Organic and Biological Chemistry

Research Output 1983 2020

Article
Chlorides
Antioxidants
Acids
Triazoles
Anti-Infective Agents

Overexpression of PDR16 confers resistance to complex sphingolipid biosynthesis inhibitor aureobasidin A in yeast Saccharomyces cerevisiae

Katsuki, Y., Yamaguchi, Y. & Tani, M., Feb 1 2018, In : FEMS microbiology letters. 365, 3, fnx255.

Research output: Contribution to journalArticle

Sphingolipids
Saccharomyces cerevisiae
Yeasts
Tetracycline
Growth
18 Citations (Scopus)

Partial amino acid sequences of two mitochondrial and two microsomal cytochrome p-450's from adrenal cortex

Ogishima, T., Okada, Y., Kominami, S., Takemori, S. & Omura, T., Nov 1983, In : Journal of Biochemistry. 94, 5, p. 1711-1714 4 p.

Research output: Contribution to journalArticle

Adrenal Cortex
Cytochromes
Cytochrome P-450 Enzyme System
Amino Acid Sequence
Amino Acids
29 Citations (Scopus)

Pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1

Miyata, N., Steffen, J., Johnson, M. E., Fargue, S., Danpure, C. J. & Koehler, C. M., Oct 7 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 40, p. 14406-14411 6 p.

Research output: Contribution to journalArticle

Peroxisomes
Oxalates
Mitochondria
Enzymes
Pyridoxine
3 Citations (Scopus)

Phosphatidylserine is involved in gene expression from Sindbis virus subgenomic promoter

Saito, K., Nishijima, M. & Kuge, O., Jun 30 2006, In : Biochemical and Biophysical Research Communications. 345, 2, p. 878-885 8 p.

Research output: Contribution to journalArticle

Sindbis Virus
Phosphatidylserines
Viruses
Gene expression
RNA
29 Citations (Scopus)

Phosphatidylserine transport by Ups2-Mdm35 in respiration-active mitochondria

Miyata, N., Watanabe, Y., Tamura, Y., Endo, T. & Kuge, O., Jul 1 2016, In : Journal of Cell Biology. 214, 1, p. 77-88 12 p.

Research output: Contribution to journalArticle

Phosphatidylserines
Mitochondria
Respiration
Mitochondrial Membranes
Endoplasmic Reticulum
13 Citations (Scopus)

Phospholipid methylation controls Atg32-mediated mitophagy and Atg8 recycling

Sakakibara, K., Eiyama, A., Suzuki, S. W., Sakoh-Nakatogawa, M., Okumura, N., Tani, M., Hashimoto, A., Nagumo, S., Kondo-Okamoto, N., Kondo-Kakuta, C., Asai, E., Kirisako, H., Nakatogawa, H., Kuge, O., Takao, T., Ohsumi, Y. & Okamoto, K., Nov 3 2015, In : EMBO Journal. 34, 21, p. 2703-2719 17 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Mitochondria
Methylation
Recycling
Phospholipids
17 Citations (Scopus)

Pigment-dispersing factor affects nocturnal activity rhythms, photic entrainment, and the free-running period of the circadian clock in the cricket gryllus bimaculatus

Hassaneen, E., El-Din Sallam, A., Abo-Ghalia, A., Moriyama, Y., Karpova, S. G., Abdelsalam, S., Matsushima, A., Shimohigashi, Y. & Tomioka, K., Feb 1 2011, In : Journal of Biological Rhythms. 26, 1, p. 3-13 11 p.

Research output: Contribution to journalArticle

Gryllidae
Circadian Clocks
Photoperiod
Light
Double-Stranded RNA
60 Citations (Scopus)

Placenta expressing the greatest quantity of bisphenol A receptor ERRγ among the human reproductive tissues: Predominant expression of type-1 ERRγ isoform

Takeda, Y., Liu, X., Sumiyoshi, M., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., Jul 1 2009, In : Journal of biochemistry. 146, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Placenta
Protein Isoforms
Estrogens
Tissue
8 Citations (Scopus)

Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly

Sakaue, H., Shiota, T., Ishizaka, N., Kawano, S., Tamura, Y., Tan, K. S., Imai, K., Motono, C., Hirokawa, T., Taki, K., Miyata, N., Kuge, O., Lithgow, T. & Endo, T., Mar 7 2019, In : Molecular Cell. 73, 5, p. 1044-1055.e8

Research output: Contribution to journalArticle

Porins
Mitochondrial Proteins
TOM translocase
5 Citations (Scopus)

Porin proteins have critical functions in mitochondrial phospholipid metabolism in yeast

Miyata, N., Fujii, S. & Kuge, O., Nov 9 2018, In : The Journal of biological chemistry. 293, 45, p. 17593-17605 13 p.

