Organic and Biological Chemistry

Research Output

2011

Structural essentials of hyperalgesic nococeptin ORL1 receptor for ligand binding and receptor activation

Nishimura, H., Li, J., Isozaki, K., Abe, Y., Inamine, S., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2011, Peptide Science 2010. p. 128

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Synthesis of 6-F-ergosterol and its influence on membrane-permeabilization of amphotericin B and amphidinol 3

Kasai, Y., Matsumori, N., Ueno, H., Nonomura, K., Yano, S., Michio, M. & Oishi, T., Mar 1 2011, In : Organic and Biomolecular Chemistry. 9, 5, p. 1437-1442 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The mucin box and signal/anchor sequence of rat neutral ceramidase recruit bacterial sphingomyelinase to the plasma membrane

Nakagawa, T., Tani, M., Sueyoshi, N. & Ito, M., Jun 6 2011, In : Bioscience, Biotechnology and Biochemistry. 75, 5, p. 987-990 4 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The Trp Residue of Opioid Receptor TM5 is Present at the Cell Membrane Interface as a Molecular Anchor for Full Activation

Nishimura, H., Li, J., Inokuchi, N., Koikawa, S., Nose, T., Matsushima, A., Costa, T. & Shimohigashi, Y., Mar 2011, Peptide Science 2010. p. 175 1 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Total synthesis of (-)-brevenal: A streamlined strategy for practical synthesis of polycyclic ethers

Ebine, M., Fuwa, H. & Sasaki, M., Dec 2 2011, In : Chemistry - A European Journal. 17, 49, p. 13754-13761 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2012

Affinity labeling of the ORL1 nociceptin receptor by Cys(Npys)-elongated RYYRIK peptide antagonist

Matsushima, A., Nishimura, H., Uemura, S., Li, J., Inamine, S. & Shimohigashi, Y., 2012, Peptide Science 2011. p. 179-180

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca 2+ influx in rat glioma C6 cells

Oishi, T., Konoki, K., Tamate, R., Torikai, K., Hasegawa, F., Matsumori, N. & Murata, M., Jun 1 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 11, p. 3619-3622 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase

Miyata, N., Okumoto, K., Mukai, S., Noguchi, M. & Fujiki, Y., Jan 1 2012, In : Traffic. 13, 1, p. 168-183 16 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Comprehensive molecular motion capture for sphingomyelin by site-specific deuterium labeling

Matsumori, N., Yasuda, T., Okazaki, H., Suzuki, T., Yamaguchi, T., Tsuchikawa, H., Doi, M., Oishi, T. & Murata, M., Oct 23 2012, In : Biochemistry. 51, 42, p. 8363-8370 8 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Confirmation of the absolute configuration at C45 of amphidinol 3

Manabe, Y., Ebine, M., Matsumori, N., Murata, M. & Oishi, T., Dec 3 2012, In : Journal of Natural Products. 75, 11, p. 2003-2006 4 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
3 Citations (Scopus)

Effects of the halogenation of Phe-phenyl group of two consecutive residues in endomorphin-2 on the interaction with the μ–opioid receptors

Nishio, K., Nishimura, H., Suyama, K., Abe, Y., Matsushima, A., Nose, T. & Shimohigashi, Y., 2012, Peptide Science 2011. p. 171-172

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Expression of budding yeast IPT1 produces mannosyldiinositol phosphorylceramide in fission yeast and inhibits cell growth

Nakase, M., Tani, M. & Takegawa, K., May 1 2012, In : Microbiology. 158, 5, p. 1219-1228 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Fine spatial assembly for construction of the phenol-binding pocket to capture bisphenol a in the human nuclear receptor estrogen-related receptor γ

Liu, X., Matsushima, A., Nakamura, M., Costa, T., Nose, T. & Shimohigashi, Y., Apr 1 2012, In : Journal of biochemistry. 151, 4, p. 403-415 13 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Head-to-tail interaction between amphotericin b and ergosterol occurs in hydrated phospholipid membrane

Umegawa, Y., Nakagawa, Y., Tahara, K., Tsuchikawa, H., Matsumori, N., Oishi, T. & Murata, M., Jan 10 2012, In : Biochemistry. 51, 1, p. 83-89 7 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
14 Citations (Scopus)

