Research Output 1977 2019

Filter
Article
Article
24 Citations (Scopus)

12-o-tetradecanoylphorbol-13-acetate inhibits osteoclast-like cell differentiation in rat bone marrow cultures by inducing macrophage polykaryons

Kukita, T., Kukita, A., Hata, K. & Kurisu, K., Jan 1 1992, In : Endocrinology. 130, 2, p. 577-534 44 p.

Research output: Contribution to journalArticle

Tetradecanoylphorbol Acetate
Osteoclasts
Cell Differentiation
Bone Marrow
Macrophages
1 Citation (Scopus)
2-Amino-5-phosphonovalerate
N-Methyl-D-Aspartate Receptors
Hippocampus
Synaptic Transmission
Population
88 Citations (Scopus)

Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor

Hisatsune, C., Nakano, K., Takahashi-Iwanaga, H., Ogawa, N., Kuroda, Y., Yoshida, R., Ninomiya, Y. & Mikoshiba, K., Dec 21 2007, In : Journal of Biological Chemistry. 282, 51, p. 37225-37231 7 p.

Research output: Contribution to journalArticle

Taste Perception
Inositol 1,4,5-Trisphosphate Receptors
Chemical activation
Physiological Phenomena
Type C Phospholipases
38 Citations (Scopus)

Acceleration of bone regeneration by local application of lithium: Wnt signal-mediated osteoblastogenesis and Wnt signal-independent suppression of osteoclastogenesis

arioka, M., Takahashi, F., Sasaki, M., Yoshihara, T., Morimoto, S., Hirata, M., Mori, Y. & Sasaguri, T., Aug 15 2014, In : Biochemical Pharmacology. 90, 4, p. 397-405 9 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Bone Regeneration
Lithium
Osteogenesis
Bone
22 Citations (Scopus)
nucleotide pyrophosphokinase
Diphosphotransferases
Oligoribonucleotides
Pyrimidine Nucleotides
Diphosphates
1 Citation (Scopus)

Acetylsalicylic Acid Treatment and Suppressive Regulation of AKT Accelerate Odontogenic Differentiation of Stem Cells from the Apical Papilla

Tanaka, Y., Sonoda, S., Yamaza, H., Murata, S., Nishida, K., Kyumoto, Y., Uehara, N., Nonaka, K., Kukita, T. & Yamaza, T., May 1 2019, In : Journal of Endodontics. 45, 5, p. 591-598.e6

Research output: Contribution to journalArticle

Aspirin
Stem Cells
Tooth Root
NFI Transcription Factors
Small Interfering RNA
14 Citations (Scopus)

A convenient chemoenzymatic synthesis of d-and l-myo-inositol 1,4,5,6-tetrakisphosphate

Ozaki, S., Ling, L., Ogasawara, T., Watanabe, Y. & Hirata, M., Jun 17 1994, In : Carbohydrate Research. 259, 2, p. 307-310 4 p.

Research output: Contribution to journalArticle

Magnetic resonance spectroscopy
Stereoisomerism
Inositol Phosphates
Chromatography
Enzymes
37 Citations (Scopus)

Actinobacillus actinomycetemcomitans Y4 capsular-polysaccharide-like polysaccharide promotes osteoclast-like cell formation by interleukin-1α production in mouse marrow cultures

Nishihara, T., Ueda, N., Amano, K., Ishihara, Y., Hayakawa, H., Kuroyanagi, T., Ohsaki, Y., Nagata, K. & Noguchi, T., Jan 1 1995, In : Infection and Immunity. 63, 5, p. 1893-1898 6 p.

Research output: Contribution to journalArticle

Aggregatibacter actinomycetemcomitans
Osteoclasts
Interleukin-1
Polysaccharides
Bone Marrow
60 Citations (Scopus)

Action potential-enhanced ATP release from taste cells through hemichannels

Murata, Y., Yasuo, T., Yoshida, R., Obata, K., Yanagawa, Y., Margolskee, R. F. & Ninomiya, Y., Aug 1 2010, In : Journal of Neurophysiology. 104, 2, p. 896-901 6 p.

