Research Output 1977 2019

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2 Citations (Scopus)

Assay of dense-core vesicle exocytosis using permeabilized PC12 cells

Gao, J., Takeuchi, H., Umebayashi, H., Zhang, Z., Matsuda, M. & Hirata, M., Aug 18 2010, In : Advances in Enzyme Regulation. 50, 1, p. 237-246 10 p.

Research output: Contribution to journalArticle

Cell Membrane Permeability
Tissue Extracts
PC12 Cells
Exocytosis
Secretory Vesicles
20 Citations (Scopus)

Asymmetric distribution of acetylcholine receptors and M channels on prepyriform neurons

ffrench-Mullen, J. M. H., Hori, N., Nakanishi, H., Slater, N. T. & Carpenter, D. O., Jun 1 1983, In : Cellular and Molecular Neurobiology. 3, 2, p. 163-181 19 p.

Research output: Contribution to journalArticle

Cholinergic Receptors
Acetylcholine
Dendrites
Neurons
Pyramidal Cells
25 Citations (Scopus)

ATP-dependent Ca2+ accumulation in intracellular membranes of guinea pig macrophages after saponin treatment

Hirata, M. & Koga, T., Feb 26 1982, In : Biochemical and Biophysical Research Communications. 104, 4, p. 1544-1549 6 p.

Research output: Contribution to journalArticle

Intracellular Membranes
Macrophages
Saponins
Guinea Pigs
Adenosine Triphosphate
101 Citations (Scopus)

Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells

Kanematsu, S., Uehara, N., Miki, H., Yoshizawa, K., Kawanaka, A., Yuri, T. & Tsubura, A., Jan 1 2010, In : Anticancer research. 30, 9, p. 3381-3390 10 p.

Research output: Contribution to journalArticle

Autophagy
Apoptosis
Breast Neoplasms
Light
Cell Death
7 Citations (Scopus)

Autophagy in superficial spinal dorsal horn accelerates the cathepsin b-dependent morphine antinociceptive tolerance

Hayashi, Y., Koga, Y., Zhang, X., Peters, C., Yanagawa, Y., Wu, Z., Yokoyama, T. & Nakanishi, H., Sep 5 2014, In : Neuroscience. 275, p. 384-394 11 p.

Research output: Contribution to journalArticle

Cathepsins
Autophagy
Morphine
Cathepsin B
Opioid Analgesics
14 Citations (Scopus)

Bidirectional regulation of telomerase activity in a subline derived from human lung adenocarcinoma

Katakura, Y., Yamamoto, K., Miyake, O., Yasuda, T., Uehara, N., Nakata, E., Kawamoto, S. & Shirahata, S., Aug 18 1997, In : Biochemical and Biophysical Research Communications. 237, 2, p. 313-317 5 p.

Research output: Contribution to journalArticle

Telomerase
Cell Aging
Tumors
Growth
Cells

Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis

Touyama, K., Khan, M., Aoki, K., Matsuda, M., Hiura, F., Takakura, N., Matsubara, T., Harada, Y., Hirohashi, Y., Tamura, Y., Gao, J., Mori, K., Kokabu, S., Yasuda, H., Fujita, Y., Watanabe, K., Takahashi, Y., Maki, K. & Jimi, E., Nov 1 2019, In : Journal of Cellular Biochemistry. 120, 11, p. 18793-18804 12 p.

Research output: Contribution to journalArticle

Bone
Homeostasis
Bone and Bones
Osteoclasts
Osteogenesis
2 Citations (Scopus)

Bilirubin reversibly affects cell death and odontogenic capacity in stem cells from human exfoliated deciduous teeth

Yamaza, H., Tomoda, E., Sonoda, S., Nonaka, K., Kukita, T. & Yamaza, T., Jul 1 2018, In : Oral Diseases. 24, 5, p. 809-819 11 p.

