Research Output 1977 2019

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1999
22 Citations (Scopus)

Immunocytochemical localization of substance P neurokinin-1 receptors in rat gingival tissue

Kido, M. A., Yamaza, T., Goto, T. & Tanaka, T., Aug 15 1999, In : Cell and tissue research. 297, 2, p. 213-222 10 p.

Research output: Contribution to journalArticle

Epithelial Attachment
Neurokinin-1 Receptors
Substance P
Rats
Tissue
17 Citations (Scopus)

Immunohistochemical and ultrastructural study of a papillary cystadenocarcinoma arising from the sublingual gland

Kobayashi, I., Kiyoshima, T., Ozeki, S., Shima, K., Shigemura, N., Matsuo, K. & Sakai, H., Jul 1 1999, In : Journal of Oral Pathology and Medicine. 28, 6, p. 282-286 5 p.

Research output: Contribution to journalArticle

Papillary Cystadenocarcinoma
Sublingual Gland
Glandular and Epithelial Neoplasms
Papillary Adenocarcinoma
Lymphoid Tissue
2 Citations (Scopus)

Intrinsic inhibitor of inositol 1,4,5-trisphosphate binding

Hirata, M., Yoshida, M., Kanematsu, T. & Takeuchi, H., 1999, In : Molecular and Cellular Biochemistry. 190, 1-2, p. 179-184 6 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate
Gels
Cytosol
Heparin
Silver Staining
32 Citations (Scopus)

Involvement of EF hand motifs in the Ca2+-dependent binding of the pleckstrin homology domain to phosphoinositides

Yamamoto, T. A., Takeuchi, H., Kanematsu, T., Allen, V., Yagisawa, H., Kikkawa, U., Watanabe, Y., Nakasima, A., Katan, M. & Hirata, M., Oct 1 1999, In : European Journal of Biochemistry. 265, 1, p. 481-490 10 p.

Research output: Contribution to journalArticle

EF Hand Motifs
Phosphatidylinositols
Type C Phospholipases
Phosphatidylinositol 4,5-Diphosphate
Peptide Elongation Factor 1
8 Citations (Scopus)

Membrane association of a new inositol 1,4,5-trisphosphate binding protein, p130 is not dependent on the pleckstrin homology domain

Takeuchi, H., Kanematsu, T., Misumi, Y. & Hirata, M., Apr 1 1999, In : Chemistry and Physics of Lipids. 98, 1-2, p. 35-47 13 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate
Carrier Proteins
Membranes
Proteins
Cytosol
41 Citations (Scopus)

Novel non-apoptotic morphological changes in neurons of the mouse hippocampus following transient hypoxic-ischemia

Fukuda, T., Wang, H., Nakanishi, H., Yamamoto, K. & Kosaka, T., Jan 1 1999, In : Neuroscience Research. 33, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

Hippocampus
Ischemia
Apoptosis
Neurons
In Situ Nick-End Labeling
73 Citations (Scopus)

Osteoclast-derived zinc finger (OCZF) protein with POZ domain, a possible transcriptional repressor, is involved in osteoclastogenesis

Kukita, A., Kukita, T., Ouchida, M., Maeda, H., Yatsuki, H. & Kohashi, O., Sep 15 1999, In : Blood. 94, 6, p. 1987-1997 11 p.

Research output: Contribution to journalArticle

Zinc Fingers
Osteoclasts
Osteogenesis
Zinc
Proteins
6 Citations (Scopus)

Phospholipase c-δ and related molecules

Yagisawa, H., Fujii, M. & Hirata, M., Jan 1 1999, In : Biochemical Society Transactions. 27, 4, p. 652-657 6 p.

Research output: Contribution to journalArticle

Phospholipases
Molecules
7 Citations (Scopus)

Relationship between hippocampal arachidonic acid content and induction of LTP in aged rats

Amamoto, T., Okada, M., Kawachi, A., Nakanishi, H., Yazawa, K., Fujiwara, M. & Tomonaga, M., Dec 1 1999, In : Japanese Journal of Psychopharmacology. 19, 5, p. 273-277 5 p.

