Organic and Biological Chemistry

Research Output 1979 2019

2019
1 Citation (Scopus)
Glycosylation
Stereoselectivity
Oligosaccharides
linkages
reactivity

Biosynthetic Short Neuropeptides: A Rational Theory Based on Experimental Results for the Missing Pain-Relief Opioid Endomorphin Precursor Gene

Matsushima, A., Sese, J. & Koyanagi, K. O., Jan 1 2019, In : ChemBioChem. 20, 16, p. 2054-2058 5 p.

Research output: Contribution to journalArticle

Neuropeptides
Opioid Analgesics
Genes
Pain
Peptides
1 Citation (Scopus)

Design and synthesis of artificial ladder-shaped polyethers for exploring biological functions

Oishi, T., Jan 1 2019, In : Heterocycles. 99, 1, p. 21-53 33 p.

Research output: Contribution to journalArticle

Dinoflagellida
Polyethers
Ladders
Molecular Structure
Biological Products

Discovery of novel oestrogen receptor α agonists and antagonists by screening a revisited privileged structure moiety for nuclear receptors

Masuya, T., Iwamoto, M., Liu, X. & Matsushima, A., Dec 1 2019, In : Scientific reports. 9, 1, 9954.

Research output: Contribution to journalArticle

Open Access
Cytoplasmic and Nuclear Receptors
Estrogens
Estrogen Receptors
Epoxy Resins
Endocrine Disruptors

Evaluation of the binding ability of an orphan nuclear receptor nurr1 to synthetic peptides.

Masuya, T., Tada, Y., Liu, X. & Matsushima, A., 2019, Peptide Science 2018. p. 133

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Chlorides
Antioxidants
Acids
Triazoles
Anti-Infective Agents
8 Citations (Scopus)

Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly

Sakaue, H., Shiota, T., Ishizaka, N., Kawano, S., Tamura, Y., Tan, K. S., Imai, K., Motono, C., Hirokawa, T., Taki, K., Miyata, N., Kuge, O., Lithgow, T. & Endo, T., Mar 7 2019, In : Molecular Cell. 73, 5, p. 1044-1055.e8

Research output: Contribution to journalArticle

Porins
Mitochondrial Proteins
TOM translocase

Receptor-binding affinities of bisphenol A and its next-generation analogs for human nuclear receptors

Liu, X., Sakai, H., Nishigori, M., Suyama, K., Nawaji, T., Ikeda, S., Nishigouchi, M., Okada, H., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., Aug 15 2019, In : Toxicology and Applied Pharmacology. 377, 114610.

Research output: Contribution to journalArticle

Cytoplasmic and Nuclear Receptors
Assays
Endocrine Disruptors
Peroxisome Proliferator-Activated Receptors
Competitive Binding

Simple Apparatus for Adding Small Amounts of Powder Materials under an Inert Atmosphere

Karak, M., Joh, Y., Khodjaniyazov, K. U., Sagdullaev, S. S., Oishi, T. & Torikai, K., Jan 1 2019, In : Synlett. 30, 18, p. 2058-2061 4 p.

Research output: Contribution to journalArticle

Powders
Glycosylation
Syringes
Contamination
Moisture

Structural Basis of Mitochondrial Scaffolds by Prohibitin Complexes: Insight into a Role of the Coiled-Coil Region

Yoshinaka, T., Kosako, H., Yoshizumi, T., Furukawa, R., Hirano, Y., Kuge, O., Tamada, T. & Koshiba, T., Sep 27 2019, In : iScience. 19, p. 1065-1078 14 p.

Research output: Contribution to journalArticle

Open Access
Signal Transduction
Mitochondria
Mitochondrial Dynamics
Biotin
prohibitin

Unified synthesis of the DEF and GhI ring systems of maitotoxin

Yasudomi, T., Yakushiji, H., Torikai, K., Ebine, M. & Oishi, T., Jan 1 2019, In : Chemistry Letters. 48, 9, p. 1156-1159 4 p.

Research output: Contribution to journalArticle

Acetals
Methylation
Ethers
Alkenes
Derivatives
2018
4 Citations (Scopus)
wildlife
Endocrine Disruptors
disrupting
bisphenols
DDT
DDT
wildlife
Endocrine Disruptors
disrupting
bisphenols
Amphotericin B
Nuclear magnetic resonance
Anti-Bacterial Agents
Membranes
Ergosterol

Cell death or survival against oxidative stress

Miyata, N., Okumoto, K. & Fujiki, Y., Jan 1 2018, Subcellular Biochemistry. Springer New York, p. 463-471 9 p. (Subcellular Biochemistry; vol. 89).

