Organic and Biological Chemistry

Research Output 1983 2020

Article
5 Citations (Scopus)

Expression of budding yeast IPT1 produces mannosyldiinositol phosphorylceramide in fission yeast and inhibits cell growth

Nakase, M., Tani, M. & Takegawa, K., May 1 2012, In : Microbiology. 158, 5, p. 1219-1228 10 p.

Research output: Contribution to journalArticle

Saccharomycetales
Schizosaccharomyces
Growth
Sphingolipids
Poisons
42 Citations (Scopus)

Extensive Ring-Expansion Strategy for the Enantioselective Synthesis of the Medium Ring Ethers, Oxepene, Oxocane, and Oxonene, of Ciguatoxin

Oishi, T., Shoji, M., Maeda, K., Kumahara, N. & Hirama, M., Jan 1 1996, In : Synlett. 1996, 12, p. 1165-1167 3 p.

Research output: Contribution to journalArticle

Oxepins
Ciguatoxins
Acylation
Ethers
Lipase
10 Citations (Scopus)

Fine spatial assembly for construction of the phenol-binding pocket to capture bisphenol a in the human nuclear receptor estrogen-related receptor γ

Liu, X., Matsushima, A., Nakamura, M., Costa, T., Nose, T. & Shimohigashi, Y., Apr 1 2012, In : Journal of biochemistry. 151, 4, p. 403-415 13 p.

Research output: Contribution to journalArticle

Cytoplasmic and Nuclear Receptors
Phenol
Estrogen Receptors
Estrogens
Benzene
1 Citation (Scopus)

Flow synthesis of (3R)- and (3S)-(E)-1-iodohexa-1,5-dien-3-ol: Chiral building blocks for natural product synthesis

Katayama, S., Koge, T., Katsuragi, S., Akai, S. & Oishi, T., Jan 1 2018, In : Chemistry Letters. 47, 9, p. 1116-1118 3 p.

Research output: Contribution to journalArticle

Ion Exchange Resins
Biological Products
Lipase
Evaporation
Acetates
23 Citations (Scopus)

FMP30 is required for the maintenance of a normal cardiolipin level and mitochondrial morphology in the absence of mitochondrial phosphatidylethanolamine synthesis

Kuroda, T., Tani, M., Moriguchi, A., Tokunaga, S., Higuchi, T., Kitada, S. & Kuge, O., Apr 1 2011, In : Molecular Microbiology. 80, 1, p. 248-265 18 p.

Research output: Contribution to journalArticle

Cardiolipins
Maintenance
Mitochondrial Genes
Growth
Genes
6 Citations (Scopus)

Fractionation of mammalian tissue mRNAs by high-performance gel filtration chromatography

Ogishima, T., Okada, Y. & Omura, T., May 1 1984, In : Analytical Biochemistry. 138, 2, p. 309-313 5 p.

Research output: Contribution to journalArticle

Fractionation
Chromatography
Gel Chromatography
Gels
Tissue
10 Citations (Scopus)

Functional analysis of Chinese hamster phosphatidylserine synthase 1 through systematic alanine mutagenesis

Ohsawa, T., Nishijima, M. & Kuge, O., Aug 1 2004, In : Biochemical Journal. 381, 3, p. 853-859 7 p.

Research output: Contribution to journalArticle

CDPdiacylglycerol-Serine O-Phosphatidyltransferase
Mutagenesis
Functional analysis
Cricetulus
Alanine
31 Citations (Scopus)

Glutamate residues required for substrate binding and cleavage activity in mitochondrial processing peptidase

Kitada, S., Kojima, K., Shimokata, K., Ogishima, T. & Ito, A., Dec 4 1998, In : Journal of Biological Chemistry. 273, 49, p. 32547-32553 7 p.

Research output: Contribution to journalArticle

Glutamic Acid
Substrates
Peptides
Glutamates
Mutation
37 Citations (Scopus)

Glycine-rich region of mitochondrial processing peptidase α-subunit is essential for binding and cleavage of the precursor proteins

Nagao, Y., Kitada, S., Kojima, K., Toh, H., Kuhara, S., Ogishima, T. & Ito, A., Nov 3 2000, In : Journal of Biological Chemistry. 275, 44, p. 34552-34556 5 p.

