Organic and Biological Chemistry

Research Output 1983 2019

Article
1 Citation (Scopus)
Glycosylation
Stereoselectivity
Oligosaccharides
linkages
reactivity
1 Citation (Scopus)

1-Naphthylmethyl and 1-naphthylmethoxymethyl protecting groups: New members of the benzyl- and benzyloxymethyl-type family

Sato, T., Joh, Y., Oishi, T. & Torikai, K., Jan 1 2017, In : Tetrahedron Letters. 58, 23, p. 2178-2181 4 p.

Research output: Contribution to journalArticle

Oxidation
Hydrogenolysis
Nucleophiles
Temperature
Acids
7 Citations (Scopus)

2,6-Bis(porphyrin)-substituted pyrazine: a new class of supramolecular synthon binding to a transition-metal ion and fullerene (C60)

Eda, Y., Itoh, K., Ito, Y. & Kawato, T., Jan 3 2009, In : Tetrahedron. 65, 1, p. 282-288 7 p.

Research output: Contribution to journalArticle

Pyrazines
Porphyrins
Transition metals
Metal ions
Metals
2 Citations (Scopus)

2-Naphthylmethoxymethyl as a Mildly Introducible and Oxidatively Removable Benzyloxymethyl-Type Protecting Group

Sato, T., Oishi, T. & Torikai, K., Jun 19 2015, In : Organic Letters. 17, 12, p. 3110-3113 4 p.

Research output: Contribution to journalArticle

Chlorides
Temperature
compatibility
chlorides
2,6-lutidine
14 Citations (Scopus)

A characteristic back support structure in the bisphenol A-binding pocket in the human nuclear receptor ERRγ

Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., Jun 30 2014, In : PloS one. 9, 6, e101252.

Research output: Contribution to journalArticle

bisphenol A
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
receptors
estrogens
69 Citations (Scopus)

Adrenal nodularity and somatic mutations in primary aldosteronism: One node is the culprit?

Dekkers, T., Ter Meer, M., Lenders, J. W. M., Hermus, A. R. M., Schultze Kool, L., Langenhuijsen, J. F., Nishimoto, K., Ogishima, T., Mukai, K., Azizan, E. A. B., Tops, B., Deinum, J. & Küsters, B., Jul 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 7, p. E1341-1351

Research output: Contribution to journalArticle

Hyperaldosteronism
Aldosterone
Adenoma
Mutation
Genes
151 Citations (Scopus)

Adrenocortical zonation in humans under normal and pathological conditions

Nishimoto, K., Nakagawa, K., Li, D., Kosaka, T., Oya, M., Mikami, S., Shibata, H., Itoh, H., Mitani, F., Yamazaki, T., Ogishima, T., Suematsu, M. & Mukai, K., May 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 5, p. 2296-2305 10 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Steroid 11-beta-Hydroxylase
Aldosterone
Adenoma
Enzymes
5 Citations (Scopus)

A facile and practical synthesis of Nicolaou's key intermediates, 2-methyl- and 2,6-dimethyltetrahydropyrans, toward the total synthesis of ladder-shaped polyethers

Nakashima, T., Baba, T., Onoue, H., Yamashita, W. & Torikai, K., Jul 24 2013, In : Synthesis (Germany). 45, 17, p. 2417-2425 9 p., SS-2013-F0387-OP.

Research output: Contribution to journalArticle

Polyethers
Ladders
Catalytic oxidation
Biological Products
Purification
26 Citations (Scopus)

A formal synthesis of aplysiatoxin: enantioselective synthesis of kishi's aldehyde

Okamura, H., Kuroda, S., Ikegami, S., Tomita, K., Sugimoto, Y. I., Sakaguchi, S. I., Ito, Y., Katsuki, T. & Yamaguchi, M., 1993, In : Tetrahedron. 49, 46, p. 10531-10554 24 p.

Research output: Contribution to journalArticle

Aldehydes
Neoplasms
aplysiatoxin
9 Citations (Scopus)

A formal total synthesis of aplysiatoxin

Okamura, H., Kuroda, S., Ikegami, S., Ito, Y., Katsuki, T. & Yamaguchi, M., Sep 16 1991, In : Tetrahedron Letters. 32, 38, p. 5141-5142 2 p.

