Oral Biological Sciences &ndash; Research Output

Article

Assay of dense-core vesicle exocytosis using permeabilized PC12 cells

Gao, J., Takeuchi, H., Umebayashi, H., Zhang, Z., Matsuda, M. & Hirata, M., Aug 18 2010, In : Advances in Enzyme Regulation. 50, 1, p. 237-246 10 p.

Research output: Contribution to journal › Article

Cell Membrane Permeability

Tissue Extracts

PC12 Cells

Exocytosis

Secretory Vesicles

20 Citations (Scopus)

Asymmetric distribution of acetylcholine receptors and M channels on prepyriform neurons

ffrench-Mullen, J. M. H., Hori, N., Nakanishi, H., Slater, N. T. & Carpenter, D. O., Jun 1 1983, In : Cellular and Molecular Neurobiology. 3, 2, p. 163-181 19 p.

Research output: Contribution to journal › Article

Cholinergic Receptors

Acetylcholine

Dendrites

Neurons

Pyramidal Cells

25 Citations (Scopus)

ATP-dependent Ca²⁺ accumulation in intracellular membranes of guinea pig macrophages after saponin treatment

Hirata, M. & Koga, T., Feb 26 1982, In : Biochemical and Biophysical Research Communications. 104, 4, p. 1544-1549 6 p.

Research output: Contribution to journal › Article

Intracellular Membranes

Macrophages

Saponins

Guinea Pigs

Adenosine Triphosphate

101 Citations (Scopus)

Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells

Kanematsu, S., Uehara, N., Miki, H., Yoshizawa, K., Kawanaka, A., Yuri, T. & Tsubura, A., Jan 1 2010, In : Anticancer research. 30, 9, p. 3381-3390 10 p.

Research output: Contribution to journal › Article

Autophagy

Apoptosis

Breast Neoplasms

Light

Cell Death

7 Citations (Scopus)

Autophagy in superficial spinal dorsal horn accelerates the cathepsin b-dependent morphine antinociceptive tolerance

Hayashi, Y., Koga, Y., Zhang, X., Peters, C., Yanagawa, Y., Wu, Z., Yokoyama, T. & Nakanishi, H., Sep 5 2014, In : Neuroscience. 275, p. 384-394 11 p.

Research output: Contribution to journal › Article

Cathepsins

Autophagy

Morphine

Cathepsin B

Opioid Analgesics

14 Citations (Scopus)

Bidirectional regulation of telomerase activity in a subline derived from human lung adenocarcinoma

Katakura, Y., Yamamoto, K., Miyake, O., Yasuda, T., Uehara, N., Nakata, E., Kawamoto, S. & Shirahata, S., Aug 18 1997, In : Biochemical and Biophysical Research Communications. 237, 2, p. 313-317 5 p.

Research output: Contribution to journal › Article

Telomerase

Cell Aging

Tumors

Growth

Cells

Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis

Touyama, K., Khan, M., Aoki, K., Matsuda, M., Hiura, F., Takakura, N., Matsubara, T., Harada, Y., Hirohashi, Y., Tamura, Y., Gao, J., Mori, K., Kokabu, S., Yasuda, H., Fujita, Y., Watanabe, K., Takahashi, Y., Maki, K. & Jimi, E., Nov 1 2019, In : Journal of Cellular Biochemistry. 120, 11, p. 18793-18804 12 p.

Research output: Contribution to journal › Article

Bone

Homeostasis

Bone and Bones

Osteoclasts

Osteogenesis

2 Citations (Scopus)

Bilirubin reversibly affects cell death and odontogenic capacity in stem cells from human exfoliated deciduous teeth

Yamaza, H., Tomoda, E., Sonoda, S., Nonaka, K., Kukita, T. & Yamaza, T., Jul 1 2018, In : Oral Diseases. 24, 5, p. 809-819 11 p.