Research output: Contribution to journalArticle

Action Potentials
Adenosine Triphosphate
Electrodes
Fluorescence
Carbenoxolone
16 Citations (Scopus)

Activation by calmodulin of inositol-1,4,5-trisphosphate 3-kinase in guinea pig peritoneal macrophages

Kimura, Y., Hirata, M., Yamaguchi, K. & Koga, T., Jan 1 1987, In : Archives of Biochemistry and Biophysics. 257, 2, p. 363-369 7 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-trisphosphate 3-kinase
Macrophages
Peritoneal Macrophages
Calmodulin
Enzyme activity
19 Citations (Scopus)

Activation of μ-calpain in developing cortical neurons following methylmercury treatment

Zhang, J., Miyamoto, K. I., Hashioka, S., Hao, H. P., Murao, K., Saido, T. C. & Nakanishi, H., Apr 14 2003, In : Developmental Brain Research. 142, 1, p. 105-110 6 p.

Research output: Contribution to journalArticle

Spectrin
Calpain
Neurons
Cerebral Cortex
Dizocilpine Maleate
35 Citations (Scopus)

Acute p38-mediated inhibition of NMDA-induced outward currents in hippocampal CA1 neurons by interleukin-1β

Zhang, R., Sun, L., Hayashi, Y., Liu, X., Koyama, S., Take, H. & Nakanishi, H., Apr 1 2010, In : Neurobiology of Disease. 38, 1, p. 68-77 10 p.

Research output: Contribution to journalArticle

Interleukin-1
Aspartic Acid
Neurons
Microglia
p38 Mitogen-Activated Protein Kinases
14 Citations (Scopus)

Adenosine abolishes MTX-induced suppression of osteoclastogenesis and inflammatory bone destruction in adjuvant-induced arthritis

Teramachi, J., Kukita, A., Li, Y. J., Ushijima, Y., Ohkuma, H., Wada, N., Watanabe, T., Nakamura, S. & Kukita, T., May 1 2011, In : Laboratory Investigation. 91, 5, p. 719-731 13 p.

Research output: Contribution to journalArticle

Experimental Arthritis
Osteogenesis
Methotrexate
Adenosine
Bone and Bones
1 Citation (Scopus)

Adenosine blocks aminopterin-induced suppression of osteoclast differentiation

Teramachi, J., Kukita, A., Qu, P., Wada, N., Li, Y. J., Nakamura, S. & Kukita, T., Jan 2013, In : Journal of Bone and Mineral Metabolism. 31, 1, p. 64-70 7 p.

Research output: Contribution to journalArticle

Aminopterin
Osteoclasts
Osteogenesis
Adenosine
Hypoxanthine
63 Citations (Scopus)

Adiponectin inhibits induction of TNF-α/RANKL-stimulated NFATc1 via the AMPK signaling

Yamaguchi, N., Kukita, T., Li, Y. J., Kamio, N., Fukumoto, S., Nonaka, K., Ninomiya, Y., Hanazawa, S. & Yamashita, Y., Feb 6 2008, In : FEBS Letters. 582, 3, p. 451-456 6 p.

Research output: Contribution to journalArticle

NFATC Transcription Factors
AMP-Activated Protein Kinases
Adiponectin
Tumor Necrosis Factor-alpha
Osteoclasts
81 Citations (Scopus)

Adiponectin inhibits osteoclast formation stimulated by lipopolysaccharide from Actinobacillus actinomycetemcomitans

Yamaguchi, N., Kukita, T., Li, Y. J., Martinez Argueta, J. G., Saito, T., Hanazawa, S. & Yamashita, Y., Feb 1 2007, In : FEMS Immunology and Medical Microbiology. 49, 1, p. 28-34 7 p.

