Research Output 1977 2019

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2008
62 Citations (Scopus)

The taste transduction channel TRPM5 is a locus for bitter-sweet taste interactions

Talavera, K., Yasumatsu, K., Yoshida, R., Margolskee, R. F., Voets, T., Ninomiya, Y. & Nilius, B., May 1 2008, In : FASEB Journal. 22, 5, p. 1343-1355 13 p.

Research output: Contribution to journalArticle

Quinine
loci
quinine
bitter-tasting compounds
Sucrose
2007
88 Citations (Scopus)

Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor

Hisatsune, C., Nakano, K., Takahashi-Iwanaga, H., Ogawa, N., Kuroda, Y., Yoshida, R., Ninomiya, Y. & Mikoshiba, K., Dec 21 2007, In : Journal of Biological Chemistry. 282, 51, p. 37225-37231 7 p.

Research output: Contribution to journalArticle

Taste Perception
Inositol 1,4,5-Trisphosphate Receptors
Chemical activation
Physiological Phenomena
Type C Phospholipases
81 Citations (Scopus)

Adiponectin inhibits osteoclast formation stimulated by lipopolysaccharide from Actinobacillus actinomycetemcomitans

Yamaguchi, N., Kukita, T., Li, Y. J., Martinez Argueta, J. G., Saito, T., Hanazawa, S. & Yamashita, Y., Feb 1 2007, In : FEMS Immunology and Medical Microbiology. 49, 1, p. 28-34 7 p.

Research output: Contribution to journalArticle

Aggregatibacter actinomycetemcomitans
Adiponectin
Osteoclasts
Lipopolysaccharides
Toll-Like Receptor 4
24 Citations (Scopus)

Cystatin C stimulates the differentiation of mouse osteoblastic cells and bone formation

Danjo, A., Yamaza, T., Kido, M. A., Shimohira, D., Tsukuba, T., Kagiya, T., Yamashita, Y., Nishijima, K., Masuko, S., Goto, M. & Tanaka, T., Aug 17 2007, In : Biochemical and Biophysical Research Communications. 360, 1, p. 199-204 6 p.

Research output: Contribution to journalArticle

Cystatin C
Osteogenesis
Bone
Cysteine Proteinase Inhibitors
Osteoblasts
124 Citations (Scopus)

Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation

Wake, H., Watanabe, M., Moorhouse, A. J., Kanematsu, T., Horibe, S., Matsukawa, N., Asai, K., Ojika, K., Hirata, M. & Nabekura, J., Feb 14 2007, In : Journal of Neuroscience. 27, 7, p. 1642-1650 9 p.

Research output: Contribution to journalArticle

Down-Regulation
Phosphorylation
Tyrosine
Neurons
Oxidative Stress
87 Citations (Scopus)

Human Hertwig's epithelial root sheath cells play crucial roles in cementum formation

Sonoyama, W., Seo, B. M., Yamaza, T. & Shi, S., Jul 1 2007, In : Journal of Dental Research. 86, 7, p. 594-599 6 p.

Research output: Contribution to journalArticle

Dental Cementum
Periodontal Ligament
Stem Cells
Epithelial-Mesenchymal Transition
Phosphatidylinositol 3-Kinases
Oral Health
Neurosciences
Health
Programmable logic controllers
Molecules
24 Citations (Scopus)

Impairment of microglial responses to facial nerve axotomy in cathepsin S-deficient mice

Hai, P. H., Doh-Ura, K. & Nakanishi, H., Aug 1 2007, In : Journal of Neuroscience Research. 85, 10, p. 2196-2206 11 p.

Research output: Contribution to journalArticle

cathepsin S
Axotomy
Facial Nerve
Microglia
Motor Neurons
24 Citations (Scopus)

Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice

Yamasaki, R., Zhang, J., Koshiishi, I., Sastradipura Suniarti, D. F., Take, H., Peters, C., Schwake, M., Uchiyama, Y., Kira, J-I., Saftig, P., Utsumi, H. & Nakanishi, H., Aug 1 2007, In : Molecular and Cellular Neuroscience. 35, 4, p. 573-584 12 p.

