Research Output 1977 2019

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Article
1998
11 Citations (Scopus)

Tolerogenic activity of polyethylene glycol-conjugated lysozyme distinct from that of the native counterpart

Ito, H. O., So, T., Hirata, M., Koga, T., Ueda, T. & Imoto, T., Mar 9 1998, In : Immunology. 93, 2, p. 200-207 8 p.

Research output: Contribution to journalArticle

Egg White
Muramidase
hen egg lysozyme
Proteins
Antigens
1997
22 Citations (Scopus)
Cathepsin H
Epithelial Attachment
Cathepsin B
Cysteine Proteases
Horseradish Peroxidase
14 Citations (Scopus)

Bidirectional regulation of telomerase activity in a subline derived from human lung adenocarcinoma

Katakura, Y., Yamamoto, K., Miyake, O., Yasuda, T., Uehara, N., Nakata, E., Kawamoto, S. & Shirahata, S., Aug 18 1997, In : Biochemical and Biophysical Research Communications. 237, 2, p. 313-317 5 p.

Research output: Contribution to journalArticle

Telomerase
Cell Aging
Tumors
Growth
Cells

Both PTB domain and PH domain of IRS-1 bind inositol polyphosphates with distinct specificity

Takeuchi, H., Matsuda, M., Kanematsu, T. & Hirata, M., 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

Insulin Receptor Substrate Proteins
Polyphosphates
Inositol
Tyrosine
Inositol Phosphates
12 Citations (Scopus)

Combined effects of sesamin with alpha-tocopherol or tocotrienols on lipid and immune indices in Brown-Norway rats

Gu, J., Tsujita, A., Wakizono, Y., Yamada, K. & Sugano, M., Feb 1 1997, In : Nutrition Research. 17, 2, p. 339-350 12 p.

Research output: Contribution to journalArticle

Tocopherols
alpha-Tocopherol
Lipids
CD4-CD8 Ratio
Leukotrienes
82 Citations (Scopus)

Distinct specificity in the binding of inositol phosphates by pleckstrin homology domains of pleckstrin, RAC-protein kinase, diacylglycerol kinase and a new 130 kDa protein

Takeuchi, H., Kanematsu, T., Misumi, Y., Sakane, F., Konishi, H., Kikkawa, U., Watanabe, Y., Katan, M. & Hirata, M., Dec 12 1997, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1359, 3, p. 275-285 11 p.

Research output: Contribution to journalArticle

Diacylglycerol Kinase
Inositol Phosphates
Protein Kinases
Inositol 1,4,5-Trisphosphate
Lipids
18 Citations (Scopus)

Electrophysiological studies of rat substantia nigra neurons in an in vitro slice preparation after middle cerebral artery occlusion

Nakanishi, H., Tamura, A., Kawai, K. & Yamamoto, K., Apr 5 1997, In : Neuroscience. 77, 4, p. 1021-1028 8 p.

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
Substantia Nigra
Neurons
Middle Cerebral Artery
Subthalamus
6 Citations (Scopus)

Establishment and characterisation of an osteoblastic clonal cell line from human mandibular osteosarcoma (HMOS-1)

Yoshikawa, H., Ohishi, M., Kohriki, S., Yoshiura, M. & Ohsaki, Y., May 1 1997, In : European Journal of Cancer Part B: Oral Oncology. 33, 3, p. 163-168 6 p.

Research output: Contribution to journalArticle

Osteosarcoma
Alkaline Phosphatase
Cell Line
Parathyroid Hormone
Phenotype
17 Citations (Scopus)

Expression and distribution of CC chemokine macrophage inflammatory protein-1α/LD78 in the human brain

Ishizuka, K., Igata-Yi, R., Kimura, T., Hieshima, K., Kukita, T., Kin, Y., Misumi, Y., Yamamoto, M., Nomiyama, H., Miura, R., Takamatsu, J., Katsuragi, S. & Miyakawa, T., Jan 1 1997, In : NeuroReport. 8, 5, p. 1215-1218 4 p.

