Organic and Biological Chemistry

Research Output

2008

Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist

Li, J., Isozaki, K., Okada, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., Mar 1 2008, In : Bioorganic and Medicinal Chemistry. 16, 5, p. 2635-2644 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Direct evidence revealing structural elements essential for the high binding ability of bisphenol a to human estrogen-related receptor-γ

Okada, H., Tokunaga, T., Liu, X., Takayanagi, S., Matsushima, A. & Shimohigashi, Y., Jan 1 2008, In : Environmental Health Perspectives. 116, 1, p. 32-38 7 p.

Research output: Contribution to journalArticle

286 Citations (Scopus)
20 Citations (Scopus)

ERRγ tethers strongly bisphenol A and 4-α-cumylphenol in an induced-fit manner

Matsushima, A., Teramoto, T., Okada, H., Liu, X., Tokunaga, T., Kakuta, Y. & Shimohigashi, Y., Aug 29 2008, In : Biochemical and Biophysical Research Communications. 373, 3, p. 408-413 6 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Optimization of the N-terminal group of Ac-RYYRIK-NH2 as ORL1 receptor antagonist

Li, J., Isozaki, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2008, Peptide Science 2007. p. 257-260

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Radar chart deviation analysis of prion protein amino acid composition defines characteristic structural abnormalities of the N-terminal octapeptide tandem repeat

Yokotani, S., Nose, T., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., Sep 1 2008, In : Protein and Peptide Letters. 15, 9, p. 949-955 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Structural requirement of housefly FMRFamide peptides in its receptor activation

Matsushima, A., Koretsune, Y., Kaneki, A., Isozaki, K., Shimohigashi, M. & Shimohigashi, Y., 2008, Peptide Science 2007. p. 313-314

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Synergistic effect of basic residues at positions 14-15 of nociceptin on binding affinity and receptor activation

Okada, K., Isozaki, K., Li, J., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., Oct 15 2008, In : Bioorganic and Medicinal Chemistry. 16, 20, p. 9261-9267 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Synthesis of pyrazine acetals by the biased reaction of symmetric 2,5-bis(chloromethyl) or 2,3,5,6-tetrakis(chloromethyl) substituents on pyrazine ring with sodium alkoxides

Eda, Y., Odazaki, Y., Mizutani, A., Ito, Y. N. & Kawato, T., Apr 14 2008, In : Tetrahedron Letters. 49, 16, p. 2519-2522 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

The Conformation Change-sensing Antibodies for Retinoid-related Orphan Receptor Family

Nose, T., Nishigori, M., Liu, X., Tokunaga, T. & Shimohigashi, Y., Mar 2008, Peptide Science 2007. p. 497-492 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

The effect of amino acid substitution on oligomerization of octapeptide repeat structure in prion protein

Hattori, E., Yokotani, S., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 2008, Peptide Science 2007. p. 239-242

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

The output mechanism of circadian pacemaker neuropeptide PDF in the regulation of bimodal locomotor distribution

Takeda, Y., Koga, K., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2008, Peptide Science 2007. p. 65-68

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Total synthesis of (-)-brevenal: A concise synthetic entry to the pentacyclic polyether core

Ebine, M., Fuwa, H. & Sasaki, M., Jun 5 2008, In : Organic Letters. 10, 11, p. 2275-2278 4 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
2009

2,6-Bis(porphyrin)-substituted pyrazine: a new class of supramolecular synthon binding to a transition-metal ion and fullerene (C60)

Eda, Y., Itoh, K., Ito, Y. & Kawato, T., Jan 3 2009, In : Tetrahedron. 65, 1, p. 282-288 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Bisphenol A-specific nuclear receptor ERRγ: structure-function analysis of the two novel isoforms lacking vital peptide fragment in the ligand binding domain

Takeda, Y., Liu, X., Sumiyoshi, M., Matsushima, A., Shimohigashi, Y. & Shimohigashi, M., 2009, Peptide Science 2008. p. 517-518

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)14, (Arg/Lys)15]nociceptin on ORL1 receptor binding and activation

Nishimura, H., Li, J., Isozaki, K., Okada, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., Aug 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 15, p. 5683-5687 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

ERα/ERRα nuclear receptor heterodimer directly linked by a flag peptide

Ikeda, S., Matsushima, A. & Shimohigashi, Y., 2009, Peptide Science 2008. p. 511-512

