Research Output 1977 2019

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Review article
2019

Phospholipase C-related catalytically inactive protein: A novel signaling molecule for modulating fat metabolism and energy expenditure

Kanematsu, T., Oue, K., Okumura, T., Harada, K., Yamawaki, Y., Asano, S., Mizokami, A., Irifune, M. & Hirata, M., Jun 1 2019, In : journal of oral biosciences. 61, 2, p. 65-72 8 p.

Research output: Contribution to journalReview article

Staphylococcal Protein A
Type C Phospholipases
Metabolism
Energy Metabolism
Fats

Regenerative medicine using stem cells from human exfoliated deciduous teeth (SHED): a promising new treatment in pediatric surgery

Taguchi, T., Yanagi, Y., Yoshimaru, K., Zhang, X. Y., Matsuura, T., Nakayama, K., Kobayashi, E., Yamaza, H., Nonaka, K., Ohga, S. & Yamaza, T., Apr 10 2019, In : Surgery today. 49, 4, p. 316-322 7 p.

Research output: Contribution to journalReview article

Biliary Atresia
Diaphragmatic Hernia
Regenerative Medicine
Deciduous Tooth
Three-Dimensional Imaging
2017

Binding properties between human sweet receptor and sweet-inhibitor, gymnemic acids

Sanematsu, K., Shigemura, N. & Ninomiya, Y., Aug 1 2017, In : journal of oral biosciences. 59, 3, p. 127-130 4 p.

Research output: Contribution to journalReview article

Cyclodextrins
Molecular Models
HEK293 Cells
gymnemic acid
Glucuronic Acid
1 Citation (Scopus)

Old and new inflammation and infection hypotheses of Alzheimer’s disease: Focus on Microglia-aging for chronic neuroinflammation

Wu, Z. & Nakanishi, H., Jan 1 2017, In : Folia Pharmacologica Japonica. 150, 3, p. 141-147 7 p.

Research output: Contribution to journalReview article

Microglia
Alzheimer Disease
Inflammation
Infection
15 Citations (Scopus)

Osteocalcin and its endocrine functions

Mizokami, A., Kawakubo-Yasukochi, T. & Hirata, M., May 15 2017, In : Biochemical Pharmacology. 132, p. 1-8 8 p.

Research output: Contribution to journalReview article

Osteocalcin
Glucose
Energy Metabolism
Bone
Insulin
2016
20 Citations (Scopus)

Nutrients, Microglia Aging, and Brain Aging

Take, H., Yu, J., Zhu, A. & Nakanishi, H., Jan 1 2016, In : Oxidative medicine and cellular longevity. 2016, 7498528.

Research output: Contribution to journalReview article

Microglia
Nutrients
Brain
Aging of materials
Food
6 Citations (Scopus)

Taste information derived from T1R-expressing taste cells in mice

Yoshida, R. & Ninomiya, Y., Mar 1 2016, In : Biochemical Journal. 473, 5, p. 525-536 12 p.

Research output: Contribution to journalReview article

Calcium
Nutrients
Animals
Taste Buds
Food
1 Citation (Scopus)

The function of glucagon-like peptide-1 in the mouse peripheral taste system

Takai, S., Yoshida, R., Nakano, K., Shigemura, N. & Ninomiya, Y., Feb 1 2016, In : journal of oral biosciences. 58, 1, p. 10-15 6 p.

Research output: Contribution to journalReview article

Glucagon-Like Peptide 1
Peptides
Nutrients
Sweetening Agents
Enteroendocrine Cells
2015
1 Citation (Scopus)

Angiotensin II and taste sensitivity

Shigemura, N., May 1 2015, In : Japanese Dental Science Review. 51, 2, p. 51-58 8 p.

Research output: Contribution to journalReview article

Angiotensin II
Sodium
Amiloride
Homeostasis
Salts

BK channel in microglia as a potent therapeutic molecular target for neuropathic pain

Hayashi, Y. & Nakanishi, H., Aug 1 2015, In : journal of oral biosciences. 57, 3, p. 131-134 4 p.

Research output: Contribution to journalReview article

Large-Conductance Calcium-Activated Potassium Channels
Ketamine
Microglia
Neuralgia
Analgesics
8 Citations (Scopus)

Lessons from Microglia Aging for the Link between Inflammatory Bone Disorders and Alzheimer's Disease

Take, H. & Nakanishi, H., Jan 1 2015, In : Journal of Immunology Research. 2015, 471342.