Research output: Chapter in Book/Report/Conference proceedingChapter

Peroxisomes
Oxidative stress
Cell death
Catalase
Cell Survival
4 Citations (Scopus)

Convergent syntheses of the WXYZ ring of maitotoxin and the HIJK ring of brevisulcenal-F

Osato, N., Onoue, H., Toma, Y., Torikai, K., Ebine, M., Satake, M. & Oishi, T., Jan 1 2018, In : Chemistry Letters. 47, 3, p. 265-268 4 p.

Research output: Contribution to journalArticle

Ketones
Stereochemistry
Methylation
Lithium
Aldehydes
1 Citation (Scopus)

Flow synthesis of (3R)- and (3S)-(E)-1-iodohexa-1,5-dien-3-ol: Chiral building blocks for natural product synthesis

Katayama, S., Koge, T., Katsuragi, S., Akai, S. & Oishi, T., Jan 1 2018, In : Chemistry Letters. 47, 9, p. 1116-1118 3 p.

Research output: Contribution to journalArticle

Ion Exchange Resins
Biological Products
Lipase
Evaporation
Acetates

Homodimer function of human nuclear receptor ERR evidenced using -helix peptides in the dimer interface

Liu, X., Nakagawa, H., Sugiyama, M., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2018, Peptide Science 2017. p. 190 191 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Identification of peroxisomal protein complexes with PTS receptors, pex5 and pex7, in mammalian cells

Okumoto, K., Miyata, N. & Fujiki, Y., Jan 1 2018, Subcellular Biochemistry. Springer New York, p. 287-298 12 p. (Subcellular Biochemistry; vol. 89).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cells
Proteins
Purification
Protein Interaction Maps
Peroxisomes
2 Citations (Scopus)

Mannosylinositol phosphorylceramides and ergosterol coodinately maintain cell wall integrity in the yeast Saccharomyces cerevisiae

Tanaka, S. & Tani, M., Jul 1 2018, In : FEBS Journal. 285, 13, p. 2405-2427 23 p.

Research output: Contribution to journalEditorial

Ergosterol
Yeast
Cell Wall
Saccharomyces cerevisiae
Yeasts

Mutual co-work between nuclear receptor ERalpha and ERRgamma requires their homodimerization

Liu, X., Shimohigashi, M., Sugiyama, M., Matsushima, A. & Shimohigashi, Y., 2018, Peptide Science 2017,. p. 198 199 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Overexpression of PDR16 confers resistance to complex sphingolipid biosynthesis inhibitor aureobasidin A in yeast Saccharomyces cerevisiae

Katsuki, Y., Yamaguchi, Y. & Tani, M., Feb 1 2018, In : FEMS microbiology letters. 365, 3, fnx255.

Research output: Contribution to journalArticle

Sphingolipids
Saccharomyces cerevisiae
Yeasts
Tetracycline
Growth

Phe 2715.39 of Thronbin Receptor PAR-1 is a specific target of Phe-2-phenl group of its tethered ligand

Sugiyama, M., Fujita, T., Liu, X., Matsuyama, Y., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2018, Peptide Science 2017. p. 94 95 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

5 Citations (Scopus)

Porin proteins have critical functions in mitochondrial phospholipid metabolism in yeast

Miyata, N., Fujii, S. & Kuge, O., Nov 9 2018, In : The Journal of biological chemistry. 293, 45, p. 17593-17605 13 p.

Research output: Contribution to journalArticle

Porins
Cardiolipins
Metabolism
Yeast
Phospholipids
6 Citations (Scopus)

Protection mechanisms against aberrant metabolism of sphingolipids in budding yeast

Tani, M. & Funato, K., Oct 1 2018, In : Current Genetics. 64, 5, p. 1021-1028 8 p.

Research output: Contribution to journalReview article

Sphingolipids
Saccharomycetales
Osmolar Concentration
Glycerol
Yeasts
5 Citations (Scopus)

Protective role of the HOG pathway against the growth defect caused by impaired biosynthesis of complex sphingolipids in yeast Saccharomyces cerevisiae

Yamaguchi, Y., Katsuki, Y., Tanaka, S., Kawaguchi, R., Denda, H., Ikeda, T., Funato, K. & Tani, M., Feb 1 2018, In : Molecular Microbiology. 107, 3, p. 363-386 24 p.

