Organic and Biological Chemistry

Research Output 1983 2020

1 Citation (Scopus)
Glycosylation
Stereoselectivity
Oligosaccharides
linkages
reactivity
1 Citation (Scopus)

1-Naphthylmethyl and 1-naphthylmethoxymethyl protecting groups: New members of the benzyl- and benzyloxymethyl-type family

Sato, T., Joh, Y., Oishi, T. & Torikai, K., Jan 1 2017, In : Tetrahedron Letters. 58, 23, p. 2178-2181 4 p.

Research output: Contribution to journalArticle

Oxidation
Hydrogenolysis
Nucleophiles
Temperature
Acids
7 Citations (Scopus)

2,6-Bis(porphyrin)-substituted pyrazine: a new class of supramolecular synthon binding to a transition-metal ion and fullerene (C60)

Eda, Y., Itoh, K., Ito, Y. & Kawato, T., Jan 3 2009, In : Tetrahedron. 65, 1, p. 282-288 7 p.

Research output: Contribution to journalArticle

Pyrazines
Porphyrins
Transition metals
Metal ions
Metals
2 Citations (Scopus)

2-Naphthylmethoxymethyl as a Mildly Introducible and Oxidatively Removable Benzyloxymethyl-Type Protecting Group

Sato, T., Oishi, T. & Torikai, K., Jun 19 2015, In : Organic Letters. 17, 12, p. 3110-3113 4 p.

Research output: Contribution to journalArticle

Chlorides
Temperature
compatibility
chlorides
2,6-lutidine
14 Citations (Scopus)

A characteristic back support structure in the bisphenol A-binding pocket in the human nuclear receptor ERRγ

Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., Jun 30 2014, In : PloS one. 9, 6, e101252.

Research output: Contribution to journalArticle

bisphenol A
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
receptors
estrogens

Activity Enhancement by Introduction of two different halogen atoms into Phe-2-phenyl group of thrombin receptor tetherd-ligand analogs.

Fujita, T., Inoue, N., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2001, Peptide Science 2000. p. 135-138

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

69 Citations (Scopus)

Adrenal nodularity and somatic mutations in primary aldosteronism: One node is the culprit?

Dekkers, T., Ter Meer, M., Lenders, J. W. M., Hermus, A. R. M., Schultze Kool, L., Langenhuijsen, J. F., Nishimoto, K., Ogishima, T., Mukai, K., Azizan, E. A. B., Tops, B., Deinum, J. & Küsters, B., Jul 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 7, p. E1341-1351

Research output: Contribution to journalArticle

Hyperaldosteronism
Aldosterone
Adenoma
Mutation
Genes
151 Citations (Scopus)

Adrenocortical zonation in humans under normal and pathological conditions

Nishimoto, K., Nakagawa, K., Li, D., Kosaka, T., Oya, M., Mikami, S., Shibata, H., Itoh, H., Mitani, F., Yamazaki, T., Ogishima, T., Suematsu, M. & Mukai, K., May 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 5, p. 2296-2305 10 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Steroid 11-beta-Hydroxylase
Aldosterone
Adenoma
Enzymes
5 Citations (Scopus)

A facile and practical synthesis of Nicolaou's key intermediates, 2-methyl- and 2,6-dimethyltetrahydropyrans, toward the total synthesis of ladder-shaped polyethers

Nakashima, T., Baba, T., Onoue, H., Yamashita, W. & Torikai, K., Jul 24 2013, In : Synthesis (Germany). 45, 17, p. 2417-2425 9 p., SS-2013-F0387-OP.

Research output: Contribution to journalArticle

Polyethers
Ladders
Catalytic oxidation
Biological Products
Purification

Affinity labeling of the ORL1 nociceptin receptor by Cys(Npys)-elongated RYYRIK peptide antagonist

Matsushima, A., Nishimura, H., Uemura, S., Li, J., Inamine, S. & Shimohigashi, Y., 2012, Peptide Science 2011. p. 179-180

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

26 Citations (Scopus)

A formal synthesis of aplysiatoxin: enantioselective synthesis of kishi's aldehyde

Okamura, H., Kuroda, S., Ikegami, S., Tomita, K., Sugimoto, Y. I., Sakaguchi, S. I., Ito, Y., Katsuki, T. & Yamaguchi, M., 1993, In : Tetrahedron. 49, 46, p. 10531-10554 24 p.

Research output: Contribution to journalArticle

Aldehydes
Neoplasms
aplysiatoxin
9 Citations (Scopus)

A formal total synthesis of aplysiatoxin

Okamura, H., Kuroda, S., Ikegami, S., Ito, Y., Katsuki, T. & Yamaguchi, M., Sep 16 1991, In : Tetrahedron Letters. 32, 38, p. 5141-5142 2 p.