Research output: Contribution to journalArticle

Aggregatibacter actinomycetemcomitans
Adiponectin
Osteoclasts
Lipopolysaccharides
Toll-Like Receptor 4
22 Citations (Scopus)
Cathepsin H
Epithelial Attachment
Cathepsin B
Cysteine Proteases
Horseradish Peroxidase
70 Citations (Scopus)

Age-dependent neuroinflammatory responses and deficits in long-term potentiation in the hippocampus during systemic inflammation

Liu, X., Take, H., Hayashi, Y. & Nakanishi, H., Aug 2 2012, In : Neuroscience. 216, p. 133-142 10 p.

Research output: Contribution to journalArticle

Long-Term Potentiation
Hippocampus
Inflammation
Experimental Arthritis
Microglia
34 Citations (Scopus)

Age-dependent responses of glial cells and leptomeninges during systemic inflammation

Take, H., Tokuda, Y., Zhang, X. W. & Nakanishi, H., Dec 1 2008, In : Neurobiology of Disease. 32, 3, p. 543-551 9 p.

Research output: Contribution to journalArticle

Occludin
Neuroglia
Experimental Arthritis
Inflammation
Transforming Growth Factors
134 Citations (Scopus)

Age-related changes in activities and localizations of cathepsins D, E, B, and L in the rat brain tissues

Nakanishi, H., Tominaga, K., Amano, T., Hirotsu, I., Inoue, T. & Yamamoto, K., Jan 1 1994, In : Experimental Neurology. 126, 1, p. 119-128 10 p.

Research output: Contribution to journalArticle

Cathepsin E
Cathepsin D
Brain
Cathepsin L
Neostriatum
33 Citations (Scopus)

Age-related changes in cellular localization and enzymatic activities of cathepsins B, L and D in the rat trigeminal ganglion neuron

Amano, T., Nakanishi, H., Kondo, T., Tanaka, T., Oka, M. & Yamamoto, K., Sep 15 1995, In : Mechanisms of Ageing and Development. 83, 3, p. 133-141 9 p.

Research output: Contribution to journalArticle

Cathepsin L
Trigeminal Ganglion
Cathepsin B
Cathepsin D
Neurons
29 Citations (Scopus)

Ameloblastoma induces osteoclastogenesis: A possible role of ameloblastoma in expanding in the bone

Sandra, F., Hendarmin, L., Kukita, T., Nakao, Y., Nakamura, N. & Nakamura, S., Jul 1 2005, In : Oral Oncology. 41, 6, p. 637-644 8 p.

Research output: Contribution to journalArticle

Ameloblastoma
Osteogenesis
Bone and Bones
p38 Mitogen-Activated Protein Kinases
Osteoclasts
12 Citations (Scopus)

Amiloride inhibition on NaCl responses of the chorda tympani nerve in two 129 substrains of mice, 129P3/J and 129X1/SvJ

Ohkuri, T., Nakano, K., Shigemura, N., Yoshida, R. & Ninomiya, Y., Jul 1 2006, In : Chemical Senses. 31, 6, p. 565-572 8 p.

Research output: Contribution to journalArticle

Chorda Tympani Nerve
129 Strain Mouse
Tympanis
Amiloride
nerve tissue
42 Citations (Scopus)

Amiloride-sensitive NaCl taste responses are associated with genetic variation of ENaC α-subunit in mice

Shigemura, N., Ohkuri, T., Sadamitsu, C., Nakano, K., Yoshida, R., Beauchamp, G. K., Bachmanov, A. A. & Ninomiya, Y., Jan 1 2008, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 294, 1

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Amiloride
Single Nucleotide Polymorphism
Salts
Chorda Tympani Nerve
214 Citations (Scopus)

AMPA-kainate subtypes of glutamate receptor in rat cerebral microglia

Noda, M., Nakanishi, H., Nabekura, J. & Akaike, N., Jan 1 2000, In : Journal of Neuroscience. 20, 1, p. 251-258 8 p.

Research output: Contribution to journalArticle

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Kainic Acid
Glutamate Receptors
Microglia
Kainic Acid Receptors
29 Citations (Scopus)

Amyloid-β fibril formation is not necessarily required for microglial activation by the peptides

Hashioka, S., Monji, A., Ueda, T., Kanba, S. & Nakanishi, H., Oct 1 2005, In : Neurochemistry International. 47, 5, p. 369-376 8 p.

