Organic and Biological Chemistry

Research Output

2000

Glycine-rich region of mitochondrial processing peptidase α-subunit is essential for binding and cleavage of the precursor proteins

Nagao, Y., Kitada, S., Kojima, K., Toh, H., Kuhara, S., Ogishima, T. & Ito, A., Nov 3 2000, In : Journal of Biological Chemistry. 275, 44, p. 34552-34556 5 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Highly potent peptide ligands for thrombin receptor

Fujita, T., Nose, T., Matsushima, A., Costa, T. & Shimohigashi, Y., 2000, Peptide Science 1999. p. 421-424

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases

Tani, M., Okino, N., Mori, K., Tanigawa, T., Izu, H. & Ito, M., Apr 14 2000, In : Journal of Biological Chemistry. 275, 15, p. 11229-11234 6 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)

Neutral/alkaline and acid ceramidase activities are actively released by murine endothelial cells

Romiti, E., Meacci, E., Tani, M., Nuti, F., Farnararo, M., Ito, M. & Bruni, P., Sep 7 2000, In : Biochemical and Biophysical Research Communications. 275, 3, p. 746-751 6 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)
71 Citations (Scopus)

Synthesis of a complete set of L-difluorophenylalanines, L-(F2)Phe, as molecular explorers for the CH/π interaction between peptide ligand and receptor

Fujita, T., Nose, T., Matsushima, A., Okada, K., Asai, D., Yamauchi, Y., Shirasu, N., Honda, T., Shigehiro, D. & Shimohigashi, Y., Feb 5 2000, In : Tetrahedron Letters. 41, 6, p. 923-927 5 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2001

Activity Enhancement by Introduction of two different halogen atoms into Phe-2-phenyl group of thrombin receptor tetherd-ligand analogs.

Fujita, T., Inoue, N., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2001, Peptide Science 2000. p. 135-138

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

A proposed common structure of substrates bound to mitochondrial processing peptidase

Kojima, K., Kitada, S., Ogishima, T. & Ito, A., Jan 19 2001, In : Journal of Biological Chemistry. 276, 3, p. 2115-2121 7 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

cDNA cloning of a circadian rhythm pacemaker hormone PDF of the house fly Musca domestica

Matsushima, A., Chuman, Y., Sato, S., Shimohigashi, Y., Tominaga, Y. & Shimohigashi, M., 2001, Comparative Biochemistry and Physiology. p. 876

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

cDNA Cloning of circadian rhythm pacemaker neuropeptide PDF in Gryllus bimaculatus and its neuclear localization

Chuman, Y., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., 2001, Peptide Science 2000. p. 59-62

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Gene expression of a circadian pacemaker hormone peptide PDF in cricket Gryllus bimaculatus

Matsushima, A., Chuman, Y., Onoue, H., Ito, Y., Tomioka, K., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2001, Peptide Science 2000. p. 63-66

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Highly diastereoselective aziridination of α,β-unsaturated amides using diaziridine

Ishihara, H., Ito, Y. N. & Katsuki, T., Jan 1 2001, In : Chemistry Letters. 10, p. 984-985 2 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

PERIOD clock protein of the summer cicada Meimuna opalifera: cDNA cloning and structural analysis

Sato, S., Chuman, Y., Matsushima, A., Shimohigashi, Y., Tominaga, Y. & Shimohigashi, M., 2001, Comparative Biochemistry and Physiology. Vol. 130. p. 876

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Purification, Characterization, Molecular Cloning, and Subcellular Distribution of Neutral Ceramidase of Rat Kidney

Mitsutake, S., Tani, M., Okino, N., Mori, K., Ichinose, S., Omori, A., Iida, H., Nakamura, T. & Ito, M., Jul 13 2001, In : Journal of Biological Chemistry. 276, 28, p. 26249-26259 11 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)

Recognition of mitochondrial protein precursor lacking arginine at position -2 by Mitochondrial Processing Peptidase: Processing of bovine cytochrome p450(SCC) precursor

Kojima, K., Yamasaki, E., Kitada, S., Ogishima, T. & Ito, A., Jan 1 2001, In : Journal of biochemistry. 130, 4, p. 497-502 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2002

cDNA cloning and nuclear localization of the circadian neuropeptide designated as pigment-dispersing factor PDF in the cricket Gryllus bimaculatus

Chuman, Y., Matsushima, A., Sato, S., Tomioka, K., Tominaga, Y., Meinertzhagen, I. A., Shimohigashi, Y. & Shimohigashi, M., Jan 1 2002, In : Journal of Biochemistry. 131, 6, p. 895-903 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

cDNA cloning of PDF peptide precursors in housefly and last summer cicada

Sato, S., Matsushima, A., Chuman, Y., Tominaga, K., Shimohigashi, Y. & Shimohigashi, M., 2002, Peptide Science 2001. p. 139-142

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Circadian rhythm pacemaker neuropeptide 'PDF' in nocturnal insect cricket gryllus bimaculatus: cDNA cloning, mRNA expression, and nuclear localization

Chuman, Y., Matsushima, A., Nose, T., Shimohigashi, Y. & Shimohigashi, M., 2002, American Peptide Society 2001. p. 797-798

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Contractile activity of Drosophila FMRFamide-related peptides in the Meretrix Lusoria heart muscle.