Research output: Contribution to journalArticle

Protein Precursors
Glycine
Mutation
Enzymes
Peptides
3 Citations (Scopus)

Guest responsivity of a two-dimensional coordination polymer incorporating a cholesterol-based co-ligand

Kajitani, K., Koshiyama, T., Hori, A., Ohtani, R., Mishima, A., Torikai, K., Ebine, M., Oishi, T., Takata, M., Kitagawa, S. & Ohba, M., Dec 7 2013, In : Dalton Transactions. 42, 45, p. 15893-15897 5 p.

Research output: Contribution to journalArticle

Polymers
Cholesterol
Ligands
15 Citations (Scopus)

Haeme-regulated degradation of δ-aminolevulinate synthase 1 in rat liver mitochondria

Yoshino, K., Munakata, H., Kuge, O., Ito, A. & Ogishima, T., Oct 1 2007, In : Journal of biochemistry. 142, 4, p. 453-458 6 p.

Research output: Contribution to journalArticle

Mitochondria
Liver Mitochondrion
Heme
Liver
Rats
26 Citations (Scopus)

Head-to-tail interaction between amphotericin b and ergosterol occurs in hydrated phospholipid membrane

Umegawa, Y., Nakagawa, Y., Tahara, K., Tsuchikawa, H., Matsumori, N., Oishi, T. & Murata, M., Jan 10 2012, In : Biochemistry. 51, 1, p. 83-89 7 p.

Research output: Contribution to journalArticle

Ergosterol
Amphotericin B
Phospholipids
Head
Membranes
26 Citations (Scopus)

Highly diastereo- and enantioselective aziridination of α,β-unsaturated amides with diaziridine and mechanistic consideration on its stereochemistry

Ishihara, H., Hori, K., Sugihara, H., Ito, Y. & Katsuki, T., Dec 1 2002, In : Helvetica Chimica Acta. 85, 12, p. 4272-4286 15 p.

Research output: Contribution to journalArticle

Stereochemistry
Enantioselectivity
stereochemistry
Amides
amides
13 Citations (Scopus)

Highly diastereoselective aziridination of α,β-unsaturated amides using diaziridine

Ishihara, H., Ito, Y. N. & Katsuki, T., Jan 1 2001, In : Chemistry Letters. 10, p. 984-985 2 p.

Research output: Contribution to journalArticle

Aziridines
Stereochemistry
Amides
Substrates
25 Citations (Scopus)

Highly efficient synthesis of medium-sized lactones via oxidative lactonization: Concise total synthesis of isolaurepanf

Ebine, M., Suga, Y., Fuwa, H. & Sasaki, M., Feb 23 2010, In : Organic and Biomolecular Chemistry. 8, 1, p. 39-42 4 p.

Research output: Contribution to journalArticle

Lactones
synthesis
TEMPO
32 Citations (Scopus)

Highly Enantioselective Epoxidation of 2,2-Dimethylchromenes

Hatayama, A., Hosoya, N., Irie, R., Ito, Y. & Katsuki, T., May 1992, In : Synlett. 1992, 5, p. 407-409 3 p.

Research output: Contribution to journalArticle

ethylenediamine
Epoxidation
Enantioselectivity
Manganese
45 Citations (Scopus)

Highly stereocontrolled synthesis of the 1β-methylcarbapenem key intermediate by the reformatsky reaction of 3-(2-bromopropionyl)-2-oxazolidone derivatives with a 4-acetoxy-2-azetidinone

Ito, Y., Sasaki, A., Tamoto, K., Sunagawa, M. & Terashima, S., 1991, In : Tetrahedron. 47, 16-17, p. 2801-2820 20 p.

Research output: Contribution to journalArticle

Oxazolidinones
Derivatives
Alkylation
Chelation
Dust
28 Citations (Scopus)

Highly stereocontrolled synthesis of the ABCD ring fragment of ciguatoxin CTX3C

Oishi, T., Tanaka, S. I., Ogasawara, Y., Maeda, K., Oguri, H. & Hirama, M., Jun 27 2001, In : Synlett. SPEC. ISS, p. 952-954 3 p.

Research output: Contribution to journalArticle

Alkylation
Derivatives
aminoindanol
ciguatoxin 3C
13 Citations (Scopus)
Hydroxylation
Sphingolipids
Yeast
Ceramides
Saccharomyces cerevisiae
35 Citations (Scopus)

Identification of outer mitochondrial membrane cytochrome b5 as a modulator for androgen synthesis in Leydig cells

Ogishima, T., Kinoshita, J. Y., Mitani, F., Suematsu, M. & Ito, A., Jun 6 2003, In : Journal of Biological Chemistry. 278, 23, p. 21204-21211 8 p.