Research output: Contribution to journal › Article

Deciduous Tooth

Bilirubin

Cell Death

Stem Cells

Mitogen-Activated Protein Kinase 3

45 Citations (Scopus)

Binding of 14-3-3β but not 14-3-3σ controls the cytoplasmic localization of CDC25B: Binding site preferences of 14-3-3 subtypes and the subcellular localization of CDC25B

Uchida, S., Kuma, A., Ohtsubo, M., Shimura, M., Hirata, M., Nakagama, H., Matsunaga, T., Ishizaka, Y. & Yamashita, K., Jun 15 2004, In : Journal of Cell Science. 117, 14, p. 3011-3020 10 p.

Research output: Contribution to journal › Article

Serine

Binding Sites

Cytoplasm

Dual-Specificity Phosphatases

Cyclin B

12 Citations (Scopus)

Binding of phospholipase C-related but catalytically inactive protein to phosphatidylinositol 4,5-bisphosphate via the PH domain

Gao, J., Takeuchi, H., Zhang, Z., Fujii, M., Kanematsu, T. & Hirata, M., Jul 1 2009, In : Cellular Signalling. 21, 7, p. 1180-1186 7 p.

Research output: Contribution to journal › Article

Type C Phospholipases

Phosphatidylinositols

Phosphatidylinositol 4,5-Diphosphate

Proteins

Cell Membrane

29 Citations (Scopus)

Biphasic effects of zeranol on the growth of estrogen receptor-positive human breast carcinoma cells

Yuri, T., Tsukamoto, R., Miki, K., Uehara, N., Matsuoka, Y. & Tsubura, A., Dec 1 2006, In : Oncology reports. 16, 6, p. 1307-1312 6 p.

Research output: Contribution to journal › Article

Zeranol

Estrogen Receptors

Breast Neoplasms

Growth

Apoptosis

2 Citations (Scopus)

Bitter Taste Responses of Gustducin-positive Taste Cells in Mouse Fungiform and Circumvallate Papillae

Yoshida, R., Takai, S., Sanematsu, K., Margolskee, R. F., Shigemura, N. & Ninomiya, Y., Jan 15 2018, In : Neuroscience. 369, p. 29-39 11 p.

Research output: Contribution to journal › Article

Transient Receptor Potential Channels

Phospholipases

gustducin

Tongue

Phenylthiourea

BK channels in microglia are required for morphine-induced hyperalgesia

Hayashi, Y., May 31 2016, In : Nature Communications. 7, 11697

Research output: Contribution to journal › Article

Open Access

morphine

Large-Conductance Calcium-Activated Potassium Channels

Hyperalgesia

Microglia

Morphine

24 Citations (Scopus)

BK channels in microglia are required for morphine-induced hyperalgesia

Hayashi, Y., Morinaga, S., Zhang, J., Satoh, Y., Meredith, A. L., Nakata, T., Take, H., Kohsaka, S., Inoue, K. & Nakanishi, H., May 31 2016, In : Nature communications. 7, 11697.

Research output: Contribution to journal › Article

morphine

Large-Conductance Calcium-Activated Potassium Channels

Hyperalgesia

Microglia

Morphine

2 Citations (Scopus)

Boi-ogi-to (TJ-20), a Kampo Formula, Suppresses the Inflammatory Bone Destruction and the Expression of Cytokines in the Synovia of Ankle Joints of Adjuvant Arthritic Rats

Zhang, X., Wu, Z., Liu, Y., Ni, J., Deng, C., Zhao, B., Nakanishi, H., He, J. & Yan, X., Jan 1 2017, In : Evidence-based Complementary and Alternative Medicine. 2017, 3679295.

Research output: Contribution to journal › Article

Kampo Medicine

Experimental Arthritis

Ankle Joint

Synovial Fluid

Rheumatoid Arthritis

Both PTB domain and PH domain of IRS-1 bind inositol polyphosphates with distinct specificity

Takeuchi, H., Matsuda, M., Kanematsu, T. & Hirata, M., 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journal › Article

Insulin Receptor Substrate Proteins

Polyphosphates

Inositol

Tyrosine

Inositol Phosphates

1 Citation (Scopus)

Brazilian Green Propolis Prevents Cognitive Decline into Mild Cognitive Impairment in Elderly People Living at High Altitude

Zhu, A., Take, H., Zhong, X., Ni, J., Li, Y., Meng, J., Du, C., Zhao, X., Nakanishi, H. & Wu, S., Jan 1 2018, In : Journal of Alzheimer's Disease. 63, 2, p. 551-560 10 p.

