Research Output 1977 2019

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1996
6 Citations (Scopus)

Synthesis of phosphorofluoridate analogues of myo-inositol 1,4,5-tris(phosphate) and their biological activity

Watanabe, Y., Sofue, S., Ozaki, S. & Hirata, M., Jan 1 1996, In : Chemical Communications. 15, p. 1815-1816 2 p.

Research output: Contribution to journalArticle

Phosphatases
Inositol
Bioactivity
Phosphoric Monoester Hydrolases
Assays
7 Citations (Scopus)

The distribution of fibronectin and laminin in the murine periodontal membrane, indicating possible functional roles in the apical migration of the junctional epithelium

Sakai, T., Ohsaki, Y., Kido, M., Goto, M., Terada, Y. & Sakai, H., Aug 1 1996, In : Archives of Oral Biology. 41, 8-9, p. 885-891 7 p.

Research output: Contribution to journalArticle

Epithelial Attachment
Laminin
Fibronectins
Membranes
Focal Adhesions
1995
37 Citations (Scopus)

Actinobacillus actinomycetemcomitans Y4 capsular-polysaccharide-like polysaccharide promotes osteoclast-like cell formation by interleukin-1α production in mouse marrow cultures

Nishihara, T., Ueda, N., Amano, K., Ishihara, Y., Hayakawa, H., Kuroyanagi, T., Ohsaki, Y., Nagata, K. & Noguchi, T., Jan 1 1995, In : Infection and Immunity. 63, 5, p. 1893-1898 6 p.

Research output: Contribution to journalArticle

Aggregatibacter actinomycetemcomitans
Osteoclasts
Interleukin-1
Polysaccharides
Bone Marrow
33 Citations (Scopus)

Age-related changes in cellular localization and enzymatic activities of cathepsins B, L and D in the rat trigeminal ganglion neuron

Amano, T., Nakanishi, H., Kondo, T., Tanaka, T., Oka, M. & Yamamoto, K., Sep 15 1995, In : Mechanisms of Ageing and Development. 83, 3, p. 133-141 9 p.

Research output: Contribution to journalArticle

Cathepsin L
Trigeminal Ganglion
Cathepsin B
Cathepsin D
Neurons
27 Citations (Scopus)
Epithelial Attachment
Capsaicin
Gingiva
Substance P
Blood Vessels
20 Citations (Scopus)

A novel mutation causing an aberrant splicing in the protein 4.2 gene associated with hereditary spherocytosis (protein 4.2Notame)

Matsuda, M., Hatano, N., Ideguchi, H., Takahira, H. & Fukumaki, Y., Jul 1 1995, In : Human Molecular Genetics. 4, 7, p. 1187-1191 5 p.

Research output: Contribution to journalArticle

Protein Splicing
Hereditary Spherocytosis
Protein Deficiency
Introns
Mutation
3 Citations (Scopus)

Characterization of cathepsins E and D accumulated at early stages of neuronal damage in hippocampal neurons of rats

Tominaga, K., Nakanishi, H., Yajima, M. & Yamamoto, K., Jan 1 1995, In : Advances in experimental medicine and biology. 362, p. 341-343 3 p.

Research output: Contribution to journalArticle

Cathepsin E
Intraventricular Injections
Cathepsins
Cerebral Ventricles
Cathepsin D
11 Citations (Scopus)

d-myo-Inositol 1,4,5-trisphosphate analogues substituted at the 3-hydroxyl group

Hirata, M., Watanabe, Y., Kanematsu, T., Ozaki, S. & Koga, T., Jun 9 1995, In : BBA - General Subjects. 1244, 2-3, p. 404-410 7 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate
Hydroxyl Radical
Phosphorylation
Erythrocyte Membrane
Enzymes
3 Citations (Scopus)

Effects of different dietary fats and proteins on cholesterol metabolism and eicosanoid production in hamsters

Gatchalian-Yee, M., Imamura, M., Nonaka, M., Gu, J. & Sugano, M., Jan 1 1995, In : Nutrition Research. 15, 8, p. 1149-1158 10 p.