Research output: Contribution to journalArticle

Cytochromes b5
Leydig Cells
Mitochondrial Membranes
Modulators
Androgens
34 Citations (Scopus)

Immunochemical identification of the pssA gene product as phosphatidylserine synthase I of Chinese hamster ovary cells

Saito, K., Kuge, O., Akamatsu, Y. & Nishijima, M., Oct 21 1996, In : FEBS Letters. 395, 2-3, p. 262-266 5 p.

Research output: Contribution to journalArticle

Cricetulus
Ovary
Mitochondria
Genes
Cells
19 Citations (Scopus)

Immunohistochemistry improves histopathologic diagnosis in primary aldosteronism

Volpe, C., Höög, A., Ogishima, T., Mukai, K., Lu, M., Thorén, M. & Hamberger, B., Apr 1 2013, In : Journal of Clinical Pathology. 66, 4, p. 351-354 4 p.

Research output: Contribution to journalArticle

Hyperaldosteronism
Aldosterone
Immunohistochemistry
Adenoma
Hyperplasia
24 Citations (Scopus)

Impaired retrograde membrane traffic through endosomes in a mutant CHO cell defective in phosphatidylserine synthesis

Lee, S., Uchida, Y., Emoto, K., Umeda, M., Kuge, O., Taguchi, T. & Arai, H., Aug 1 2012, In : Genes to Cells. 17, 8, p. 728-736 9 p.

Research output: Contribution to journalArticle

CHO Cells
Endosomes
Phosphatidylserines
Membranes
Cell Membrane
16 Citations (Scopus)
Serine
Peptide Hydrolases
Peptides
Arginine
Substrates
35 Citations (Scopus)

Import and processing of the precursor of cytochrome P-450(SCC) by bovine adrenal cortex mitochondria

Ogishima, T., Okada, Y. & Omura, T., Jan 1 1985, In : Journal of biochemistry. 98, 3, p. 781-791 11 p.

Research output: Contribution to journalArticle

Mitochondria
Adrenal Cortex
Cytochrome P-450 Enzyme System
Membranes
Processing
24 Citations (Scopus)

In vitro import of peroxisome-targeting signal type 2 (PTS2) receptor Pex7p into peroxisomes

Miyata, N., Hosoi, K. I., Mukai, S. & Fujiki, Y., May 1 2009, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1793, 5, p. 860-870 11 p.

Research output: Contribution to journalArticle

Peroxisomes
Adenosine Triphosphate
Ethylmaleimide
In Vitro Techniques
peroxisomal targeting signal 2 receptor
10 Citations (Scopus)
Sphingolipids
Phosphatidylserines
Saccharomyces cerevisiae
Yeasts
Endosomes
41 Citations (Scopus)

Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu

Tani, M., Igarashi, Y. & Ito, M., Nov 4 2005, In : Journal of Biological Chemistry. 280, 44, p. 36592-36600 9 p.

Research output: Contribution to journalArticle

Neutral Ceramidase
Ceramides
Cell membranes
Sphingosine
Metabolism
8 Citations (Scopus)
Phosphatidylserines
Phosphatases
Phosphatidylinositols
Phosphoric Monoester Hydrolases
Metabolism
45 Citations (Scopus)

Isolation of a somatic-cell mutant defective in phosphatidylserine biosynthesis

Kuge, O., Nishijima, M. & Akamatsu, Y., Jan 1 1985, In : Proceedings of the National Academy of Sciences of the United States of America. 82, 7, p. 1926-1930 5 p.

Research output: Contribution to journalArticle

Phosphatidylserines
Choline
Cricetulus
Ovary
Immobilized Cells
65 Citations (Scopus)

Klotho-related protein is a novel cytosolic neutral β- glycosylceramidase

Hayashi, Y., Okino, N., Kakuta, Y., Shikanai, T., Tani, M., Narimatsu, H. & Ito, M., Oct 19 2007, In : Journal of Biological Chemistry. 282, 42, p. 30889-30900 12 p.