Research output: Contribution to journalArticle

Stereochemistry
Communication
aplysiatoxin
18 Citations (Scopus)

A Highly Stereoselective Synthesis of (3A,4iS)-Statine and (SS^AJ-Cyclohexylstatine^

Takemoto, Y., Matsumoto, T., Ito, Y. & Terashima, S., Jan 1 1991, In : Chemical and Pharmaceutical Bulletin. 39, 9, p. 2425-2428 4 p.

Research output: Contribution to journalArticle

Acetals
Titanium
Phenylalanine
Renin
Aldehydes
8 Citations (Scopus)

AlCl3-mediated aldol cyclocondensation of 1,6- and 1,7-diones to cyclopentene and cyclohexene derivatives

Miyahara, Y. & Ito, Y. N., Jan 1 2014, In : Journal of Organic Chemistry. 79, 15, p. 6801-6807 7 p.

Research output: Contribution to journalArticle

Cyclopentanes
Condensation
Derivatives
Water
Temperature
124 Citations (Scopus)

Aldosterone synthase cytochrome P-450 expressed in the adrenals of patients with primary aldosteronism

Ogishima, T., Shibata, H., Shimada, H., Mitani, F., Suzuki, H., Saruta, T. & Ishimura, Y., Sep 6 1991, In : Journal of Biological Chemistry. 266, 17, p. 10731-10734 4 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Hyperaldosteronism
Cytochrome P-450 Enzyme System
Genes
Aldosterone
9 Citations (Scopus)
Vacuolar Proton-Translocating ATPases
Sphingolipids
Saccharomyces cerevisiae
Yeasts
Ceramides
46 Citations (Scopus)

Analysis of elements in the substrate required for processing by mitochondrial processing peptidase

Ogishima, T., Niidome, T., Shimokata, K., Kitada, S. & Ito, A., Dec 22 1995, In : Journal of Biological Chemistry. 270, 51, p. 30322-30326 5 p.

Research output: Contribution to journalArticle

Arginine
Peptide Hydrolases
Proline
Glycine
Substrates
59 Citations (Scopus)

Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase

Briggs, L. C., Baldwin, G. S., Miyata, N., Kondo, H., Zhang, X. & Freemont, P. S., May 16 2008, In : Journal of Biological Chemistry. 283, 20, p. 13745-13752 8 p.

Research output: Contribution to journalArticle

Adenosine Triphosphatases
Nucleotides
Adenosine Diphosphate
Endoplasmic Reticulum-Associated Degradation
Organelle Biogenesis
8 Citations (Scopus)
Arginine
Amino Acids
Protein Precursors
Mitochondrial Proteins
Peptide Hydrolases
16 Citations (Scopus)

An endocrine disruptor, bisphenol A, affects development in the protochordate Ciona intestinalis: Hatching rates and swimming behavior alter in a dose-dependent manner

Matsushima, A., Ryan, K., Shimohigashi, Y. & Meinertzhagen, I. A., Feb 1 2013, In : Environmental Pollution. 173, p. 257-263 7 p.

Research output: Contribution to journalArticle

Ciona intestinalis
Endocrine Disruptors
Mammals
Neurology
Polycarbonates
20 Citations (Scopus)

A neutral ceramidase homologue from Dictyostelium discoideum exhibits an acidic pH optimum

Monjusho, H., Okino, N., Tani, M., Maeda, M., Yoshida, M. & Ito, M., Dec 1 2003, In : Biochemical Journal. 376, 2, p. 473-479 7 p.

Research output: Contribution to journalArticle

Neutral Ceramidase
Dictyostelium
Fungi
Alkaline Ceramidase
Acid Ceramidase
6 Citations (Scopus)

An IκB-β COOH terminal region protein is essential for the proliferation of CHO cells under acidic stress

Lao, Q., Kuge, O., Fukamachi, T., Kakegawa, T., Saito, H., Nishijima, M. & Kobayashi, H., Apr 1 2005, In : Journal of cellular physiology. 203, 1, p. 186-192 7 p.