Research output: Contribution to journalArticle

Soybean Proteins
Dietary Proteins
Eicosanoids
Dietary Fats
Cricetinae
32 Citations (Scopus)

Effects of Sesamin and α-Tocopherol, Individually or in Combination, on the Polyunsaturated Fatty Acid Metabolism, Chemical Mediator Production, and Immunoglobulin Levels in Sprague-Dawley Rats

Gu, J., Wakizono, Y., Tsujita, A., Lim, B. O., Nonaka, M., Yamada, K. & Sugano, M., Jan 1 1995, In : Bioscience, biotechnology, and biochemistry. 59, 12, p. 2198-2202 5 p.

Research output: Contribution to journalArticle

Tocopherols
Unsaturated Fatty Acids
Metabolism
Sprague Dawley Rats
Immunoglobulins
9 Citations (Scopus)

Increased expression and specific localization of cathepsins E and D in vulnerable brain regions of aged and postischemic rats

Nakanishi, H., Tominaga, K. & Yamamoto, K., Jan 1 1995, In : Advances in experimental medicine and biology. 362, p. 335-339 5 p.

Research output: Contribution to journalArticle

Cathepsin E
Neostriatum
Cathepsins
Nerve Degeneration
Cathepsin D
44 Citations (Scopus)

Increased expression of cathepsins E and D in reactive microglial cells associated with spongiform degeneration in the brain stem of senescence-accelerated mouse

Amano, T., Nakanishi, H., Oka, M. & Yamamoto, K., Jan 1 1995, In : Experimental Neurology. 136, 2, p. 171-182 12 p., 71094.

Research output: Contribution to journalArticle

Cathepsin E
Cathepsin D
Brain Stem
Cerebral Cortex
Atrophy
34 Citations (Scopus)

Induction of Apoptosis in B Lineage Cells by Activin a Derived from Macrophages

Nishihara, T., Ohsaki, Y., Ueda, N., Koseki, T. & Eto, Y., Jan 1 1995, In : Journal of Interferon and Cytokine Research. 15, 6, p. 509-516 8 p.

Research output: Contribution to journalArticle

Activins
Macrophages
Apoptosis
Cell Death
DNA
22 Citations (Scopus)

Inositol 1,4,5-trisphosphate binding to porcine tracheal smooth muscle aldolase

Baron, C. B., Ozaki, S., Watanabe, Y., Hirata, M., LaBelle, E. F. & Coburn, R. F., Jan 1 1995, In : Journal of Biological Chemistry. 270, 35, p. 20459-20465 7 p.

Research output: Contribution to journalArticle

Fructose-Bisphosphate Aldolase
Inositol 1,4,5-Trisphosphate
Smooth Muscle
Muscle
Swine
63 Citations (Scopus)

Interleukin‐10 selectively inhibits osteoclastogenesis by inhibiting differentiation of osteoclast progenitors into preosteoclast‐like cells in rat bone marrow culture system

Xu, L. X., Kukita, T., Kukita, A., Otsuka, T., Niho, Y. & Iijima, T., Jan 1 1995, In : Journal of cellular physiology. 165, 3, p. 624-629 6 p.

Research output: Contribution to journalArticle

Osteoclasts
Osteogenesis
Rats
Bone
Bone Marrow
18 Citations (Scopus)

Lipopolysaccharides from periodontal pathogens prime neutrophils for enhanced respiratory burst: differential effect of a synthetic lipid a Precursor IVA(LA‐14‐PP)

Aida, Y., Kukita, T., Takada, H., Maeda, K. & Pabst, M. J., Jan 1 1995, In : Journal of Periodontal Research. 30, 2, p. 116-123 8 p.

Research output: Contribution to journalArticle

Respiratory Burst
Lipopolysaccharides
Neutrophils
Lipids
Polymyxin B
6 Citations (Scopus)

Localization of types I and III collagen and fibronectin in the developing mouse palatal shelves

Ohsaki, Y., Nagata, K. & Kurisu, K., Jan 1 1995, In : Cells Tissues Organs. 153, 3, p. 161-167 7 p.