Research output: Contribution to journalArticle

Deciduous Tooth
Bilirubin
Cell Death
Stem Cells
Mitogen-Activated Protein Kinase 3
45 Citations (Scopus)

Binding of 14-3-3β but not 14-3-3σ controls the cytoplasmic localization of CDC25B: Binding site preferences of 14-3-3 subtypes and the subcellular localization of CDC25B

Uchida, S., Kuma, A., Ohtsubo, M., Shimura, M., Hirata, M., Nakagama, H., Matsunaga, T., Ishizaka, Y. & Yamashita, K., Jun 15 2004, In : Journal of Cell Science. 117, 14, p. 3011-3020 10 p.

Research output: Contribution to journalArticle

Serine
Binding Sites
Cytoplasm
Dual-Specificity Phosphatases
Cyclin B
12 Citations (Scopus)

Binding of phospholipase C-related but catalytically inactive protein to phosphatidylinositol 4,5-bisphosphate via the PH domain

Gao, J., Takeuchi, H., Zhang, Z., Fujii, M., Kanematsu, T. & Hirata, M., Jul 1 2009, In : Cellular Signalling. 21, 7, p. 1180-1186 7 p.

Research output: Contribution to journalArticle

Type C Phospholipases
Phosphatidylinositols
Phosphatidylinositol 4,5-Diphosphate
Proteins
Cell Membrane
29 Citations (Scopus)

Biphasic effects of zeranol on the growth of estrogen receptor-positive human breast carcinoma cells

Yuri, T., Tsukamoto, R., Miki, K., Uehara, N., Matsuoka, Y. & Tsubura, A., Dec 1 2006, In : Oncology reports. 16, 6, p. 1307-1312 6 p.

Research output: Contribution to journalArticle

Zeranol
Estrogen Receptors
Breast Neoplasms
Growth
Apoptosis
2 Citations (Scopus)

Bitter Taste Responses of Gustducin-positive Taste Cells in Mouse Fungiform and Circumvallate Papillae

Yoshida, R., Takai, S., Sanematsu, K., Margolskee, R. F., Shigemura, N. & Ninomiya, Y., Jan 15 2018, In : Neuroscience. 369, p. 29-39 11 p.

Research output: Contribution to journalArticle

Transient Receptor Potential Channels
Phospholipases
gustducin
Tongue
Phenylthiourea

BK channels in microglia are required for morphine-induced hyperalgesia

Hayashi, Y., May 31 2016, In : Nature Communications. 7, 11697

Research output: Contribution to journalArticle

Open Access
morphine
Large-Conductance Calcium-Activated Potassium Channels
Hyperalgesia
Microglia
Morphine
24 Citations (Scopus)

BK channels in microglia are required for morphine-induced hyperalgesia

Hayashi, Y., Morinaga, S., Zhang, J., Satoh, Y., Meredith, A. L., Nakata, T., Take, H., Kohsaka, S., Inoue, K. & Nakanishi, H., May 31 2016, In : Nature communications. 7, 11697.

Research output: Contribution to journalArticle

morphine
Large-Conductance Calcium-Activated Potassium Channels
Hyperalgesia
Microglia
Morphine
2 Citations (Scopus)

Boi-ogi-to (TJ-20), a Kampo Formula, Suppresses the Inflammatory Bone Destruction and the Expression of Cytokines in the Synovia of Ankle Joints of Adjuvant Arthritic Rats

Zhang, X., Wu, Z., Liu, Y., Ni, J., Deng, C., Zhao, B., Nakanishi, H., He, J. & Yan, X., Jan 1 2017, In : Evidence-based Complementary and Alternative Medicine. 2017, 3679295.

