Research Output 1977 2019

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2004
83 Citations (Scopus)

Direct stimulation of osteoclastogenesis by MIP-1α: Evidence obtained from studies using RAW264 cell clone highly responsive to RANKL

Watanabe, T., Kukita, T., Kukita, A., Wada, N., Toh, K., Nagata, K., Nomiyama, H. & Iijima, T., Jan 1 2004, In : Journal of Endocrinology. 180, 1, p. 193-201 9 p.

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
Osteogenesis
Clone Cells
Osteoclasts
Stromal Cells
6 Citations (Scopus)
Th1-Th2 Balance
CCR4 Receptors
CXCR3 Receptors
Experimental Arthritis
Ankle Joint
83 Citations (Scopus)

GABAA receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein

Terunuma, M., Jang, I. S., Ha, S. H., Kittler, J. T., Kanematsu, T., Jovanovic, J. N., Nakayama, K., Akaike, N., Ryu, S. H., Moss, S. J. & Hirata, M., Aug 11 2004, In : Journal of Neuroscience. 24, 32, p. 7074-7084 11 p.

Research output: Contribution to journalArticle

Protein Phosphatase 1
Type C Phospholipases
GABA-A Receptors
Proteins
Phosphorylation
36 Citations (Scopus)

Glycogen synthase kinase-3β is tyrosine-phosphorylated by MEK1 in human skin fibroblasts

Takahashi, F., Shiraishi, F., Hirata, M., Miwa, Y., Morimoto, S. & Sasaguri, T., Apr 2 2004, In : Biochemical and Biophysical Research Communications. 316, 2, p. 411-415 5 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Fibroblasts
Tyrosine
Skin
Phosphorylation
4 Citations (Scopus)

Hypersensitivity to pentylenetetrazol-induced convulsion in mice lacking the PLC-related inactive protein-1

Yamaguchi, T., Kubota, T., Kanematsu, T., Nakayama, K., Hirata, M. & Yamamoto, T., Oct 29 2004, In : Brain Research. 1025, 1-2, p. 237-240 4 p.

Research output: Contribution to journalArticle

Pentylenetetrazole
Type C Phospholipases
Hypersensitivity
Seizures
Proteins
133 Citations (Scopus)

Leptin Modulates Behavioral Responses to Sweet Substances by Influencing Peripheral Taste Structures

Shigemura, N., Ohta, R., Kusakabe, Y., Miura, H., Hino, A., Koyano, K., Nakashima, K. & Ninomiya, Y., Feb 1 2004, In : Endocrinology. 145, 2, p. 839-847 9 p.

Research output: Contribution to journalArticle

Leptin
Appetite Regulation
Leptin Receptors
Saccharin
Polymerase Chain Reaction
13 Citations (Scopus)

Nuclear export signal in CDC25B

Uchida, S., Ohtsubo, M., Shimura, M., Hirata, M., Nakagama, H., Matsunaga, T., Yoshida, M., Ishizaka, Y. & Yamashita, K., Mar 26 2004, In : Biochemical and Biophysical Research Communications. 316, 1, p. 226-232 7 p.

Research output: Contribution to journalArticle

Nuclear Export Signals
Amino Acids
Dual-Specificity Phosphatases
Cyclin B
Mutant Proteins
20 Citations (Scopus)

Oxidative stress-induced DNA damage in the synovial cells of the temporomandibular joint in the rat

Yamaza, T., Masuda, K. F., Ikiru, A., Nishijima, K., Kido, M. A. & Tanaka, T., Jan 1 2004, In : Journal of Dental Research. 83, 8, p. 619-624 6 p.

Research output: Contribution to journalArticle

Temporomandibular Joint
DNA Damage
Oxidative Stress
Hyperplasia
Peroxynitrous Acid
31 Citations (Scopus)

Possible involvement of MIP-1α in the recruitment of osteoclast progenitors to the distal tibia in rats with adjuvant-induced arthritis

Toh, K., Kukita, T., Take, H., Kukita, A., Sandra, F., Tang, Q. Y., Nomiyama, H. & Iijima, T., Sep 1 2004, In : Laboratory Investigation. 84, 9, p. 1092-1102 11 p.

