Research Output 1977 2019

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2010
56 Citations (Scopus)

Involvement of cathepsin B in the processing and secretion of interleukin-1β in chromogranin a-stimulated microglia

Terada, K., Yamada, J., Hayashi, Y., Wu, Z., Uchiyama, Y., Peters, C. & Nakanishi, H., Jan 8 2010, In : GLIA. 58, 1, p. 114-124 11 p.

Research output: Contribution to journalArticle

Chromogranins
Cathepsin B
Microglia
Interleukin-1
Interleukins
20 Citations (Scopus)

New insights into the signal transmission from taste cells to gustatory nerve fibers

Yoshida, R. & Ninomiya, Y., Jan 1 2010, In : International Review of Cell and Molecular Biology. 279, C, p. 101-134 34 p.

Research output: Contribution to journalArticle

Nerve Fibers
Fibers
Chemical compounds
Taste Buds
Transmitters
5 Citations (Scopus)

Orofacial movements in phospholipase C-related catalytically inactive protein-1/2 double knockout mice: Effect of the GABAergic agent diazepam and the D1 dopamine receptor agonist SKF 83959

Tomiyama, K., Song, L., Kobayashi, M., Kinsella, A., Kanematsu, T., Hirata, M., Koshikawa, N. & Waddington, J. L., Jan 1 2010, In : Synapse. 64, 9, p. 714-720 7 p.

Research output: Contribution to journalArticle

GABA Agents
Dopamine Agonists
Type C Phospholipases
Diazepam
Knockout Mice
24 Citations (Scopus)

Phosphatidylserine-containing liposomes inhibit the differentiation of osteoclasts and trabecular bone loss

Take, H., Ma, H. M., Kukita, T., Nakanishi, Y. & Nakanishi, H., Mar 15 2010, In : Journal of Immunology. 184, 6, p. 3191-3201 11 p.

Research output: Contribution to journalArticle

Phosphatidylserines
Osteoclasts
Liposomes
Dinoprostone
Experimental Arthritis
40 Citations (Scopus)

Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of γ-aminobutyric acid type A receptors

Fujii, M., Kanematsu, T., Ishibashi, H., Fukami, K., Takenawa, T., Nakayama, K., Moss, S. J., Nabekura, J. & Hirata, M., Feb 12 2010, In : Journal of Biological Chemistry. 285, 7, p. 4837-4846 10 p.

Research output: Contribution to journalArticle

Aminobutyrates
Type C Phospholipases
GABA-A Receptors
Insulin
Neurons
52 Citations (Scopus)

Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors

Parsa, S., Kuremoto, K. I., Seidel, K., Tabatabai, R., MacKenzie, B. A., Yamaza, T., Akiyama, K., Branch, J., Koh, C. J., Al Alam, D., Klein, O. D. & Bellusci, S., Nov 15 2010, In : Development. 137, 22, p. 3743-3752 10 p.

Research output: Contribution to journalArticle

Receptor, Fibroblast Growth Factor, Type 2
Incisor
Ameloblasts
Dental Enamel
Stem Cells

Surface expression of gabaA receptors: Roles for the binding partners

Kanematsu, T., Fujii, M., Tanaka, H., Umebayashi, H. & Hirata, M., Jan 1 2010, In : journal of oral biosciences. 52, 4, p. 322-329 8 p.

Research output: Contribution to journalArticle

Phosphorylation
GABA-A Receptors
Endocytosis
Mastication
Ligand-Gated Ion Channels
246 Citations (Scopus)

Taste preference for fatty acids is mediated by GPR40 and GPR120

Cartoni, C., Nakano, K., Ohkuri, T., Shigemura, N., Yoshida, R., Godinot, N., Le Coutre, J., Ninomiya, Y. & Damak, S., Jun 23 2010, In : Journal of Neuroscience. 30, 25, p. 8376-8382 7 p.