Research output: Contribution to journalArticle

CHO Cells
Symporters
Proton-Translocating ATPases
Homeostasis
Protons
128 Citations (Scopus)

A novel cell layer without corticosteroid-synthesizing enzymes in rat adrenal cortex: Histochemical detection and possible physiological role

Mitani, F., Suzuki, H., Hata, J. I., Ogishima, T., Shimada, H. & Ishimura, Y., Jul 1994, In : Endocrinology. 135, 1, p. 431-438 8 p.

Research output: Contribution to journalArticle

Adrenal Cortex
Adrenal Cortex Hormones
Enzymes
Cytochrome P-450 CYP11B2
Zona Fasciculata
8 Citations (Scopus)

A novel sperm-activating and attracting factor from the ascidian Ascidia sydneiensis

Matsumori, N., Hiradate, Y., Shibata, H., Oishi, T., Shimma, S., Toyoda, M., Hayashi, F., Yoshida, M., Murata, M. & Morisawa, M., Jan 18 2013, In : Organic Letters. 15, 2, p. 294-297 4 p.

Research output: Contribution to journalArticle

tactics
Urochordata
Chemotaxis
Biological Products
Spermatozoa
23 Citations (Scopus)

A proposed common structure of substrates bound to mitochondrial processing peptidase

Kojima, K., Kitada, S., Ogishima, T. & Ito, A., Jan 19 2001, In : Journal of Biological Chemistry. 276, 3, p. 2115-2121 7 p.

Research output: Contribution to journalArticle

Introns
Substrates
Fluorescence Resonance Energy Transfer
Peptides
ethylenediamine
21 Citations (Scopus)

A protein from a parasitic microorganism, Rickettsia prowazekii, can cleave the signal sequences of proteins targeting mitochondria

Kitada, S., Uchiyama, T., Funatsu, T., Kitada, Y., Ogishima, T. & Ito, A., Feb 1 2007, In : Journal of bacteriology. 189, 3, p. 844-850 7 p.

Research output: Contribution to journalArticle

Rickettsia prowazekii
Protein Transport
Protein Sorting Signals
Mitochondria
Peptide Hydrolases
56 Citations (Scopus)

A putative metal-binding site in the β subunit of rat mitochondrial processing peptidase is essential for its catalytic activity

Kitada, S., Shimokata, K., Niidome, T., Ogishima, T. & Ito, A., Jan 1 1995, In : Journal of biochemistry. 117, 6, p. 1148-1150 3 p.

Research output: Contribution to journalArticle

Rats
Catalyst activity
Metals
Binding Sites
Catalytic Domain
60 Citations (Scopus)

Arginine residues in the extension peptide are required for cleavage of a precursor by mitochondrial processing peptidase. Demonstration using synthetic peptide as a substrate

Niidome, T., Kitada, S., Shimokata, K., Ogishima, T. & Ito, A., Jan 1 1994, In : Journal of Biological Chemistry. 269, 40, p. 24719-24722 4 p.

Research output: Contribution to journalArticle

Arginine
Demonstrations
Peptides
Substrates
Amino Acids
7 Citations (Scopus)

Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca 2+ influx in rat glioma C6 cells

Oishi, T., Konoki, K., Tamate, R., Torikai, K., Hasegawa, F., Matsumori, N. & Murata, M., Jun 1 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 11, p. 3619-3622 4 p.

Research output: Contribution to journalArticle

Dinoflagellida
Polyethers
Ladders
Glioma
Rats
5 Citations (Scopus)

Ascorbate stimulates monooxygenase-dependent steroidogenesis in adrenal zona glomerulosa

Mitani, F., Ogishima, T., Mukai, K. & Suematsu, M., Dec 9 2005, In : Biochemical and Biophysical Research Communications. 338, 1, p. 483-490 8 p.

Research output: Contribution to journalArticle

Zona Glomerulosa
Mixed Function Oxygenases
Ascorbic Acid
Aldosterone
Adrenal Cortex

Asymmetric aziridination by using optically active (Salen)manganese(III) complexes

Noda, K., Hosoya, N., Irie, R., Ito, Y. & Katsuki, T., Jul 1993, In : Synlett. 1993, 7, p. 469-471 3 p.

Research output: Contribution to journalArticle

Styrene
Manganese
disalicylaldehyde ethylenediamine
204 Citations (Scopus)

Asymmetric catalysis of new generation chiral metallosalen complexes

Ito, Y. & Katsuki, T., Apr 1 1999, In : Bulletin of the Chemical Society of Japan. 72, 4, p. 603-619 17 p.