Research output: Contribution to journalArticle

Kampo Medicine
Experimental Arthritis
Ankle Joint
Synovial Fluid
Rheumatoid Arthritis

Both PTB domain and PH domain of IRS-1 bind inositol polyphosphates with distinct specificity

Takeuchi, H., Matsuda, M., Kanematsu, T. & Hirata, M., 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Polyphosphates
Inositol
Tyrosine
Inositol Phosphates
1 Citation (Scopus)

Brazilian Green Propolis Prevents Cognitive Decline into Mild Cognitive Impairment in Elderly People Living at High Altitude

Zhu, A., Take, H., Zhong, X., Ni, J., Li, Y., Meng, J., Du, C., Zhao, X., Nakanishi, H. & Wu, S., Jan 1 2018, In : Journal of Alzheimer's Disease. 63, 2, p. 551-560 10 p.

Research output: Contribution to journalArticle

Propolis
Placebos
Inflammation
Serum
Interleukin-1
16 Citations (Scopus)

Brazilian green propolis suppresses the hypoxia-induced neuroinflammatory responses by inhibiting NF- B activation in microglia

Wu, Z., Zhu, A., Takayama, F., Okada, R., Liu, Y., Harada, Y., Wu, S. & Nakanishi, H., Sep 3 2013, In : Oxidative medicine and cellular longevity. 906726.

Research output: Contribution to journalArticle

Propolis
Microglia
Chemical activation
Interleukin-1
Interleukin-6
1 Citation (Scopus)

Ca2+/calmodulin independent inositol 1,4,5-trisphosphate 3-kinase activity in guinea pig peritoneal macrophages

Kimura, Y., Watanabe, Y., Ozaki, S., Koga, T. & Hirata, M., Jan 1 1990, In : Comparative Biochemistry and Physiology -- Part B: Biochemistry and. 97, 3, p. 527-533 7 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-trisphosphate 3-kinase
Macrophages
Peritoneal Macrophages
Calmodulin
Guinea Pigs
1 Citation (Scopus)

Ca 2+ dependence of inositol 1,4,5-trisphosphate 3-kinase activity in the cytosol fraction of pig coronary artery

Yamaguchi, K., Hirata, M., Ishimatsu, T. & Kuriyama, H., Jan 1 1989, In : Comparative Biochemistry and Physiology. Part C, Comparative. 92, 1, p. 163-166 4 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-trisphosphate 3-kinase
Cytosol
Coronary Vessels
Phosphotransferases
Swine

Ca2+ dependence of inositol 1,4,5-trisphosphate 3-kinase activity in the cytosol fraction of pig coronary artery.

Yamaguchi, K., Hirata, M., Ishimatsu, T. & Kuriyama, H., Jan 1 1989, In : Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. 92, 1, p. 163-166 4 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-trisphosphate 3-kinase
Cytosol
Muscle
Coronary Vessels
Phosphotransferases
12 Citations (Scopus)

Ca2+-dependent regulation of calcitonin gene expression by the transcriptional repressor DREAM

Matsuda, M., Yamamoto, T. A. & Hirata, M., Sep 22 2006, In : Endocrinology. 147, 10, p. 4608-4617 10 p.

Research output: Contribution to journalArticle

Calcitonin
Gene Expression Regulation
Cyclic AMP Response Element Modulator
Kv Channel-Interacting Proteins
Gene Expression
10 Citations (Scopus)

Ca2+ influx evoked by inositol-3,4,5,6-tetrakisphosphate in ras-transformed NIH/3T3 fibroblasts

Hashii, M., Hirata, M., Ozaki, S., Nozawa, Y. & Higashida, H., Mar 7 1994, In : FEBS Letters. 340, 3, p. 276-280 5 p.

Research output: Contribution to journalArticle

Fibroblasts
Bradykinin Receptors
NIH 3T3 Cells
Inositol 1,4,5-Trisphosphate
Second Messenger Systems
10 Citations (Scopus)

Ca2+-influx gated by inositol-3,4,5,6-tetrakisphosphate in NIH/3T3 fibroblasts

Hashii, M., Hirata, M., Ozaki, S., Nozawa, Y. & Higashida, H., May 15 1994, In : Biochemical and Biophysical Research Communications. 200, 3, p. 1300-1306 7 p.