Research output: Contribution to journalArticle

Hard Palate
Collagen Type III
Collagen Type I
Fibronectins
Extracellular Matrix
49 Citations (Scopus)

Long-term spatial cognitive impairment after middle cerebral artery occlusion in rats: No involvement of the hippocampus

Okada, M., Nakanishi, H., Tamura, A., Urae, A., Mine, K., Yamamoto, K. & Fujiwara, M., Jan 1 1995, In : Journal of Cerebral Blood Flow and Metabolism. 15, 6, p. 1012-1021 10 p.

Research output: Contribution to journalArticle

Middle Cerebral Artery Infarction
Hippocampus
Microtubule-Associated Proteins
Long-Term Potentiation
Glial Fibrillary Acidic Protein
3 Citations (Scopus)

Neuronal cell death and intracellular proteinase functions

Nakanishi, H. & Yamamoto, K., Jan 1 1995, In : Folia Pharmacologica Japonica. 105, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Cathepsin E
Peptide Hydrolases
Cell Death
Cathepsin D
Cathepsin G
7 Citations (Scopus)

The Changes in the Immunocytochemical Localization of Cathepsin L and Type I Collagen in Rat Osteoclasts Treated with E-64

Moroi, R., Yamaza, T., Ayukawa, Y., Kiyoshima, T., Ohsaki, Y., Nishimura, Y., Terada, Y., Himeno, M. & Tanaka, T., Jan 1 1995, In : Acta Histochemica et Cytochemica. 28, 6, p. 523-531 9 p.

Research output: Contribution to journalArticle

Cathepsin L
Osteoclasts
Collagen Type I
Rats
Vacuoles
1994
14 Citations (Scopus)

A convenient chemoenzymatic synthesis of d-and l-myo-inositol 1,4,5,6-tetrakisphosphate

Ozaki, S., Ling, L., Ogasawara, T., Watanabe, Y. & Hirata, M., Jun 17 1994, In : Carbohydrate Research. 259, 2, p. 307-310 4 p.

Research output: Contribution to journalArticle

Magnetic resonance spectroscopy
Stereoisomerism
Inositol Phosphates
Chromatography
Enzymes
134 Citations (Scopus)

Age-related changes in activities and localizations of cathepsins D, E, B, and L in the rat brain tissues

Nakanishi, H., Tominaga, K., Amano, T., Hirotsu, I., Inoue, T. & Yamamoto, K., Jan 1 1994, In : Experimental Neurology. 126, 1, p. 119-128 10 p.

Research output: Contribution to journalArticle

Cathepsin E
Cathepsin D
Brain
Cathepsin L
Neostriatum
1 Citation (Scopus)

A novel monoclonal antibody recognizing a unique antigen of rat osteoclasts induced by the calcified matrices

Hata, K., Akamine, A., Kukita, T., Iijima, T., Kukita, A. & Kurisu, K., Jun 1 1994, In : Histochemistry. 101, 5, p. 347-354 8 p.

Research output: Contribution to journalArticle

osteoclasts
Osteoclasts
monoclonal antibodies
Monoclonal Antibodies
antigens
27 Citations (Scopus)

A novel mutation in the erythrocyte protein 4.2 gene of Japanese patients with hereditary spherocytosis (protein 4.2(Fukuoka))

Takaoka, Y., Ideguchi, H., Matsuda, M., Sakamoto, N., Takeuchi, T. & Fukumaki, Y., Jan 1 1994, In : British Journal of Haematology. 88, 3, p. 527-533 7 p.

Research output: Contribution to journalArticle

Hereditary Spherocytosis
Codon
Erythrocytes
Mutation
Missense Mutation
10 Citations (Scopus)

Ca2+ influx evoked by inositol-3,4,5,6-tetrakisphosphate in ras-transformed NIH/3T3 fibroblasts

Hashii, M., Hirata, M., Ozaki, S., Nozawa, Y. & Higashida, H., Mar 7 1994, In : FEBS Letters. 340, 3, p. 276-280 5 p.