Impaired retrograde membrane traffic through endosomes in a mutant CHO cell defective in phosphatidylserine synthesis

Lee, S., Uchida, Y., Emoto, K., Umeda, M., Kuge, O., Taguchi, T. & Arai, H., Aug 1 2012, In : Genes to Cells. 17, 8, p. 728-736 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
10 Citations (Scopus)
28 Citations (Scopus)

NMR-based conformational analysis of sphingomyelin in bicelles

Yamaguchi, T., Suzuki, T., Yasuda, T., Oishi, T., Matsumori, N. & Murata, M., Jan 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 1, p. 270-278 9 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Receptor Binding Characteristics of Tritium-labeled Pure antagonist Peptide for Hyperalgesic nociceptin ORL1 receptor

Inamine, S., Nishimura, H., Li, J., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2012, Peptide Science 2011. p. 183-184

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Selenium Compound Protects Corneal Epithelium against Oxidative Stress

Higuchi, A., Inoue, H., Kawakita, T., Ogishima, T. & Tsubota, K., Sep 25 2012, In : PloS one. 7, 9, e45612.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Structural Analysis of Delta Opioid Receptor Dimer by Bivalent Deltorphin II Analogs

Ito, N., Nishimura, H., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., Mar 2012, Peptide Science 2011. p. 173-174 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural Characteristics of Thr-Gly Dipeptide Repeat in the Drosophila Clock Protein PERIOD

Matsuo, A., Nishimura, H., Masayuki, N., Koga, K., Sumiyoshi, M., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., Mar 2012, Peptide Science 2011. p. 351-352 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural Essentials of Hyperalgesic Nociceptin ORL1 Receptor for Ligand Binding and Receptor Activation

Nishimura, H., Li, J., Isozaki, K., Abe, Y., Inamine, S., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2012, Peptide Science 2011. p. 33-34

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2013

A facile and practical synthesis of Nicolaou's key intermediates, 2-methyl- and 2,6-dimethyltetrahydropyrans, toward the total synthesis of ladder-shaped polyethers

Nakashima, T., Baba, T., Onoue, H., Yamashita, W. & Torikai, K., Jul 24 2013, In : Synthesis (Germany). 45, 17, p. 2417-2425 9 p., SS-2013-F0387-OP.

Research output: Contribution to journalArticle

5 Citations (Scopus)

An endocrine disruptor, bisphenol A, affects development in the protochordate Ciona intestinalis: Hatching rates and swimming behavior alter in a dose-dependent manner

Matsushima, A., Ryan, K., Shimohigashi, Y. & Meinertzhagen, I. A., Feb 1 2013, In : Environmental Pollution. 173, p. 257-263 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

A novel sperm-activating and attracting factor from the ascidian Ascidia sydneiensis

Matsumori, N., Hiradate, Y., Shibata, H., Oishi, T., Shimma, S., Toyoda, M., Hayashi, F., Yoshida, M., Murata, M. & Morisawa, M., Jan 18 2013, In : Organic Letters. 15, 2, p. 294-297 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Bisphenol-binding pocket of constitutively active nuclear receptor CAR: Docking modeling for close-packing

Matsuyama, Y., Liu, X., Nishimura, H., Matsushima, A., Nose, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 401-402

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro

Vecchiola, A., Lagos, C. F., Fuentes, C. A., Allende, F., Campino, C., Valdivia, C., Tapia-Castillo, A., Ogishima, T., Mukai, K., Owen, G., Solari, S., Carvajal, C. A. & Fardella, C. E., Aug 13 2013, In : Reproductive Biology and Endocrinology. 11, 1, 76.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Exploration of pharmacological chaperone for rescue of misfolded and/or unfolded ORL1 nociceptin receptor proteins

Nishimura, H., Inamine, S., Li, J., Matsushima, A. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 115-118

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Guest responsivity of a two-dimensional coordination polymer incorporating a cholesterol-based co-ligand

Kajitani, K., Koshiyama, T., Hori, A., Ohtani, R., Mishima, A., Torikai, K., Ebine, M., Oishi, T., Takata, M., Kitagawa, S. & Ohba, M., Dec 7 2013, In : Dalton Transactions. 42, 45, p. 15893-15897 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Halogenated Phe-containing endomorphin-2 analogs with mixed agonist and antagonist activities