Research output: Contribution to journalArticle

Amyloid
Peptides
Microglia
Aptitude
Tumor Necrosis Factor-alpha
1 Citation (Scopus)

An EP2 Agonist Facilitates NMDA-Induced Outward Currents and Inhibits Dendritic Beading through Activation of BK Channels in Mouse Cortical Neurons

Hayashi, Y., Morinaga, S., Liu, X., Zhang, J., Take, H., Yokoyama, T. & Nakanishi, H., Jan 1 2016, In : Mediators of Inflammation. 2016, 5079597.

Research output: Contribution to journalArticle

Large-Conductance Calcium-Activated Potassium Channels
N-Methylaspartate
Neurons
Protein Kinase Inhibitors
Cyclic AMP-Dependent Protein Kinases

An epidemiologic examination on the prevalence of the periodontal diseases and oral pigmentation in Yusho patients in 2000

Hashiguchi, I., Yamaza, T., Koishi, Y., Goto, Y., Yoshito, Y., Akamine, A., Fukuyama, H. & Okumura, H., Jan 1 2001, In : Fukuoka igaku zasshi = Hukuoka acta medica. 92, 5, p. 115-119 5 p.

Research output: Contribution to journalArticle

Pigmentation
Periodontal Diseases
Periodontal Pocket
Tooth
Polychlorinated Biphenyls
89 Citations (Scopus)

A new inositol 1,4,5-trisphosphate binding protein similar to phospholipase C-δ1

Kanematsu, T., Misumi, Y., Watanabe, Y., Ozaki, S., Koga, T., Iwanaga, S., Ikehara, Y. & Hirata, M., Jan 1 1996, In : Biochemical Journal. 313, 1, p. 319-325 7 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate
Type C Phospholipases
Carrier Proteins
Programmable logic controllers
Proteins
2 Citations (Scopus)

An extract from pork bones containing osteocalcin improves glucose metabolism in mice by oral administration

Mizokami, A., Wang, D. G., Tanaka, M., Gao, J., Takeuchi, H., Matsui, T. & Hirata, M., Jan 1 2016, In : Bioscience, Biotechnology and Biochemistry. 80, 11, p. 2176-2183 8 p.

Research output: Contribution to journalArticle

Osteocalcin
Metabolism
Oral Administration
Bone
Bone and Bones
29 Citations (Scopus)

Angiotensin II modulates salty and sweet taste sensitivities

Shigemura, N., Iwata, S., Nakano, K., Ohkuri, T., Horio, N., Sanematsu, K., Yoshida, R., Margolskee, R. F. & Ninomiya, Y., Apr 10 2013, In : Journal of Neuroscience. 33, 15, p. 6267-6277 11 p.

Research output: Contribution to journalArticle

Angiotensin II
Sweetening Agents
Amiloride
Sodium
Salts
27 Citations (Scopus)
Epithelial Attachment
Capsaicin
Gingiva
Substance P
Blood Vessels

An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain

Ni, J., Wu, Z., Meng, J., Saito, T., Saido, T. C., Qing, H. & Nakanishi, H., Aug 30 2019, In : Journal of neuroinflammation. 16, 1, 173.

Research output: Contribution to journalArticle

Open Access
Amyloid beta-Protein Precursor
Microglia
Brain
Alzheimer Disease
Genes
7 Citations (Scopus)

An improved mounting method for observation of thick specimens using confocal microscopy

Kagayama, M., Sasano, Y., Hirata, M., Mizoguchi, I. & Takahashi, I., Jan 1 1996, In : Biotechnic and Histochemistry. 71, 5, p. 231-233 3 p.

Research output: Contribution to journalArticle

Confocal Microscopy
Air
Observation
Immersion
Lenses
6 Citations (Scopus)

An inhibitor of lipoxygenase, nordihydroguaiaretic acid, shortens actin filaments

Hirata, M., Inamitsu, T., Hashimoto, T. & Koga, T., Jan 1 1984, In : Journal of biochemistry. 95, 3, p. 891-894 4 p.

