasts, accompanied by suppressed expression of kindlin-3 and Talin-1

Shiratori, T., Kyumoto, Y., Kukita, A., Uehara, N., Zhang, J., Koda, K., Kamiya, M., Badawy, T., Tomoda, E., Xu, X., Yamaza, T., Urano, Y., Koyano, K. & Kukita, T., Jan 1 2018, In : Journal of Immunology. 200, 1, p. 218-228 11 p.

Research output: Contribution to journalArticle

Talin
Osteoclasts
Interleukin-1
Bone and Bones
Confocal Microscopy
2 Citations (Scopus)

Osteocalcin triggers Fas/FasL-mediated necroptosis in adipocytes via activation of p300

Otani, T., Matsuda, M., Mizokami, A., Kitagawa, N., Takeuchi, H., Jimi, E., Inai, T. & Hirata, M., Dec 1 2018, In : Cell Death and Disease. 9, 12, 1194.

Research output: Contribution to journalArticle

Fas Ligand Protein
Osteocalcin
Cyclic AMP Response Element-Binding Protein
Adipocytes
Serine
1 Citation (Scopus)
pamidronate
Hyperbilirubinemia
Deciduous Tooth
Cell death
Stem cells
3 Citations (Scopus)

Pmepa1 induced by RANKL-p38 MAPK pathway has a novel role in osteoclastogenesis

Funakubo, N., Xu, X., Kukita, T., Nakamura, S., Miyamoto, H. & Kukita, A., Apr 1 2018, In : Journal of cellular physiology. 233, 4, p. 3105-3118 14 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Osteogenesis
Androgens
Prostate
Osteoclasts
5 Citations (Scopus)
Tooth Fractures
Tooth
Retrospective Studies
Fixed Partial Denture
zirconium oxide
18 Citations (Scopus)

Sodium butyrate abolishes lipopolysaccharide-induced depression-like behaviors and hippocampal microglial activation in mice

Yamawaki, Y., Yoshioka, N., Nozaki, K., Ito, H., Oda, K., Harada, K., Shirawachi, S., Asano, S., Aizawa, H., Yamawaki, S., Kanematsu, T. & Akagi, H., Feb 1 2018, In : Brain Research. 1680, p. 13-38 26 p.

Research output: Contribution to journalArticle

Butyric Acid
Lipopolysaccharides
Depression
Epigenomics
Genes
4 Citations (Scopus)

Suppression of AKT-mTOR signal pathway enhances osteogenic/dentinogenic capacity of stem cells from apical papilla

Tanaka, Y., Sonoda, S., Yamaza, H., Murata, S., Nishida, K., Hama, S., Kyumoto, Y., Uehara, N., Nonaka, K., Kukita, T. & Yamaza, T., Nov 29 2018, In : Stem Cell Research and Therapy. 9, 1, 334.

Research output: Contribution to journalArticle

Sirolimus
Stem cells
Signal Transduction
Stem Cells
1-Phosphatidylinositol 4-Kinase
2 Citations (Scopus)

The critical role of IL-10 in the antineuroinflammatory and antioxidative effects of Rheum tanguticum on activated microglia

Meng, J., Ni, J., Wu, Z., Jiang, M., Zhu, A., Qing, H. & Nakanishi, H., Jan 1 2018, In : Oxidative medicine and cellular longevity. 2018, 1083596.

Research output: Contribution to journalArticle

Rheum
Microglia
Interleukin-10
Catechin
Interleukin-1
2 Citations (Scopus)

The effective design of zirconia coping on titanium base in dental implant superstructure

Mieda, M., Ikiru, A., Matsushita, Y., Morita, T., Ayukawa, Y., Tsukiyama, Y., Sawae, Y. & Koyano, K., Jan 1 2018, In : dental materials journal. 37, 2, p. 237-243 7 p., dmj/2017-022.

Research output: Contribution to journalArticle

Dental prostheses
Dental Implants
Titanium
Zirconia
Fracture toughness
2017

Binding properties between human sweet receptor and sweet-inhibitor, gymnemic acids

Sanematsu, K., Shigemura, N. & Ninomiya, Y., Aug 1 2017, In : journal of oral biosciences. 59, 3, p. 127-130 4 p.

Research output: Contribution to journalReview article

Cyclodextrins
Molecular Models
HEK293 Cells
gymnemic acid
Glucuronic Acid
2 Citations (Scopus)

Boi-ogi-to (TJ-20), a Kampo Formula, Suppresses the Inflammatory Bone Destruction and the Expression of Cytokines in the Synovia of Ankle Joints of Adjuvant Arthritic Rats

Zhang, X., Wu, Z., Liu, Y., Ni, J., Deng, C., Zhao, B., Nakanishi, H., He, J. & Yan, X., Jan 1 2017, In : Evidence-based Complementary and Alternative Medicine. 2017, 3679295.

Research output: Contribution to journalArticle

Kampo Medicine
Experimental Arthritis
Ankle Joint
Synovial Fluid
Rheumatoid Arthritis
24 Citations (Scopus)

Cathepsin B plays a critical role in inducing Alzheimer's disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice

Take, H., Ni, J., Liu, Y., Teeling, J. L., Takayama, F., Collcutt, A., Ibbett, P. & Nakanishi, H., Oct 1 2017, In : Brain, Behavior, and Immunity. 65, p. 350-361 12 p.

Research output: Contribution to journalArticle

Cathepsin B
Porphyromonas gingivalis
Microglia
Lipopolysaccharides
Alzheimer Disease
2 Citations (Scopus)
cathepsin S
PAR-2 Receptor
Porphyromonas gingivalis
Lipopolysaccharides
Interleukin-6

Correction: MSLN gene silencing has an anti-malignant effect on cell lines overexpressing mesothelin deriving from malignant pleural mesothelioma (PLoS ONE (2017) 12:6 (e0180317) DOI: 10.1371/journal.pone.0085935)

Melaiu, O., Stebbing, J., Lombardo, Y., Bracci, E., Uehara, N., Bonotti, A., Cristaudo, A., Foddis, R., Mutti, L., Barale, R., Gemignani, F., Giamas, G. & Landi, S., Jun 2017, In : PloS one. 12, 6, e0180317.

Research output: Contribution to journalComment/debate

mesothelioma
Gene Silencing
gene silencing
Genes
Cells
5 Citations (Scopus)

Dysfunction in diurnal synaptic responses and social behavior abnormalities in cathepsin S-deficient mice

Takayama, F., Zhang, X., Hayashi, Y., Take, H. & Nakanishi, H., Aug 19 2017, In : Biochemical and Biophysical Research Communications. 490, 2, p. 447-452 6 p.

Research output: Contribution to journalArticle

cathepsin S
Social Behavior
Neurons
Clocks
Cats