Organic and Biological Chemistry

Research Output

2005

Ascorbate stimulates monooxygenase-dependent steroidogenesis in adrenal zona glomerulosa

Mitani, F., Ogishima, T., Mukai, K. & Suematsu, M., Dec 9 2005, In : Biochemical and Biophysical Research Communications. 338, 1, p. 483-490 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Bioactive conformation of a D-Trp-containing cardioexcitatory tripeptide isolated from the sea hare Aplysia

Yokotani, S., Matsushima, A., Nose, T., Morishita, F. & Shimohigashi, Y., 2005, Peptide Science 2004. p. 539-540

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

C18:3-GM1a induces apoptosis in Neuro2a cells: Enzymatic remodeling of fatty acyl chains of glycosphingolipids

Nakagawa, T., Morotomi, A., Tani, M., Sueyoshi, N., Komori, H. & Ito, M., Dec 1 2005, In : Journal of Lipid Research. 46, 6, p. 1103-1112 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

cDNA cloning and mRNA expression of the circadian neuropeptide PDF in the silk moth Bombyx mori

Sato, S., Sumida, K., Hiramura, D., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004. p. 197-200

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Conformation change-senseing assay using monoclonal antibody for N-terminal octapeptide repreat region of prion protein

Kawano, M., Honda, T., Horiuchi, Y., Yokotani, S., Matsushima, A., Nose, T. & Shimohigashi, Y., 2005, Peptide Science 2004.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Convergent total synthesis of gymnocin-A and evaluation of synthetic analogues

Tsukano, C., Ebine, M. & Sasaki, M., Mar 30 2005, In : Journal of the American Chemical Society. 127, 12, p. 4326-4335 10 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

FMRFamide-related peptides in the nervous system of the housefly Musca domestica: cDNA cloning and actions on clam heart contraction.

Matsushima, A., Yokotani, S., Koretsune, Y., Meinertzhagen, I. A., Tominaga, Y., Shimohigashi, M. & Shimohigashi, Y., 2005, Peptide Science 2004. p. 157-160

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Immunocytochemical identification of mature peptide formation for the circadian neuromodulator PDF in the housefly Musca domestica

Sumida, K., Honda, T., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Immunocytochemical studies on the circadian neuropeptide PDF in the Cricket Gryllus bimaculatus

Shimohigashi, M., Honda, T., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004. p. 339-342

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu

Tani, M., Igarashi, Y. & Ito, M., Nov 4 2005, In : Journal of Biological Chemistry. 280, 44, p. 36592-36600 9 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Recognition and processing of a nuclear-encoded polyprotein precursor by mitochondrial processing peptidase

Oshima, T., Yamasaki, E., Ogishima, T., Kadowaki, K. I., Ito, A. & Kitada, S., Feb 1 2005, In : Biochemical Journal. 385, 3, p. 755-761 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Shuttling mechanism of peroxisome targeting signal type 1 receptor Pex5: ATP-independent import and ATP-dependent export

Miyata, N. & Fujiki, Y., Dec 1 2005, In : Molecular and cellular biology. 25, 24, p. 10822-10832 11 p.

Research output: Contribution to journalArticle

149 Citations (Scopus)

Structural characteristics of Drosophila estrogen-related receptor ligand binding domain to capture the peptide and non-peptide ligands

Liu, X., Matsushima, A., Shirasu, N., Tominaga, Y., Shimohigashi, M., Shimohigashi, Y. & Nose, T., 2005, Peptide Science 2004. p. 303-304

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural characteristics of the N-Terminal octapeptide repeat region of Prion protein in self-polymerization

Horiuchi, Y., Kawano, M., Yokotani, S., Honda, T., Matsushima, A., Nose, T. & Shimohigashi, Y., 2005, Peptide Science 2004. p. 317-318

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Subcellular localization of human neutral ceramidase expressed in HEK293 cells

Hwang, Y. H., Tani, M., Nakagawa, T., Okino, N. & Ito, M., May 27 2005, In : Biochemical and Biophysical Research Communications. 331, 1, p. 37-42 6 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Triplicate alternative splicings that produce multiple variants of the PERIOD protein in the silk moth Bombyx mori by deletion/Insertion of peptides

Takeda, Y., Shirasu, N., Sato, S., Matsushima, A., Chuman, Y., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004. p. 203-206

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2006

a-helix peptides for bio-panning in the phage display method to obtain the antibodies specific for conformation-change nuclear receptors

Okada, H., Tokunaga, T., Shirasu, N., Matsushima, A., Nose, T. & Shimohigashi, Y., 2006, Science 2005. p. 209-210