Research output: Contribution to journalArticle

Catalysis
Epoxidation
Manganese
Derivatives
Styrene
2 Citations (Scopus)

Asymmetric OsO4 Oxidation with 2,2’-Bipyrrolidine Ligands

Oishi, T. & Hirama, M., Jan 1 1990, In : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 48, 11, p. 1006-1007 2 p.

Research output: Contribution to journalArticle

Ligands
Oxidation
Amphotericin B
Nuclear magnetic resonance
Anti-Bacterial Agents
Membranes
Ergosterol
41 Citations (Scopus)

AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase

Miyata, N., Okumoto, K., Mukai, S., Noguchi, M. & Fujiki, Y., Jan 1 2012, In : Traffic. 13, 1, p. 168-183 16 p.

Research output: Contribution to journalArticle

Peroxisomes
Adenosine Triphosphatases
Assays
Fibroblasts
Fractionation
5 Citations (Scopus)

BAK regulates catalase release from peroxisomes

Fujiki, Y., Miyata, N., Mukai, S., Okumoto, K. & Cheng, E. H., Mar 17 2017, In : Molecular & Cellular Oncology . 4, 3, e1306610.

Research output: Contribution to journalArticle

Voltage-Dependent Anion Channel 2
Peroxisomes
Catalase
Permeability
Mitochondria

Biosynthetic Short Neuropeptides: A Rational Theory Based on Experimental Results for the Missing Pain-Relief Opioid Endomorphin Precursor Gene

Matsushima, A., Sese, J. & Koyanagi, K. O., Jan 1 2019, In : ChemBioChem. 20, 16, p. 2054-2058 5 p.

Research output: Contribution to journalArticle

Neuropeptides
Opioid Analgesics
Genes
Pain
Peptides
109 Citations (Scopus)

Bisphenol AF is a full agonist for the estrogen receptor ERα but a highly specific antagonist for ERβ

Matsushima, A., Liu, X., Okada, H., Shimohigashi, M. & Shimohigashi, Y., Sep 1 2010, In : Environmental Health Perspectives. 118, 9, p. 1267-1272 6 p.

Research output: Contribution to journalArticle

Estrogens
Reporter Genes
Estradiol
4,4'-hexafluorisopropylidene diphenol
Physiological Phenomena
8 Citations (Scopus)

C18:3-GM1a induces apoptosis in Neuro2a cells: Enzymatic remodeling of fatty acyl chains of glycosphingolipids

Nakagawa, T., Morotomi, A., Tani, M., Sueyoshi, N., Komori, H. & Ito, M., Dec 1 2005, In : Journal of Lipid Research. 46, 6, p. 1103-1112 10 p.

Research output: Contribution to journalArticle

Glycosphingolipids
Gangliosides
Apoptosis
Chemical activation
Lipids
2 Citations (Scopus)

Capturing of the free cysteine residue in the ligand-binding site by affinity labeling of the ORL1 nociceptin receptor

Matsushima, A., Nishimura, H., Inamine, S., Uemura, S. & Shimohigashi, Y., Dec 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 24, p. 7597-7602 6 p.

Research output: Contribution to journalArticle

Labeling
Ethylmaleimide
Cysteine
Binding Sites
Sulfhydryl Compounds
618 Citations (Scopus)

Catalytic asymmetric epoxidation of unfunctionalized olefins

Irie, R., Noda, K., Ito, Y., Matsumoto, N. & Katsuki, T., Jan 1 1990, In : Tetrahedron Letters. 31, 50, p. 7345-7348 4 p.

Research output: Contribution to journalArticle

Epoxidation
Enantioselectivity
Alkenes
Manganese
Ligands
176 Citations (Scopus)

Catalytic asymmetric epoxidation of unfunctionalized olefins using chiral (salen)manganese(III) complexes

Irie, R., Noda, K., Ito, Y., Matsumoto, N. & Katsuki, T., 1991, In : Tetrahedron: Asymmetry. 2, 7, p. 481-494 14 p.