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Induced-fit type ligand binding guided by free-rotatory Leu residue present in the 7th α-helix peptide in the estrogen-related receptor γ (ERRγ)

Matsushima, A., Okada, H., Liu, X., Tokunaga, T., Teramoto, T., Kakuta, Y. & Shimohigashi, Y., 2009, Peptide Science 2008. p. 521-522

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

In vitro import of peroxisome-targeting signal type 2 (PTS2) receptor Pex7p into peroxisomes

Miyata, N., Hosoi, K. I., Mukai, S. & Fujiki, Y., May 1 2009, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1793, 5, p. 860-870 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase

Inoue, T., Okino, N., Kakuta, Y., Hijikata, A., Okano, H., Goda, H. M., Tani, M., Sueyoshi, N., Kambayashi, K., Matsumura, H., Kai, Y. & Ito, M., Apr 3 2009, In : Journal of Biological Chemistry. 284, 14, p. 9566-9577 12 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Molecular recognition of prion protein via its N-terminal octapeptide repeat Structure

Horiuchi, Y., Hattori, E., Yokotani, S., Matsushima, A. & Shimohigashi, Y., 2009, Peptide Science 2008. p. 513-516

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Placenta expressing the greatest quantity of bisphenol A receptor ERRγ among the human reproductive tissues: Predominant expression of type-1 ERRγ isoform

Takeda, Y., Liu, X., Sumiyoshi, M., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., Jul 1 2009, In : Journal of biochemistry. 146, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Purification and characterization of human phosphatidylserine synthases 1 and 2

Tomohiro, S., Kawaguti, A., Kawabe, Y., Kitada, S. & Kuge, O., Mar 1 2009, In : Biochemical Journal. 418, 2, p. 421-429 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
25 Citations (Scopus)
2010

Adrenocortical zonation in humans under normal and pathological conditions

Nishimoto, K., Nakagawa, K., Li, D., Kosaka, T., Oya, M., Mikami, S., Shibata, H., Itoh, H., Mitani, F., Yamazaki, T., Ogishima, T., Suematsu, M. & Mukai, K., May 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 5, p. 2296-2305 10 p.

Research output: Contribution to journalArticle

159 Citations (Scopus)

Bisphenol AF is a full agonist for the estrogen receptor ERα but a highly specific antagonist for ERβ

Matsushima, A., Liu, X., Okada, H., Shimohigashi, M. & Shimohigashi, Y., Sep 1 2010, In : Environmental Health Perspectives. 118, 9, p. 1267-1272 6 p.

Research output: Contribution to journalArticle

113 Citations (Scopus)
15 Citations (Scopus)

Detection of Rap1A as a yessotoxin binding protein from blood cell membranes

Ujihara, S., Oishi, T., Mouri, R., Tamate, R., Konoki, K., Matsumori, N., Murata, M., Oshima, Y., Sugiyama, N., Tomita, M. & Ishihama, Y., Nov 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 22, p. 6443-6446 4 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Distinction of the binding modes for human nuclear receptor ERRγ between bisphenol A and 4-hydroxytamoxifen

Liu, X., Matsushima, A., Okada, H. & Shimohigashi, Y., Aug 1 2010, In : Journal of biochemistry. 148, 2, p. 247-254 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Functional role of the C-terminal Helix 12 peptide in the receptor activation mechanism of estrogen-related receptor γ (ERRγ)

Liu, X., Matsushima, A., Nose, T., Okada, H. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 435–436

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Highly efficient synthesis of medium-sized lactones via oxidative lactonization: Concise total synthesis of isolaurepanf

Ebine, M., Suga, Y., Fuwa, H. & Sasaki, M., Feb 23 2010, In : Organic and Biomolecular Chemistry. 8, 1, p. 39-42 4 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Identification of circadian neuropeptide PDF mRNA isoforms in the housefly Musca domestica

Kawanaka, C., Matsushima, A., Takeda, Y., Shimohigashi, M. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 145–146

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Mannosylinositol phosphorylceramide is a major sphingolipid component and is required for proper localization of plasma-membrane proteins in Schizosaccharomyces pombe

Nakase, M., Tani, M., Morita, T., Kitamoto, H. K., Kashiwazaki, J., Nakamura, T., Hosomi, A., Tanaka, N. & Takegawa, K., May 1 2010, In : Journal of Cell Science. 123, 9, p. 1578-1587 10 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
18 Citations (Scopus)

Structure-function analysis of nociceptin receptor ORL1 by the site-directed mutagenesis