Research output: Contribution to journalArticle

Arachidonic Acid
Membranes
Carbachol
Lipid Peroxidation
Muscarinic Receptors

Structure and regulation of phospholipase C-δ

Yagisawa, H., Fujii, M. & Hirata, M., Dec 1 1999, In : Seikagaku. 71, 9, p. 1156-1162 7 p.

Research output: Contribution to journalArticle

Phospholipase C delta
Type C Phospholipases
Inositol
Tertiary Protein Structure
GTP-Binding Proteins

Studies on new ins(1,4,5)P3 binding proteins with reference to the pH domains

Kanematsu, T., Takeuchi, H. & Hirata, M., Dec 1 1999, In : ACS Symposium Series. 718, p. 55-78 24 p.

Research output: Contribution to journalArticle

Programmable logic controllers
Carrier Proteins
Proteins
Inositol Phosphates
Inositol
47 Citations (Scopus)

The distribution of BrdU- and TUNEL-positive cells during odontogenesis in mouse lower first molars

Shigemura, N., Kiyoshima, T., Kobayashi, I., Matsuo, K., Yamaza, H., Akamine, A. & Sakai, H., Aug 11 1999, In : Histochemical Journal. 31, 6, p. 367-377 11 p.

Research output: Contribution to journalArticle

Odontogenesis
Deoxyuridine
In Situ Nick-End Labeling
Tooth Germ
Tooth
26 Citations (Scopus)

The human and rat forms of multiple inositol polyphosphate phosphatase: Functional homology with a histidine acid phosphatase up-regulated during endochondral ossification

Caffrey, J. J., Hidaka, K., Matsuda, M., Hirata, M. & Shears, S. B., Jan 8 1999, In : FEBS Letters. 442, 1, p. 99-104 6 p.

Research output: Contribution to journalArticle

Acid Phosphatase
Histidine
Osteogenesis
Rats
Salvaging
16 Citations (Scopus)

The molecular weight ratio of monomethoxypolyethylene glycol (mPEG) to protein determines the immunotolerogenicity of mPEG proteins

So, T., Ito, H. O., Tsujihata, Y., Hirata, M., Ueda, T. & Imoto, T., Jan 1 1999, In : Protein Engineering. 12, 8, p. 701-705 5 p.

Research output: Contribution to journalArticle

Glycols
Molecular Weight
Molecular weight
Proteins
gamma-Globulins
3 Citations (Scopus)

Use of phosphorofluoridate analogues of D-myo-inositol 1,4,5-trisphosphate to assess the involvement of ionic interactions in its recognition by the receptor and metabolising enzymes

Yoshimura, K., Watanabe, Y., Erneux, C. & Hirata, M., Feb 1 1999, In : Cellular Signalling. 11, 2, p. 117-125 9 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate
Phosphates
Phosphotransferases
Enzymes
Phosphoric Monoester Hydrolases
1998
4 Citations (Scopus)

Cathepsin E in the central nervous system

Nakanishi, H. & Yamamoto, K., Jan 1 1998, In : Advances in experimental medicine and biology. 436, p. 213-217 5 p.

Research output: Contribution to journalArticle

Cathepsin E
Central Nervous System
29 Citations (Scopus)

Effect of dietary fats and sesamin on the lipid metabolism and immune function of sprague-dawley rats

Gu, J., Wakizono, Y., Dohi, A., Nonaka, M. & Sugano, M., Jan 1 1998, In : Bioscience, Biotechnology and Biochemistry. 62, 10, p. 1917-1924 8 p.

Research output: Contribution to journalArticle

Dietary Fats
Lipid Metabolism
Sprague Dawley Rats
Rats
Safflower Oil
23 Citations (Scopus)

Excitotoxin-induced neuronal death is associated with response of a unique intracellular aspartic proteinase, cathepsin E

Tominaga, K., Nakanishi, H., Yasuda, Y. & Yamamoto, K., Dec 1 1998, In : Journal of Neurochemistry. 71, 6, p. 2574-2584 11 p.