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
CC Chemokines
Neuroglia
Brain
Schizophrenia
2 Citations (Scopus)

Hen egg-white lysozyme inhibits biological activities of lipopolysaccharides from periodontopathic bacteria

Ito, H. O., Hirata, M. & Koga, T., Jan 1 1997, In : Journal of Periodontal Research. 32, 3, p. 295-299 5 p.

Research output: Contribution to journalArticle

Egg White
Lipopolysaccharides
Bacteria
Prevotella intermedia
Aggregatibacter actinomycetemcomitans
16 Citations (Scopus)

Immunocytochemical study of cathepsin l and rat salivary cystatin-3 in rat osteoclasts treated with e-64 in vivo

Moroi, R., Yamaza, T., Nishiura, T., Nishimura, Y., Terada, Y., Abe, K., Himeno, M. & Tanaka, T., Apr 1 1997, In : Archives of Oral Biology. 42, 4, p. 305-315 11 p.

Research output: Contribution to journalArticle

Salivary Cystatins
Cystatin C
Cathepsins
Osteoclasts
Cathepsin L
85 Citations (Scopus)

Increased expression of cathepsins E and D in neurons of the aged rat brain and their colocalization with lipofuscin and carboxy-terminal fragments of Alzheimer amyloid precursor protein

Nakanishi, H., Amano, T., Sastradipura, D. F., Yoshito, Y., Tsukuba, T., Tanabe, K., Hirotsu, I., Ohono, T. & Yamamoto, K., Feb 1 1997, In : Journal of Neurochemistry. 68, 2, p. 739-749 11 p.

Research output: Contribution to journalArticle

Cathepsin E
Lipofuscin
Cathepsin D
Amyloid beta-Protein Precursor
Neurons
8 Citations (Scopus)

Inositol 1,4,5-trisphosphate receptor subtypes differentially recognize regioisomers of D-myo-inositol 1,4,5-trisphosphate

Hirata, M., Takeuchi, H., Riley, A. M., Mills, S. J., Watanabe, Y. & Potter, B. V. L., Nov 15 1997, In : Biochemical Journal. 328, 1, p. 93-98 6 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate Receptors
Inositol 1,4,5-Trisphosphate
Rats
Saponins
Inositol
14 Citations (Scopus)

Linoleic and α-linolenic acids differently modify the effects of elaidic acid on polyunsaturated fatty acid metabolism and some immune indices in rats

Koga, T., Nonaka, M., Gu, J. Y. & Sugano, M., Apr 1 1997, In : British Journal of Nutrition. 77, 4, p. 645-656 12 p.

Research output: Contribution to journalArticle

Linolenic Acids
Linoleic Acids
Unsaturated Fatty Acids
Trans Fatty Acids
Oils
79 Citations (Scopus)

Macrophage inflammatory protein-1α (LD78) expressed in human bone marrow: Its role in regulation of hematopoiesis and osteoclast recruitment

Kukita, T., Nomiyama, H., Ohmoto, Y., Kukita, A., Shuto, T., Hotokebuchi, T., Sugioka, Y., Miura, R. & Iijima, T., Mar 1 1997, In : Laboratory Investigation. 76, 3, p. 399-406 8 p.

Research output: Contribution to journalArticle

Macrophage Inflammatory Proteins
Hematopoiesis
Osteoclasts
Bone Marrow
Granulocyte Precursor Cells

Pleckstrin homology domain as inositol poiyphosphate binding module

Yoshimura, K., Takeuchi, H., Kancmatsu, T. & Hirata, M., 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

pleckstrin
Inositol
Phosphatidylinositols
sequence homology
Inositol 1,4,5-Trisphosphate
5 Citations (Scopus)

Regulation of osteoclastogenesis by antisense oligodeoxynucleotides specific to zinc finger nuclear transcription factors Egr-1 and WT1 in rat bone marrow culture system

Kukita, T., Kukita, A., Harada, H. & Iijima, T., Jan 1 1997, In : Endocrinology. 138, 10, p. 4384-4389 6 p.