Research output: Contribution to journalArticle

Fibroblasts
Bradykinin Receptors
NIH 3T3 Cells
Inositol 1,4,5-Trisphosphate
Second Messenger Systems
10 Citations (Scopus)

Ca2+-influx gated by inositol-3,4,5,6-tetrakisphosphate in NIH/3T3 fibroblasts

Hashii, M., Hirata, M., Ozaki, S., Nozawa, Y. & Higashida, H., May 15 1994, In : Biochemical and Biophysical Research Communications. 200, 3, p. 1300-1306 7 p.

Research output: Contribution to journalArticle

Fibroblasts
Bradykinin
Inositol
NIH 3T3 Cells
Fura-2
10 Citations (Scopus)

Calcium-dependent hyperexcitability of hippocampal CA1 pyramidal cells in an in vitro slice after ethanol withdrawal of the rat

Shindou, T., Watanabe, S., Kamata, O., Yamamoto, K. & Nakanishi, H., Sep 12 1994, In : Brain Research. 656, 2, p. 432-436 5 p.

Research output: Contribution to journalArticle

Pyramidal Cells
Ethanol
Calcium
Neurons
Calcium Signaling
12 Citations (Scopus)

Contraction and depolarization induced by fetal bovine serum in airway smooth muscle

Abdullah, N. A., Hirata, M., Matsumoto, K., Aizawa, H., Inoue, R., Hamano, S., Ikeda, S., Xie, Z., Hara, N. & Ito, Y., Jan 1 1994, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 266, 5 10-5

Research output: Contribution to journalArticle

Smooth Muscle
Serum
Serotonin
Muscles
Membrane Potentials
Osteoclasts
Granulocyte-Macrophage Colony-Stimulating Factor
Dexamethasone
Bone Marrow
Glucocorticoids
64 Citations (Scopus)

Dexamethasone stimulates osteoclast-like cell formation by inhibiting granulocyte-macrophage colony-stimulating factor production in mouse bone marrow cultures

Shuto, T., Kukita, T., Hirata, M., Jimi, E. & Koga, T., Jan 1 1994, In : Endocrinology. 134, 3, p. 1121-1126 6 p.

Research output: Contribution to journalArticle

Osteoclasts
Granulocyte-Macrophage Colony-Stimulating Factor
Dexamethasone
Bone Marrow
Glucocorticoids

Diversity in the Incorporation into Tissue Phospholipids and Effects on Eicosanoid Production of trans-Monoene Fatty Acidin Rats Fed with Different Dietary Proteins

Koga, T., Yamato, T., Gu, J., Nonaka, M., Yamada, K. & Sugano, M., Jan 1 1994, In : Bioscience, biotechnology, and biochemistry. 58, 2, p. 384-387 4 p.

Research output: Contribution to journalArticle

Trans Fatty Acids
Soybean Proteins
Dietary Proteins
Eicosanoids
Caseins
6 Citations (Scopus)

Diversity in the incorporation into tissue phospholipids and effects on eicosanoid production of trans-monoene fatty acid in rats fed with different dietary proteins

Koga, T., Yamato, T., Gu, J., Nonaka, M., Yamada, K. & Sugano, M., Jan 1 1994, In : Bioscience, Biotechnology and Biochemistry. 58, 2, p. 384-387 4 p.

Research output: Contribution to journalArticle

Trans Fatty Acids
Dietary Proteins
Eicosanoids
Soybean Proteins
Rats
22 Citations (Scopus)

DL-myo-inositol 1,2,4,5-tetrakisphosphate, a potent analog of D-myo- inositol 1,4,5-trisphosphate

Hirata, M., Narumoto, N., Watanabe, Y., Kanematsu, T., Koga, T. & Ozaki, S., 1994, In : Molecular Pharmacology. 45, 2, p. 271-276 6 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate
Erythrocyte Membrane
Cytosol
Hydrolysis
Phosphotransferases
28 Citations (Scopus)

D-myo-inositol 1,4,5-trisphosphate binding domain of phospholipase C-δ1

Hirata, M., Kanematsu, T., Sakuma, K., Koga, T., Watanabe, Y., Ozaki, S. & Yagisawa, H., Jan 1 1994, In : Biochemical and Biophysical Research Communications. 205, 3, p. 1563-1571 9 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate
Type C Phospholipases
Peptides
Immunoglobulin Fab Fragments
Antibodies
59 Citations (Scopus)