Research output: Contribution to journalArticle

Cathepsin E
Aspartic Acid Proteases
Neurotoxins
Neurons
Rats
8 Citations (Scopus)

Expression of the mRNA for types I and II interleukin-1 receptors in dental tissues of mice during tooth development

Xu, L. X., Kukita, T., Yu, H., Nakano, Y. & Koga, T., Oct 1 1998, In : Calcified Tissue International. 63, 4, p. 351-356 6 p.

Research output: Contribution to journalArticle

Interleukin-1 Type II Receptors
Interleukin-1 Type I Receptors
Ameloblasts
Tooth
Odontoblasts
8 Citations (Scopus)

Hyperexcitability of amygdala neurons of senescence-accelerated mouse revealed by electrical and optical recordings in an in vitro slice preparation

Nakanishi, H., Miyazaki, M., Takai, N., Wang, H. D., Yamamoto, T., Watanabe, S. & Yamamoto, K., Nov 23 1998, In : Brain Research. 812, 1-2, p. 142-149 8 p.

Research output: Contribution to journalArticle

Amygdala
Neurons
6-Cyano-7-nitroquinoxaline-2,3-dione
Kainic Acid Receptors
AMPA Receptors
80 Citations (Scopus)

Identification of cellular compartments involved in processing of cathepsin E in primary cultures of rat microglia

Sastradipura, D. F., Nakanishi, H., Tsukuba, T., Nishishita, K., Sakai, H., Kato, Y., Gotow, T., Uchiyama, Y. & Yamamoto, K., May 1 1998, In : Journal of Neurochemistry. 70, 5, p. 2045-2056 12 p.

Research output: Contribution to journalArticle

Cathepsin E
Microglia
Rats
Endosomes
Endoplasmic Reticulum
59 Citations (Scopus)

Involvement of caspase-like proteinases in apoptosis of neuronal PC12 cells and primary cultured microglia induced by 6-hydroxydopamine

Takai, N., Nakanishi, H., Tanabe, K., Nishioku, T., Sugiyama, T., Fujiwara, M. & Yamamoto, K., Oct 15 1998, In : Journal of Neuroscience Research. 54, 2, p. 214-222 9 p.

Research output: Contribution to journalArticle

Oxidopamine
PC12 Cells
Microglia
Caspases
Peptide Hydrolases
42 Citations (Scopus)

Involvement of lymphocyte function-associated antigen-1 and intercellular adhesion molecule-1 in osteoclastogenesis: A possible role in direct interaction between osteoclast precursors

Harada, H., Kukita, T., Kukita, A., Iwamoto, Y. & Iijima, T., Jan 1 1998, In : Endocrinology. 139, 9, p. 3967-3975 9 p.

Research output: Contribution to journalArticle

Lymphocyte Function-Associated Antigen-1
Osteoclasts
Intercellular Adhesion Molecule-1
Osteogenesis
Antigens
6 Citations (Scopus)

Laminin, a major basement membrane component of the blood vessel, as a negative regulator of osteoclastogenesis

Kukita, T., Hata, K., Kukita, A. & Iijima, T., Aug 1 1998, In : Calcified Tissue International. 63, 2, p. 140-142 3 p.

Research output: Contribution to journalArticle

Laminin
Basement Membrane
Osteogenesis
Blood Vessels
Osteoclasts
102 Citations (Scopus)

Light- and electron-microscopic study of the distribution of axons containing substance P and the localization of neurokinin-1 receptor in bone

Goto, T., Yamaza, T., Kido, M. A. & Tanaka, T., Jul 29 1998, In : Cell and tissue research. 293, 1, p. 87-93 7 p.