Research output: Contribution to journalArticle

Microglia
p38 Mitogen-Activated Protein Kinases
Nitric Oxide
Ceroid
Lipofuscin
22 Citations (Scopus)
Transforming Growth Factors
Dinoprostone
Neuroglia
Inflammation
Neurons
13 Citations (Scopus)

Multistep mouse mammary tumorigenesis through preneoplasia to neoplasia and acquisition of metastatic potential

Tsubura, A., Yoshizawa, K., Uehara, N., Yuri, T. & Matsuoka, Y., Mar 1 2007, In : Medical Molecular Morphology. 40, 1, p. 9-17 9 p.

Research output: Contribution to journalArticle

Carcinogenesis
Breast
Hyperplasia
Breast Neoplasms
Neoplasms
4 Citations (Scopus)

PARP inhibitors accelerate N-methyl-N-nitrosourea-induced cataractogenesis in Sprague-Dawley rats

Miki, K., Yoshizawa, K., Uehara, N., Yuri, T., Matsuoka, Y. & Tsubura, A., Sep 1 2007, In : In Vivo. 21, 5, p. 739-744 6 p.

Research output: Contribution to journalArticle

Methylnitrosourea
Sprague Dawley Rats
Rats
Niacinamide
Cataract
71 Citations (Scopus)

Phosholipase C-related inactive protein is involved in trafficking of γ2 subunit-containing GABAA receptors to the cell surface

Mizokami, A., Kanematsu, T., Ishibashi, H., Yamaguchi, T., Tanida, I., Takenaka, K., Nakayama, K., Fukami, K., Takenawa, T., Kominami, E., Moss, S. J., Yamamoto, T., Nabekura, J. & Hirata, M., Feb 14 2007, In : Journal of Neuroscience. 27, 7, p. 1692-1701 10 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Knockout Mice
Proteins
Binding Sites
Type C Phospholipases
51 Citations (Scopus)

Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid β and interferon-γ-induced microglial activation

Hashioka, S., Han, Y. H., Fujii, S., Kato, T., Monji, A., Utsumi, H., Sawada, M., Nakanishi, H. & Kanba, S., Apr 1 2007, In : Free Radical Biology and Medicine. 42, 7, p. 945-954 10 p.

Research output: Contribution to journalArticle

Phosphatidylserines
Phosphatidylcholines
Amyloid
Liposomes
Interferons
38 Citations (Scopus)

Phospholipase C-related inactive protein is implicated in the constitutive internalization of GABAA receptors mediated by clathrin and AP2 adaptor complex

Kanematsu, T., Fujii, M., Mizokami, A., Kittler, J. T., Nabekura, J., Moss, S. J. & Hirata, M., May 1 2007, In : Journal of Neurochemistry. 101, 4, p. 898-905 8 p.

Research output: Contribution to journalArticle

Adaptor Protein Complex 2
Vesicular Transport Adaptor Proteins
Type C Phospholipases
GABA-A Receptors
Proteins
13 Citations (Scopus)

Phospholipids modulate superoxide and nitric oxide production by lipopolysaccharide and phorbol 12-myristate-13-acetate-activated microglia

Hashioka, S., Han, Y. H., Fujii, S., Kato, T., Monji, A., Utsumi, H., Sawada, M., Nakanishi, H. & Kanba, S., Feb 1 2007, In : Neurochemistry International. 50, 3, p. 499-506 8 p.

Research output: Contribution to journalArticle

Microglia
Phosphatidylcholines
Superoxides
Lipopolysaccharides
Phospholipids
13 Citations (Scopus)

Recovery of two independent sweet taste systems during regeneration of the mouse chorda tympani nerve after nerve crush

Nakano, K., Kusuhara, Y., Shigemura, N. & Ninomiya, Y., Sep 1 2007, In : European Journal of Neuroscience. 26, 6, p. 1521-1529 9 p.