Research output: Contribution to journalArticle

Fatty Acids
Taste Buds
Smell
Linoleic Acid
Oleic Acid
168 Citations (Scopus)

Utility of PDL progenitors for in vivo tissue regeneration: A report of 3 cases

Feng, F., Akiyama, K., Liu, Y., Yamaza, T., Wang, T. M., Chen, J. H., Wang, B. B., Huang, G. T. J., Wang, S. & Shi, S., Jan 1 2010, In : Oral Diseases. 16, 1, p. 20-28 9 p.

Research output: Contribution to journalArticle

Regeneration
Periodontal Ligament
Stem Cells
Transplantation
Gingival Recession
2009
36 Citations (Scopus)

A possible suppressive role of galectin-3 in upregulated osteoclastogenesis accompanying adjuvant-induced arthritis in rats

Li, Y. J., Kukita, A., Teramachi, J., Nagata, K., Take, H., Akamine, A. & Kukita, T., Jan 1 2009, In : Laboratory Investigation. 89, 1, p. 26-37 12 p.

Research output: Contribution to journalArticle

Galectin 3
Experimental Arthritis
Osteogenesis
Osteoclasts
Bone and Bones
12 Citations (Scopus)

Binding of phospholipase C-related but catalytically inactive protein to phosphatidylinositol 4,5-bisphosphate via the PH domain

Gao, J., Takeuchi, H., Zhang, Z., Fujii, M., Kanematsu, T. & Hirata, M., Jul 1 2009, In : Cellular Signalling. 21, 7, p. 1180-1186 7 p.

Research output: Contribution to journalArticle

Type C Phospholipases
Phosphatidylinositols
Phosphatidylinositol 4,5-Diphosphate
Proteins
Cell Membrane
62 Citations (Scopus)

Discrimination of taste qualities among mouse fungiform taste bud cells

Yoshida, R., Miyauchi, A., Yasuo, T., Jyotaki, M., Murata, Y., Nakano, K., Shigemura, N., Yanagawa, Y., Obata, K., Ueno, H., Margolskee, R. F. & Ninomiya, Y., Sep 1 2009, In : Journal of Physiology. 587, 18, p. 4425-4439 15 p.

Research output: Contribution to journalArticle

Taste Buds
5 Citations (Scopus)

Distribution of substance P and neurokinin-1 receptors in the peri-implant epithelium around titanium dental implants in rats

Yamaza, T., Kido, M. A., Wang, B., Danjo, A., Shimohira, D., Murata, N., Yoshinari, M. & Tanaka, T., Feb 1 2009, In : Cell and tissue research. 335, 2, p. 407-415 9 p.

Research output: Contribution to journalArticle

Neurokinin-1 Receptors
Dental Implants
Substance P
Titanium
Epithelium
39 Citations (Scopus)

Ganoderic acid DM: Anti-androgenic osteoclastogenesis inhibitor

Liu, J., Shiono, J., Shimizu, K., Kukita, A., Kukita, T. & Kondo, R., Apr 15 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 8, p. 2154-2157 4 p.

Research output: Contribution to journalArticle

Androgen Receptors
Cell growth
Osteogenesis
Prostatic Neoplasms
Oxidoreductases
7 Citations (Scopus)

Genetically-increased taste cell population with Gα-gustducin-coupled sweet receptors is associated with increase of gurmarin-sensitive taste nerve fibers in mice

Nakano, K., Ohkuri, T., Sanematsu, K., Shigemura, N., Katsukawa, H., Sako, N. & Ninomiya, Y., Dec 22 2009, In : BMC Neuroscience. 10, 152.

Research output: Contribution to journalArticle

Nerve Fibers
Population
Vulnerable Populations
gustducin
Gymnema sylvestre Gurmarin protein
59 Citations (Scopus)

Genetic and molecular basis of individual differences in human umami taste perception

Shigemura, N., Shirosaki, S., Sanematsu, K., Yoshida, R. & Ninomiya, Y., Aug 21 2009, In : PLoS One. 4, 8, e6717.

Research output: Contribution to journalArticle

Taste Perception
umami
Sodium Glutamate
Individuality
Molecular Biology
6 Citations (Scopus)

hnRNP U interacts with the c-Myc-Max complex on the E-box promoter region inducing the ornithine decarboxylase gene

Matsuoka, Y., Uehara, N. & Tsubura, A., Aug 13 2009, In : Oncology reports. 22, 2, p. 249-255 7 p.