Research output: Contribution to journalArticle

Fibroblasts
Bradykinin
Inositol
NIH 3T3 Cells
Fura-2
25 Citations (Scopus)

Ca2+ regulation in vascular smooth muscle

Hirata, M., Mikawa, T., Nonomura, Y. & Ebashi, S., Jan 1 1977, In : Journal of biochemistry. 82, 6, p. 1793-1796 4 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Smooth Muscle
Muscle
Aorta
Tropomyosin
30 Citations (Scopus)

Ca2+ regulation in vascular smooth muscle: II. Ca2+ binding of aorta leiotonin

Hirata, M., Mikawa, T., Nonomura, Y. & Ebashi, S., Jan 1 1980, In : Journal of biochemistry. 87, 2, p. 369-378 10 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Muscle
Aorta
Phosphorylation
Actins
10 Citations (Scopus)

Calcium-dependent hyperexcitability of hippocampal CA1 pyramidal cells in an in vitro slice after ethanol withdrawal of the rat

Shindou, T., Watanabe, S., Kamata, O., Yamamoto, K. & Nakanishi, H., Sep 12 1994, In : Brain Research. 656, 2, p. 432-436 5 p.

Research output: Contribution to journalArticle

Pyramidal Cells
Ethanol
Calcium
Neurons
Calcium Signaling
10 Citations (Scopus)

Calcium imaging for detection and estimation of spike activities in Aplysia neurons

Yoshida, R., Iwamoto, A. & Nagahama, T., Jul 1 2001, In : Zoological science. 18, 5, p. 631-643 13 p.

Research output: Contribution to journalArticle

neurons
image analysis
calcium
dyes
cells
31 Citations (Scopus)

Calmodulin activates inositol 1,4,5-trisphosphate 3-kinase activity in pig aortic smooth muscle.

Yamaguchi, K., Hirata, M. & Kuriyama, H., Jan 1 1987, In : The Biochemical journal. 244, 3, p. 787-791 5 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-trisphosphate 3-kinase
Calmodulin
Smooth Muscle
Muscle
Swine
19 Citations (Scopus)

Calmodulin antagonists inhibit Ca 2+ uptake of mitochondria of guinea pig peritoneal macrophages

Hirata, M., Suematsu, E. & Koga, T., Apr 14 1982, In : Biochemical and Biophysical Research Communications. 105, 3, p. 1176-1181 6 p.

Research output: Contribution to journalArticle

Mitochondria
Macrophages
Peritoneal Macrophages
Calmodulin
Guinea Pigs
20 Citations (Scopus)

Calpain inhibition restores basal autophagy and suppresses MNU-induced photoreceptor cell death in mice

Kuro, M., Yoshizawa, K., Uehara, N., Miki, H., Takahashi, K. & Tsubura, A., Jul 1 2011, In : In Vivo. 25, 4, p. 617-623 7 p.

Research output: Contribution to journalArticle

Photoreceptor Cells
Calpain
Autophagy
Cell death
Cell Death
18 Citations (Scopus)

Capsaicin receptor expression in the rat temporomandibular joint

Ioi, H., Kido, M. A., Zhang, J. Q., Yamaza, T., Nakata, S., Nakasima, A. & Tanaka, T., Jul 1 2006, In : Cell and tissue research. 325, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

TRPV Cation Channels
Temporomandibular Joint
Joint Capsule
Nociception
Synovial Membrane
15 Citations (Scopus)

Ca release in the endoplasmic reticulum of Guinea pig peritoneal macrophages 1

Hirata, M., Hamachi, T., Hashimoto, T., Suematsu, E. & Koga, T., Jan 1 1983, In : Journal of biochemistry. 94, 4, p. 1155-1163 9 p.

Research output: Contribution to journalArticle

Macrophages
Peritoneal Macrophages
Endoplasmic Reticulum
Guinea Pigs
Adenine
2 Citations (Scopus)

Catabolic effects of muramyl dipeptide on rabbit chondrocytes

Ikebe, T., Iribe, H., Hirata, M., Yanaga, F. & Koga, T., 1990, In : Arthritis and Rheumatism. 33, 12, p. 1801-1806 6 p.