Research output: Contribution to journalArticle

Chorda Tympani Nerve
Nerve Crush
Regeneration
Taste Buds
Sucrose

Roles of PRIP in GABAA Receptor Signaling

Mizokami, A., Kanematsu, T. & Hirata, M., Jan 1 2007, In : journal of oral biosciences. 49, 2, p. 105-112 8 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Neurology
Neurotransmitter Agents
Ligand-Gated Ion Channels
Aminobutyrates
15 Citations (Scopus)

Sequential expression of endothelial nitric oxide synthase, inducible nitric oxide synthase, and nitrotyrosine in odontoblasts and pulp cells during dentin repair after tooth preparation in rat molars

Mei, Y. F., Yamaza, T., Atsuta, I., Danjo, A., Yamashita, Y., Kido, M. A., Goto, M., Akamine, A. & Tanaka, T., Apr 1 2007, In : Cell and tissue research. 328, 1, p. 117-127 11 p.

Research output: Contribution to journalArticle

Tooth Preparation
Odontoblasts
Nitric Oxide Synthase Type III
Nitric Oxide Synthase Type II
Dentin
33 Citations (Scopus)

TAK1 represses transcription of the human telomerase reverse transcriptase gene

Fujiki, T., Miura, T., Maura, M., Shiraishi, H., Nishimura, S., Imada, Y., Uehara, N., Tashiro, K., Shirahata, S. & Katakura, Y., Aug 9 2007, In : Oncogene. 26, 36, p. 5258-5266 9 p.

Research output: Contribution to journalArticle

Phosphotransferases
Genes
Cell Aging
Transforming Growth Factors
Histone Deacetylases
53 Citations (Scopus)

Transplantation of mesenchymal stem cells is an optimal approach for plastic surgery

Fang, D., Seo, B. M., Liu, Y., Sonoyama, W., Yamaza, T., Zhang, C., Wang, S. & Shi, S., Apr 18 2007, In : STEM CELLS. 25, 4, p. 1021-1028 8 p.

Research output: Contribution to journalArticle

Mesenchymal Stem Cell Transplantation
Plastic Surgery
Mesenchymal Stromal Cells
Bone Marrow
Regeneration
2006
12 Citations (Scopus)

Amiloride inhibition on NaCl responses of the chorda tympani nerve in two 129 substrains of mice, 129P3/J and 129X1/SvJ

Ohkuri, T., Yasumatsu, K., Shigemura, N., Yoshida, R. & Ninomiya, Y., Jul 1 2006, In : Chemical Senses. 31, 6, p. 565-572 8 p.

Research output: Contribution to journalArticle

Chorda Tympani Nerve
129 Strain Mouse
Tympanis
Amiloride
nerve tissue
29 Citations (Scopus)

Biphasic effects of zeranol on the growth of estrogen receptor-positive human breast carcinoma cells

Yuri, T., Tsukamoto, R., Miki, K., Uehara, N., Matsuoka, Y. & Tsubura, A., Dec 1 2006, In : Oncology reports. 16, 6, p. 1307-1312 6 p.

Research output: Contribution to journalArticle

Zeranol
Estrogen Receptors
Breast Neoplasms
Growth
Apoptosis
12 Citations (Scopus)

Ca2+-dependent regulation of calcitonin gene expression by the transcriptional repressor DREAM

Matsuda, M., Yamamoto, T. A. & Hirata, M., Sep 22 2006, In : Endocrinology. 147, 10, p. 4608-4617 10 p.

Research output: Contribution to journalArticle

Calcitonin
Gene Expression Regulation
Cyclic AMP Response Element Modulator
Kv Channel-Interacting Proteins
Gene Expression
18 Citations (Scopus)

Capsaicin receptor expression in the rat temporomandibular joint

Ioi, H., Kido, M. A., Zhang, J. Q., Yamaza, T., Nakata, S., Nakasima, A. & Tanaka, T., Jul 1 2006, In : Cell and tissue research. 325, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

TRPV Cation Channels
Temporomandibular Joint
Joint Capsule
Nociception
Synovial Membrane
16 Citations (Scopus)

Cell cycle-dependent regulation of kainate-induced inward currents in microglia

Yamada, J., Sawada, M. & Nakanishi, H., Oct 27 2006, In : Biochemical and Biophysical Research Communications. 349, 3, p. 913-919 7 p.