Research output: Contribution to journalArticle

Oligodeoxyribonucleotides
Zinc Fingers
Osteogenesis
Transcription Factors
Bone Marrow
36 Citations (Scopus)

Role of CD14 molecules in internalization of Actinobacillus actinomycetemcomitans by macrophages and subsequent induction of apoptosis

Muro, M., Koseki, T., Akifusa, S., Kato, S., Kowashi, Y., Ohsaki, Y., Yamato, K., Nishijima, M. & Nishihara, T., Apr 15 1997, In : Infection and Immunity. 65, 4, p. 1147-1151 5 p.

Research output: Contribution to journalArticle

Aggregatibacter actinomycetemcomitans
Macrophages
Apoptosis
Cell Death
DNA Nucleotidylexotransferase
23 Citations (Scopus)

The conformation formed by the domain after Alanine-155 induces inversion of aspartic acid-151 in αA-crystallin from aged human lenses

Fujii, N., Momose, Y., Yamasaki, M., Yamagaki, T., Nakanishi, H., Uemura, T., Takita, M. & Ishii, N., Oct 29 1997, In : Biochemical and Biophysical Research Communications. 239, 3, p. 918-923 6 p.

Research output: Contribution to journalArticle

Crystallins
Aspartic Acid
Isomers
Alanine
Lenses
1996
89 Citations (Scopus)

A new inositol 1,4,5-trisphosphate binding protein similar to phospholipase C-δ1

Kanematsu, T., Misumi, Y., Watanabe, Y., Ozaki, S., Koga, T., Iwanaga, S., Ikehara, Y. & Hirata, M., Jan 1 1996, In : Biochemical Journal. 313, 1, p. 319-325 7 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate
Type C Phospholipases
Carrier Proteins
Programmable logic controllers
Proteins
7 Citations (Scopus)

An improved mounting method for observation of thick specimens using confocal microscopy

Kagayama, M., Sasano, Y., Hirata, M., Mizoguchi, I. & Takahashi, I., Jan 1 1996, In : Biotechnic and Histochemistry. 71, 5, p. 231-233 3 p.

Research output: Contribution to journalArticle

Confocal Microscopy
Air
Observation
Immersion
Lenses
19 Citations (Scopus)

Immunocytochemical study of nerve fibers containing substance P in the junctional epithelium of rats

Tanaka, T., Kido, M. A., Ibuki, T., Yamaza, T., Kondo, T. & Nagata, E., Jan 1 1996, In : Journal of Periodontal Research. 31, 3, p. 187-194 8 p.

Research output: Contribution to journalArticle

Epithelial Attachment
Substance P
Nerve Fibers
Dental Enamel
Neutrophils
36 Citations (Scopus)

Lipopolysaccharides from Porphyromonas gingivalis, Prevotella intermedia and Actinobacillus actinomycetemcomitans promote osteoclastic differentiation in vitro

Ito, H. O., Shuto, T., Takada, H., Koga, T., Aida, Y., Hirata, M. & Koga, T., Jan 1 1996, In : Archives of Oral Biology. 41, 5, p. 439-444 6 p.

Research output: Contribution to journalArticle

Prevotella intermedia
Aggregatibacter actinomycetemcomitans
Porphyromonas gingivalis
Lipopolysaccharides
Osteoclasts
60 Citations (Scopus)

Localization of a high-affinity inositol 1,4,5-trisphosphate/inositol 1,4,5,6-tetrakisphosphate binding domain to the pleckstrin homology module of a new 130 KDa protein: Characterization of the determinants of structural specificity

Takeuchi, H., Kanematsu, T., Misumi, Y., Yaakob, H. B., Yagisawa, H., Ikehara, Y., Watanabe, Y., Tan, Z., Shears, S. B. & Hirata, M., Sep 1 1996, In : Biochemical Journal. 318, 2, p. 561-568 8 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate
Phosphates
Proteins
Ligands
Polyphosphates
31 Citations (Scopus)

Osteoclasts in normal and adjuvant arthritis bone tissues express the mRNA for both type I and II interleukin-1 receptors

Xu, L. X., Kukita, T., Nakano, Y., Yu, H., Hotokebuchi, T., Kuratani, T., Iijima, T. & Koga, T., Nov 1 1996, In : Laboratory Investigation. 75, 5, p. 677-687 11 p.