Li, J., Isozaki, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 219–220

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Synthesis and properties of fullerene (C70) complexes of 2,6-bis(porphyrin)-substituted pyrazine derivatives bound to a Pd(II) ion

Eda, Y., Itoh, K., Ito, Y. N., Fujitsuka, M., Majima, T. & Kawato, T., Sep 1 2010, In : Supramolecular Chemistry. 22, 9, p. 517-523 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The AAA+ ATPase ATAD3A controls mitochondrial dynamics at the interface of the inner and outer membranes

Gilquin, B., Taillebourg, E., Cherradi, N., Hubstenberger, A., Gay, O., Merle, N., Assard, N., Fauvarque, M. O., Tomohiro, S., Kuge, O. & Baudier, J., Apr 2010, In : Molecular and cellular biology. 30, 8, p. 1984-1996 13 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

The direct measure of intermolecular interaction of prion protein N-terminal octapeptide repeats by the quarts crystal microbalance (QCM)

Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 207–208

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

The functional role of Trp present at the cell membrane interface in the opioid receptor activation

Nishimura, H., Li, J., Inokuchi, N., Koikawa, A., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 23–24

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

The preparation and purification of prion protein N-terminal domain with fluctuations in the number of octapeptide repeat

Sato, K., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 219–220

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

The role of the peptide PAP coded in pdf gene

Shimohigashi, M., Ito, T., Honda, T., Saito, M., Koga, K., Takahashi, K., Matsushima, A., Ueda, R., Tanimura, T., Shimohigashi, Y. & Matsumoto, A., 2010, Peptide Science 2009. p. 207–208

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2011

Capturing of the free cysteine residue in the ligand-binding site by affinity labeling of the ORL1 nociceptin receptor

Matsushima, A., Nishimura, H., Inamine, S., Uemura, S. & Shimohigashi, Y., Dec 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 24, p. 7597-7602 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

"Click-made" biaryl-linker improving efficiency in protein labelling for the membrane target protein of a bioactive compound

Nakamura, Y., Inomata, S., Ebine, M., Manabe, Y., Iwakura, I. & Ueda, M., Jan 1 2011, In : Organic and Biomolecular Chemistry. 9, 1, p. 83-85 3 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Cysteine ubiquitination of PTS1 receptor Pex5p regulates Pex5p recycling

Okumoto, K., Misono, S., Miyata, N., Matsumoto, Y., Mukai, S. & Fujiki, Y., Aug 1 2011, In : Traffic. 12, 8, p. 1067-1083 17 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Endocrine disrupter bisphenol a increases in situ estrogen production in the mouse urogenital sinus

Arase, S., Ishii, K., Igarashi, K., Aisaki, K., Yoshio, Y., Matsushima, A., Shimohigashi, Y., Arima, K., Kanno, J. & Sugimura, Y., Apr 1 2011, In : Biology of Reproduction. 84, 4, p. 734-742 9 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Exploration of the binding site of ORL1 nociceptin receptor antagonist

Inamine, S., Nishimura, H., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2011, Peptide Science 2010. p. 167

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

FMP30 is required for the maintenance of a normal cardiolipin level and mitochondrial morphology in the absence of mitochondrial phosphatidylethanolamine synthesis

Kuroda, T., Tani, M., Moriguchi, A., Tokunaga, S., Higuchi, T., Kitada, S. & Kuge, O., Apr 1 2011, In : Molecular Microbiology. 80, 1, p. 248-265 18 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Metabolic machinery of sphingolipid signaling molecules

Tani, M., Dec 1 2011, In : Seikagaku. 83, 7, p. 623-627 5 p.

Research output: Contribution to journalArticle

Pigment-dispersing factor affects nocturnal activity rhythms, photic entrainment, and the free-running period of the circadian clock in the cricket gryllus bimaculatus

Hassaneen, E., El-Din Sallam, A., Abo-Ghalia, A., Moriyama, Y., Karpova, S. G., Abdelsalam, S., Matsushima, A., Shimohigashi, Y. & Tomioka, K., Feb 1 2011, In : Journal of Biological Rhythms. 26, 1, p. 3-13 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Practical synthesis of DOPA derivative for biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 743

Torikai, K., Saruwatari, T., Kitano, T., Sano, T., Nakane, A., Noguchi, H. & Watanabe, K., Dec 1 2011, In : Letters in Organic Chemistry. 8, 10, p. 686-689 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)