Research output: Contribution to journalArticle

Kainic Acid
Induced currents
Microglia
Cell Cycle
Cells
4 Citations (Scopus)

Characterization of the human PRIP-1 gene structure and transcriptional regulation

Murakami, A., Matsuda, M., Nakasima, A. & Hirata, M., Nov 1 2006, In : Gene. 382, p. 129-139 11 p.

Research output: Contribution to journalArticle

Exons
Genes
Type C Phospholipases
Luciferases
Brain
31 Citations (Scopus)

Differentiation-inducing factor-1 alters canonical Wnt signaling and suppresses alkaline phosphatase expression in osteoblast-like cell lines

Matsuzaki, E., Takahashi, F., Miwa, Y., Hirata, M., Watanabe, Y., Sato, N., Morimoto, S., Hirofuji, T., Maeda, K. & Sasaguri, T., Aug 1 2006, In : Journal of Bone and Mineral Research. 21, 8, p. 1307-1316 10 p.

Research output: Contribution to journalArticle

Osteoblasts
Alkaline Phosphatase
TCF Transcription Factors
Cell Line
Catenins
NSC 153174
Eicosanoids
Oleic acid
Insulin
Oleic Acid
37 Citations (Scopus)

Involvement of COX-1 and up-regulated prostaglandin e synthases in phosphatidylserine liposome-induced prostaglandin E2 production by microglia

Zhang, J., Fujii, S., Wu, Z., Hashioka, S., Tanaka, Y., Shiratsuchi, A., Nakanishi, Y. & Nakanishi, H., Mar 1 2006, In : Journal of Neuroimmunology. 172, 1-2, p. 112-120 9 p.

Research output: Contribution to journalArticle

Cyclooxygenase 1
Phosphatidylserines
Microglia
Prostaglandin-Endoperoxide Synthases
Dinoprostone
39 Citations (Scopus)

Involvement of GSK-3β and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells

Takahashi, F., Mori, J., Matsuzaki, E., Watanabe, Y., Hirata, M., Miwa, Y., Morimoto, S. & Sasaguri, T., Dec 15 2006, In : Journal of Biological Chemistry. 281, 50, p. 38489-38497 9 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Phosphorylation
Cyclin D1
HeLa Cells
Degradation
24 Citations (Scopus)

Lysosomal turnover of GABARAP-phospholipid conjugate is activated during differentiation of C2C12 cells to myotubes without inactivation of the mTor kinase-signaling pathway

Tanida, I., Wakabayashi, M., Kanematsu, T., Minematsu-Ikeguchi, N., Sou, Y. S., Hirata, M., Ueno, T. & Kominami, E., Jan 1 2006, In : Autophagy. 2, 4, p. 264-271 8 p.

Research output: Contribution to journalArticle

Skeletal Muscle Fibers
Cell Differentiation
Phospholipids
Phosphotransferases
Starvation
675 Citations (Scopus)

Mesenchymal stem cell-mediated functional tooth regeneration in Swine

Sonoyama, W., Liu, Y., Fang, D., Yamaza, T., Seo, B. M., Zhang, C., Liu, H., Gronthos, S., Wang, C. Y., Shi, S. & Wang, S., Dec 20 2006, In : PloS one. 1, 1, e79.

Research output: Contribution to journalArticle

Stem cells
Mesenchymal Stromal Cells
stem cells
Regeneration
Tooth
73 Citations (Scopus)

Modulation of GABAA receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibition

Kanematsu, T., Yasunaga, A., Mizoguchi, Y., Kuratani, A., Kittler, J. T., Jovanovic, J. N., Takenaka, K., Nakayama, K. I., Fukami, K., Takenawa, T., Moss, S. J., Nabekura, J. & Hirata, M., Aug 4 2006, In : Journal of Biological Chemistry. 281, 31, p. 22180-22189 10 p.

