Organic and Biological Chemistry

Research Output

2016

Comparative analysis of the ligand binding domain secondary structures of human nuclear receptors

Matsuyama, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 337-338

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Comprehensive structural analysis of the nociceptin ORL1 receptor by means of virtual and experimental Ala-scanning combinated methods

Matsushima, A., Nishimura, H., Liu, X., Takesue, Y., Matsuyama, Y. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 149-150

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Do the estrogen receptors function as a homodimer? experimental validation of homodimerization by inhibitory peptides

Sakito, S., Fujiyama, A., Motomatsu, Y., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 335-336

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Do the estrogen receptors function as a homodimer? experimental validation of homodimerization by inhibitory peptides

Sakito, S., Liu, X., Fujiyama, A., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 335-336

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling

Otera, H., Miyata, N., Kuge, O. & Mihara, K., Jan 1 2016, In : Journal of Cell Biology. 212, 5, p. 531-544 14 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

Expression analysis of neuropeptide PDF mRNA in the hypoactive and hyperactive fruit flies Drosophila melanogaster

Asuka, T., Matsuo, A., Shotaro, U., Matsuyama, Y., masayuki, N., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 317-318

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Functional role of the Phe-Phe stacking microswitch in the ORL1 nociceptin receptor activation

Takesue, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 147-148

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

ORL1 Nociceptin receptor response of opioid peptides derived from proenkephalin precursor protein

Motomatsu, Y., Nishimura, H., Matsuyama, Y., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 181-182

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Phosphatidylserine transport by Ups2-Mdm35 in respiration-active mitochondria

Miyata, N., Watanabe, Y., Tamura, Y., Endo, T. & Kuge, O., Jul 1 2016, In : Journal of Cell Biology. 214, 1, p. 77-88 12 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

SCN Circadian rhythm signal transduction neuropeptides evoke hypoactive phenotype differently in male and female mice

Sugiyama, M., Motomatsu, Y., Matsuyama, Y., Kajiyama, S., Kameda, T., Uchimura, E., Saito, T., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 53-54

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Specific affinity-labeling of the nociceptin ORL1 receptor using a thiol-activated Cys(Npys)-containing peptide ligand

Matsushima, A., Nishimura, H., Matsuyama, Y., Liu, X., Costa, T. & Shimohigashi, Y., Nov 4 2016, In : Biopolymers. p. 460-469 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Structure-function relationship of complex sphingolipids in yeast

Tani, M., Jan 1 2016, In : Trends in Glycoscience and Glycotechnology. 28, 164, p. E109-E116

Research output: Contribution to journalReview article

3 Citations (Scopus)

Structure-function relationship of complex sphingolipids in yeast

Tani, M., Jan 1 2016, In : Trends in Glycoscience and Glycotechnology. 28, 164, p. J107-J114

Research output: Contribution to journalReview article

Structure-function studies between the hormone-disrupting chemical bisphenols and the nuclear receptors

Matsushima, A., Jan 1 2016, In : Seikagaku. 88, 6, p. 733-743 11 p.

Research output: Contribution to journalReview article

The stereoselective construction of E- and Z-Δ-Ile from E-dehydroamino acid ester: the synthesis of the phomopsin A tripeptide side chain

Yasuno, Y., Nishimura, A., Yasukawa, Y., Karita, Y., Ohfune, Y. & Shinada, T., Jan 25 2016, In : Chemical Communications. 52, 7, p. 1478-1481 4 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

The Structure of the Bimolecular Complex between Amphotericin B and Ergosterol in Membranes Is Stabilized by Face-to-Face van der Waals Interaction with Their Rigid Cyclic Cores

Nakagawa, Y., Umegawa, Y., Matsushita, N., Yamamoto, T., Tsuchikawa, H., Hanashima, S., Oishi, T., Matsumori, N. & Murata, M., Jun 21 2016, In : Biochemistry. 55, 24, p. 3392-3402 11 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Yeast lacking the amphiphysin family protein Rvs167 is sensitive to disruptions in sphingolipid levels

Toume, M. & Tani, M., Aug 1 2016, In : FEBS Journal. p. 2911-2928 18 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

α-Helix-peptides comprising the human nuclear receptor ERRγ competitively provoke inhibition of functional homomeric dimerization

Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., Nov 4 2016, In : Biopolymers. p. 547-554 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

核内受容体が示す有害化学物質ビスフェノール応答

Translated title of the contribution: Structure-function studies between the hormone-disrupting chemical bisphenols and the nuclear receptorsMatsushima, A., Dec 2016, In : Seikagaku. The Journal of Japanese Biochemical Society. 88, 6, p. 733-43 11 p.