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
Experimental Arthritis
Osteoclasts
Tibia
Bone Marrow
205 Citations (Scopus)

RANKL-induced DC-STAMP is essential for osteoclastogenesis

Kukita, T., Wada, N., Kukita, A., Kakimoto, T., Sandra, F., Toh, K., Nagata, K., Iijima, T., Horiuchi, M., Matsusaki, H., Hieshima, K., Yoshie, O. & Nomiyama, H., Oct 4 2004, In : Journal of Experimental Medicine. 200, 7, p. 941-946 6 p.

Research output: Contribution to journalArticle

Osteogenesis
Dendritic Cells
Osteoclasts
Proteins
Cell Fusion
8 Citations (Scopus)

Sibutramine induces potential-dependent exocytotic release but not carrier-mediated release of dopamine and 5-hydroxytryptamine

Ukai, K., Nakagawa, T., Ohyama, T. & Nakanishi, H., Jan 26 2004, In : European Journal of Pharmacology. 484, 2-3, p. 209-215 7 p.

Research output: Contribution to journalArticle

sibutramine
Dopamine
Serotonin
Perfusion
Microdialysis
2003
19 Citations (Scopus)

Activation of μ-calpain in developing cortical neurons following methylmercury treatment

Zhang, J., Miyamoto, K. I., Hashioka, S., Hao, H. P., Murao, K., Saido, T. C. & Nakanishi, H., Apr 14 2003, In : Developmental Brain Research. 142, 1, p. 105-110 6 p.

Research output: Contribution to journalArticle

Spectrin
Calpain
Neurons
Cerebral Cortex
Dizocilpine Maleate
49 Citations (Scopus)

A Rapid Increase in the Total Number of Cell Surface Functional GABA A Receptors Induced by Brain-derived Neurotrophic Factor in Rat Visual Cortex

Mizoguchi, Y., Kanematsu, T., Hirata, M. & Nabekura, J., Nov 7 2003, In : Journal of Biological Chemistry. 278, 45, p. 44097-44102 6 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Visual Cortex
GABA-A Receptors
Rats
Cell Count
20 Citations (Scopus)

Conditioned taste aversion learning in leptin-receptor-deficient db/db mice

Ohta, R., Shigemura, N., Sasamoto, K., Koyano, K. & Ninomiya, Y., Jan 1 2003, In : Neurobiology of Learning and Memory. 80, 2, p. 105-112 8 p.

Research output: Contribution to journalArticle

Leptin Receptors
Saccharin
Learning
Leptin
Sucrose
77 Citations (Scopus)

Dictyostelium differentiation-inducing factor-3 activates glycogen synthase kinase-3β and degrades cyclin D1 in mammalian cells

Takahashi, F., Taba, Y., Miwa, Y., Kubohara, Y., Watanabe, Y., Hirata, M., Morimoto, S. & Sasaguri, T., Mar 14 2003, In : Journal of Biological Chemistry. 278, 11, p. 9663-9670 8 p.

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Cyclin D1
Cells
Proteolysis
1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone
98 Citations (Scopus)

Effects of static magnetic fields on bone formation in rat osteoblast cultures

Yamamoto, Y., Ohsaki, Y., Goto, T., Nakasima, A. & Iijima, T., Jan 1 2003, In : Journal of Dental Research. 82, 12, p. 962-966 5 p.

Research output: Contribution to journalArticle

Magnetic Fields
Osteoblasts
Osteogenesis
Electromagnetic Fields
Magnets
38 Citations (Scopus)

Expression of leptin receptor (Ob-R) isoforms and signal transducers and activators of transcription (STATs) mRNAs in the mouse taste buds

Shigemura, N., Miura, H., Kusakabe, Y., Hino, A. & Ninomiya, Y., Aug 1 2003, In : Archives of Histology and Cytology. 66, 3, p. 253-260 8 p.