Research output: Contribution to journalReview article

Bone Diseases
Microglia
Periodontitis
Alzheimer Disease
Bone and Bones

Modulation of taste responsiveness by angiotensin II

Shigemura, N., Jan 1 2015, In : Food Science and Technology Research. 21, 6, p. 757-764 8 p.

Research output: Contribution to journalReview article

angiotensin II
taste sensitivity
Angiotensin II
aldosterone
Aldosterone
2 Citations (Scopus)

The downward spiral of periodontitis and diabetes in Alzheimer's disease: Extending healthy life expectancy through oral health

Nakanishi, H. & Take, H., Jan 1 2015, In : Journal of Oral Biosciences. 57, 3, p. 139-142 4 p.

Research output: Contribution to journalReview article

Periodontitis
Oral Health
Medical problems
Life Expectancy
Alzheimer Disease
2014
24 Citations (Scopus)

Connection between periodontitis and Alzheimer's disease: Possible roles of microglia and leptomeningeal cells

Take, H. & Nakanishi, H., Jan 1 2014, In : Journal of Pharmacological Sciences. 126, 1, p. 8-13 6 p.

Research output: Contribution to journalReview article

Periodontitis
Microglia
Alzheimer Disease
Chronic Periodontitis
Inflammation
2 Citations (Scopus)

Novel roles of microglia

Nakanishi, H., Jan 1 2014, In : Clinical and Experimental Neuroimmunology. 5, s1, p. 35-40 6 p.

Research output: Contribution to journalReview article

Microglia
Brain
Dendritic Spines
Circadian Clocks
Autistic Disorder
2013
24 Citations (Scopus)

Modulation of sweet responses of taste receptor cells

Yoshida, R., Niki, M., Jyotaki, M., Sanematsu, K., Shigemura, N. & Ninomiya, Y., Jan 1 2013, In : Seminars in Cell and Developmental Biology. 24, 3, p. 226-231 6 p.

Research output: Contribution to journalReview article

Endocannabinoids
Leptin
Eating
Cannabinoid Receptors
Hypothalamus
13 Citations (Scopus)

Multifunctional properties of RANKL/RANK in cell differentiation, proliferation and metastasis

Kukita, A. & Kukita, T., Nov 1 2013, In : Future Oncology. 9, 11, p. 1609-1622 14 p.

Research output: Contribution to journalReview article

Cell Differentiation
Cell Proliferation
Neoplasm Metastasis
Organogenesis
Neoplasms
11 Citations (Scopus)

Phospholipase C-related but catalytically inactive protein, PRIP as a scaffolding protein for phospho-regulation

Sugiyama, G., Takeuchi, H., Kanematsu, T., Gao, J., Matsuda, M. & Hirata, M., Jan 1 2013, In : Advances in Biological Regulation. 53, 3, p. 331-340 10 p.

Research output: Contribution to journalReview article

Type C Phospholipases
Phosphorylation
Phosphoprotein Phosphatases
Cyclic AMP-Dependent Protein Kinases
Proteins
2 Citations (Scopus)

Synaptic plasticity and synaptic reorganization regulated by microglia

Hayashi, Y. & Nakanishi, H., Nov 2013, In : Japanese Journal of Neuropsychopharmacology. 33, 5-6, p. 211-216 6 p.

Research output: Contribution to journalReview article

Neuronal Plasticity
Microglia
N-Methyl-D-Aspartate Receptors
cathepsin S
Synaptic Transmission
2012
4 Citations (Scopus)

Hormones and bioactive substances that affect peripheral taste sensitivity

Yoshida, R., Jan 1 2012, In : journal of oral biosciences. 54, 2, p. 67-72 6 p.

Research output: Contribution to journalReview article

Animals
Hormones
Leptin
Endocannabinoids
Chemical compounds
2011
17 Citations (Scopus)
Phosphatidylserines
Immune System Diseases
Phagocytes
Dinoprostone
Liposomes
2010
41 Citations (Scopus)

Modulation of sweet taste sensitivity by orexigenic and anorexigenic factors

Jyotaki, M., Shigemura, N. & Ninomiya, Y., Jan 1 2010, In : Endocrine Journal. 57, 6, p. 467-475 9 p.