Research output: Contribution to journal › Article

Propolis

Placebos

Inflammation

Serum

Interleukin-1

16 Citations (Scopus)

Brazilian green propolis suppresses the hypoxia-induced neuroinflammatory responses by inhibiting NF- B activation in microglia

Wu, Z., Zhu, A., Takayama, F., Okada, R., Liu, Y., Harada, Y., Wu, S. & Nakanishi, H., Sep 3 2013, In : Oxidative medicine and cellular longevity. 906726.

Research output: Contribution to journal › Article

Propolis

Microglia

Chemical activation

Interleukin-1

Interleukin-6

1 Citation (Scopus)

Ca²⁺/calmodulin independent inositol 1,4,5-trisphosphate 3-kinase activity in guinea pig peritoneal macrophages

Kimura, Y., Watanabe, Y., Ozaki, S., Koga, T. & Hirata, M., Jan 1 1990, In : Comparative Biochemistry and Physiology -- Part B: Biochemistry and. 97, 3, p. 527-533 7 p.

Research output: Contribution to journal › Article

Inositol 1,4,5-trisphosphate 3-kinase

Macrophages

Peritoneal Macrophages

Calmodulin

Guinea Pigs

1 Citation (Scopus)

Ca ²⁺ dependence of inositol 1,4,5-trisphosphate 3-kinase activity in the cytosol fraction of pig coronary artery

Yamaguchi, K., Hirata, M., Ishimatsu, T. & Kuriyama, H., Jan 1 1989, In : Comparative Biochemistry and Physiology. Part C, Comparative. 92, 1, p. 163-166 4 p.

Research output: Contribution to journal › Article

Inositol 1,4,5-trisphosphate 3-kinase

Cytosol

Coronary Vessels

Phosphotransferases

Swine

Ca2+ dependence of inositol 1,4,5-trisphosphate 3-kinase activity in the cytosol fraction of pig coronary artery.

Yamaguchi, K., Hirata, M., Ishimatsu, T. & Kuriyama, H., Jan 1 1989, In : Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. 92, 1, p. 163-166 4 p.

Research output: Contribution to journal › Article

Inositol 1,4,5-trisphosphate 3-kinase

Cytosol

Muscle

Coronary Vessels

Phosphotransferases

12 Citations (Scopus)

Ca²⁺-dependent regulation of calcitonin gene expression by the transcriptional repressor DREAM

Matsuda, M., Yamamoto, T. A. & Hirata, M., Sep 22 2006, In : Endocrinology. 147, 10, p. 4608-4617 10 p.

Research output: Contribution to journal › Article

Calcitonin

Gene Expression Regulation

Cyclic AMP Response Element Modulator

Kv Channel-Interacting Proteins

Gene Expression

10 Citations (Scopus)

Ca²⁺ influx evoked by inositol-3,4,5,6-tetrakisphosphate in ras-transformed NIH/3T3 fibroblasts

Hashii, M., Hirata, M., Ozaki, S., Nozawa, Y. & Higashida, H., Mar 7 1994, In : FEBS Letters. 340, 3, p. 276-280 5 p.

Research output: Contribution to journal › Article

Fibroblasts

Bradykinin Receptors

NIH 3T3 Cells

Inositol 1,4,5-Trisphosphate

Second Messenger Systems

10 Citations (Scopus)

Ca²⁺-influx gated by inositol-3,4,5,6-tetrakisphosphate in NIH/3T3 fibroblasts

Hashii, M., Hirata, M., Ozaki, S., Nozawa, Y. & Higashida, H., May 15 1994, In : Biochemical and Biophysical Research Communications. 200, 3, p. 1300-1306 7 p.

Research output: Contribution to journal › Article

Fibroblasts

Bradykinin

Inositol

NIH 3T3 Cells

Fura-2

25 Citations (Scopus)

Ca²⁺ regulation in vascular smooth muscle

Hirata, M., Mikawa, T., Nonomura, Y. & Ebashi, S., Jan 1 1977, In : Journal of biochemistry. 82, 6, p. 1793-1796 4 p.