Research output: Contribution to journalArticle

Taste Buds
Leptin Receptors
Transducers
Protein Isoforms
Leptin

Extremely high expression of β-actin mRNA in osteoclasts resorbing alveolar bone located at the distal area of the developing molar tooth germ in newborn rats

Kukita, T., Kukita, A., Xu, L., Toh, K., Tang, Q., Nomiyama, H. & Iijima, T., Dec 1 2003, In : Journal of Electron Microscopy. 52, 6, p. 545-550 6 p.

Research output: Contribution to journalArticle

Tooth Germ
Osteoclasts
teeth
bones
rats
21 Citations (Scopus)

Gurmarin suppression of licking responses to sweetener-quinine mixtures in C57BL mice

Murata, Y., Nakashima, K., Yamada, A., Shigemura, N., Sasamoto, K. & Ninomiya, Y., Mar 1 2003, In : Chemical Senses. 28, 3, p. 237-243 7 p.

Research output: Contribution to journalArticle

Sweetening Agents
Quinine
Inbred C57BL Mouse
Sucrose
Chorda Tympani Nerve
18 Citations (Scopus)

How does prolonged caloric restriction ameliorate age-related impairment of long-term potentiation in the hippocampus?

Okada, M., Nakanishi, H., Amamoto, T., Urae, R., Ando, S., Yazawa, K. & Fujiwara, M., Mar 17 2003, In : Molecular Brain Research. 111, 1-2, p. 175-181 7 p.

Research output: Contribution to journalArticle

Caloric Restriction
Long-Term Potentiation
Hippocampus
Arachidonic Acid
N-Methylaspartate
16 Citations (Scopus)

Id-1 is not expressed in the luminal epithelial cells of mammary glands

Uehara, N., Chou, Y. C., Galvez, J. J., de-Candia, P., Cardiff, R. D., Benezra, R. & Shyamala, G., Apr 1 2003, In : Breast Cancer Research. 5, 2, R25.

Research output: Contribution to journalArticle

Human Mammary Glands
Epithelial Cells
Carcinogenesis
Breast
DNA-Binding Proteins
25 Citations (Scopus)

Immunodominance of conformation-dependent B-cell epitopes of protein antigens

Ito, H. O., Nakashima, T., So, T., Hirata, M. & Inoue, M., Sep 5 2003, In : Biochemical and Biophysical Research Communications. 308, 4, p. 770-776 7 p.

Research output: Contribution to journalArticle

B-Lymphocyte Epitopes
Conformations
Epitopes
Monoclonal Antibodies
Antigens
106 Citations (Scopus)

Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice

Koike, M., Shibata, M., Ohsawa, Y., Nakanishi, H., Koga, T., Kametaka, S., Waguri, S., Momoi, T., Kominami, E., Peters, C., Von Figura, K., Saftig, P. & Uchiyama, Y., Feb 1 2003, In : Molecular and Cellular Neuroscience. 22, 2, p. 146-161 16 p.

Research output: Contribution to journalArticle

Atrophy
Cell Death
Nitric Oxide Synthase
Retina
Cathepsin L
10 Citations (Scopus)

Loss of p53 induces M-phase retardation following G2 DNA damage checkpoint abrogation

Minemoto, Y., Uchida, S., Ohtsubo, M., Shimura, M., Sasagawa, T., Hirata, M., Nakagama, H., Ishizaka, Y. & Yamashita, K., Apr 1 2003, In : Archives of Biochemistry and Biophysics. 412, 1, p. 13-19 7 p.

Research output: Contribution to journalArticle

Cell Division
DNA Damage
Cells
DNA
Cyclin B1
25 Citations (Scopus)

NF-κB activation and iNOS expression in the synovial membrane of rat temporomandibular joints after induced synovitis

Yamaza, T., Masuda, K. F., Tsukiyama, Y., Nishijima, K., Murakami, R., Kido, M. A., Koyano, K. & Tanaka, T., Jan 1 2003, In : Journal of Dental Research. 82, 3, p. 183-188 6 p.

Research output: Contribution to journalArticle

Synovitis
Synovial Membrane
Temporomandibular Joint
Nitric Oxide Synthase Type II
Inflammation
6 Citations (Scopus)

Pepstatin a induces extracellular acidification distinct from aspartic protease inhibition in microglial cell lines

Okada, M., Irie, S., Sawada, M., Urae, R., Urae, A., Iwata, N., Ozaki, N., Akazawa, K. & Nakanishi, H., Aug 1 2003, In : GLIA. 43, 2, p. 167-174 8 p.