Research output: Contribution to journalArticle

2015

2-Naphthylmethoxymethyl as a Mildly Introducible and Oxidatively Removable Benzyloxymethyl-Type Protecting Group

Sato, T., Oishi, T. & Torikai, K., Jun 19 2015, In : Organic Letters. 17, 12, p. 3110-3113 4 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
10 Citations (Scopus)

Alternative polyadenylation analyses of neuropeptide genes in bisphenol A-exposed hypoactive mouse brain

Sugiyama, M., Kajiyama, S., Saito, T., Uchimura, E., Motomatsu, Y., Matsuo, A., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 345-346

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

An in silico genomic search of endomorphin-like opioid peptides

Matsushima, A., Koyanagi, K. O., Nishimura, H., Inamine, S., Motomatsu, Y. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 281-282

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

A novel method identify and quantify the coactivator proteins that couple with human nuclear receptor: the use of interacting interface a-helix peptide for quantitative inhibition

Liu, X., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 203-204

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Bisphenol A-induced substantial peak decay of Drosophila circadian neuropeptide hugin mRNA expression

Shotaro, U., Matsuo, A., Matsuyama, Y., Nakamura, M., Koga, K., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 41-42

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

COX assembly factor ccdc56 regulates mitochondrial morphology by affecting mitochondrial recruitment of Drp1

Ban-Ishihara, R., Tomohiro-Takamiya, S., Tani, M., Baudier, J., Ishihara, N. & Kuge, O., Oct 7 2015, In : FEBS Letters. 589, 20, p. 3126-3132 7 p., 37349.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Ergosteryl-β-glucosidase (Egh1) involved in sterylglucoside catabolism and vacuole formation in Saccharomyces cerevisiae

Watanabe, T., Tani, M., Ishibashi, Y., Endo, I., Okino, N. & Ito, M., Apr 14 2015, In : Glycobiology. 25, 10, p. 1079-1089 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

GPCR functional role of Phe-269 and Phe-221 in the molecular switching of ORL1 nociceptin receptor activation

Takesue, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 203-204

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Phospholipid methylation controls Atg32-mediated mitophagy and Atg8 recycling

Sakakibara, K., Eiyama, A., Suzuki, S. W., Sakoh-Nakatogawa, M., Okumura, N., Tani, M., Hashimoto, A., Nagumo, S., Kondo-Okamoto, N., Kondo-Kakuta, C., Asai, E., Kirisako, H., Nakatogawa, H., Kuge, O., Takao, T., Ohsumi, Y. & Okamoto, K., Nov 3 2015, In : EMBO Journal. 34, 21, p. 2703-2719 17 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Receptor selectivity and specificity of a series of opioid peptides latent in the proenkephalin precursor protein

Motomatsu, Y., Nishimura, H., Matsumoto, Y., Kuramitsu, Y., Inamine, S., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 201-202

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Stereoselective synthesis of the C1-C29 part of amphidinol 3

Tsuruda, T., Ebine, M., Umeda, A. & Oishi, T., Jan 16 2015, In : Journal of Organic Chemistry. 80, 2, p. 859-871 13 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Structural and molecular evolutionary analysis of the ligand-binding domain of forty-eight human nuclear receptors

Matsuyama, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 347-348

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structure-activity Studies on the Halogenated Phe-containing Neuropeptide Substance P Analogs

Kuramitsu, Y., Nishimura, H., Nakamura, M., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 319-320

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Synthesis of mannosylinositol phosphorylceramides is involved in maintenance of cell integrity of yeast Saccharomyces cerevisiae

Morimoto, Y. & Tani, M., Feb 1 2015, In : Molecular Microbiology. 95, 4, p. 706-722 17 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The molecular switching of ORL1 nociceptin receptor in activation/inactivation

Nishimura, H., Li, J., Isozaki, K., yuuki, T., Matsushima, A., Liu, X., Shimohigashi, M. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 201-202

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Tuned Classical Thermal Aromatization Furnishing an Estrogenic Benzoacridine

Koga, R., Oishi, T. & Torikai, K., Dec 17 2015, In : Synlett. 26, 20, p. 2801-2805 5 p., st-2015-s0585-c.