Research output: Contribution to journalArticle

epoxidation
Epoxidation
Alkenes
Manganese
alkenes
45 Citations (Scopus)

Catalytic epoxidation with molecular oxygen using nickel complex

Irie, R., Ito, Y. & Katsuki, T., Nov 18 1991, In : Tetrahedron Letters. 32, 47, p. 6891-6894 4 p.

Research output: Contribution to journalArticle

Epoxidation
Molecular oxygen
Alkenes
Nickel
Oxygen
21 Citations (Scopus)

cDNA cloning and nuclear localization of the circadian neuropeptide designated as pigment-dispersing factor PDF in the cricket Gryllus bimaculatus

Chuman, Y., Matsushima, A., Sato, S., Tomioka, K., Tominaga, Y., Meinertzhagen, I. A., Shimohigashi, Y. & Shimohigashi, M., Jan 1 2002, In : Journal of Biochemistry. 131, 6, p. 895-903 9 p.

Research output: Contribution to journalArticle

Gryllidae
Cloning
Neuropeptides
Pigments
Insects
19 Citations (Scopus)

cDNA cloning of the housefly pigment-dispersing factor (PDF) precursor protein and its peptides comparison among the insect circadian neuropeptides

Matsushima, A., Sato, S., Chuman, Y., Takeda, Y., Yokotani, S., Nose, T., Tominaga, Y., Shimohigashi, M. & Shimohigashi, Y., Feb 1 2004, In : Journal of Peptide Science. 10, 2, p. 82-91 10 p.

Research output: Contribution to journalArticle

Houseflies
Protein Precursors
Cloning
Neuropeptides
Pigments
8 Citations (Scopus)

Change in activity of serine palmitoyltransferase affects sensitivity to syringomycin E in yeast Saccharomyces cerevisiae

Toume, M. & Tani, M., Jan 1 2014, In : FEMS microbiology letters. 358, 1, p. 64-71 8 p.

Research output: Contribution to journalArticle

Serine C-Palmitoyltransferase
Sphingolipids
Saccharomyces cerevisiae
Yeasts
Pseudomonas syringae

Chiral Leaving Group: Synthesis of Optically Active Benzimidazole and its Application to Asymmetric Acylation

Ogata, M., Yoshimura, T., Fujii, H., Ito, Y. & Katsuki, T., Oct 1993, In : Synlett. 1993, 10, p. 728-730 3 p.

Research output: Contribution to journalArticle

Acylation
Amides
Derivatives
benzimidazole
mandelic acid
31 Citations (Scopus)

cis-selective aziridination of cis- or trans-α,β-unsaturated amides using diaziridine

Hori, K., Sugihara, H., Ito, Y. N. & Katsuki, T., Jul 9 1999, In : Tetrahedron Letters. 40, 28, p. 5207-5210 4 p.

Research output: Contribution to journalArticle

Amides
Nitrogen
Atoms
Geometry
Substrates
19 Citations (Scopus)

"Click-made" biaryl-linker improving efficiency in protein labelling for the membrane target protein of a bioactive compound

Nakamura, Y., Inomata, S., Ebine, M., Manabe, Y., Iwakura, I. & Ueda, M., Jan 1 2011, In : Organic and Biomolecular Chemistry. 9, 1, p. 83-85 3 p.

Research output: Contribution to journalArticle

activity (biology)
Labeling
marking
Membrane Proteins
membranes
38 Citations (Scopus)

Comprehensive molecular motion capture for sphingomyelin by site-specific deuterium labeling

Matsumori, N., Yasuda, T., Okazaki, H., Suzuki, T., Yamaguchi, T., Tsuchikawa, H., Doi, M., Oishi, T. & Murata, M., Oct 23 2012, In : Biochemistry. 51, 42, p. 8363-8370 8 p.

Research output: Contribution to journalArticle

Sphingomyelins
Deuterium
Labeling
Cholesterol
Sphingosine
14 Citations (Scopus)

Confirmation of the absolute configuration at C45 of amphidinol 3

Manabe, Y., Ebine, M., Matsumori, N., Murata, M. & Oishi, T., Dec 3 2012, In : Journal of Natural Products. 75, 11, p. 2003-2006 4 p.

Research output: Contribution to journalArticle

Dinoflagellida
Biological Products
Degradation
Esters
Carbon
7 Citations (Scopus)
Neutral Ceramidase
Enzyme activity
Tail
Amino Acids
Enzymes