Research output: Contribution to journalArticle

Neurokinin-1 Receptors
Substance P
Axons
Bone
Electrons
31 Citations (Scopus)

Localization of a novel inositol 1,4,5-trisphosphate binding protein, p130 in rat brain

Matsuda, M., Kanematsu, T., Takeuchi, H., Kukita, T. & Hirata, M., Nov 27 1998, In : Neuroscience Letters. 257, 2, p. 97-100 4 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate
Carrier Proteins
Type C Phospholipases
Messenger RNA
Brain
30 Citations (Scopus)

PTB domain of insulin receptor substrate-1 binds inositol compounds

Takeuchi, H., Matsuda, M., Yamamoto, T. A., Kanematsu, T., Kikkawa, U., Yagisawa, H., Watanabe, Y. & Hirata, M., Aug 15 1998, In : Biochemical Journal. 334, 1, p. 211-218 8 p.

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Phosphotyrosine
Inositol
Inositol Phosphates
Phosphatidylinositols
118 Citations (Scopus)

Replacements of single basic amino acids in the pleckstrin homology domain of phospholipase C-δ1 alter the ligand binding, phospholipase activity, and interaction with the plasma membrane

Yagisawa, H., Sakuma, K., Paterson, H. F., Cheung, R., Allen, V., Hirata, H., Watanabe, Y., Hirata, M., Williams, R. L. & Katan, M., Jan 2 1998, In : Journal of Biological Chemistry. 273, 1, p. 417-424 8 p.

Research output: Contribution to journalArticle

Basic Amino Acids
Phospholipases
Type C Phospholipases
Cell membranes
Phosphatidylinositols
99 Citations (Scopus)

Study of immunoelectron microscopic localization of cathepsin K in osteoclasts and other bone cells in the mouse femur

Yamaza, T., Goto, T., Kamiya, T., Kobayashi, Y., Sakai, H. & Tanaka, T., Dec 1 1998, In : Bone. 23, 6, p. 499-509 11 p.

Research output: Contribution to journalArticle

Cathepsin K
Osteoclasts
Femur
Bone and Bones
Bone Resorption
10 Citations (Scopus)

Successful detection of active osteoclasts in situ by systemic administration of an osteoclast-specific monoclonal antibody

Kukita, T., Kukita, A., Xu, L., Maeda, H. & Iijima, T., Aug 1 1998, In : Calcified Tissue International. 63, 2, p. 148-153 6 p.

Research output: Contribution to journalArticle

Osteoclasts
Monoclonal Antibodies
Antigens
Immunoelectron Microscopy
Bone Remodeling
11 Citations (Scopus)

Tolerogenic activity of polyethylene glycol-conjugated lysozyme distinct from that of the native counterpart

Ito, H. O., So, T., Hirata, M., Koga, T., Ueda, T. & Imoto, T., Mar 9 1998, In : Immunology. 93, 2, p. 200-207 8 p.

Research output: Contribution to journalArticle

Egg White
Muramidase
hen egg lysozyme
Proteins
Antigens
1997
22 Citations (Scopus)
Cathepsin H
Epithelial Attachment
Cathepsin B
Cysteine Proteases
Horseradish Peroxidase
14 Citations (Scopus)

Bidirectional regulation of telomerase activity in a subline derived from human lung adenocarcinoma

Katakura, Y., Yamamoto, K., Miyake, O., Yasuda, T., Uehara, N., Nakata, E., Kawamoto, S. & Shirahata, S., Aug 18 1997, In : Biochemical and Biophysical Research Communications. 237, 2, p. 313-317 5 p.

Research output: Contribution to journalArticle

Telomerase
Cell Aging
Tumors
Growth
Cells

Both PTB domain and PH domain of IRS-1 bind inositol polyphosphates with distinct specificity

Takeuchi, H., Matsuda, M., Kanematsu, T. & Hirata, M., 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Polyphosphates
Inositol
Tyrosine
Inositol Phosphates
12 Citations (Scopus)

Combined effects of sesamin with alpha-tocopherol or tocotrienols on lipid and immune indices in Brown-Norway rats

Gu, J., Tsujita, A., Wakizono, Y., Yamada, K. & Sugano, M., Feb 1 1997, In : Nutrition Research. 17, 2, p. 339-350 12 p.