Research output: Contribution to journalArticle

Lactase-Phlorizin Hydrolase
Glucosylceramides
Proteins
Enzymes
Substrates
13 Citations (Scopus)

Loss of hydroxyl groups from the ceramide moiety can modify the lateral diffusion of membrane proteins in S. cerevisiae

Uemura, S., Shishido, F., Tani, M., Mochizuki, T., Abe, F. & Inokuchi, J. I., Jul 2014, In : Journal of Lipid Research. 55, 7, p. 1343-1356 14 p.

Research output: Contribution to journalArticle

Ceramides
Protein S
Inositol
Hydroxyl Radical
Yeast
18 Citations (Scopus)

Macrocytic anemia and mitochondriopathy resulting from a defect in sideroflexin 4

Hildick-Smith, G. J., Cooney, J. D., Garone, C., Kremer, L. S., Haack, T. B., Thon, J. N., Miyata, N., Lieber, D. S., Calvo, S. E., Akman, H. O., Yien, Y. Y., Huston, N. C., Branco, D. S., Shah, D. I., Freedman, M. L., Koehler, C. M., Italiano, J. E., Merkenschlager, A., Beblo, S., Strom, T. M. & 7 others, Meitinger, T., Freisinger, P., Donati, M. A., Prokisch, H., Mootha, V. K., DiMauro, S. & Paw, B. H., Nov 7 2013, In : American journal of human genetics. 93, 5, p. 906-914 9 p.

Research output: Contribution to journalArticle

Macrocytic Anemia
Zebrafish
Exome
Mitochondrial Diseases
Mutation
33 Citations (Scopus)

Mannosylinositol phosphorylceramide is a major sphingolipid component and is required for proper localization of plasma-membrane proteins in Schizosaccharomyces pombe

Nakase, M., Tani, M., Morita, T., Kitamoto, H. K., Kashiwazaki, J., Nakamura, T., Hosomi, A., Tanaka, N. & Takegawa, K., May 1 2010, In : Journal of Cell Science. 123, 9, p. 1578-1587 10 p.

Research output: Contribution to journalArticle

Sphingolipids
Schizosaccharomyces
Blood Proteins
Membrane Proteins
Cell Membrane
80 Citations (Scopus)

Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets

Tani, M., Sano, T., Ito, M. & Igarashi, Y., Nov 1 2005, In : Journal of Lipid Research. 46, 11, p. 2458-2467 10 p.

Research output: Contribution to journalArticle

Sphingosine
Platelets
Blood Platelets
Sphingomyelin Phosphodiesterase
Neutral Ceramidase
22 Citations (Scopus)

Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase

Inoue, T., Okino, N., Kakuta, Y., Hijikata, A., Okano, H., Goda, H. M., Tani, M., Sueyoshi, N., Kambayashi, K., Matsumura, H., Kai, Y. & Ito, M., Apr 3 2009, In : Journal of Biological Chemistry. 284, 14, p. 9566-9577 12 p.

Research output: Contribution to journalArticle

Neutral Ceramidase
Ceramides
Exotoxins
Hydrolysis
Ceramidases
94 Citations (Scopus)

Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis

Chida, D., Nakagawa, S., Nagai, S., Sagara, H., Katsumata, H., Imaki, T., Suzuki, H., Mitani, F., Ogishima, T., Shimizu, C., Kotaki, H., Kakuta, S., Sudo, K., Koike, T., Kubo, M. & Iwakura, Y., Nov 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 46, p. 18205-18210 6 p.

Research output: Contribution to journalArticle

Receptor, Melanocortin, Type 2
Gluconeogenesis
Adrenal Glands
Knockout Mice
Adrenocorticotropic Hormone

Metabolic machinery of sphingolipid signaling molecules

Tani, M., Dec 1 2011, In : Seikagaku. 83, 7, p. 623-627 5 p.

Research output: Contribution to journalArticle

Biological Transport
Intracellular Space
Sphingolipids
Signal Transduction
Transferases (Other Substituted Phosphate Groups)
47 Citations (Scopus)

Molecular cloning and characterization of a secretory neutral ceramidase of Drosophila melanogaster

Yoshimura, Y., Okino, N., Tani, M. & Ito, M., Aug 2002, In : Journal of biochemistry. 132, 2, p. 229-236 8 p.

Research output: Contribution to journalArticle

Neutral Ceramidase
Ceramidases
Cloning
Molecular Cloning
Drosophila melanogaster
7 Citations (Scopus)

Molecular cloning and circadian expression profile of insect neuropeptide PDF in black blowfly, Phormia regina

Matsushima, A., Yokotani, S., Lui, X., Sumida, K., Honda, T., Sato, S., Kaneki, A., Takeda, Y., Chuman, Y., Ozaki, M., Asai, D., Nose, T., Onoue, H., Ito, Y., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., Nov 1 2003, In : Letters in Peptide Science. 10, 5-6, p. 419-430 12 p.