Research output: Contribution to journalArticle

Protein Phosphatase 1
Protein Phosphatase 2
Phosphorylation
Brain-Derived Neurotrophic Factor
Type C Phospholipases
38 Citations (Scopus)
Methylnitrosourea
Photoreceptor Cells
Niacinamide
Poly(ADP-ribose) Polymerases
Transcription Factor AP-1
66 Citations (Scopus)

Potentiation of the NMDA receptor-mediated responses through the activation of the glycine site by microglia secreting soluble factors

Hayashi, Y., Ishibashi, H., Hashimoto, K. & Nakanishi, H., Apr 15 2006, In : GLIA. 53, 6, p. 660-668 9 p.

Research output: Contribution to journalArticle

Microglia
Glycine
Conditioned Culture Medium
Serine
Hippocampus
23 Citations (Scopus)

Protein phosphatase regulation by PRIP, a PLC-related catalytically inactive protein-Implications in the phospho-modulation of the GABAA receptor

Yanagihori, S., Terunuma, M., Koyano, K., Kanematsu, T., Ho Ryu, S. & Hirata, M., 2006, In : Advances in Enzyme Regulation. 46, 1, p. 203-222 20 p.

Research output: Contribution to journalArticle

Phosphoprotein Phosphatases
GABA-A Receptors
Phosphorylation
Inositol 1,4,5-Trisphosphate
Cyclic AMP-Dependent Protein Kinases
22 Citations (Scopus)

Regulation of osteoclastogenesis by Simon extracts composed of caffeic acid and related compounds: Successful suppression of bone destruction accompanied with adjuvant-induced arthritis in rats

Quan, Y. T., Kukita, T., Ushijima, Y., Kukita, A., Nagata, K., Sandra, F., Watanabe, T., Toh, K., Okuma, Y., Kawasaki, S., Rasubala, L., Teramachi, J., Miyamoto, I., Wu, Z. & Iijima, T., Mar 1 2006, In : Histochemistry and Cell Biology. 125, 3, p. 215-225 11 p.

Research output: Contribution to journalArticle

Experimental Arthritis
Osteogenesis
Vitamin K
Osteoclasts
Bone and Bones
61 Citations (Scopus)

Taste responsiveness of fungiform taste cells with action potentials

Yoshida, R., Shigemura, N., Sanematsu, K., Nakano, K., Ishizuka, S. & Ninomiya, Y., Dec 1 2006, In : Journal of Neurophysiology. 96, 6, p. 3088-3095 8 p.

Research output: Contribution to journalArticle

Action Potentials
Nerve Fibers
Taste Buds
Saccharin
Quinine
75 Citations (Scopus)
Platelet-Rich Plasma
Platelet-Derived Growth Factor
Transforming Growth Factors
Osteoblasts
Insulin-Like Growth Factor I
39 Citations (Scopus)

The intra-arterial injection of microglia protects hippocampal CA1 neurons against global ischemia-induced functional deficits in rats

Hayashi, Y., Tomimatsu, Y., Suzuki, H., Yamada, J., Take, H., Yao, H., Kagamiishi, Y., Tateishi, N., Sawada, M. & Nakanishi, H., Sep 14 2006, In : Neuroscience. 142, 1, p. 87-96 10 p.

Research output: Contribution to journalArticle

Intra-Arterial Injections
Microglia
Ischemia
Neurons
Hippocampus
222 Citations (Scopus)

Trpm5 null mice respond to bitter, sweet, and umami compounds

Damak, S., Rong, M., Yasumatsu, K., Kokrashvili, Z., Pérez, C. A., Shigemura, N., Yoshida, R., Mosinger, B., Glendinning, J. I., Ninomiya, Y. & Margolskee, R. F., Mar 1 2006, In : Chemical Senses. 31, 3, p. 253-264 12 p.

Research output: Contribution to journalArticle

Exons
Chorda Tympani Nerve
Glossopharyngeal Nerve
Tongue
Genetic Promoter Regions
2005
29 Citations (Scopus)

Ameloblastoma induces osteoclastogenesis: A possible role of ameloblastoma in expanding in the bone

Sandra, F., Hendarmin, L., Kukita, T., Nakao, Y., Nakamura, N. & Nakamura, S., Jul 1 2005, In : Oral Oncology. 41, 6, p. 637-644 8 p.