Research output: Contribution to journalArticle

Tocopherols
alpha-Tocopherol
Lipids
CD4-CD8 Ratio
Leukotrienes
82 Citations (Scopus)

Distinct specificity in the binding of inositol phosphates by pleckstrin homology domains of pleckstrin, RAC-protein kinase, diacylglycerol kinase and a new 130 kDa protein

Takeuchi, H., Kanematsu, T., Misumi, Y., Sakane, F., Konishi, H., Kikkawa, U., Watanabe, Y., Katan, M. & Hirata, M., Dec 12 1997, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1359, 3, p. 275-285 11 p.

Research output: Contribution to journalArticle

Diacylglycerol Kinase
Inositol Phosphates
Protein Kinases
Inositol 1,4,5-Trisphosphate
Lipids
18 Citations (Scopus)

Electrophysiological studies of rat substantia nigra neurons in an in vitro slice preparation after middle cerebral artery occlusion

Nakanishi, H., Tamura, A., Kawai, K. & Yamamoto, K., Apr 5 1997, In : Neuroscience. 77, 4, p. 1021-1028 8 p.

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
Substantia Nigra
Neurons
Middle Cerebral Artery
Subthalamus
6 Citations (Scopus)

Establishment and characterisation of an osteoblastic clonal cell line from human mandibular osteosarcoma (HMOS-1)

Yoshikawa, H., Ohishi, M., Kohriki, S., Yoshiura, M. & Ohsaki, Y., May 1 1997, In : European Journal of Cancer Part B: Oral Oncology. 33, 3, p. 163-168 6 p.

Research output: Contribution to journalArticle

Osteosarcoma
Alkaline Phosphatase
Cell Line
Parathyroid Hormone
Phenotype
17 Citations (Scopus)

Expression and distribution of CC chemokine macrophage inflammatory protein-1α/LD78 in the human brain

Ishizuka, K., Igata-Yi, R., Kimura, T., Hieshima, K., Kukita, T., Kin, Y., Misumi, Y., Yamamoto, M., Nomiyama, H., Miura, R., Takamatsu, J., Katsuragi, S. & Miyakawa, T., Jan 1 1997, In : NeuroReport. 8, 5, p. 1215-1218 4 p.

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
CC Chemokines
Neuroglia
Brain
Schizophrenia
2 Citations (Scopus)

Hen egg-white lysozyme inhibits biological activities of lipopolysaccharides from periodontopathic bacteria

Ito, H. O., Hirata, M. & Koga, T., Jan 1 1997, In : Journal of Periodontal Research. 32, 3, p. 295-299 5 p.

Research output: Contribution to journalArticle

Egg White
Lipopolysaccharides
Bacteria
Prevotella intermedia
Aggregatibacter actinomycetemcomitans
16 Citations (Scopus)

Immunocytochemical study of cathepsin l and rat salivary cystatin-3 in rat osteoclasts treated with e-64 in vivo

Moroi, R., Yamaza, T., Nishiura, T., Nishimura, Y., Terada, Y., Abe, K., Himeno, M. & Tanaka, T., Apr 1 1997, In : Archives of Oral Biology. 42, 4, p. 305-315 11 p.

Research output: Contribution to journalArticle

Salivary Cystatins
Cystatin C
Cathepsins
Osteoclasts
Cathepsin L
85 Citations (Scopus)

Increased expression of cathepsins E and D in neurons of the aged rat brain and their colocalization with lipofuscin and carboxy-terminal fragments of Alzheimer amyloid precursor protein

Nakanishi, H., Amano, T., Sastradipura, D. F., Yoshito, Y., Tsukuba, T., Tanabe, K., Hirotsu, I., Ohono, T. & Yamamoto, K., Feb 1 1997, In : Journal of Neurochemistry. 68, 2, p. 739-749 11 p.