Research output: Contribution to journalArticle

Ornithine Decarboxylase
Nuclear Proteins
Genetic Promoter Regions
Genes
Heterogeneous-Nuclear Ribonucleoprotein U
24 Citations (Scopus)

Involvement of phospholipase C-related inactive protein in the mouse reproductive system through the regulation of gonadotropin levels

Matsuda, M., Tsutsumi, K., Kanematsu, T., Fukami, K., Terada, Y., Takenawa, T., Nakayama, K. & Hirata, M., Dec 1 2009, In : Biology of Reproduction. 81, 4, p. 681-689 9 p.

Research output: Contribution to journalArticle

Type C Phospholipases
Gonadotropins
Knockout Mice
Luteinizing Hormone
Proteins
31 Citations (Scopus)

Mesenchymal stem cell-mediated ectopic hematopoiesis alleviates aging-related phenotype in immunocompromised mice

Yamaza, T., Miura, Y., Akiyama, K., Bi, Y., Sonoyama, W., Gronthos, S., Chen, W., Le, A. & Shi, S., Mar 12 2009, In : Blood. 113, 11, p. 2595-2604 10 p.

Research output: Contribution to journalArticle

Hematopoiesis
Stem cells
Mesenchymal Stromal Cells
Bone
Aging of materials
373 Citations (Scopus)

Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans

Sun, L., Akiyama, K., Zhang, H., Yamaza, T., Hou, Y., Zhao, S., Xu, T., Le, A. & Shi, S., Jun 1 2009, In : STEM CELLS. 27, 6, p. 1421-1432 12 p.

Research output: Contribution to journalArticle

Mesenchymal Stem Cell Transplantation
Systemic Lupus Erythematosus
Bone Marrow
Inbred MRL lpr Mouse
Salvage Therapy
52 Citations (Scopus)

Multiple receptors underlie glutamate taste responses in mice

Nakano, K., Horio, N., Murata, Y., Shirosaki, S., Ohkuri, T., Yoshida, R. & Ninomiya, Y., Sep 1 2009, In : American Journal of Clinical Nutrition. 90, 3

Research output: Contribution to journalArticle

Glutamate Receptors
Brain
Nerve Fibers
Knockout Mice
Glutamic Acid
53 Citations (Scopus)

NaCl responsive taste cells in the mouse fungiform taste buds

Yoshida, R., Horio, N., Murata, Y., Nakano, K., Shigemura, N. & Ninomiya, Y., Mar 17 2009, In : Neuroscience. 159, 2, p. 795-803 9 p.

Research output: Contribution to journalArticle

Taste Buds
Amiloride
Chorda Tympani Nerve
Epithelial Sodium Channel Blockers
Nerve Fibers
12 Citations (Scopus)

N-methyl-N-nitrosourea-induced retinal degeneration in mice is independent of the p53 gene.

Yoshizawa, K., Kuwata, M., Kawanaka, A., Uehara, N., Yuri, T. & Tsubura, A., Jan 1 2009, In : Molecular vision. 15, p. 2919-2925 7 p.

Research output: Contribution to journalArticle

Methylnitrosourea
Retinal Degeneration
p53 Genes
Photoreceptor Cells
Vertebrate Photoreceptor Cells
25 Citations (Scopus)
Osteoprotegerin
Platelet-Rich Plasma
Osteogenesis
Bone Marrow Cells
Blood Platelets
25 Citations (Scopus)

Predominant promotion by tacrolimus of chondrogenic differentiation to proliferating chondrocytes

Kyumoto, Y., Takarada, T., Kodama, A., Hinoi, E. & Yoneda, Y., Jun 22 2009, In : Journal of Pharmacological Sciences. 109, 3, p. 413-423 11 p.