Research output: Contribution to journalArticle

Peptide Hydrolases
Cell Line
Dicyclohexylcarbodiimide
Proton-Translocating ATPases
Protein Kinase C
43 Citations (Scopus)

Potentiation of NMDA receptor-mediated synaptic responses by microglia

Moriguchi, S., Mizoguchi, Y., Tomimatsu, Y., Hayashi, Y., Kadowaki, T., Kagamiishi, Y., Katsube, N., Yamamoto, K., Inoue, K., Watanabe, S., Nabekura, J. & Nakanishi, H., Nov 26 2003, In : Molecular Brain Research. 119, 2, p. 160-169 10 p.

Research output: Contribution to journalArticle

Microglia
N-Methyl-D-Aspartate Receptors
N-Methylaspartate
Glutamic Acid
Endopeptidase K
13 Citations (Scopus)

Requirements for distinct steps of phospholipase Cγ2 regulation, membrane-raft-dependent targeting and subsequent enzyme activation in B-cell signalling

Rodriguez, R., Matsuda, M., Storey, A. & Katan, M., Aug 15 2003, In : Biochemical Journal. 374, 1, p. 269-280 12 p.

Research output: Contribution to journalArticle

Cell signaling
Enzyme Activation
Phospholipases
Hydrolysis
B-Lymphocytes

Search for cerebral G cluster neurons responding to taste stimulation with seaweed in Aplysia kurodai by the use of calcium imaging

Yoshida, R. & Nagahama, T., Jan 1 2003, In : Journal of Neurobiology. 55, 3, p. 299-314 16 p.

Research output: Contribution to journalArticle

Seaweed
Aplysia
Calcium
Neurons
Motor Neurons
6 Citations (Scopus)

The importance to chondrocyte differentiation of changes in expression of the multiple inositol polyphosphate phosphatase

Hidaka, K., Kanematsu, T., Caffrey, J. J., Takeuchi, H., Shears, S. B. & Hirata, M., Nov 1 2003, In : Experimental Cell Research. 290, 2, p. 254-264 11 p.

Research output: Contribution to journalArticle

Chondrocytes
Growth Plate
Inositol
Alkaline Phosphatase
Bone Plates
128 Citations (Scopus)

Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages

Rahman, M., Kukita, A., Kukita, T., Shobuike, T., Nakamura, T. & Kohashi, O., May 1 2003, In : Blood. 101, 9, p. 3451-3459 9 p.

Research output: Contribution to journalArticle

trichostatin A
Histone Deacetylase Inhibitors
Butyric Acid
Macrophages
Osteoclasts
77 Citations (Scopus)

Vanilloid receptor expression in the rat tongue and palate

Kido, M. A., Muroya, H., Yamaza, T., Terada, Y. & Tanaka, T., Jan 1 2003, In : Journal of Dental Research. 82, 5, p. 393-397 5 p.

Research output: Contribution to journalArticle

TRPV Cation Channels
Palate
Tongue
Capsaicin
Pain
2002
48 Citations (Scopus)

Difference in penetration of horseradish peroxidase tracer as a foreign substance into the peri-implant or junctional epithelium of rat gingivae

Ikeda, H., Shiraiwa, M., Yamaza, T., Yoshinari, M., Kido, M. A., Ayukawa, Y., Inoue, T., Koyano, K. & Tanaka, T., Jun 1 2002, In : Clinical Oral Implants Research. 13, 3, p. 243-251 9 p.

Research output: Contribution to journalArticle

Epithelial Attachment
Gingiva
Horseradish Peroxidase
Epithelium
Basement Membrane
5 Citations (Scopus)

Distribution of inducible nitric oxide synthase, interleukin-1β, and interleukin-1 receptor in the temporomandibular joint of normal rats

Masuda, K. F., Yamaza, T., Tsukiyama, Y., Murakami, R., Nishijima, K., Kido, M. A., Koyano, K. & Tanaka, T., May 14 2002, In : Acta Histochemica et Cytochemica. 35, 1, p. 11-21 11 p.