Research output: Contribution to journalArticle

Sphingolipids
Osmolar Concentration
Glycerol
Saccharomyces cerevisiae
Yeasts
1 Citation (Scopus)

Synthesis and complete structure determination of a sperm-activating and -attracting factor isolated from the ascidian ascidia sydneiensis

Watanabe, T., Shibata, H., Ebine, M., Tsuchikawa, H., Matsumori, N., Murata, M., Yoshida, M., Morisawa, M., Lin, S., Yamauchi, K., Sakai, K. & Oishi, T., Apr 27 2018, In : Journal of Natural Products. 81, 4, p. 985-997 13 p.

Research output: Contribution to journalArticle

Ergosterol
Urochordata
Biological Products
Ketones
Eggs
3 Citations (Scopus)

Synthesis and Stereochemical Revision of the C31–C67 Fragment of Amphidinol 3

Wakamiya, Y., Ebine, M., Murayama, M., Omizu, H., Matsumori, N., Murata, M. & Oishi, T., May 22 2018, In : Angewandte Chemie - International Edition. 57, 21, p. 6060-6064 5 p.

Research output: Contribution to journalArticle

Degradation
Biological Products
Carbon
Nuclear magnetic resonance
Availability
1 Citation (Scopus)

Synthesis of 6/6/6-tricyclic ether system via Achmatowicz and intramolecular oxa-michael reactions

Yamamoto, H., Torikai, K., Ebine, M. & Oishi, T., Jan 1 2018, In : Heterocycles. 97, 1, p. 158-162 5 p.

Research output: Contribution to journalArticle

Ethers
Aldehydes
Isomers
Ether
Alcohols

Synthesis of an analog of amphidinol 3 corresponding to the c31-c67 section

Koge, T., Wakamiya, Y., Ebine, M. & Oishi, T., Jan 1 2018, In : Heterocycles. 96, 7, p. 1197-1202 6 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Derivatives
amphidinol 3
polyol
2 Citations (Scopus)

Synthesis of anti-tubercular marine alkaloids denigrins A and B

Karak, M., Oishi, T. & Torikai, K., Jul 18 2018, In : Tetrahedron Letters. 59, 29, p. 2800-2803 4 p.

Research output: Contribution to journalArticle

Maleic Anhydrides
Alkaloids
Cross Reactions
Palladium
Salts
2017
1 Citation (Scopus)

1-Naphthylmethyl and 1-naphthylmethoxymethyl protecting groups: New members of the benzyl- and benzyloxymethyl-type family

Sato, T., Joh, Y., Oishi, T. & Torikai, K., Jan 1 2017, In : Tetrahedron Letters. 58, 23, p. 2178-2181 4 p.

Research output: Contribution to journalArticle

Oxidation
Hydrogenolysis
Nucleophiles
Temperature
Acids
2 Citations (Scopus)

Adaptation of a genetic screen reveals an inhibitor for mitochondrial protein import component Tim44

Miyata, N., Tang, Z., Conti, M. A., Johnson, M. E., Douglas, C. J., Hasson, S. A., Damoiseaux, R., Chang, C. E. A. & Koehler, C. M., Mar 31 2017, In : Journal of Biological Chemistry. 292, 13, p. 5429-5442 14 p.

Research output: Contribution to journalArticle

Mitochondrial Proteins
Membranes
Mitochondria
Proteins
Molecules
5 Citations (Scopus)

BAK regulates catalase release from peroxisomes

Fujiki, Y., Miyata, N., Mukai, S., Okumoto, K. & Cheng, E. H., Mar 17 2017, In : Molecular & Cellular Oncology . 4, 3, e1306610.

Research output: Contribution to journalArticle

Voltage-Dependent Anion Channel 2
Peroxisomes
Catalase
Permeability
Mitochondria
5 Citations (Scopus)

Cooperative function of Fmp30, Mdm31, and Mdm32 in Ups1-independent cardiolipin accumulation in the yeast Saccharomyces cerevisiae

Miyata, N., Goda, N., Matsuo, K., Hoketsu, T. & Kuge, O., Dec 1 2017, In : Scientific reports. 7, 1, 16447.