Research output: Contribution to journalArticle

Masoprocol
Lipoxygenase Inhibitors
Actin Cytoskeleton
Actins
Arachidonate Lipoxygenases
1 Citation (Scopus)
nucleotide pyrophosphokinase
Diphosphotransferases
Streptomyces
Nucleosides
Phosphates
1 Citation (Scopus)

A Novel Autoantibody against Plexin D1 in Patients with Neuropathic Pain

Fujii, T., Yamasaki, R., Iinuma, K., Tsuchimoto, D., Hayashi, Y., Saitoh, B. Y., Matsushita, T., Kido, M. A., Aishima, S., Nakanishi, H., Nakabeppu, Y. & Kira, J. I., Aug 2018, In : Annals of Neurology. 84, 2, p. 208-224 17 p.

Research output: Contribution to journalArticle

Neuralgia
Autoantibodies
Spinal Ganglia
Neurons
Unmyelinated Nerve Fibers
1 Citation (Scopus)

A novel monoclonal antibody recognizing a unique antigen of rat osteoclasts induced by the calcified matrices

Hata, K., Akamine, A., Kukita, T., Iijima, T., Kukita, A. & Kurisu, K., Jun 1 1994, In : Histochemistry. 101, 5, p. 347-354 8 p.

Research output: Contribution to journalArticle

osteoclasts
Osteoclasts
monoclonal antibodies
Monoclonal Antibodies
antigens
20 Citations (Scopus)

A novel mutation causing an aberrant splicing in the protein 4.2 gene associated with hereditary spherocytosis (protein 4.2Notame)

Matsuda, M., Hatano, N., Ideguchi, H., Takahira, H. & Fukumaki, Y., Jul 1 1995, In : Human Molecular Genetics. 4, 7, p. 1187-1191 5 p.

Research output: Contribution to journalArticle

Protein Splicing
Hereditary Spherocytosis
Protein Deficiency
Introns
Mutation
27 Citations (Scopus)

A novel mutation in the erythrocyte protein 4.2 gene of Japanese patients with hereditary spherocytosis (protein 4.2(Fukuoka))

Takaoka, Y., Ideguchi, H., Matsuda, M., Sakamoto, N., Takeuchi, T. & Fukumaki, Y., Jan 1 1994, In : British Journal of Haematology. 88, 3, p. 527-533 7 p.

Research output: Contribution to journalArticle

Hereditary Spherocytosis
Codon
Erythrocytes
Mutation
Missense Mutation
95 Citations (Scopus)

A novel role of IL-15 in the development of osteoclasts: Inability to replace its activity with IL-2

Ogata, Y., Kukita, A., Kukita, T., Komine, M., Miyahara, A., Miyazaki, S. & Kohashi, O., Mar 1 1999, In : Journal of Immunology. 162, 5, p. 2754-2760 7 p.

Research output: Contribution to journalArticle

Interleukin-15
Osteoclasts
Interleukin-2
Interleukin-7
Calcitonin Receptors
14 Citations (Scopus)

Anti-angiogenic effects of differentiation-inducing factor-1 involving VEGFR-2 expression inhibition independent of the Wnt/β-catenin signaling pathway.

Yoshihara, T., Takahashi, F., Shiraishi, F., Morimoto, S., Watanabe, Y., Hirata, M., Hoka, S. & Sasaguri, T., Jan 1 2010, In : Molecular cancer. 9, 1 p.

Research output: Contribution to journalArticle

Catenins
Vascular Endothelial Growth Factor Receptor-2
Wnt Signaling Pathway
Human Umbilical Vein Endothelial Cells
Neoplasms
3 Citations (Scopus)

Antibodies against the PH domain of phospholipase C-δ1 inhibit Ins(1,4,5)P3-Mediated Ca2+ release from the endoplasmic reticulum

Matsuki, N. A., Tateishi, K., Takeuchi, H., Yagisawa, H., Kanematsu, T., Oishi, M. & Hirata, M., Jun 24 1999, In : Biochemical and Biophysical Research Communications. 260, 1, p. 42-47 6 p.