Tokunaga, T., Ohtani, M., Matsushima, A., Chuman, Y., Nose, T. & Shimohigashi, Y., 2002, Peptide Science 2001. p. 167-170

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Design and preparation of universal anti-PERIOD antibodies and their immunoresponses.

Asai, D., Tokunaga, T., Matsushima, A., Sato, S., Chuman, Y., Nose, T., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2002, Peptide Science 2001. p. 399-402

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Highly diastereo- and enantioselective aziridination of α,β-unsaturated amides with diaziridine and mechanistic consideration on its stereochemistry

Ishihara, H., Hori, K., Sugihara, H., Ito, Y. & Katsuki, T., Dec 1 2002, In : Helvetica Chimica Acta. 85, 12, p. 4272-4286 15 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Molecular cloning and characterization of a secretory neutral ceramidase of Drosophila melanogaster

Yoshimura, Y., Okino, N., Tani, M. & Ito, M., Aug 2002, In : Journal of biochemistry. 132, 2, p. 229-236 8 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Structure and function of nuclear localization signal peptide present in circadian rhythm hormone peptide precursor

Matsushima, A., Chuman, Y., Sato, S., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2002, Peptide Science 2001. p. 159-162

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2003

A neutral ceramidase homologue from Dictyostelium discoideum exhibits an acidic pH optimum

Monjusho, H., Okino, N., Tani, M., Maeda, M., Yoshida, M. & Ito, M., Dec 1 2003, In : Biochemical Journal. 376, 2, p. 473-479 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Identification of outer mitochondrial membrane cytochrome b5 as a modulator for androgen synthesis in Leydig cells

Ogishima, T., Kinoshita, J. Y., Mitani, F., Suematsu, M. & Ito, A., Jun 6 2003, In : Journal of Biological Chemistry. 278, 23, p. 21204-21211 8 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Localization profiles of the precursor protein of circadian rhythm pacemaker hormone PDF in Gryllus brain

Honda, T., Chuman, Y., Matsushima, A., Asai, D., Nose, T., Sakaguchi, K., Onoue, H., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2003, Peptide Science 2002. p. 433-436

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Molecular cloning and circadian expression profile of insect neuropeptide PDF in black blowfly, Phormia regina

Matsushima, A., Yokotani, S., Lui, X., Sumida, K., Honda, T., Sato, S., Kaneki, A., Takeda, Y., Chuman, Y., Ozaki, M., Asai, D., Nose, T., Onoue, H., Ito, Y., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., Nov 1 2003, In : Letters in Peptide Science. 10, 5-6, p. 419-430 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Mutations in novel peroxin gene PEX26 that cause peroxisome-biogenesis disorders of complementation group 8 provide a genotype-phenotype correlation

Matsumoto, N., Tamura, S., Furuki, S., Miyata, N., Moser, A., Shimozawa, N., Moser, H. W., Suzuki, Y., Kondo, N. & Fujiki, Y., Aug 1 2003, In : American journal of human genetics. 73, 2, p. 233-246 14 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)
52 Citations (Scopus)

Purification and Characterization of Chinese Hamster Phosphatidylserine Synthase 2

Kuge, O., Hasegawa, K., Ohsawa, T., Saito, K. & Nishijima, M., Oct 24 2003, In : Journal of Biological Chemistry. 278, 43, p. 42692-42698 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Structural analysis of PERIOD-PAS domain binding regions in insect clock protein TIMELESS

Sato, S., Oka, H., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2003, Peptide Science 2002. p. 429-432

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural characterization of the house fly PDF, a circadian rhythm pacemaker hormone

Matsushima, A., Nose, T., Tomioka, K., Shimohigashi, M. & Shimohigashi, Y., 2003, Peptide Science 2002. p. 333-336

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

The Structure-activity studies of Drosophila FMRFamide-related peptides

Tokunaga, T., Ohtahi, M., Matsushima, A., Nose, T., Aimoto, S. & Shimohigashi, Y., 2003, Peptide Science 2002. p. 265-268

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2004

cDNA cloning and in situ hybridization studies of sulfated peptide, sulfakinin, on housefly Musca domestica

Matsushima, A., Yokotani, S., Shimohigashi, Y., Tominaga, Y. & Shimohigashi, M., 2004, Peptide Science 2003. p. 459-462