Research output: Contribution to journalArticle

Cardiolipins
Saccharomyces cerevisiae
Mitochondrial Membranes
Yeasts
Phosphatidic Acids
5 Citations (Scopus)

Design and synthesis of benzoacridines as estrogenic and anti-estrogenic agents

Torikai, K., Koga, R., Liu, X., Umehara, K., Kitano, T., Watanabe, K., Oishi, T., Noguchi, H. & Shimohigashi, Y., Jan 1 2017, In : Bioorganic and Medicinal Chemistry. 25, 20, p. 5216-5237 22 p.

Research output: Contribution to journalArticle

Estrogens
Estrogen Receptors
Orphan Nuclear Receptors
Selective Estrogen Receptor Modulators
Inhibitory Concentration 50

Docking simulation to elucidate the labeled cysteine residue of the nociception receptor ORL1 using a Cys(Npys)-containing peptide ligand

Matsushima, A., Nishimura, H., Matsuyama, Y., Liu, X. & Shimohigashi, Y., 2017, Peptide Science 2016. p. 87-88

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

21 Citations (Scopus)

Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism

Nishimoto, K., Koga, M., Seki, T., Oki, K., Gomez-Sanchez, E. P., Gomez-Sanchez, C. E., Naruse, M., Sakaguchi, T., Morita, S., Kosaka, T., Oya, M., Ogishima, T., Yasuda, M., Suematsu, M., Kabe, Y., Omura, M., Nishikawa, T. & Mukai, K., Feb 5 2017, In : Molecular and Cellular Endocrinology. 441, p. 124-133 10 p.

Research output: Contribution to journalReview article

Cytochrome P-450 CYP11B2
Hyperaldosteronism
Steroid 11-beta-Hydroxylase
Zona Glomerulosa
Aldosterone
3 Citations (Scopus)

Syntheses and Biological Activities of the LMNO, ent-LMNO, and NOPQR(S) Ring Systems of Maitotoxin

Onoue, H., Marubayashi, R., Ishikawa, E., Konoki, K., Torikai, K., Ebine, M., Murata, M. & Oishi, T., Jan 1 2017, In : Journal of Organic Chemistry. 82, 18, p. 9595-9618 24 p.

Research output: Contribution to journalArticle

Bioactivity
Enantiomers
Aldehydes
Alkynes
Biological Products
3 Citations (Scopus)

Synthesis of a truncated analog of amphidinol 3 corresponding to the C21C39/C52C67 section

Ebine, M., Takada, Y., Yanai, N. & Oishi, T., Jan 1 2017, In : Chemistry Letters. 46, 5, p. 662-664 3 p.

Research output: Contribution to journalArticle

Polyenes
amphidinol 3
21 Citations (Scopus)

The VDAC2-BAK axis regulates peroxisomal membrane permeability

Hosoi, K., Miyata, N., Mukai, S., Furuki, S., Okumoto, K., Cheng, E. H. & Fujiki, Y., Mar 6 2017, In : Journal of Cell Biology. 216, 3, p. 709-722

Research output: Contribution to journalArticle

Peroxisomes
Permeability
Membranes
Peroxisomal Disorders
Inborn Genetic Diseases
2016

Comparative analysis of the ligand binding domain secondary structures of human nuclear receptors

Matsuyama, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 337-338

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Comprehensive structural analysis of the nociceptin ORL1 receptor by means of virtual and experimental Ala-scanning combinated methods

Matsushima, A., Nishimura, H., Liu, X., Takesue, Y., Matsuyama, Y. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 149-150

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Do the estrogen receptors function as a homodimer? experimental validation of homodimerization by inhibitory peptides

Sakito, S., Liu, X., Fujiyama, A., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 335-336

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Do the estrogen receptors function as a homodimer? experimental validation of homodimerization by inhibitory peptides

Sakito, S., Fujiyama, A., Motomatsu, Y., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 335-336

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

72 Citations (Scopus)

Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling

Otera, H., Miyata, N., Kuge, O. & Mihara, K., Jan 1 2016, In : Journal of Cell Biology. 212, 5, p. 531-544 14 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Cytochromes c
Apoptosis
Cytoplasm
Phenotype

Expression analysis of neuropeptide PDF mRNA in the hypoactive and hyperactive fruit flies Drosophila melanogaster

Asuka, T., Matsuo, A., Shotaro, U., Matsuyama, Y., masayuki, N., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 317-318

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Functional role of the Phe-Phe stacking microswitch in the ORL1 nociceptin receptor activation

Takesue, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 147-148

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

ORL1 Nociceptin receptor response of opioid peptides derived from proenkephalin precursor protein

Motomatsu, Y., Nishimura, H., Matsuyama, Y., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 181-182

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)