Research output: Contribution to journalArticle

Acetylmuramyl-Alanyl-Isoglutamine
Proteoglycans
Chondrocytes
Glycosaminoglycans
Rabbits
21 Citations (Scopus)

Cathepsin B-dependent motor neuron death after nerve injury in the adult mouse

Sun, L., Take, H., Baba, M., Peters, C., Uchiyama, Y. & Nakanishi, H., Aug 1 2010, In : Biochemical and Biophysical Research Communications. 399, 3, p. 391-395 5 p.

Research output: Contribution to journalArticle

Cathepsin B
Motor Neurons
Neurons
Wounds and Injuries
Noxae
24 Citations (Scopus)

Cathepsin B plays a critical role in inducing Alzheimer's disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice

Take, H., Ni, J., Liu, Y., Teeling, J. L., Takayama, F., Collcutt, A., Ibbett, P. & Nakanishi, H., Oct 1 2017, In : Brain, Behavior, and Immunity. 65, p. 350-361 12 p.

Research output: Contribution to journalArticle

Cathepsin B
Porphyromonas gingivalis
Microglia
Lipopolysaccharides
Alzheimer Disease
11 Citations (Scopus)

Cathepsin B Regulates Collagen Expression by Fibroblasts via Prolonging TLR2/NF-κB Activation

Li, X., Wu, Z., Ni, J., Liu, Y., Meng, J., Yu, W., Nakanishi, H. & Zhou, Y., Jan 1 2016, In : Oxidative medicine and cellular longevity. 2016, 7894247.

Research output: Contribution to journalArticle

Cathepsin B
Fibroblasts
Collagen
Chemical activation
yeast proteinase B
287 Citations (Scopus)

Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons

Koike, M., Nakanishi, H., Saftig, P., Ezaki, J., Isahara, K., Ohsawa, Y., Schulz-Schaeffer, W., Watanabe, T., Waguri, S., Kametaka, S., Shibata, M., Yamamoto, K., Kominami, E., Peters, C., Von Figura, K. & Uchiyama, Y., Sep 15 2000, In : Journal of Neuroscience. 20, 18, p. 6898-6906 9 p.

Research output: Contribution to journalArticle

Ceroid
Lipofuscin
Cathepsin D
Neurons
Brain
16 Citations (Scopus)

Cathepsin D deficiency induces oxidative damage in brain pericytes and impairs the blood-brain barrier

Okada, R., Take, H., Zhu, A., Ni, J., Zhang, J., Yoshito, Y., Peters, C., Saftig, P. & Nakanishi, H., Jan 1 2015, In : Molecular and Cellular Neuroscience. 64, p. 51-60 10 p.

Research output: Contribution to journalArticle

Pericytes
Cathepsin D
Blood-Brain Barrier
Brain
Blood Cells
1 Citation (Scopus)

Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis

Harada, Y., Zhang, J., Imari, K., Yamasaki, R., Ni, J., Take, H., Yamamoto, K., Kira, J-I., Nakanishi, H. & Hayashi, Y., Sep 1 2019, In : Pain. 160, 9, p. 2050-2062 13 p.

Research output: Contribution to journalArticle

Cathepsin E
Autoimmune Experimental Encephalomyelitis
Neuralgia
Neutrophils
Hyperalgesia
4 Citations (Scopus)

Cathepsin E in the central nervous system

Nakanishi, H. & Yamamoto, K., Jan 1 1998, In : Advances in experimental medicine and biology. 436, p. 213-217 5 p.

Research output: Contribution to journalArticle

Cathepsin E
Neurology

Cathepsin H deficiency in mice induces excess Th1 cell activation and early-onset of EAE though impairment of toll-like receptor 3 cascade

Okada, R., Zhang, X., Harada, Y., Take, H. & Nakanishi, H., May 1 2018, In : Inflammation Research. 67, 5, p. 371-374 4 p.