Research output: Contribution to journalArticle

Tacrolimus
Chondrocytes
Alcian Blue
Alkaline Phosphatase
Transcription Factors
35 Citations (Scopus)

Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum

Miyamoto, I., Liu, J., Shimizu, K., Sato, M., Kukita, A., Kukita, T. & Kondo, R., Jan 5 2009, In : European Journal of Pharmacology. 602, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Reishi
Osteogenesis
Bone Density
Ethanol
NFATC Transcription Factors
76 Citations (Scopus)

Stem cell property of postmigratory cranial neural crest cells and their utility in alveolar bone regeneration and tooth development

Chung, I. H., Yamaza, T., Zhao, H., Choung, P. H., Shi, S. & Chai, Y., Apr 1 2009, In : STEM CELLS. 27, 4, p. 866-877 12 p.

Research output: Contribution to journalArticle

Bone Regeneration
Neural Crest
Tooth
Stem Cells
Tooth Germ
179 Citations (Scopus)

Sweet taste receptor expressed in pancreatic β-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion

Nakagawa, Y., Nagasawa, M., Yamada, S., Hara, A., Mogami, H., Nikolaev, V. O., Lohse, M. J., Shigemura, N., Ninomiya, Y. & Kojima, I., Apr 8 2009, In : PloS one. 4, 4, e5106.

Research output: Contribution to journalArticle

trichlorosucrose
insulin secretion
cyclic AMP
Cyclic AMP
sucralose
15 Citations (Scopus)

TRPV2 expression in rat oral mucosa

Shimohira, D., Kido, M. A., Danjo, A., Takao, T., Wang, B., Zhang, J. Q., Yamaza, T., Masuko, S., Goto, M. & Tanaka, T., Oct 1 2009, In : Histochemistry and Cell Biology. 132, 4, p. 423-433 11 p.

Research output: Contribution to journalArticle

Mouth Mucosa
Epithelial Cells
Axons
Epithelium
Macrophages
47 Citations (Scopus)

Tumor-like stem cells derived from human keloid are governed by the inflammatory niche driven by IL-17/IL-6 axis

Zhang, Q., Yamaza, T., Kelly, A. P., Shi, S., Wang, S., Brown, J., Wang, L., French, S. W., Shi, S. & Le, A. D., Nov 11 2009, In : PloS one. 4, 11, e7798.

Research output: Contribution to journalArticle

Keloid
Neoplastic Stem Cells
Interleukin-17
Stem cells
interleukin-6
51 Citations (Scopus)

Variation in umami perception and in candidate genes for the umami receptor in mice and humans

Shigemura, N., Shirosaki, S., Ohkuri, T., Sanematsu, K., Islam, A. A. S., Ogiwara, Y., Kawai, M., Yoshida, R. & Ninomiya, Y., Sep 1 2009, In : American Journal of Clinical Nutrition. 90, 3, p. 764S-769S

Research output: Contribution to journalArticle

Genes
Rodentia
Taste Perception
Guanosine Monophosphate
Purine Nucleotides
2008
63 Citations (Scopus)

Adiponectin inhibits induction of TNF-α/RANKL-stimulated NFATc1 via the AMPK signaling

Yamaguchi, N., Kukita, T., Li, Y. J., Kamio, N., Fukumoto, S., Nonaka, K., Ninomiya, Y., Hanazawa, S. & Yamashita, Y., Feb 6 2008, In : FEBS Letters. 582, 3, p. 451-456 6 p.

Research output: Contribution to journalArticle

NFATC Transcription Factors
AMP-Activated Protein Kinases
Adiponectin
Tumor Necrosis Factor-alpha
Osteoclasts
34 Citations (Scopus)

Age-dependent responses of glial cells and leptomeninges during systemic inflammation

Take, H., Tokuda, Y., Zhang, X. W. & Nakanishi, H., Dec 1 2008, In : Neurobiology of Disease. 32, 3, p. 543-551 9 p.