Research output: Contribution to journalArticle

Stereochemistry
Communication
aplysiatoxin

a-helix peptides for bio-panning in the phage display method to obtain the antibodies specific for conformation-change nuclear receptors

Okada, H., Tokunaga, T., Shirasu, N., Matsushima, A., Nose, T. & Shimohigashi, Y., 2006, Science 2005. p. 209-210

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

18 Citations (Scopus)

A Highly Stereoselective Synthesis of (3A,4iS)-Statine and (SS^AJ-Cyclohexylstatine^

Takemoto, Y., Matsumoto, T., Ito, Y. & Terashima, S., Jan 1 1991, In : Chemical and Pharmaceutical Bulletin. 39, 9, p. 2425-2428 4 p.

Research output: Contribution to journalArticle

Acetals
Titanium
Phenylalanine
Renin
Aldehydes
8 Citations (Scopus)

AlCl3-mediated aldol cyclocondensation of 1,6- and 1,7-diones to cyclopentene and cyclohexene derivatives

Miyahara, Y. & Ito, Y. N., Jan 1 2014, In : Journal of Organic Chemistry. 79, 15, p. 6801-6807 7 p.

Research output: Contribution to journalArticle

Cyclopentanes
Condensation
Derivatives
Water
Temperature
124 Citations (Scopus)

Aldosterone synthase cytochrome P-450 expressed in the adrenals of patients with primary aldosteronism

Ogishima, T., Shibata, H., Shimada, H., Mitani, F., Suzuki, H., Saruta, T. & Ishimura, Y., Sep 6 1991, In : Journal of Biological Chemistry. 266, 17, p. 10731-10734 4 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Hyperaldosteronism
Cytochrome P-450 Enzyme System
Genes
Aldosterone
9 Citations (Scopus)
Vacuolar Proton-Translocating ATPases
Sphingolipids
Saccharomyces cerevisiae
Yeasts
Ceramides

Alternative polyadenylation analyses of neuropeptide genes in bisphenol A-exposed hypoactive mouse brain

Sugiyama, M., Kajiyama, S., Saito, T., Uchimura, E., Motomatsu, Y., Matsuo, A., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 345-346

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

46 Citations (Scopus)

Analysis of elements in the substrate required for processing by mitochondrial processing peptidase

Ogishima, T., Niidome, T., Shimokata, K., Kitada, S. & Ito, A., Dec 22 1995, In : Journal of Biological Chemistry. 270, 51, p. 30322-30326 5 p.

Research output: Contribution to journalArticle

Arginine
Peptide Hydrolases
Proline
Glycine
Substrates
59 Citations (Scopus)

Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase

Briggs, L. C., Baldwin, G. S., Miyata, N., Kondo, H., Zhang, X. & Freemont, P. S., May 16 2008, In : Journal of Biological Chemistry. 283, 20, p. 13745-13752 8 p.

Research output: Contribution to journalArticle

Adenosine Triphosphatases
Nucleotides
Adenosine Diphosphate
Endoplasmic Reticulum-Associated Degradation
Organelle Biogenesis
8 Citations (Scopus)
Arginine
Amino Acids
Protein Precursors
Mitochondrial Proteins
Peptide Hydrolases
16 Citations (Scopus)

An endocrine disruptor, bisphenol A, affects development in the protochordate Ciona intestinalis: Hatching rates and swimming behavior alter in a dose-dependent manner

Matsushima, A., Ryan, K., Shimohigashi, Y. & Meinertzhagen, I. A., Feb 1 2013, In : Environmental Pollution. 173, p. 257-263 7 p.

Research output: Contribution to journalArticle

Ciona intestinalis
Endocrine Disruptors
Mammals
Neurology
Polycarbonates
20 Citations (Scopus)

A neutral ceramidase homologue from Dictyostelium discoideum exhibits an acidic pH optimum

Monjusho, H., Okino, N., Tani, M., Maeda, M., Yoshida, M. & Ito, M., Dec 1 2003, In : Biochemical Journal. 376, 2, p. 473-479 7 p.

Research output: Contribution to journalArticle

Neutral Ceramidase
Dictyostelium
Fungi
Alkaline Ceramidase
Acid Ceramidase

An in silico genomic search of endomorphin-like opioid peptides

Matsushima, A., Koyanagi, K. O., Nishimura, H., Inamine, S., Motomatsu, Y. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 281-282

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

6 Citations (Scopus)

An IκB-β COOH terminal region protein is essential for the proliferation of CHO cells under acidic stress

Lao, Q., Kuge, O., Fukamachi, T., Kakegawa, T., Saito, H., Nishijima, M. & Kobayashi, H., Apr 1 2005, In : Journal of cellular physiology. 203, 1, p. 186-192 7 p.