D-myo-inositol 1,4,5-trisphosphate-binding proteins in rat brain membranes

Yoshida, M., Kanematsu, T., Watanabe, Y., Koga, T., Ozaki, S., Iwanaga, S. & Hirata, M., Jan 1 1994, In : Journal of biochemistry. 115, 5, p. 973-980 8 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate
Rats
Brain
Carrier Proteins
Membranes
8 Citations (Scopus)

Effect of Dietary Fats on Cholesterol Metabolism and Eicosanoid Production in Hamsters Fed Undigested Fraction of Soybean Protein

Gatchalian-Yee, M., Imamura, M., Nonaka, M., Gu, J. & Sugano, M., Jan 1 1994, In : Journal of Nutritional Science and Vitaminology. 40, 5, p. 499-504 6 p.

Research output: Contribution to journalArticle

Soybean Proteins
Eicosanoids
Dietary Fats
Safflower Oil
Cricetinae
6 Citations (Scopus)

Effects of epithelial cell supernatant on membrane potential and contraction of dog airway smooth muscles.

Matsumoto, K., Aizawa, H., Inoue, R., Hamano, S., Ikeda, S., Xie, Z., Hirata, M., Hara, N. & Ito, Y., Jan 1 1994, In : American journal of respiratory cell and molecular biology. 10, 3, p. 322-330 9 p.

Research output: Contribution to journalArticle

Membrane Potentials
Smooth Muscle
Muscle
Epithelial Cells
Dogs
25 Citations (Scopus)

Effects of Sesamin and α-Tocopherol on the Production of Chemical Mediators and Immunoglobulins in Brown-Norway Rats

Gu, J., Nonaka, M., Yamada, K., Yoshimura, K., Takasugi, M., Ito, Y. & Sugano, M., Jan 1 1994, In : Bioscience, biotechnology, and biochemistry. 58, 10, p. 1855-1858 4 p.

Research output: Contribution to journalArticle

Tocopherols
Immunoglobulins
Rats
Leukotriene C4
Phosphatidylcholines
130 Citations (Scopus)

Expression and characterization of an inositol 1,4,5-trisphosphate binding domain of phosphatidylinositol-specific phospholipase C-δ1

Yagisawa, H., Hirata, M., Kanematsu, T., Watanabe, Y., Ozaki, S., Sakuma, K., Tanaka, H., Yabuta, N., Kamata, H., Hirata, H. & Nojima, H., Aug 5 1994, In : Journal of Biological Chemistry. 269, 31, p. 20179-20188 10 p.

Research output: Contribution to journalArticle

Phosphoinositide Phospholipase C
Inositol 1,4,5-Trisphosphate
Type C Phospholipases
Enzymes
Phosphatidylinositols
36 Citations (Scopus)

Expression of the type I collagen gene in rat periodontal ligament during tooth movement as revealed by in situ hybridization

Nakagawa, M., Kukita, T., Nakasima, A. & Kurisu, K., Jan 1 1994, In : Archives of Oral Biology. 39, 4, p. 289-294 6 p.

Research output: Contribution to journalArticle

Tooth Movement Techniques
Periodontal Ligament
Collagen Type I
In Situ Hybridization
Genes
27 Citations (Scopus)

Granulocyte-macrophage colony stimulating factor suppresses lipopolysaccharide-induced osteoclast-like cell formation in mouse bone marrow cultures

Shuto, T., Jimi, E., Kukita, T., Hirata, M. & Koga, T., Jan 1 1994, In : Endocrinology. 134, 2, p. 831-837 7 p.

Research output: Contribution to journalArticle

Osteoclasts
Granulocyte-Macrophage Colony-Stimulating Factor
Lipopolysaccharides
Bone Marrow
Dexamethasone
15 Citations (Scopus)

Interrelationships of Cyclic GMP, Inositol Phosphates, and Calcium

Hirata, M. & Murad, F., Jan 1 1994, In : Advances in Pharmacology. 26, C, p. 195-216 22 p.