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Conformation change of α-helix peptide for sensing of deactivation of nuclear peceptor: Immunoassay using polyclonal antibody specific for the C-terminal a-helix 12 of estrogen-related receptor γ (ERRγ)

Tokunaga, T., Liu, X., Okada, H., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 176

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Cytocidal actions of parasporin-2, an anti-tumor crystal toxin from Bacillus thuringiensis

Kitada, S., Abe, Y., Shimada, H., Kusaka, Y., Matsuo, Y., Katayama, H., Okumura, S., Akao, T., Mizuki, E., Kuge, O., Sasaguri, Y., Ohba, M. & Ito, A., Sep 8 2006, In : Journal of Biological Chemistry. 281, 36, p. 26350-26360 11 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Design and synthesis of a-helix peptide binding to prion protein N-terminal octarepeat domain

Koga, K., Sato, S., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 2006, Science 2005. p. 209-210

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Endocrine disruptor bisphenol A strongly binds to human estrogen-related receptor γ (ERRγ) with high constitutive activity

Takayanagi, S., Tokunaga, T., Liu, X., Okada, H., Matsushima, A. & Shimohigashi, Y., Dec 1 2006, In : Toxicology Letters. 167, 2, p. 95-105 11 p.

Research output: Contribution to journalArticle

242 Citations (Scopus)

Identification of novel isoforms of the circadian neuropeptide PDF in the silk moth Bombyx mori and their expression in brain

Sato, S., Jonathan, C., Takeda, Y., Kaneki, A., Matsushima, A. & Shimohigashi, Y., 2006, Science 2005. p. 99-100

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Immunological confirmation of circadian-related neuropeptide PDF-isoform peptide in the cricket Gryllus bimaculatus

Koga, K., Hiramura, D., Takeda, Y., Kaneki, A., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 262

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Molecular cloning and in situ hybridization of circadian neuropeptide PDF receptor in the fruit fly Drosophila melanogaster

Kaneki, A., Yoshida, T., Isozaki, K., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 263

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Monoclonal antibody sensing assay for conformation change induced by metal binding to prion protein N-terminal octarepear domain

Yokotani, S., Honda, T., Kawano, M., Matsushima, A. & Shimohigashi, Y., 2006, Science 2005. p. 455-456

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Multiple post-transcriptional regulations in circadian pacemaker neuropeptide pdf gene

Takeda, Y., Sumiyoshi, M., Koga, K., Ito, M., Matsushima, A., Shimohigashi, Y. & Shimohigashi, M., 2006, Peptide Science 2006. p. 260

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

33 Citations (Scopus)

Neutral ceramidase as an integral modulator for the generation of S1P and S1P-mediated signaling

Ito, M., Tani, M. & Yoshimura, Y., 2006, Sphingolipid Biology. Springer Japan, p. 183-196 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Phosphatidylserine is involved in gene expression from Sindbis virus subgenomic promoter

Saito, K., Nishijima, M. & Kuge, O., Jun 30 2006, In : Biochemical and Biophysical Research Communications. 345, 2, p. 878-885 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Requirement of an IκB-β COOH terminal region protein for acidic-adaptation in CHO cells

Lao, Q., Fukamachi, T., Saito, H., Kuge, O., Nishijima, M. & Kobayashi, H., Apr 1 2006, In : Journal of cellular physiology. 207, 1, p. 238-243 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Rescue of cell growth by sphingosine with disruption of lipid microdomain formation in Saccharomyces cerevisiae deficient in sphingolipid biosynthesis

Tani, M., Kihara, A. & Igarashi, Y., Feb 15 2006, In : Biochemical Journal. 394, 1, p. 237-242 6 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Specific dimerization of prion protein N-terminal domain

Matsushima, A., Horiuchi, Y., Yokotani, S., Kawano, M. & Shimohigashi, Y., 2006, Science 2005. p. 209-210

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural isoforms of the circadian neuropeptide PDF expressed in the optic lobes of the cricket Gryllus bimaculatus: Immunocytochemical evidence from specific monoclonal antibodies

Honda, T., Matsushima, A., Sumida, K., Chuman, Y., Sakaguchi, K., Onoue, H., Meinertzhagen, I. A., Shimohigashi, Y. & Shimohigashi, M., Nov 20 2006, In : Journal of Comparative Neurology. 499, 3, p. 404-421 18 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Structure-activity studies of FMRFamide-related peptides in activating the specific receptor present in the housefly Musca domestica

Matsushima, A., Koretsune, Y., Kaneki, A., Isozaki, K., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 174

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Total synthesis, structure revision, and absolute configuration of (-)-brevenal

Fuwa, H., Ebine, M., Bourdelais, A. J., Baden, D. G. & Sasaki, M., Dec 27 2006, In : Journal of the American Chemical Society. 128, 51, p. 16989-16999 11 p.