Research output: Contribution to journalArticle

1 Citation (Scopus)

VID22 is required for transcriptional activation of the PSD2 gene in the yeast Saccharomyces cerevisiae

Miyata, N., Miyoshi, T., Yamaguchi, T., Nakazono, T., Tani, M. & Kuge, O., Dec 15 2015, In : Biochemical Journal. 472, 3, p. 319-328 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Voltammetric study of the boric acid-salicylaldehyde-H-acid ternary system and its application to the voltammetric determination of boron

Kajiwara, M., Ito, Y. N., Miyazaki, Y., Fujimori, T., Takehara, K. & Yoshimura, K., Feb 14 2015, In : Physical Chemistry Chemical Physics. 17, 6, p. 4578-4588 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2014

A characteristic back support structure in the bisphenol A-binding pocket in the human nuclear receptor ERRγ

Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., Jun 30 2014, In : PloS one. 9, 6, e101252.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Adrenal nodularity and somatic mutations in primary aldosteronism: One node is the culprit?

Dekkers, T., Ter Meer, M., Lenders, J. W. M., Hermus, A. R. M., Schultze Kool, L., Langenhuijsen, J. F., Nishimoto, K., Ogishima, T., Mukai, K., Azizan, E. A. B., Tops, B., Deinum, J. & Küsters, B., Jul 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 7, p. E1341-1351

Research output: Contribution to journalArticle

73 Citations (Scopus)

AlCl3-mediated aldol cyclocondensation of 1,6- and 1,7-diones to cyclopentene and cyclohexene derivatives

Miyahara, Y. & Ito, Y. N., Jan 1 2014, In : Journal of Organic Chemistry. 79, 15, p. 6801-6807 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Bisphenol A-induced Epigenetic Mutations in Circadian Pacemaker Neuropeptide mRNAs of Hyperactive Drosophila Fruit Flies

Matsuo, A., Umeno, S., Matsuyama, Y., Nakamura, M., Takeda, Y., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 457-458

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Change in activity of serine palmitoyltransferase affects sensitivity to syringomycin E in yeast Saccharomyces cerevisiae

Toume, M. & Tani, M., Jan 1 2014, In : FEMS microbiology letters. 358, 1, p. 64-71 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Constitutive α-Helix-peptides Required for Functional Dimerization of Estrogen-related Receptor γ (ERRγ).

Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 429-430

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Expression and Mutation Analyses of Brain Neuropeptide Genes of Rndocrine-disrupting Bisphenol A-exposed Hypoactive Mouse

Sugiyama, M., Matsuo, A., Saito, T., Uchimura, E., Liu, X., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 453-454

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Functionally Essential Amino Acid Residues in ORL1 Nociceptin Receptor for Ligand-stimulated Receptor Activation

Nishimura, H., Li, J., abe, Y., Isozaki, K., Matsushima, A., Inamine, S., Costa, T. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 333-334

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Influence Analysis of the Circadian Evening Pacemaker Neuropeptide hugγ Gene in the Bisphenol A-exposed Fruit Fly Drosophila Brain

Umeno, S., Matsuo, A., Matsuyama, Y., Nakamura, M., Takeda, Y., Sumiyoshi, M., Liu, X., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 455-456

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

9 Citations (Scopus)

Loss of hydroxyl groups from the ceramide moiety can modify the lateral diffusion of membrane proteins in S. cerevisiae

Uemura, S., Shishido, F., Tani, M., Mochizuki, T., Abe, F. & Inokuchi, J. I., Jul 2014, In : Journal of Lipid Research. 55, 7, p. 1343-1356 14 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Multiple and Simultaneous Cys→Ala Mutations of ORL1 Nociceptin Receptor to Identify the Affinity Binding site of Cys(Npys)-Elongated RYYRIK Peptide Antagonist

Matsushima, A., Nishimura, H., Inamine, S. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 413-414

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)