Research output: Contribution to journalArticle

Occludin
Neuroglia
Experimental Arthritis
Inflammation
Transforming Growth Factors
42 Citations (Scopus)

Amiloride-sensitive NaCl taste responses are associated with genetic variation of ENaC α-subunit in mice

Shigemura, N., Ohkuri, T., Sadamitsu, C., Nakano, K., Yoshida, R., Beauchamp, G. K., Bachmanov, A. A. & Ninomiya, Y., Jan 1 2008, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 294, 1

Research output: Contribution to journalArticle

Epithelial Sodium Channels
Amiloride
Single Nucleotide Polymorphism
Salts
Chorda Tympani Nerve
17 Citations (Scopus)

Celecoxib-induced degradation of T-cell factors-1 and -4 in human colon cancer cells

Takahashi-Yanaga, F., Yoshihara, T., Jingushi, K., Miwa, Y., Morimoto, S., Hirata, M. & Sasaguri, T., Dec 26 2008, In : Biochemical and Biophysical Research Communications. 377, 4, p. 1185-1190 6 p.

Research output: Contribution to journalArticle

Celecoxib
Transcription Factor 7-Like 2 Protein
T Cell Transcription Factor 1
Colonic Neoplasms
Cells
85 Citations (Scopus)

Diurnal variation of human sweet taste recognition thresholds is correlated with plasma leptin levels

Nakamura, Y., Sanematsu, K., Ohta, R., Shirosaki, S., Koyano, K., Nonaka, K., Shigemura, N. & Ninomiya, Y., Oct 1 2008, In : Diabetes. 57, 10, p. 2661-2665 5 p.

Research output: Contribution to journalArticle

Taste Threshold
Leptin
Meals
Leptin Receptors
Sodium Glutamate
25 Citations (Scopus)

Gurmarin sensitivity of sweet taste responses is associated with co-expression patterns of T1r2, T1r3, and gustducin

Shigemura, N., Nakao, K., Yasuo, T., Murata, Y., Nakano, K., Nakashima, A., Katsukawa, H., Sako, N. & Ninomiya, Y., Mar 7 2008, In : Biochemical and Biophysical Research Communications. 367, 2, p. 356-363 8 p.

Research output: Contribution to journalArticle

gustducin
Gymnema sylvestre Gurmarin protein
Congenic Mice
GTP-Binding Proteins
Tongue
12 Citations (Scopus)

Induction of a novel histone deacetylase 1/c-Myc/Mnt/Max complex formation is implicated in parity-induced refractoriness to mammary carcinogenesis

Matsuoka, Y., Fukamachi, K., Uehara, N., Tsuda, H. & Tsubura, A., Feb 1 2008, In : Cancer Science. 99, 2, p. 309-315 7 p.

Research output: Contribution to journalArticle

Histone Deacetylase 1
Human Mammary Glands
Parity
Carcinogenesis
Breast
17 Citations (Scopus)

Possible involvement of cathepsin B released by microglia in methylmercury-induced cerebellar pathological changes in the adult rat

Sakamoto, M., Miyamoto, K. I., Take, H. & Nakanishi, H., Sep 19 2008, In : Neuroscience Letters. 442, 3, p. 292-296 5 p.

Research output: Contribution to journalArticle

Cathepsin B
Microglia
Cerebellum
Cysteine Proteases
Poisons
34 Citations (Scopus)

Reduced synaptic activity precedes synaptic stripping in vagal motoneurons after axotomy

Yamada, J., Hayashi, Y., Jinno, S., Take, H., Inoue, K., Kohsaka, S. & Nakanishi, H., Oct 1 2008, In : GLIA. 56, 13, p. 1448-1462 15 p.

Research output: Contribution to journalArticle

Axotomy
Motor Neurons
Neurons
Wounds and Injuries
Microglia
104 Citations (Scopus)

Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor A in mice

Hayashi, Y., Yoshida, M., Yamato, M., Ide, T., Take, H., Ochi-Shindou, M., Kanki, T., Kang, D., Sunagawa, K., Tsutsui, H. & Nakanishi, H., Aug 20 2008, In : Journal of Neuroscience. 28, 34, p. 8624-8634 11 p.

Research output: Contribution to journalArticle

Microglia
Mitochondrial DNA
Transgenic Mice
DNA Damage
Lipopolysaccharides
62 Citations (Scopus)

The taste transduction channel TRPM5 is a locus for bitter-sweet taste interactions

Talavera, K., Nakano, K., Yoshida, R., Margolskee, R. F., Voets, T., Ninomiya, Y. & Nilius, B., May 1 2008, In : FASEB Journal. 22, 5, p. 1343-1355 13 p.