Research output: Contribution to journalArticle

Inositol Phosphates
Cyclic GMP
Calcium
Cell Surface Receptors
Neurotransmitter Agents
16 Citations (Scopus)

Localization of osteopontin in resorption lacunae formed by osteoclast-like cells: a study by a novel monoclonal antibody which recognizes rat osteopontin

Maeda, H., Akamine, A., Kukita, T., Iijima, T. & Kukita, A., Oct 1 1994, In : Histochemistry. 102, 4, p. 247-254 8 p.

Research output: Contribution to journalArticle

osteopontin
Osteopontin
osteoclasts
resorption
Osteoclasts
36 Citations (Scopus)

Mouse interleukin-1 receptor antagonist induced by Actinobacillus actinomycetemcomitans lipopolysaccharide blocks the effects of interleukin-1 on bone resorption and osteoclast-like cell formation

Nishihara, T., Ohsaki, Y., Ueda, N., Saito, N. & Mundy, G. R., Jan 1 1994, In : Infection and Immunity. 62, 2, p. 390-397 8 p.

Research output: Contribution to journalArticle

Aggregatibacter actinomycetemcomitans
Interleukin-1 Receptors
Osteoclasts
Bone Resorption
Interleukin-1
24 Citations (Scopus)

Novel cell-surface Ag expressed on rat osteoclasts regulating the function of the calcitonin receptor

Kukita, T., Kukita, A., Nagata, K., Maeda, H., Kurisu, K., Watanabe, T. & Iijima, T., Dec 1 1994, In : Journal of Immunology. 153, 11, p. 5265-5273 9 p.

Research output: Contribution to journalArticle

Calcitonin Receptors
Osteoclasts
Calcitonin
Antigens
Membrane Proteins
33 Citations (Scopus)

Synthesis of 2-substituted myo-inositol 1,3,4,5-tetrakis(phosphate) and 1,3,4,5,6-pentakis(phosphate) analogs

Ozaki, S., Koga, Y., Ling, L., Watanabe, Y., Kimura, Y. & Hirata, M., Jun 29 1994, In : Bulletin of the Chemical Society of Japan. 67, 4, p. 1058-1063 6 p.

Research output: Contribution to journalArticle

Inositol
Phosphates
Carrier Proteins
Derivatives
Membranes
14 Citations (Scopus)

Synthesis of myo-inositol 1,4,6-trisphosphate, an analogue of myo-inositol 1,4,5-trisphosphate

Watanabe, Y., Ogasawara, T., Ozaki, S. & Hirata, M., May 20 1994, In : Carbohydrate Research. 258, C, p. 87-92 6 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate
Bioactivity
inositol 1,4,6-trisphosphate
inositol-1,3,4,6-tetrakisphosphate
11 Citations (Scopus)

Type III collagen is a major component of interodontoblastic fibers of the developing mouse molar root

Ohsaki, Y. & Nagata, K., Jan 1 1994, In : The Anatomical Record. 240, 3, p. 308-313 6 p.

Research output: Contribution to journalArticle

Collagen Type III
Dentin
Odontoblasts
collagen
teeth
1993
44 Citations (Scopus)

Heat-treated osteoblastic cell (ROS17/2.8)-conditioned medium induces the formation of osteoclast-like cells

Kukita, A., Kukita, T., Hata, K., Kurisu, K. & Kohashi, O., Jan 1 1993, In : Bone and Mineral. 23, 2, p. 113-127 15 p.

Research output: Contribution to journalArticle

Osteoclasts
Conditioned Culture Medium
Hot Temperature
Cells
Acid Phosphatase
11 Citations (Scopus)

Immunohistochemical Studies on the Distributions and Age-related Changes of Types I and III Collagen in the Oral Mucosa of Mice

Xu, L. X., Ohsaki, Y., Nagata, K., Xu, L. X. & Kurisu, K., Jan 1 1993, In : Journal of Dental Research. 72, 9, p. 1336-1343 8 p.

Research output: Contribution to journalArticle

Collagen Type III
Age Distribution
Mouth Mucosa
Collagen Type I
Connective Tissue