Research output: Contribution to journalArticle

Cloning
Molecular Cloning
Neuropeptides
Peptides
Protein Precursors
45 Citations (Scopus)

Molecular cloning and functional analysis of zebrafish neutral ceramidase

Yoshimura, Y., Tani, M., Okino, N., Iida, H. & Ito, M., Oct 15 2004, In : Journal of Biological Chemistry. 279, 42, p. 44012-44022 11 p.

Research output: Contribution to journalArticle

Functional analysis
Cloning
Molecular Cloning
Morpholinos
Antisense Oligonucleotides
87 Citations (Scopus)

Molecular cloning of a cDNA encoding aldosterone synthase cytochrome P-450 in rat adrenal cortex

Imai, M., Shimada, H., Okada, Y., Matsushima-Hibiya, Y., Ogishima, T. & Ishimura, Y., Apr 24 1990, In : FEBS Letters. 263, 2, p. 299-302 4 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Cloning
Adrenal Cortex
Molecular Cloning
Rats
92 Citations (Scopus)

Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases

Tani, M., Okino, N., Mori, K., Tanigawa, T., Izu, H. & Ito, M., Apr 14 2000, In : Journal of Biological Chemistry. 275, 15, p. 11229-11234 6 p.

Research output: Contribution to journalArticle

Alkaline Ceramidase
Neutral Ceramidase
Ceramidases
Cloning
Molecular Cloning
14 Citations (Scopus)

Molecular Cloning of the Smaller Subunit (P52) of Rat Liver Mitochondrial Processing Protease

Kitada, S., Niidome, T., Nagano, T., Ogishima, T. & Ito, A., Jan 1 1993, In : Biochemical and Biophysical Research Communications. 190, 1, p. 289-293 5 p.

Research output: Contribution to journalArticle

Cloning
Molecular Cloning
Liver
Yeast
Rats
55 Citations (Scopus)

Mutations in novel peroxin gene PEX26 that cause peroxisome-biogenesis disorders of complementation group 8 provide a genotype-phenotype correlation

Matsumoto, N., Tamura, S., Furuki, S., Miyata, N., Moser, A., Shimozawa, N., Moser, H. W., Suzuki, Y., Kondo, N. & Fujiki, Y., Aug 1 2003, In : American journal of human genetics. 73, 2, p. 233-246 14 p.

Research output: Contribution to journalArticle

Genetic Association Studies
Zellweger Syndrome
Infantile Refsum's Disease
Phenotype
Peroxisomal Disorders
32 Citations (Scopus)
Infantile Refsum's Disease
Zellweger Syndrome
Mutation
Peroxisomes
Genes
41 Citations (Scopus)

Neutral/alkaline and acid ceramidase activities are actively released by murine endothelial cells

Romiti, E., Meacci, E., Tani, M., Nuti, F., Farnararo, M., Ito, M. & Bruni, P., Sep 7 2000, In : Biochemical and Biophysical Research Communications. 275, 3, p. 746-751 6 p.

Research output: Contribution to journalArticle

Alkaline Ceramidase
Neutral Ceramidase
Acid Ceramidase
Endothelial cells
Endothelial Cells
3 Citations (Scopus)

N-methylthioacetylation of RYYRIK-NH2 with enhanced specific binding affinity and high antagonist activity for nociceptin ORL1 receptor

Li, J., Nishimura, H., Matsushima, A. & Shimohigashi, Y., Nov 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 21, p. 5721-5726 6 p.

Research output: Contribution to journalArticle

Peptide Library
Atoms
Peptides
Peptide Receptors
Neuropeptides
29 Citations (Scopus)

NMR-based conformational analysis of sphingomyelin in bicelles

Yamaguchi, T., Suzuki, T., Yasuda, T., Oishi, T., Matsumori, N. & Murata, M., Jan 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 1, p. 270-278 9 p.

Research output: Contribution to journalArticle

Sphingomyelins
Nuclear magnetic resonance
Conformations
Lipid bilayers
Membranes
52 Citations (Scopus)
Neutral Ceramidase
Glycosylation
Mucins
Cell membranes
Membrane Proteins