Research output: Contribution to journalArticle

CHO Cells
Symporters
Proton-Translocating ATPases
Homeostasis
Protons
4 Citations (Scopus)
wildlife
Endocrine Disruptors
disrupting
bisphenols
DDT
DDT
wildlife
Endocrine Disruptors
disrupting
bisphenols
128 Citations (Scopus)

A novel cell layer without corticosteroid-synthesizing enzymes in rat adrenal cortex: Histochemical detection and possible physiological role

Mitani, F., Suzuki, H., Hata, J. I., Ogishima, T., Shimada, H. & Ishimura, Y., Jul 1994, In : Endocrinology. 135, 1, p. 431-438 8 p.

Research output: Contribution to journalArticle

Adrenal Cortex
Adrenal Cortex Hormones
Enzymes
Cytochrome P-450 CYP11B2
Zona Fasciculata

A novel method identify and quantify the coactivator proteins that couple with human nuclear receptor: the use of interacting interface a-helix peptide for quantitative inhibition

Liu, X., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 203-204

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

8 Citations (Scopus)

A novel sperm-activating and attracting factor from the ascidian Ascidia sydneiensis

Matsumori, N., Hiradate, Y., Shibata, H., Oishi, T., Shimma, S., Toyoda, M., Hayashi, F., Yoshida, M., Murata, M. & Morisawa, M., Jan 18 2013, In : Organic Letters. 15, 2, p. 294-297 4 p.

Research output: Contribution to journalArticle

tactics
Urochordata
Chemotaxis
Biological Products
Spermatozoa
23 Citations (Scopus)

A proposed common structure of substrates bound to mitochondrial processing peptidase

Kojima, K., Kitada, S., Ogishima, T. & Ito, A., Jan 19 2001, In : Journal of Biological Chemistry. 276, 3, p. 2115-2121 7 p.

Research output: Contribution to journalArticle

Introns
Substrates
Fluorescence Resonance Energy Transfer
Peptides
ethylenediamine
21 Citations (Scopus)

A protein from a parasitic microorganism, Rickettsia prowazekii, can cleave the signal sequences of proteins targeting mitochondria

Kitada, S., Uchiyama, T., Funatsu, T., Kitada, Y., Ogishima, T. & Ito, A., Feb 1 2007, In : Journal of bacteriology. 189, 3, p. 844-850 7 p.

Research output: Contribution to journalArticle

Rickettsia prowazekii
Protein Transport
Protein Sorting Signals
Mitochondria
Peptide Hydrolases
56 Citations (Scopus)

A putative metal-binding site in the β subunit of rat mitochondrial processing peptidase is essential for its catalytic activity

Kitada, S., Shimokata, K., Niidome, T., Ogishima, T. & Ito, A., Jan 1 1995, In : Journal of biochemistry. 117, 6, p. 1148-1150 3 p.

Research output: Contribution to journalArticle

Rats
Catalyst activity
Metals
Binding Sites
Catalytic Domain
60 Citations (Scopus)

Arginine residues in the extension peptide are required for cleavage of a precursor by mitochondrial processing peptidase. Demonstration using synthetic peptide as a substrate

Niidome, T., Kitada, S., Shimokata, K., Ogishima, T. & Ito, A., Jan 1 1994, In : Journal of Biological Chemistry. 269, 40, p. 24719-24722 4 p.

Research output: Contribution to journalArticle

Arginine
Demonstrations
Peptides
Substrates
Amino Acids
7 Citations (Scopus)

Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca 2+ influx in rat glioma C6 cells

Oishi, T., Konoki, K., Tamate, R., Torikai, K., Hasegawa, F., Matsumori, N. & Murata, M., Jun 1 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 11, p. 3619-3622 4 p.

Research output: Contribution to journalArticle

Dinoflagellida
Polyethers
Ladders
Glioma
Rats
5 Citations (Scopus)

Ascorbate stimulates monooxygenase-dependent steroidogenesis in adrenal zona glomerulosa

Mitani, F., Ogishima, T., Mukai, K. & Suematsu, M., Dec 9 2005, In : Biochemical and Biophysical Research Communications. 338, 1, p. 483-490 8 p.

Research output: Contribution to journalArticle

Zona Glomerulosa
Mixed Function Oxygenases
Ascorbic Acid
Aldosterone
Adrenal Cortex

Asymmetric aziridination by using optically active (Salen)manganese(III) complexes

Noda, K., Hosoya, N., Irie, R., Ito, Y. & Katsuki, T., Jul 1993, In : Synlett. 1993, 7, p. 469-471 3 p.