Research output: Contribution to journalReview article

Leptin
Endocannabinoids
Homeostasis
Central Nervous System
Eating

Reception and transmission of taste information in type ii and type ie taste bud cells

Yoshida, R., Niki, M., Murata, Y., Shigemura, N. & Ninomiya, Y., Jan 1 2010, In : journal of oral biosciences. 52, 4, p. 358-364 7 p.

Research output: Contribution to journalReview article

Taste Buds
Adenosine Triphosphate
Fibers
Transmitters
Serotonin
2009
80 Citations (Scopus)

Microglia-aging: Roles of microglial lysosome- and mitochondria-derived reactive oxygen species in brain aging

Nakanishi, H. & Take, H., Jul 19 2009, In : Behavioural Brain Research. 201, 1, p. 1-7 7 p.

Research output: Contribution to journalReview article

Microglia
Lysosomes
Reactive Oxygen Species
Mitochondria
Brain
5 Citations (Scopus)

Multiple umami receptors and their variants in human and mice

Jyotaki, M., Shigemura, N. & Ninomiya, Y., Oct 1 2009, In : Journal of Health Science. 55, 5, p. 674-681 8 p.

Research output: Contribution to journalReview article

Brain
Ribonucleotides
Molecular biology
Glutamic Acid
Salts
1 Citation (Scopus)

Role of vasopressin receptor in psychological and cognitive functions

Egashira, N., Mishima, K., Iwasaki, K., Nakanishi, H., Oishi, R. & Fujiwara, M., Oct 1 2009, In : Folia Pharmacologica Japonica. 134, 1, p. 3-7 5 p.

Research output: Contribution to journalReview article

Mental Processes
Vasopressin Receptors
Mental Disorders
Cognition
Psychology
2007
33 Citations (Scopus)
Type C Phospholipases
GABA-A Receptors
Proteins
Ligand-Gated Ion Channels
Clathrin
2006
24 Citations (Scopus)

Coding channels for taste perception: Information transmission from taste cells to gustatory nerve fibers

Yoshida, R., Nakano, K., Shigemura, N. & Ninomiya, Y., Dec 1 2006, In : Archives of Histology and Cytology. 69, 4, p. 233-242 10 p.

Research output: Contribution to journalReview article

Taste Perception
Nerve Fibers
Action Potentials
Taste Buds
Epiglottis
2004

The life cycle of the GABAA receptor and its regulating molecules

Kanematsu, T., Terunuma, M., Goto, H., Kuratani, A. & Hirata, M., Feb 23 2004, In : Folia Pharmacologica Japonica. 123, 2, p. 105-112 8 p.

Research output: Contribution to journalReview article

GABA-A Receptors
Life Cycle Stages
Synaptic Transmission
Ligand-Gated Ion Channels
Cluster Analysis
2003
69 Citations (Scopus)

Biological characteristics of the junctional epithelium

Shimono, M., Ishikawa, T., Enokiya, Y., Muramatsu, T., Matsuzaka, K. I., Inoue, T., Abiko, Y., Yamaza, T., Kido, M. A., Tanaka, T. & Hashimoto, S., Jan 1 2003, In : Journal of Electron Microscopy. 52, 6, p. 627-639 13 p.

Research output: Contribution to journalReview article

Epithelial Attachment
epithelium
Epithelium
Enamels
Adhesives
69 Citations (Scopus)

Cathepsins in the osteoclast

Goto, T., Yamaza, T. & Tanaka, T., Dec 1 2003, In : Journal of Electron Microscopy. 52, 6, p. 551-558 8 p.

Research output: Contribution to journalReview article

Cathepsins
Osteoclasts
bones
Cathepsin K
Bone
120 Citations (Scopus)

Microglial functions and proteases

Nakanishi, H., Apr 1 2003, In : Molecular Neurobiology. 27, 2, p. 163-176 14 p.

Research output: Contribution to journalReview article

Microglia
Peptide Hydrolases
cathepsin S
Antigen Presentation
Major Histocompatibility Complex
97 Citations (Scopus)

Neuronal and microglial cathepsins in aging and age-related diseases

Nakanishi, H., Jan 1 2003, In : Ageing Research Reviews. 2, 4, p. 367-381 15 p.

Research output: Contribution to journalReview article

Cathepsins
Aging of materials
Lysosomal Storage Diseases
Microglia
Ceroid
1 Citation (Scopus)

PRIP-1 involved in GABAA receptor trafficking

Kanematsu, T. & Hirata, M., Jan 1 2003, In : Seikagaku. The Journal of Japanese Biochemical Society. 75, 5, p. 378-382 5 p.