Research output: Contribution to journalArticle

Type C Phospholipases
Endoplasmic Reticulum
Antibodies
Immunoglobulin Fab Fragments
Peptides
6 Citations (Scopus)

A peptide that blocks the interaction of NF-κB p65 subunit with Smad4 enhances BMP2-induced osteogenesis

Urata, M., Kokabu, S., Matsubara, T., Sugiyama, G., Nakatomi, C., Takeuchi, H., Hirata-Tsuchiya, S., Aoki, K., Tamura, Y., Moriyama, Y., Ayukawa, Y., Matsuda, M., Zhang, M., Koyano, K., Kitamura, C. & Jimi, E., Sep 1 2018, In : Journal of cellular physiology. 233, 9, p. 7356-7366 11 p.

Research output: Contribution to journalArticle

Osteogenesis
Bone Morphogenetic Proteins
Bone
Peptides
Osteoblasts
36 Citations (Scopus)

A possible suppressive role of galectin-3 in upregulated osteoclastogenesis accompanying adjuvant-induced arthritis in rats

Li, Y. J., Kukita, A., Teramachi, J., Nagata, K., Take, H., Akamine, A. & Kukita, T., Jan 1 2009, In : Laboratory Investigation. 89, 1, p. 26-37 12 p.

Research output: Contribution to journalArticle

Galectin 3
Experimental Arthritis
Osteogenesis
Osteoclasts
Bone and Bones
34 Citations (Scopus)

A predominant apoptotic death pathway of neuronal PC12 cells induced by activated microglia is displaced by a non-apoptotic death pathway following blockage of caspase-3-dependent cascade

Tanabe, K., Nakanishi, H., Maeda, H., Nishioku, T., Hashimoto, K., Liou, S. Y., Akamine, A. & Yamamoto, K., May 28 1999, In : Journal of Biological Chemistry. 274, 22, p. 15725-15731 7 p.

Research output: Contribution to journalArticle

PC12 Cells
Microglia
Caspase 3
Cell death
Peptide Hydrolases
50 Citations (Scopus)

A Rapid Increase in the Total Number of Cell Surface Functional GABA A Receptors Induced by Brain-derived Neurotrophic Factor in Rat Visual Cortex

Mizoguchi, Y., Kanematsu, T., Hirata, M. & Nabekura, J., Nov 7 2003, In : Journal of Biological Chemistry. 278, 45, p. 44097-44102 6 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Visual Cortex
GABA-A Receptors
Rats
Cell Count
41 Citations (Scopus)

Arg-gingipain is responsible for the degradation of cell adhesion molecules of human gingival fibroblasts and their death induced by Porphyromonas gingivalis

Baba, A., Abe, N., Kadowaki, T., Nakanishi, H., Ohishi, M., Asao, T. & Yamamoto, K., Jul 21 2001, In : Biological chemistry. 382, 5, p. 817-824 8 p.

Research output: Contribution to journalArticle

Porphyromonas gingivalis
Cell Adhesion Molecules
Fibroblasts
Degradation
Fibronectins
84 Citations (Scopus)

A role for inositol 1,4,5‐trisphosphate in the initiation of agonist‐induced contractions of dog tracheal smooth muscle

Hashimoto, T., Hirata, M. & Ito, Y., Jan 1 1985, In : British Journal of Pharmacology. 86, 1, p. 191-199 9 p.

Research output: Contribution to journalArticle

Inositol
Smooth Muscle Myocytes
Smooth Muscle
Dogs
Phosphatidic Acids
2 Citations (Scopus)

Assay of dense-core vesicle exocytosis using permeabilized PC12 cells

Gao, J., Takeuchi, H., Umebayashi, H., Zhang, Z., Matsuda, M. & Hirata, M., Aug 18 2010, In : Advances in Enzyme Regulation. 50, 1, p. 237-246 10 p.

Research output: Contribution to journalArticle

Cell Membrane Permeability
Tissue Extracts
PC12 Cells
Exocytosis
Secretory Vesicles