Research output: Contribution to journalArticle

Quinine
loci
quinine
bitter-tasting compounds
Sucrose
2007
88 Citations (Scopus)

Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor

Hisatsune, C., Nakano, K., Takahashi-Iwanaga, H., Ogawa, N., Kuroda, Y., Yoshida, R., Ninomiya, Y. & Mikoshiba, K., Dec 21 2007, In : Journal of Biological Chemistry. 282, 51, p. 37225-37231 7 p.

Research output: Contribution to journalArticle

Taste Perception
Inositol 1,4,5-Trisphosphate Receptors
Chemical activation
Physiological Phenomena
Type C Phospholipases
81 Citations (Scopus)

Adiponectin inhibits osteoclast formation stimulated by lipopolysaccharide from Actinobacillus actinomycetemcomitans

Yamaguchi, N., Kukita, T., Li, Y. J., Martinez Argueta, J. G., Saito, T., Hanazawa, S. & Yamashita, Y., Feb 1 2007, In : FEMS Immunology and Medical Microbiology. 49, 1, p. 28-34 7 p.

Research output: Contribution to journalArticle

Aggregatibacter actinomycetemcomitans
Adiponectin
Osteoclasts
Lipopolysaccharides
Toll-Like Receptor 4
23 Citations (Scopus)

Cystatin C stimulates the differentiation of mouse osteoblastic cells and bone formation

Danjo, A., Yamaza, T., Kido, M. A., Shimohira, D., Tsukuba, T., Kagiya, T., Yamashita, Y., Nishijima, K., Masuko, S., Goto, M. & Tanaka, T., Aug 17 2007, In : Biochemical and Biophysical Research Communications. 360, 1, p. 199-204 6 p.

Research output: Contribution to journalArticle

Cystatin C
Osteogenesis
Bone
Cysteine Proteinase Inhibitors
Osteoblasts
124 Citations (Scopus)

Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation

Wake, H., Watanabe, M., Moorhouse, A. J., Kanematsu, T., Horibe, S., Matsukawa, N., Asai, K., Ojika, K., Hirata, M. & Nabekura, J., Feb 14 2007, In : Journal of Neuroscience. 27, 7, p. 1642-1650 9 p.

Research output: Contribution to journalArticle

Down-Regulation
Phosphorylation
Tyrosine
Neurons
Oxidative Stress
87 Citations (Scopus)

Human Hertwig's epithelial root sheath cells play crucial roles in cementum formation

Sonoyama, W., Seo, B. M., Yamaza, T. & Shi, S., Jul 1 2007, In : Journal of Dental Research. 86, 7, p. 594-599 6 p.

Research output: Contribution to journalArticle

Dental Cementum
Periodontal Ligament
Stem Cells
Epithelial-Mesenchymal Transition
Phosphatidylinositol 3-Kinases
Oral Health
Neurosciences
Health
Programmable logic controllers
Molecules
24 Citations (Scopus)

Impairment of microglial responses to facial nerve axotomy in cathepsin S-deficient mice

Hai, P. H., Doh-Ura, K. & Nakanishi, H., Aug 1 2007, In : Journal of Neuroscience Research. 85, 10, p. 2196-2206 11 p.

Research output: Contribution to journalArticle

cathepsin S
Axotomy
Facial Nerve
Microglia
Motor Neurons
24 Citations (Scopus)

Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice

Yamasaki, R., Zhang, J., Koshiishi, I., Sastradipura Suniarti, D. F., Take, H., Peters, C., Schwake, M., Uchiyama, Y., Kira, J-I., Saftig, P., Utsumi, H. & Nakanishi, H., Aug 1 2007, In : Molecular and Cellular Neuroscience. 35, 4, p. 573-584 12 p.

Research output: Contribution to journalArticle

Microglia
p38 Mitogen-Activated Protein Kinases
Nitric Oxide
Ceroid
Lipofuscin