Research output: Contribution to journalReview article

Inositol 1,4,5-Trisphosphate
GABA-A Receptors
Calcium Channels
Protein Binding
Epilepsy
2002
88 Citations (Scopus)

Inositol hexakisphosphate blocks tumor cell growth by activating apoptotic machinery as well as by inhibiting the Akt/NFκB-mediated cell survival pathway

Ferry, S., Matsuda, M., Yoshida, H. & Hirata, M., Dec 1 2002, In : Carcinogenesis. 23, 12, p. 2031-2041 11 p.

Research output: Contribution to journalReview article

Phytic Acid
Cell Survival
HeLa Cells
Apoptosis
Growth
2001
29 Citations (Scopus)

Substance P and substance P receptors in bone and gingival tissues

Goto, T., Kido, M. A., Yamaza, T. & Tanaka, T., Dec 17 2001, In : Medical Electron Microscopy. 34, 2, p. 77-85 9 p.

Research output: Contribution to journalReview article

Neurokinin-1 Receptors
Substance P
Bone and Bones
Neurotransmitter Agents
Axons
2000
67 Citations (Scopus)

New functional aspects of cathepsin D and cathepsin E

Tsukuba, T., Okamoto, K., Yasuda, Y., Morikawa, W., Nakanishi, H. & Yamamoto, K., Dec 31 2000, In : Molecules and Cells. 10, 6, p. 601-611 11 p.

Research output: Contribution to journalReview article

Cathepsin E
Cathepsin D
Angiostatins
Ceroid
Growth

Novel Ins(1,4,5)P3 binding protein and GABA-A receptor signaling

Kanematsu, T. & Hirata, M., Jan 1 2000, In : Fukuoka igaku zasshi = Hukuoka acta medica. 91, 7, p. 159-164 6 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Osteoclast differentiation antigen involved in the induction of calcitonin escape phenomenon

Kukita, T., Kukita, A. & Iijima, T., Oct 2000, In : Kaibogaku zasshi. Journal of anatomy. 75, 5, p. 433-438 6 p.

Research output: Contribution to journalReview article

Cell Fusion
Differentiation Antigens
Calcitonin
Osteoclasts
Surface Antigens
1998

Involvement of proteinases produced by both neurons and microglia in neuronal lesion and death pathways

Nakanishi, H. & Yamamoto, K., Jan 1 1998, In : Folia Pharmacologica Japonica. 112, 2, p. 77-88 12 p.

Research output: Contribution to journalReview article

Microglia
Peptide Hydrolases
Cathepsin E
Neurons
Caspases
31 Citations (Scopus)

Pleckstrin homology domain as an inositol compound binding module

Hirata, M., Kanematsu, T., Takeuchi, H. & Yagisawa, H., Mar 1 1998, In : Japanese Journal of Pharmacology. 76, 3, p. 255-263 9 p.

Research output: Contribution to journalReview article

Inositol
Phosphatidylinositols
Signal Transduction
Heterotrimeric GTP-Binding Proteins
Inositol 1,4,5-Trisphosphate
1996
7 Citations (Scopus)

Osteoclast differentiation antigen

Kukita, T. & Kukita, A., Jul 30 1996, In : Histology and Histopathology. 11, 3, p. 821-830 10 p.

Research output: Contribution to journalReview article

Differentiation Antigens
Osteoclasts
Monoclonal Antibodies
Surface Antigens
Bone Resorption
1995

Regulation of phospholipase C-delta 1

Hirata, M. & Yagisawa, H., Jan 1 1995, In : Seikagaku. The Journal of Japanese Biochemical Society. 67, 9, p. 1128-1132 5 p.

Research output: Contribution to journalReview article

Phospholipase C delta
GTPase-Activating Proteins
Type C Phospholipases
Phosphatidylinositols
GTP-Binding Proteins
1994
1 Citation (Scopus)

Trans fatty acids: effects on eicosanoid production.

Sugano, M., Koga, T., Yamato, T., Nonaka, M. & Gu, J., Dec 1 1994, In : World review of nutrition and dietetics. 75, p. 179-182 4 p.

Research output: Contribution to journalReview article

eicosanoids
hydrogenation
trans fatty acids
arachidonic acid
prostaglandins