Research output: Contribution to journalArticle

Styrene
Manganese
disalicylaldehyde ethylenediamine
204 Citations (Scopus)

Asymmetric catalysis of new generation chiral metallosalen complexes

Ito, Y. & Katsuki, T., Apr 1 1999, In : Bulletin of the Chemical Society of Japan. 72, 4, p. 603-619 17 p.

Research output: Contribution to journalArticle

Catalysis
Epoxidation
Manganese
Derivatives
Styrene
2 Citations (Scopus)

Asymmetric OsO4 Oxidation with 2,2’-Bipyrrolidine Ligands

Oishi, T. & Hirama, M., Jan 1 1990, In : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 48, 11, p. 1006-1007 2 p.

Research output: Contribution to journalArticle

Ligands
Oxidation
Amphotericin B
Nuclear magnetic resonance
Anti-Bacterial Agents
Membranes
Ergosterol
41 Citations (Scopus)

AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase

Miyata, N., Okumoto, K., Mukai, S., Noguchi, M. & Fujiki, Y., Jan 1 2012, In : Traffic. 13, 1, p. 168-183 16 p.

Research output: Contribution to journalArticle

Peroxisomes
Adenosine Triphosphatases
Assays
Fibroblasts
Fractionation
5 Citations (Scopus)

BAK regulates catalase release from peroxisomes

Fujiki, Y., Miyata, N., Mukai, S., Okumoto, K. & Cheng, E. H., Mar 17 2017, In : Molecular & Cellular Oncology . 4, 3, e1306610.

Research output: Contribution to journalArticle

Voltage-Dependent Anion Channel 2
Peroxisomes
Catalase
Permeability
Mitochondria
6 Citations (Scopus)

Binding of glycoglycerolipid derived from membranes of Acholeplasma laidlawii PG8 and synthetic analogues to lymphoid cells

Toujima, S., Kuwano, K., Zhang, Y., Fujimoto, N., Hirama, M., Oishi, T., Fukuda, S., Nagumo, Y., Imai, H., Kikuchi, T. & Arai, S., Jan 1 2000, In : Microbiology. 146, 9, p. 2317-2323 7 p.

Research output: Contribution to journalArticle

Acholeplasma laidlawii
Lymphocytes
Cell Line
Membranes
T-Lymphocytes

Bioactive conformation of a D-Trp-containing cardioexcitatory tripeptide isolated from the sea hare Aplysia

Yokotani, S., Matsushima, A., Nose, T., Morishita, F. & Shimohigashi, Y., 2005, Peptide Science 2004. p. 539-540

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Biosynthetic Short Neuropeptides: A Rational Theory Based on Experimental Results for the Missing Pain-Relief Opioid Endomorphin Precursor Gene

Matsushima, A., Sese, J. & Koyanagi, K. O., Jan 1 2019, In : ChemBioChem. 20, 16, p. 2054-2058 5 p.

Research output: Contribution to journalArticle

Neuropeptides
Opioid Analgesics
Genes
Pain
Peptides

Bisphenol AF: Halogen bonding effect is a major driving force for the dual ERα-agonist and ERβ-antagonist activities

Liu, X., Suyama, K., Shiki, J., Torikai, K., Nose, T., Shimohigashi, M. & Shimohigashi, Y., Feb 1 2020, In : Bioorganic and Medicinal Chemistry. 28, 3, 115274.

Research output: Contribution to journalArticle

109 Citations (Scopus)

Bisphenol AF is a full agonist for the estrogen receptor ERα but a highly specific antagonist for ERβ

Matsushima, A., Liu, X., Okada, H., Shimohigashi, M. & Shimohigashi, Y., Sep 1 2010, In : Environmental Health Perspectives. 118, 9, p. 1267-1272 6 p.

Research output: Contribution to journalArticle

Estrogens
Reporter Genes
Estradiol
4,4'-hexafluorisopropylidene diphenol
Physiological Phenomena

Bisphenol A-induced Epigenetic Mutations in Circadian Pacemaker Neuropeptide mRNAs of Hyperactive Drosophila Fruit Flies

Matsuo, A., Umeno, S., Matsuyama, Y., Nakamura, M., Takeda, Y., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 457-458

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Bisphenol A-induced substantial peak decay of Drosophila circadian neuropeptide hugin mRNA expression

Shotaro, U., Matsuo, A., Matsuyama, Y., Nakamura, M., Koga, K., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 41-42

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Bisphenol A-specific nuclear receptor ERRγ: structure-function analysis of the two novel isoforms lacking vital peptide fragment in the ligand binding domain

Takeda, Y., Liu, X., Sumiyoshi, M., Matsushima, A., Shimohigashi, Y. & Shimohigashi, M., 2009, Peptide Science 2008. p. 517-518

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)