Research output: Contribution to journalArticle

107 Citations (Scopus)

Total synthesis of the proposed structure of brevenal

Fuwa, H., Ebine, M. & Sasaki, M., Aug 2 2006, In : Journal of the American Chemical Society. 128, 30, p. 9648-9650 3 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)
2007

A protein from a parasitic microorganism, Rickettsia prowazekii, can cleave the signal sequences of proteins targeting mitochondria

Kitada, S., Uchiyama, T., Funatsu, T., Kitada, Y., Ogishima, T. & Ito, A., Feb 1 2007, In : Journal of bacteriology. 189, 3, p. 844-850 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Double-labelled in situ hybridization reveals the lack of co-localization of mRNAs for the circadian neuropeptide PDF and FMRFamide in brains of the flies Musca domestica and Drosophila melanogaster

Matsushima, A., Takano, K., Yoshida, T., Takeda, Y., Yokotani, S., Shimohigashi, Y. & Shimohigashi, M., Jun 1 2007, In : Journal of biochemistry. 141, 6, p. 867-877 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Haeme-regulated degradation of δ-aminolevulinate synthase 1 in rat liver mitochondria

Yoshino, K., Munakata, H., Kuge, O., Ito, A. & Ogishima, T., Oct 1 2007, In : Journal of biochemistry. 142, 4, p. 453-458 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Klotho-related protein is a novel cytosolic neutral β- glycosylceramidase

Hayashi, Y., Okino, N., Kakuta, Y., Shikanai, T., Tani, M., Narimatsu, H. & Ito, M., Oct 19 2007, In : Journal of Biological Chemistry. 282, 42, p. 30889-30900 12 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes

Ito, K., Anada, Y., Tani, M., Ikeda, M., Sano, T., Kihara, A. & Igarashi, Y., May 25 2007, In : Biochemical and Biophysical Research Communications. 357, 1, p. 212-217 6 p.

Research output: Contribution to journalArticle

129 Citations (Scopus)

Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis

Chida, D., Nakagawa, S., Nagai, S., Sagara, H., Katsumata, H., Imaki, T., Suzuki, H., Mitani, F., Ogishima, T., Shimizu, C., Kotaki, H., Kakuta, S., Sudo, K., Koike, T., Kubo, M. & Iwakura, Y., Nov 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 46, p. 18205-18210 6 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)
29 Citations (Scopus)

Spatial orientation of mitochondrial processing peptidase and a preprotein revealed by fluorescence resonance energy transfer

Nishino, T. G., Kitano, K., Kojima, K., Ogishima, T., Ito, A. & Kitada, S., Jun 1 2007, In : Journal of biochemistry. 141, 6, p. 889-895 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERRγ

Matsushima, A., Kakuta, Y., Teramoto, T., Koshiba, T., Liu, X., Okada, H., Tokunaga, T., Kawabata, S. I., Kimura, M. & Shimohigashi, Y., Oct 1 2007, In : Journal of biochemistry. 142, 4, p. 517-524 8 p.

Research output: Contribution to journalArticle

146 Citations (Scopus)

Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: A mechanism involving an initial effect on gonadotropin synthesis in the pituitary

Taketoh, J., Mutoh, J., Takeda, T., Ogishima, T., Takeda, S., Ishii, Y., Ishida, T. & Yamada, H., Mar 13 2007, In : Life Sciences. 80, 14, p. 1259-1267 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2008

Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase

Briggs, L. C., Baldwin, G. S., Miyata, N., Kondo, H., Zhang, X. & Freemont, P. S., May 16 2008, In : Journal of Biological Chemistry. 283, 20, p. 13745-13752 8 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Cytochrome P-45017α in β-cells of rat pancreas and its local steroidogenesis

Ogishima, T., Mitani, F. & Suematsu, M., Jul 1 2008, In : Journal of Steroid Biochemistry and Molecular Biology. 111, 1-2, p. 80-86 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist

Li, J., Isozaki, K., Okada, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., Mar 1 2008, In : Bioorganic and Medicinal Chemistry. 16, 5, p. 2635-2644 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Direct evidence revealing structural elements essential for the high binding ability of bisphenol a to human estrogen-related receptor-γ

Okada, H., Tokunaga, T., Liu, X., Takayanagi, S., Matsushima, A. & Shimohigashi, Y., Jan 1 2008, In : Environmental Health Perspectives. 116, 1, p. 32-38 7 p.

Research output: Contribution to journalArticle

282 Citations (Scopus)