Research output: Contribution to journalArticle

Interleukin-1 Type II Receptors
Interleukin-1 Type I Receptors
Experimental Arthritis
Osteoclasts
Interleukin-1

Pleckstrin homology domain of phospholipase C-δ1: Its importance in lns(1,4,5)P3 / Ptdlns(4,5)P2 binding, enzymatic activity and translocation

Tegisawa, H., Sakuma, K., Tamaoka, Y., Mizobata, T., Fujii, M., Kamata, H., Hirata, M. & Hirata, H., Jan 1 1996, In : Biochemical Society Transactions. 24, 4

Research output: Contribution to journalArticle

Type C Phospholipases
Basic Amino Acids
Allura Red AC Dye
Catalyst activity
Acidic Amino Acids
14 Citations (Scopus)

Protective effect of MK-801 on the anoxia-aglycemia induced damage in the fluorocitrate-treated hippocampal slice of the rat

Nakanishi, H., Kawachi, A., Okada, M., Fujiwara, M. & Yamamoto, K., Sep 2 1996, In : Brain Research. 732, 1-2, p. 232-236 5 p.

Research output: Contribution to journalArticle

Dizocilpine Maleate
Neuroglia
Pyramidal Cells
Excitatory Postsynaptic Potentials
N-Methyl-D-Aspartate Receptors

Significance of alpha-1-antitrypsin mRNA expression in esophageal carcinoma

Mimori, K., Mori, M., Mafune, K., Tanaka, Y., Li, J., Fukumaki, Y., Matsuda, M., Sugimachi, K. & Akiyoshi, T., Nov 1 1996, In : International journal of oncology. 9, 5, p. 907-910 4 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 7
alpha 1-Antitrypsin
Carcinoma
Messenger RNA
Esophageal Neoplasms
6 Citations (Scopus)

Synthesis of phosphorofluoridate analogues of myo-inositol 1,4,5-tris(phosphate) and their biological activity

Watanabe, Y., Sofue, S., Ozaki, S. & Hirata, M., Jan 1 1996, In : Chemical Communications. 15, p. 1815-1816 2 p.

Research output: Contribution to journalArticle

Phosphatases
Inositol
Bioactivity
Phosphoric Monoester Hydrolases
Assays
7 Citations (Scopus)

The distribution of fibronectin and laminin in the murine periodontal membrane, indicating possible functional roles in the apical migration of the junctional epithelium

Sakai, T., Ohsaki, Y., Kido, M., Goto, M., Terada, Y. & Sakai, H., Aug 1 1996, In : Archives of Oral Biology. 41, 8-9, p. 885-891 7 p.

Research output: Contribution to journalArticle

Epithelial Attachment
Laminin
Fibronectins
Membranes
Focal Adhesions
1995
37 Citations (Scopus)

Actinobacillus actinomycetemcomitans Y4 capsular-polysaccharide-like polysaccharide promotes osteoclast-like cell formation by interleukin-1α production in mouse marrow cultures

Nishihara, T., Ueda, N., Amano, K., Ishihara, Y., Hayakawa, H., Kuroyanagi, T., Ohsaki, Y., Nagata, K. & Noguchi, T., Jan 1 1995, In : Infection and Immunity. 63, 5, p. 1893-1898 6 p.

Research output: Contribution to journalArticle

Aggregatibacter actinomycetemcomitans
Osteoclasts
Interleukin-1
Polysaccharides
Bone Marrow
33 Citations (Scopus)

Age-related changes in cellular localization and enzymatic activities of cathepsins B, L and D in the rat trigeminal ganglion neuron

Amano, T., Nakanishi, H., Kondo, T., Tanaka, T., Oka, M. & Yamamoto, K., Sep 15 1995, In : Mechanisms of Ageing and Development. 83, 3, p. 133-141 9 p.

Research output: Contribution to journalArticle

Cathepsin L
Trigeminal Ganglion
Cathepsin B
Cathepsin D
Neurons
27 Citations (Scopus)
Epithelial Attachment
Capsaicin
Gingiva
Substance P
Blood Vessels
20 Citations (Scopus)

A novel mutation causing an aberrant splicing in the protein 4.2 gene associated with hereditary spherocytosis (protein 4.2Notame)

Matsuda, M., Hatano, N., Ideguchi, H., Takahira, H. & Fukumaki, Y., Jul 1 1995, In : Human Molecular Genetics. 4, 7, p. 1187-1191 5 p.