Research output: Contribution to journalArticle

Ameloblastoma
Osteogenesis
Bone and Bones
p38 Mitogen-Activated Protein Kinases
Osteoclasts
29 Citations (Scopus)

Amyloid-β fibril formation is not necessarily required for microglial activation by the peptides

Hashioka, S., Monji, A., Ueda, T., Kanba, S. & Nakanishi, H., Oct 1 2005, In : Neurochemistry International. 47, 5, p. 369-376 8 p.

Research output: Contribution to journalArticle

Amyloid
Peptides
Microglia
Aptitude
Tumor Necrosis Factor-alpha
43 Citations (Scopus)

Changes in the distribution of laminin-5 during peri-implant epithelium formation after immediate titanium implantation in rats

Ikiru, A., Yamaza, T., Yoshinari, M., Mino, S., Goto, T., Kido, M. A., Terada, Y. & Tanaka, T., May 1 2005, In : Biomaterials. 26, 14, p. 1751-1760 10 p.

Research output: Contribution to journalArticle

Titanium
Rats
Epithelium
Cells
Antibodies
21 Citations (Scopus)

Comparison of transforming growth factor-β/Smad signaling between normal dermal fibroblasts and fibroblasts derived from central and peripheral areas of keloid lesions

Tsujita-Kyutoku, M., Uehara, N., Matsuoka, Y., Kyutoku, S., Ogawa, Y. & Tsubura, A., Nov 1 2005, In : In Vivo. 19, 6, p. 959-964 6 p.

Research output: Contribution to journalArticle

Keloid
Transforming Growth Factors
Fibroblasts
Skin
Growth
26 Citations (Scopus)

Differentiation-inducing factor-1 induces cyclin D1 degradation through the phosphorylation of Thr286 in squamous cell carcinoma

Mori, J., Takahashi, F., Miwa, Y., Watanabe, Y., Hirata, M., Morimoto, S., Shirasuna, K. & Sasaguri, T., Nov 1 2005, In : Experimental Cell Research. 310, 2, p. 426-433 8 p.

Research output: Contribution to journalArticle

Cyclin D1
Squamous Cell Carcinoma
Phosphorylation
Glycogen Synthase Kinase 3
1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone
24 Citations (Scopus)

Differentiation-inducing factor-1 suppresses gene expression of cyclin D1 in tumor cells

Yasmin, T., Takahashi-Yanaga, F., Mori, J., Miwa, Y., Hirata, M., Watanabe, Y., Morimoto, S. & Sasaguri, T., Dec 16 2005, In : Biochemical and Biophysical Research Communications. 338, 2, p. 903-909 7 p.

Research output: Contribution to journalArticle

Cyclin D1
Gene expression
Tumors
Cells
TCF Transcription Factors
37 Citations (Scopus)

Direct interaction of N-ethylmaleimide-sensitive factor with GABA A receptor β subunits

Goto, H., Terunuma, M., Kanematsu, T., Misumi, Y., Moss, S. J. & Hirata, M., Oct 1 2005, In : Molecular and Cellular Neuroscience. 30, 2, p. 197-206 10 p.

Research output: Contribution to journalArticle

N-Ethylmaleimide-Sensitive Proteins
GABA-A Receptors
Cell Surface Receptors
Protein Transport
Immunoprecipitation
20 Citations (Scopus)

Expression of amiloride-sensitive epithelial sodium channels in mouse taste cells after chorda tympani nerve crush

Shigemura, N., Islam, A. A. S., Sadamitsu, C., Yoshida, R., Yasumatsu, K. & Ninomiya, Y., Jul 1 2005, In : Chemical Senses. 30, 6, p. 531-538 8 p.

Research output: Contribution to journalArticle

Chorda Tympani Nerve
Tympanis
Nerve Crush
Epithelial Sodium Channels
sodium channels