Research output: Contribution to journal › Article

Vascular Smooth Muscle

Smooth Muscle

Muscle

Aorta

Tropomyosin

30 Citations (Scopus)

Ca²⁺ regulation in vascular smooth muscle: II. Ca²⁺ binding of aorta leiotonin

Hirata, M., Mikawa, T., Nonomura, Y. & Ebashi, S., Jan 1 1980, In : Journal of biochemistry. 87, 2, p. 369-378 10 p.

Research output: Contribution to journal › Article

Vascular Smooth Muscle

Muscle

Aorta

Phosphorylation

Actins

10 Citations (Scopus)

Calcium-dependent hyperexcitability of hippocampal CA1 pyramidal cells in an in vitro slice after ethanol withdrawal of the rat

Shindou, T., Watanabe, S., Kamata, O., Yamamoto, K. & Nakanishi, H., Sep 12 1994, In : Brain Research. 656, 2, p. 432-436 5 p.

Research output: Contribution to journal › Article

Pyramidal Cells

Ethanol

Calcium

Neurons

Calcium Signaling

10 Citations (Scopus)

Calcium imaging for detection and estimation of spike activities in Aplysia neurons

Yoshida, R., Iwamoto, A. & Nagahama, T., Jul 1 2001, In : Zoological science. 18, 5, p. 631-643 13 p.

Research output: Contribution to journal › Article

neurons

image analysis

calcium

dyes

cells

31 Citations (Scopus)

Calmodulin activates inositol 1,4,5-trisphosphate 3-kinase activity in pig aortic smooth muscle.

Yamaguchi, K., Hirata, M. & Kuriyama, H., Jan 1 1987, In : The Biochemical journal. 244, 3, p. 787-791 5 p.

Research output: Contribution to journal › Article

Inositol 1,4,5-trisphosphate 3-kinase

Calmodulin

Smooth Muscle

Muscle

Swine

19 Citations (Scopus)

Calmodulin antagonists inhibit Ca ²⁺ uptake of mitochondria of guinea pig peritoneal macrophages

Hirata, M., Suematsu, E. & Koga, T., Apr 14 1982, In : Biochemical and Biophysical Research Communications. 105, 3, p. 1176-1181 6 p.

Research output: Contribution to journal › Article

Mitochondria

Macrophages

Peritoneal Macrophages

Calmodulin

Guinea Pigs

20 Citations (Scopus)

Calpain inhibition restores basal autophagy and suppresses MNU-induced photoreceptor cell death in mice

Kuro, M., Yoshizawa, K., Uehara, N., Miki, H., Takahashi, K. & Tsubura, A., Jul 1 2011, In : In Vivo. 25, 4, p. 617-623 7 p.

Research output: Contribution to journal › Article

Photoreceptor Cells

Calpain

Autophagy

Cell death

Cell Death

18 Citations (Scopus)

Capsaicin receptor expression in the rat temporomandibular joint

Ioi, H., Kido, M. A., Zhang, J. Q., Yamaza, T., Nakata, S., Nakasima, A. & Tanaka, T., Jul 1 2006, In : Cell and tissue research. 325, 1, p. 47-54 8 p.

Research output: Contribution to journal › Article

TRPV Cation Channels

Temporomandibular Joint

Joint Capsule

Nociception

Synovial Membrane

15 Citations (Scopus)

Ca release in the endoplasmic reticulum of Guinea pig peritoneal macrophages ¹

Hirata, M., Hamachi, T., Hashimoto, T., Suematsu, E. & Koga, T., Jan 1 1983, In : Journal of biochemistry. 94, 4, p. 1155-1163 9 p.

Research output: Contribution to journal › Article

Macrophages

Peritoneal Macrophages

Endoplasmic Reticulum

Guinea Pigs

Adenine

2 Citations (Scopus)

Catabolic effects of muramyl dipeptide on rabbit chondrocytes

Ikebe, T., Iribe, H., Hirata, M., Yanaga, F. & Koga, T., 1990, In : Arthritis and Rheumatism. 33, 12, p. 1801-1806 6 p.