Research output: Contribution to journalArticle

Protein Splicing
Hereditary Spherocytosis
Protein Deficiency
Introns
Mutation
3 Citations (Scopus)

Characterization of cathepsins E and D accumulated at early stages of neuronal damage in hippocampal neurons of rats

Tominaga, K., Nakanishi, H., Yajima, M. & Yamamoto, K., Jan 1 1995, In : Advances in experimental medicine and biology. 362, p. 341-343 3 p.

Research output: Contribution to journalArticle

Cathepsin E
Intraventricular Injections
Cathepsins
Cerebral Ventricles
Cathepsin D
11 Citations (Scopus)

d-myo-Inositol 1,4,5-trisphosphate analogues substituted at the 3-hydroxyl group

Hirata, M., Watanabe, Y., Kanematsu, T., Ozaki, S. & Koga, T., Jun 9 1995, In : BBA - General Subjects. 1244, 2-3, p. 404-410 7 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate
Hydroxyl Radical
Phosphorylation
Erythrocyte Membrane
Enzymes
3 Citations (Scopus)

Effects of different dietary fats and proteins on cholesterol metabolism and eicosanoid production in hamsters

Gatchalian-Yee, M., Imamura, M., Nonaka, M., Gu, J. & Sugano, M., Jan 1 1995, In : Nutrition Research. 15, 8, p. 1149-1158 10 p.

Research output: Contribution to journalArticle

Soybean Proteins
Dietary Proteins
Eicosanoids
Dietary Fats
Cricetinae
32 Citations (Scopus)

Effects of Sesamin and α-Tocopherol, Individually or in Combination, on the Polyunsaturated Fatty Acid Metabolism, Chemical Mediator Production, and Immunoglobulin Levels in Sprague-Dawley Rats

Gu, J., Wakizono, Y., Tsujita, A., Lim, B. O., Nonaka, M., Yamada, K. & Sugano, M., Jan 1 1995, In : Bioscience, biotechnology, and biochemistry. 59, 12, p. 2198-2202 5 p.

Research output: Contribution to journalArticle

Tocopherols
Unsaturated Fatty Acids
Metabolism
Sprague Dawley Rats
Immunoglobulins
9 Citations (Scopus)

Increased expression and specific localization of cathepsins E and D in vulnerable brain regions of aged and postischemic rats

Nakanishi, H., Tominaga, K. & Yamamoto, K., Jan 1 1995, In : Advances in experimental medicine and biology. 362, p. 335-339 5 p.

Research output: Contribution to journalArticle

Cathepsin E
Neostriatum
Cathepsins
Nerve Degeneration
Cathepsin D
44 Citations (Scopus)

Increased expression of cathepsins E and D in reactive microglial cells associated with spongiform degeneration in the brain stem of senescence-accelerated mouse

Amano, T., Nakanishi, H., Oka, M. & Yamamoto, K., Jan 1 1995, In : Experimental Neurology. 136, 2, p. 171-182 12 p., 71094.

Research output: Contribution to journalArticle

Cathepsin E
Cathepsin D
Brain Stem
Cerebral Cortex
Atrophy
35 Citations (Scopus)

Induction of Apoptosis in B Lineage Cells by Activin a Derived from Macrophages

Nishihara, T., Ohsaki, Y., Ueda, N., Koseki, T. & Eto, Y., Jan 1 1995, In : Journal of Interferon and Cytokine Research. 15, 6, p. 509-516 8 p.

Research output: Contribution to journalArticle

Activins
Macrophages
Apoptosis
Cell Death
DNA
22 Citations (Scopus)

Inositol 1,4,5-trisphosphate binding to porcine tracheal smooth muscle aldolase

Baron, C. B., Ozaki, S., Watanabe, Y., Hirata, M., LaBelle, E. F. & Coburn, R. F., Jan 1 1995, In : Journal of Biological Chemistry. 270, 35, p. 20459-20465 7 p.