Nishio, K., Nishimura, H., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 25-26

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

High-precision binding assay procedure of tachykinin receptor NK-1 for highly potent Substance P analogs

Kuramitsu, Y., Nishimura, H., Nakamura, R., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 213-214

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Identification of affinity binding site of Cys(Npys)-elongated RYYRIK peptide antagonist by means of Cys→Ala mutated ORL1 nociceptin receptors

Matsushima, A., Nishimura, H., Inamine, S. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 207-208

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Immunohistochemistry improves histopathologic diagnosis in primary aldosteronism

Volpe, C., Höög, A., Ogishima, T., Mukai, K., Lu, M., Thorén, M. & Hamberger, B., Apr 1 2013, In : Journal of Clinical Pathology. 66, 4, p. 351-354 4 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Synthesis and structure revision of the C43-C67 part of amphidinol 3

Ebine, M., Kanemoto, M., Manabe, Y., Konno, Y., Sakai, K., Matsumori, N., Murata, M. & Oishi, T., Jun 26 2013, In : Organic Letters. 15, 11, p. 2846-2849 4 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria

Tamura, Y., Harada, Y., Nishikawa, S. I., Yamano, K., Kamiya, M., Shiota, T., Kuroda, T., Kuge, O., Sesaki, H., Imai, K., Tomii, K. & Endo, T., May 7 2013, In : Cell metabolism. 17, 5, p. 709-718 10 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

The impact of bisphenol A-feeding on the Drosophila neuropeptide PDF mRNA structure

Matsuo, A., Nakamura, M., Takeda, Y., Matsuyama, Y., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 75-76

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Triazoyl-phenyl linker system enhancing the aqueous solubility of a molecular probe and its efficiency in affinity labeling of a target protein for jasmonate glucoside

Tamura, S., Inomata, S., Ebine, M., Genji, T., Iwakura, I., Mukai, M., Shoji, M., Sugai, T. & Ueda, M., Jan 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 188-193 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Two different binding modes of peptide library-based antagonist acyl-RYYRIK amide in the orl1 nociceptin receptor

Inamine, S., Nishimura, H., Li, J., Matsushima, A., Costa, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 229-230

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2014

A characteristic back support structure in the bisphenol A-binding pocket in the human nuclear receptor ERRγ

Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., Jun 30 2014, In : PloS one. 9, 6, e101252.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Adrenal nodularity and somatic mutations in primary aldosteronism: One node is the culprit?

Dekkers, T., Ter Meer, M., Lenders, J. W. M., Hermus, A. R. M., Schultze Kool, L., Langenhuijsen, J. F., Nishimoto, K., Ogishima, T., Mukai, K., Azizan, E. A. B., Tops, B., Deinum, J. & Küsters, B., Jul 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 7, p. E1341-1351

Research output: Contribution to journalArticle

71 Citations (Scopus)

AlCl3-mediated aldol cyclocondensation of 1,6- and 1,7-diones to cyclopentene and cyclohexene derivatives

Miyahara, Y. & Ito, Y. N., Jan 1 2014, In : Journal of Organic Chemistry. 79, 15, p. 6801-6807 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Bisphenol A-induced Epigenetic Mutations in Circadian Pacemaker Neuropeptide mRNAs of Hyperactive Drosophila Fruit Flies

Matsuo, A., Umeno, S., Matsuyama, Y., Nakamura, M., Takeda, Y., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 457-458

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Change in activity of serine palmitoyltransferase affects sensitivity to syringomycin E in yeast Saccharomyces cerevisiae

Toume, M. & Tani, M., Jan 1 2014, In : FEMS microbiology letters. 358, 1, p. 64-71 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Constitutive α-Helix-peptides Required for Functional Dimerization of Estrogen-related Receptor γ (ERRγ).

Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 429-430

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Expression and Mutation Analyses of Brain Neuropeptide Genes of Rndocrine-disrupting Bisphenol A-exposed Hypoactive Mouse

Sugiyama, M., Matsuo, A., Saito, T., Uchimura, E., Liu, X., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 453-454

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Functionally Essential Amino Acid Residues in ORL1 Nociceptin Receptor for Ligand-stimulated Receptor Activation

Nishimura, H., Li, J., abe, Y., Isozaki, K., Matsushima, A., Inamine, S., Costa, T. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 333-334

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)