Research output: Contribution to journal › Article

Acetylmuramyl-Alanyl-Isoglutamine

Proteoglycans

Chondrocytes

Glycosaminoglycans

Rabbits

21 Citations (Scopus)

Cathepsin B-dependent motor neuron death after nerve injury in the adult mouse

Sun, L., Take, H., Baba, M., Peters, C., Uchiyama, Y. & Nakanishi, H., Aug 1 2010, In : Biochemical and Biophysical Research Communications. 399, 3, p. 391-395 5 p.

Research output: Contribution to journal › Article

Cathepsin B

Motor Neurons

Neurons

Wounds and Injuries

Noxae

24 Citations (Scopus)

Cathepsin B plays a critical role in inducing Alzheimer's disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice

Take, H., Ni, J., Liu, Y., Teeling, J. L., Takayama, F., Collcutt, A., Ibbett, P. & Nakanishi, H., Oct 1 2017, In : Brain, Behavior, and Immunity. 65, p. 350-361 12 p.

Research output: Contribution to journal › Article

Cathepsin B

Porphyromonas gingivalis

Microglia

Lipopolysaccharides

Alzheimer Disease

11 Citations (Scopus)

Cathepsin B Regulates Collagen Expression by Fibroblasts via Prolonging TLR2/NF-κB Activation

Li, X., Wu, Z., Ni, J., Liu, Y., Meng, J., Yu, W., Nakanishi, H. & Zhou, Y., Jan 1 2016, In : Oxidative medicine and cellular longevity. 2016, 7894247.

Research output: Contribution to journal › Article

Cathepsin B

Fibroblasts

Collagen

Chemical activation

yeast proteinase B

287 Citations (Scopus)

Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons

Koike, M., Nakanishi, H., Saftig, P., Ezaki, J., Isahara, K., Ohsawa, Y., Schulz-Schaeffer, W., Watanabe, T., Waguri, S., Kametaka, S., Shibata, M., Yamamoto, K., Kominami, E., Peters, C., Von Figura, K. & Uchiyama, Y., Sep 15 2000, In : Journal of Neuroscience. 20, 18, p. 6898-6906 9 p.

Research output: Contribution to journal › Article

Ceroid

Lipofuscin

Cathepsin D

Neurons

Brain

16 Citations (Scopus)

Cathepsin D deficiency induces oxidative damage in brain pericytes and impairs the blood-brain barrier

Okada, R., Take, H., Zhu, A., Ni, J., Zhang, J., Yoshito, Y., Peters, C., Saftig, P. & Nakanishi, H., Jan 1 2015, In : Molecular and Cellular Neuroscience. 64, p. 51-60 10 p.

Research output: Contribution to journal › Article

Pericytes

Cathepsin D

Blood-Brain Barrier

Brain

Blood Cells

1 Citation (Scopus)

Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis

Harada, Y., Zhang, J., Imari, K., Yamasaki, R., Ni, J., Take, H., Yamamoto, K., Kira, J-I., Nakanishi, H. & Hayashi, Y., Sep 1 2019, In : Pain. 160, 9, p. 2050-2062 13 p.

Research output: Contribution to journal › Article

Cathepsin E

Autoimmune Experimental Encephalomyelitis

Neuralgia

Neutrophils

Hyperalgesia

4 Citations (Scopus)

Cathepsin E in the central nervous system

Nakanishi, H. & Yamamoto, K., Jan 1 1998, In : Advances in experimental medicine and biology. 436, p. 213-217 5 p.

Research output: Contribution to journal › Article

Cathepsin E

Neurology

Cathepsin H deficiency in mice induces excess Th1 cell activation and early-onset of EAE though impairment of toll-like receptor 3 cascade

Okada, R., Zhang, X., Harada, Y., Take, H. & Nakanishi, H., May 1 2018, In : Inflammation Research. 67, 5, p. 371-374 4 p.