Research output: Contribution to journalArticle

Interleukin-1 Receptors
Synovial Membrane
Temporomandibular Joint
Nitric Oxide Synthase Type II
Interleukin-1
27 Citations (Scopus)

Enhancement of N-methyl-D-aspartate receptor-mediated excitatory postsynaptic potentials in the neostriatum after methamphetamine sensitization: An in vitro slice study

Moriguchi, S., Watanabe, S., Kita, H. & Nakanishi, H., May 20 2002, In : Experimental Brain Research. 144, 2, p. 238-246 9 p.

Research output: Contribution to journalArticle

Neostriatum
Methamphetamine
Excitatory Postsynaptic Potentials
N-Methyl-D-Aspartate Receptors
Cyclic AMP-Dependent Protein Kinases
40 Citations (Scopus)

Fibroblasts from the inner granulation tissue of the pseudocapsule in hips at revision arthroplasty induce osteoclast differentiation, as do stromal cells

Sakai, H., Jingushi, S., Shuto, T., Urabe, K., Ikenoue, T., Okazaki, K., Kukita, T., Kukita, A. & Iwamoto, Y., Jan 1 2002, In : Annals of the Rheumatic Diseases. 61, 2, p. 103-109 7 p.

Research output: Contribution to journalArticle

Arthroplasty
Granulation
Granulation Tissue
Osteoclasts
Fibroblasts
79 Citations (Scopus)

Involvement of cathepsin E in exogenous antigen processing in primary cultured murine microglia

Nishioku, T., Hashimoto, K., Yamashita, K., Liou, S. Y., Kagamiishi, Y., Maegawa, H., Katsube, N., Peters, C., Von Figura, K., Saftig, P., Katunuma, N., Yamamoto, K. & Nakanishi, H., Feb 15 2002, In : Journal of Biological Chemistry. 277, 7, p. 4816-4822 7 p.

Research output: Contribution to journalArticle

Cathepsin E
Antigen Presentation
Microglia
Antigens
Processing
31 Citations (Scopus)
Osteophyte
Experimental Arthritis
Ankle Joint
Calcitonin Gene-Related Peptide
Synovial Fluid
1 Citation (Scopus)

Ion channels and second messengers involved in transduction and modulation of sweet taste in mouse taste cells

Sugimoto, K., Shigemura, N., Nakano, K., Ohta, R., Nakashima, K., Kawai, K. & Ninomiya, Y., Jul 1 2002, In : Pure and Applied Chemistry. 74, 7, p. 1141-1151 11 p.

Research output: Contribution to journalArticle

Second Messenger Systems
Leptin
Ion Channels
Cells
Depolarization
11 Citations (Scopus)

Letter to the editor: 1H, 13C and 15N resonance assignments of GABARAP, GABAA receptor associated protein [4]

Kouno, T., Miura, K., Kanematsu, T., Shirakawa, M., Hirata, M. & Kawano, K., Feb 28 2002, In : Journal of Biomolecular NMR. 22, 1, p. 97-98 2 p.

Research output: Contribution to journalArticle

Signal Transducing Adaptor Proteins
Nitrogen Isotopes
Carbon Isotopes
Recombinant Fusion Proteins
Microtubule-Associated Proteins
55 Citations (Scopus)

Molecules interacting with PRIP-2, a novel Ins(1,4,5)P3 binding protein type 2: Comparison with PRIP-1

Uji, A., Matsuda, M., Kukita, T., Maeda, K., Kanematsu, T. & Hirata, M., Dec 20 2002, In : Life Sciences. 72, 4-5, p. 443-453 11 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate
Butyric Acid
Carrier Proteins
Amino Acid Receptors
Protein Phosphatase 1
61 Citations (Scopus)

Phospholipase D2 directly interacts with aldolase via its PH domain

Kim, J. H., Lee, S., Kim, J. H., Lee, T. G., Hirata, M., Suh, P. G. & Ryu, S. H., Mar 12 2002, In : Biochemistry. 41, 10, p. 3414-3421 8 p.