Research output: Contribution to journalArticle

Cathepsin E
Lipofuscin
Cathepsin D
Amyloid beta-Protein Precursor
Neurons
8 Citations (Scopus)

Inositol 1,4,5-trisphosphate receptor subtypes differentially recognize regioisomers of D-myo-inositol 1,4,5-trisphosphate

Hirata, M., Takeuchi, H., Riley, A. M., Mills, S. J., Watanabe, Y. & Potter, B. V. L., Nov 15 1997, In : Biochemical Journal. 328, 1, p. 93-98 6 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate Receptors
Inositol 1,4,5-Trisphosphate
Rats
Saponins
Inositol
14 Citations (Scopus)

Linoleic and α-linolenic acids differently modify the effects of elaidic acid on polyunsaturated fatty acid metabolism and some immune indices in rats

Koga, T., Nonaka, M., Gu, J. & Sugano, M., Apr 1 1997, In : British Journal of Nutrition. 77, 4, p. 645-656 12 p.

Research output: Contribution to journalArticle

Linolenic Acids
Linoleic Acids
Unsaturated Fatty Acids
Trans Fatty Acids
Oils
79 Citations (Scopus)

Macrophage inflammatory protein-1α (LD78) expressed in human bone marrow: Its role in regulation of hematopoiesis and osteoclast recruitment

Kukita, T., Nomiyama, H., Ohmoto, Y., Kukita, A., Shuto, T., Hotokebuchi, T., Sugioka, Y., Miura, R. & Iijima, T., Mar 1 1997, In : Laboratory Investigation. 76, 3, p. 399-406 8 p.

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
Hematopoiesis
Osteoclasts
Bone Marrow
Granulocyte Precursor Cells

Pleckstrin homology domain as inositol poiyphosphate binding module

Yoshimura, K., Takeuchi, H., Kancmatsu, T. & Hirata, M., 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

pleckstrin
Inositol
Phosphatidylinositols
sequence homology
Inositol 1,4,5-Trisphosphate
5 Citations (Scopus)

Regulation of osteoclastogenesis by antisense oligodeoxynucleotides specific to zinc finger nuclear transcription factors Egr-1 and WT1 in rat bone marrow culture system

Kukita, T., Kukita, A., Harada, H. & Iijima, T., Jan 1 1997, In : Endocrinology. 138, 10, p. 4384-4389 6 p.

Research output: Contribution to journalArticle

Oligodeoxyribonucleotides
Zinc Fingers
Osteogenesis
Transcription Factors
Bone Marrow
36 Citations (Scopus)

Role of CD14 molecules in internalization of Actinobacillus actinomycetemcomitans by macrophages and subsequent induction of apoptosis

Muro, M., Koseki, T., Akifusa, S., Kato, S., Kowashi, Y., Ohsaki, Y., Yamato, K., Nishijima, M. & Nishihara, T., Apr 15 1997, In : Infection and Immunity. 65, 4, p. 1147-1151 5 p.

Research output: Contribution to journalArticle

Aggregatibacter actinomycetemcomitans
Macrophages
Apoptosis
Cell Death
DNA Nucleotidylexotransferase
23 Citations (Scopus)

The conformation formed by the domain after Alanine-155 induces inversion of aspartic acid-151 in αA-crystallin from aged human lenses

Fujii, N., Momose, Y., Yamasaki, M., Yamagaki, T., Nakanishi, H., Uemura, T., Takita, M. & Ishii, N., Oct 29 1997, In : Biochemical and Biophysical Research Communications. 239, 3, p. 918-923 6 p.

Research output: Contribution to journalArticle

Crystallins
Aspartic Acid
Isomers
Alanine
Lenses
1996
89 Citations (Scopus)

A new inositol 1,4,5-trisphosphate binding protein similar to phospholipase C-δ1

Kanematsu, T., Misumi, Y., Watanabe, Y., Ozaki, S., Koga, T., Iwanaga, S., Ikehara, Y. & Hirata, M., Jan 1 1996, In : Biochemical Journal. 313, 1, p. 319-325 7 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate
Type C Phospholipases
Carrier Proteins
Programmable logic controllers
Proteins