Research output: Contribution to journal › Article

Cathepsin H

Toll-Like Receptor 3

Th1 Cells

Autoimmune Experimental Encephalomyelitis

Interferon Regulatory Factor-3

2 Citations (Scopus)

Cathepsin S Is Involved in Th17 Differentiation Through the Upregulation of IL-6 by Activating PAR-2 after Systemic Exposure to Lipopolysaccharide from Porphyromonas gingivalis

Dekita, M., Wu, Z., Ni, J., Zhang, X., Liu, Y., Yan, X., Nakanishi, H. & Takahashi, I., 2017, In : Frontiers in Pharmacology. 8, p. 470

Research output: Contribution to journal › Article

cathepsin S

PAR-2 Receptor

Porphyromonas gingivalis

Lipopolysaccharides

Interleukin-6

Ccr7 null mice are protected against diet-induced obesity via Ucp1 upregulation and enhanced energy expenditure

Sano, T., Sanada, T., Sotomaru, Y., Shinjo, T., Iwashita, M., Yamashita, A., Fukuda, T., Sanui, T., Asano, T., Kanematsu, T. & Nishimura, F., Jul 4 2019, In : Nutrition and Metabolism. 16, 1, 43.

Research output: Contribution to journal › Article

Open Access

Energy Metabolism

Up-Regulation

Obesity

Diet

White Adipose Tissue

18 Citations (Scopus)

Celecoxib-induced degradation of T-cell factors-1 and -4 in human colon cancer cells

Takahashi-Yanaga, F., Yoshihara, T., Jingushi, K., Miwa, Y., Morimoto, S., Hirata, M. & Sasaguri, T., Dec 26 2008, In : Biochemical and Biophysical Research Communications. 377, 4, p. 1185-1190 6 p.

Research output: Contribution to journal › Article

Celecoxib

Transcription Factor 7-Like 2 Protein

T Cell Transcription Factor 1

Colonic Neoplasms

Cells

116 Citations (Scopus)

Cell-based immunotherapy with mesenchymal stem cells cures bisphosphonate-related osteonecrosis of the jaw-like disease in mice

Kikuiri, T., Kim, I., Yamaza, T., Akiyama, K., Zhang, Q., Li, Y., Chen, C., Chen, W. J., Wang, S., Le, A. D. & Shi, S., Jul 1 2010, In : Journal of Bone and Mineral Research. 25, 7, p. 1668-1679 12 p.

Research output: Contribution to journal › Article

Jaw Diseases

Bisphosphonate-Associated Osteonecrosis of the Jaw

Mesenchymal Stromal Cells

Immunotherapy

zoledronic acid

16 Citations (Scopus)

Cell cycle-dependent regulation of kainate-induced inward currents in microglia

Yamada, J., Sawada, M. & Nakanishi, H., Oct 27 2006, In : Biochemical and Biophysical Research Communications. 349, 3, p. 913-919 7 p.

Research output: Contribution to journal › Article

Kainic Acid

Induced currents

Microglia

Cell Cycle

Cells

1 Citation (Scopus)

Cerebromalacia with epilepsy and cortical blindness in a laboratory Japanese macaque (Macaca fuscata).

Yoshizawa, K., Nakao, K., Habiro, M., Hayashi, K., Kuwata, M., Uehara, N., Yuri, T., Nakamura, K. & Tsubura, A., Dec 1 2010, In : Toxicologic pathology. 38, 7, p. 1058-1063 6 p.

Research output: Contribution to journal › Article

Encephalomalacia

Cortical Blindness

Macaca

Epilepsy

Haplorhini

17 Citations (Scopus)

Changes in amygdaloid afterdischarges and kindling effect following olfactory bulbectomy in the rat

Watanabe, S., Nakanishi, H., Shibata, S. & Ueki, S., Jan 1 1982, In : Physiology and Behavior. 28, 4, p. 687-692 6 p.

Research output: Contribution to journal › Article

Amygdala

Electrodes

Corticomedial Nuclear Complex

Changes in neuronal activity and in susceptibility to noradrenaline in the amygdala following olfactory bulbectomy

Nakanishi, H., Hori, N. & Katsuda, N., 1981, In : Japanese Journal of Pharmacology. 31, Suppl.

Research output: Contribution to journal › Article

Amygdala

Norepinephrine