Research output: Contribution to journalArticle

Cathepsin H
Toll-Like Receptor 3
Th1 Cells
Autoimmune Experimental Encephalomyelitis
Interferon Regulatory Factor-3
2 Citations (Scopus)
cathepsin S
PAR-2 Receptor
Porphyromonas gingivalis
Lipopolysaccharides
Interleukin-6

Ccr7 null mice are protected against diet-induced obesity via Ucp1 upregulation and enhanced energy expenditure

Sano, T., Sanada, T., Sotomaru, Y., Shinjo, T., Iwashita, M., Yamashita, A., Fukuda, T., Sanui, T., Asano, T., Kanematsu, T. & Nishimura, F., Jul 4 2019, In : Nutrition and Metabolism. 16, 1, 43.

Research output: Contribution to journalArticle

Open Access
Energy Metabolism
Up-Regulation
Obesity
Diet
White Adipose Tissue
18 Citations (Scopus)

Celecoxib-induced degradation of T-cell factors-1 and -4 in human colon cancer cells

Takahashi-Yanaga, F., Yoshihara, T., Jingushi, K., Miwa, Y., Morimoto, S., Hirata, M. & Sasaguri, T., Dec 26 2008, In : Biochemical and Biophysical Research Communications. 377, 4, p. 1185-1190 6 p.

Research output: Contribution to journalArticle

Celecoxib
Transcription Factor 7-Like 2 Protein
T Cell Transcription Factor 1
Colonic Neoplasms
Cells
116 Citations (Scopus)

Cell-based immunotherapy with mesenchymal stem cells cures bisphosphonate-related osteonecrosis of the jaw-like disease in mice

Kikuiri, T., Kim, I., Yamaza, T., Akiyama, K., Zhang, Q., Li, Y., Chen, C., Chen, W. J., Wang, S., Le, A. D. & Shi, S., Jul 1 2010, In : Journal of Bone and Mineral Research. 25, 7, p. 1668-1679 12 p.

Research output: Contribution to journalArticle

Jaw Diseases
Bisphosphonate-Associated Osteonecrosis of the Jaw
Mesenchymal Stromal Cells
Immunotherapy
zoledronic acid
16 Citations (Scopus)

Cell cycle-dependent regulation of kainate-induced inward currents in microglia

Yamada, J., Sawada, M. & Nakanishi, H., Oct 27 2006, In : Biochemical and Biophysical Research Communications. 349, 3, p. 913-919 7 p.

Research output: Contribution to journalArticle

Kainic Acid
Induced currents
Microglia
Cell Cycle
Cells
1 Citation (Scopus)

Cerebromalacia with epilepsy and cortical blindness in a laboratory Japanese macaque (Macaca fuscata).

Yoshizawa, K., Nakao, K., Habiro, M., Hayashi, K., Kuwata, M., Uehara, N., Yuri, T., Nakamura, K. & Tsubura, A., Dec 1 2010, In : Toxicologic pathology. 38, 7, p. 1058-1063 6 p.

Research output: Contribution to journalArticle

Encephalomalacia
Cortical Blindness
Macaca
Epilepsy
Haplorhini
17 Citations (Scopus)

Changes in amygdaloid afterdischarges and kindling effect following olfactory bulbectomy in the rat

Watanabe, S., Nakanishi, H., Shibata, S. & Ueki, S., Jan 1 1982, In : Physiology and Behavior. 28, 4, p. 687-692 6 p.

Research output: Contribution to journalArticle

Amygdala
Electrodes
Corticomedial Nuclear Complex

Changes in neuronal activity and in susceptibility to noradrenaline in the amygdala following olfactory bulbectomy

Nakanishi, H., Hori, N. & Katsuda, N., 1981, In : Japanese Journal of Pharmacology. 31, Suppl.

Research output: Contribution to journalArticle

Amygdala
Norepinephrine