Research output: Contribution to journalArticle

Fructose-Bisphosphate Aldolase
Phospholipase D
Metabolites
Glyceraldehyde 3-Phosphate
phospholipase D2
76 Citations (Scopus)

Proteases involved in long-term potentiation

Tomimatsu, Y., Idemoto, S., Moriguchi, S., Watanabe, S. & Nakanishi, H., Dec 20 2002, In : Life Sciences. 72, 4-5, p. 355-361 7 p.

Research output: Contribution to journalArticle

Long-Term Potentiation
Peptide Hydrolases
N-Methyl-D-Aspartate Receptors
Chemical activation
Calpain
106 Citations (Scopus)

Role of the PLC-related, catalytically inactive protein p130 in GABAA receptor function

Kanematsu, T., Jang, I. S., Yamaguchi, T., Nagahama, H., Yoshimura, K., Hidaka, K., Matsuda, M., Takeuchi, H., Misumi, Y., Nakayama, K., Yamamoto, T., Akaike, N., Hirata, M. & Nakayama, K., Mar 1 2002, In : EMBO Journal. 21, 5, p. 1004-1011 8 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Programmable logic controllers
Proteins
Diazepam
gamma-Aminobutyric Acid
2 Citations (Scopus)

The analysis of protein-protein interaction with special reference to PRIP-1

Kanematsu, T. & Hirata, M., May 11 2002, In : Folia Pharmacologica Japonica. 119, 4, p. 241-246 6 p.

Research output: Contribution to journalArticle

Protein Phosphatase 1
GABA-A Receptors
Proteins
Galactosidases
EF Hand Motifs
24 Citations (Scopus)

The role of MDM2 in the proliferative activity of ameloblastoma

Sandra, F., Nakamura, N., Kanematsu, T., Hirata, M. & Ohishi, M., Mar 4 2002, In : Oral Oncology. 38, 2, p. 153-157 5 p.

Research output: Contribution to journalArticle

Ameloblastoma
Proto-Oncogene Proteins c-mdm2
Neoplasms
Western Blotting
Enzyme-Linked Immunosorbent Assay
27 Citations (Scopus)

TNF inhibited the apoptosis by activation of Akt serine/threonine kinase in the human head and neck squamous cell carcinoma

Sandra, F., Matsuki, N. A., Takeuchi, H., Ikebe, T., Kanematsu, T., Ohishi, M. & Hirata, M., Jun 17 2002, In : Cellular Signalling. 14, 9, p. 771-778 8 p.

Research output: Contribution to journalArticle

Protein-Serine-Threonine Kinases
Tumor Necrosis Factor-alpha
Apoptosis
Cell Survival
Phosphatidylinositol 3-Kinases
2001

An epidemiologic examination on the prevalence of the periodontal diseases and oral pigmentation in Yusho patients in 2000

Hashiguchi, I., Yamaza, T., Koishi, Y., Goto, Y., Yoshito, Y., Akamine, A., Fukuyama, H. & Okumura, H., Jan 1 2001, In : Fukuoka igaku zasshi = Hukuoka acta medica. 92, 5, p. 115-119 5 p.

Research output: Contribution to journalArticle

Pigmentation
Periodontal Diseases
Periodontal Pocket
Tooth
Polychlorinated Biphenyls
41 Citations (Scopus)

Arg-gingipain is responsible for the degradation of cell adhesion molecules of human gingival fibroblasts and their death induced by Porphyromonas gingivalis

Baba, A., Abe, N., Kadowaki, T., Nakanishi, H., Ohishi, M., Asao, T. & Yamamoto, K., Jul 21 2001, In : Biological chemistry. 382, 5, p. 817-824 8 p.

Research output: Contribution to journalArticle

Porphyromonas gingivalis
Cell Adhesion Molecules
Fibroblasts
Degradation
Fibronectins
10 Citations (Scopus)

Calcium imaging for detection and estimation of spike activities in Aplysia neurons

Yoshida, R., Iwamoto, A. & Nagahama, T., Jul 1 2001, In : Zoological science. 18, 5, p. 631-643 13 p.

Research output: Contribution to journalArticle

neurons
image analysis
calcium
dyes
cells