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

cDNA cloning of the housefly pigment-dispersing factor (PDF) precursor protein and its peptides comparison among the insect circadian neuropeptides

Matsushima, A., Sato, S., Chuman, Y., Takeda, Y., Yokotani, S., Nose, T., Tominaga, Y., Shimohigashi, M. & Shimohigashi, Y., Feb 1 2004, In : Journal of Peptide Science. 10, 2, p. 82-91 10 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
7 Citations (Scopus)

Effect of the Phe-Phenyl H-F subsutitution in the sea hare Aplysia neuropeptide H-Asn-d-Phe-NH2 on the conformation and contraction activity

Kaneki, A., Matsushima, A., Takeda, Y., Yokotani, S., Ozaki, M., Shimohigashi, M. & Shimohigashi, Y., 2004, Peptide Science 2003. p. 459-462

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Effects of the Phe-Phenyl H→F Substitutions in the Sea Hare Aplysia Neuropeptide H-Asn-D-Trp-Phe-NH2 on the Conformation and Contractile Activity

Yokotani, S., Matsushima, A., Nose, T., Shimohigashi, Y. & Morishita, F., Mar 2004, Peptide Science 2003. p. 263-266 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Functional analysis of Chinese hamster phosphatidylserine synthase 1 through systematic alanine mutagenesis

Ohsawa, T., Nishijima, M. & Kuge, O., Aug 1 2004, In : Biochemical Journal. 381, 3, p. 853-859 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Localization profiles of circadian neuropeptide PDF in brain of the cricket Gryllus bimaculatus

Honda, T., Chuman, Y., Matsushima, A., Nose, T., Sakaguchi, K., Onoue, H., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2004, Peptide Science 2003. p. 483-486

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Molecular cloning and functional analysis of zebrafish neutral ceramidase

Yoshimura, Y., Tani, M., Okino, N., Iida, H. & Ito, M., Oct 15 2004, In : Journal of Biological Chemistry. 279, 42, p. 44012-44022 11 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Possible participation of outer mitochondrial membrane cytochrome B 5 in steroidogenesis in zona glomerulosa of rat adrenal cortex

Mitani, F., Ogishima, T., Mukai, K., Hoshino, R., Watanabe, K. & Suematsu, M., Dec 1 2004, In : Endocrine Research. 30, 4, p. 639-644 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Structural analysis and identification of novel isoforms of the circadian clock gene period in the silk moth Bombyx mori

Takeda, Y., Chuman, Y., Shirasu, N., Sato, S., Matsushima, A., Kaneki, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., Sep 1 2004, In : Zoological science. 21, 9, p. 903-915 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Structural requirements of the N-terminal octapeptide repeat of prion protein

Kawano, M., Horiuchi, Y., Honda, T., Yokotani, S., Matsushima, A., Nose, T. & Shimohigashi, Y., 2004, Peptide Science 2003. p. 483-486

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Synthesis of the CDE/FG ring models of prymnesins: Reassignment of the relative configuration of the E/F ring juncture

Sasaki, M., Ebine, M., Takagi, H., Takakura, H., Shida, T., Satake, M., Oshima, Y., Igarashi, T. & Yasumoto, T., Apr 29 2004, In : Organic Letters. 6, 9, p. 1501-1504 4 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Two distinctly different isoforms with/without pentapeptide fragment in the silk moth clock protein peptide

Takeda, Y., Shirasu, N., Sato, S., Matsushima, A., Chuman, Y., Shimohigashi, M. & Shimohigashi, Y., 2004, Peptide Science 2003. p. 473-476

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2005

An IκB-β COOH terminal region protein is essential for the proliferation of CHO cells under acidic stress

Lao, Q., Kuge, O., Fukamachi, T., Kakegawa, T., Saito, H., Nishijima, M. & Kobayashi, H., Apr 1 2005, In : Journal of cellular physiology. 203, 1, p. 186-192 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Ascorbate stimulates monooxygenase-dependent steroidogenesis in adrenal zona glomerulosa

Mitani, F., Ogishima, T., Mukai, K. & Suematsu, M., Dec 9 2005, In : Biochemical and Biophysical Research Communications. 338, 1, p. 483-490 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Bioactive conformation of a D-Trp-containing cardioexcitatory tripeptide isolated from the sea hare Aplysia

Yokotani, S., Matsushima, A., Nose, T., Morishita, F. & Shimohigashi, Y., 2005, Peptide Science 2004. p. 539-540

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

C18:3-GM1a induces apoptosis in Neuro2a cells: Enzymatic remodeling of fatty acyl chains of glycosphingolipids

Nakagawa, T., Morotomi, A., Tani, M., Sueyoshi, N., Komori, H. & Ito, M., Dec 1 2005, In : Journal of Lipid Research. 46, 6, p. 1103-1112 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)