Research output: Contribution to journalArticle

Fructose-Bisphosphate Aldolase
Inositol 1,4,5-Trisphosphate
Smooth Muscle
Muscle
Swine
65 Citations (Scopus)

Interleukin‐10 selectively inhibits osteoclastogenesis by inhibiting differentiation of osteoclast progenitors into preosteoclast‐like cells in rat bone marrow culture system

Xu, L. X., Kukita, T., Kukita, A., Otsuka, T., Niho, Y. & Iijima, T., Jan 1 1995, In : Journal of cellular physiology. 165, 3, p. 624-629 6 p.

Research output: Contribution to journalArticle

Osteoclasts
Osteogenesis
Rats
Bone
Bone Marrow
19 Citations (Scopus)

Lipopolysaccharides from periodontal pathogens prime neutrophils for enhanced respiratory burst: differential effect of a synthetic lipid a Precursor IVA(LA‐14‐PP)

Aida, Y., Kukita, T., Takada, H., Maeda, K. & Pabst, M. J., Jan 1 1995, In : Journal of Periodontal Research. 30, 2, p. 116-123 8 p.

Research output: Contribution to journalArticle

Respiratory Burst
Lipopolysaccharides
Neutrophils
Lipids
Polymyxin B
6 Citations (Scopus)

Localization of types I and III collagen and fibronectin in the developing mouse palatal shelves

Ohsaki, Y., Nagata, K. & Kurisu, K., Jan 1 1995, In : Cells Tissues Organs. 153, 3, p. 161-167 7 p.

Research output: Contribution to journalArticle

Hard Palate
Collagen Type III
Collagen Type I
Fibronectins
Extracellular Matrix
50 Citations (Scopus)

Long-term spatial cognitive impairment after middle cerebral artery occlusion in rats: No involvement of the hippocampus

Okada, M., Nakanishi, H., Tamura, A., Urae, A., Mine, K., Yamamoto, K. & Fujiwara, M., Jan 1 1995, In : Journal of Cerebral Blood Flow and Metabolism. 15, 6, p. 1012-1021 10 p.

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
Hippocampus
Microtubule-Associated Proteins
Long-Term Potentiation
Glial Fibrillary Acidic Protein
3 Citations (Scopus)

Neuronal cell death and intracellular proteinase functions

Nakanishi, H. & Yamamoto, K., Jan 1 1995, In : Folia Pharmacologica Japonica. 105, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Cathepsin E
Peptide Hydrolases
Cell Death
Cathepsin D
Cathepsin G
7 Citations (Scopus)

The Changes in the Immunocytochemical Localization of Cathepsin L and Type I Collagen in Rat Osteoclasts Treated with E-64

Moroi, R., Yamaza, T., Ayukawa, Y., Kiyoshima, T., Ohsaki, Y., Nishimura, Y., Terada, Y., Himeno, M. & Tanaka, T., Jan 1 1995, In : Acta Histochemica et Cytochemica. 28, 6, p. 523-531 9 p.

Research output: Contribution to journalArticle

Cathepsin L
Osteoclasts
Collagen Type I
Rats
Vacuoles
1994
14 Citations (Scopus)

A convenient chemoenzymatic synthesis of d-and l-myo-inositol 1,4,5,6-tetrakisphosphate

Ozaki, S., Ling, L., Ogasawara, T., Watanabe, Y. & Hirata, M., Jun 17 1994, In : Carbohydrate Research. 259, 2, p. 307-310 4 p.

Research output: Contribution to journalArticle

Magnetic resonance spectroscopy
Stereoisomerism
Inositol Phosphates
Chromatography
Enzymes
134 Citations (Scopus)

Age-related changes in activities and localizations of cathepsins D, E, B, and L in the rat brain tissues

Nakanishi, H., Tominaga, K., Amano, T., Hirotsu, I., Inoue, T. & Yamamoto, K., Jan 1 1994, In : Experimental Neurology. 126, 1, p. 119-128 10 p.

Research output: Contribution to journalArticle

Cathepsin E
Cathepsin D
Brain
Cathepsin L
Neostriatum