Research output: Contribution to journalArticle

Porins
Cardiolipins
Metabolism
Yeast
Phospholipids
3 Citations (Scopus)

Possible participation of outer mitochondrial membrane cytochrome B 5 in steroidogenesis in zona glomerulosa of rat adrenal cortex

Mitani, F., Ogishima, T., Mukai, K., Hoshino, R., Watanabe, K. & Suematsu, M., Dec 1 2004, In : Endocrine Research. 30, 4, p. 639-644 6 p.

Research output: Contribution to journalArticle

Zona Glomerulosa
Adrenal Cortex
Mitochondrial Membranes
Cytochromes
monodehydroascorbate reductase (NADH)
2 Citations (Scopus)

Practical synthesis of DOPA derivative for biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 743

Torikai, K., Saruwatari, T., Kitano, T., Sano, T., Nakane, A., Noguchi, H. & Watanabe, K., Dec 1 2011, In : Letters in Organic Chemistry. 8, 10, p. 686-689 4 p.

Research output: Contribution to journalArticle

trabectedin
Biological Products
Purification
Crystallization
High Pressure Liquid Chromatography
159 Citations (Scopus)
Titanium
structural analysis
Structural analysis
reagents
titanium
22 Citations (Scopus)
Sphingolipids
Sphingomyelins
Hydrolysis
Assays
Carrier Proteins
4 Citations (Scopus)

Presence of a prepiece at the NH2-terminai end of pre-cytochrome P-450(SCC) peptide

Ogishima, T., Okada, Y. & Omura, T., Jan 1 1984, In : Journal of biochemistry. 95, 5, p. 1525-1528 4 p.

Research output: Contribution to journalArticle

Cytochrome P-450 Enzyme System
Peptides
Radio
Amino Acids
Acids
5 Citations (Scopus)

Protective role of the HOG pathway against the growth defect caused by impaired biosynthesis of complex sphingolipids in yeast Saccharomyces cerevisiae

Yamaguchi, Y., Katsuki, Y., Tanaka, S., Kawaguchi, R., Denda, H., Ikeda, T., Funato, K. & Tani, M., Feb 1 2018, In : Molecular Microbiology. 107, 3, p. 363-386 24 p.

Research output: Contribution to journalArticle

Sphingolipids
Osmolar Concentration
Glycerol
Saccharomyces cerevisiae
Yeasts
92 Citations (Scopus)

Purification, Characterization, Molecular Cloning, and Subcellular Distribution of Neutral Ceramidase of Rat Kidney

Mitsutake, S., Tani, M., Okino, N., Mori, K., Ichinose, S., Omori, A., Iida, H., Nakamura, T. & Ito, M., Jul 13 2001, In : Journal of Biological Chemistry. 276, 28, p. 26249-26259 11 p.

Research output: Contribution to journalArticle

Neutral Ceramidase
Ceramidases
Cloning
Molecular Cloning
Purification
71 Citations (Scopus)
Neutral Ceramidase
Ceramides
Liver
Purification
Ceramidases
81 Citations (Scopus)

Purification and characterization of a novel ceramidase from pseudomonas aeruginosa

Okino, N., Tani, M., Imayama, S. & Ito, M., Jun 5 1998, In : Journal of Biological Chemistry. 273, 23, p. 14368-14373 6 p.

Research output: Contribution to journalArticle

Ceramidases
Pseudomonas aeruginosa
Ceramides
Purification
Enzymes
12 Citations (Scopus)

Purification and Characterization of Chinese Hamster Phosphatidylserine Synthase 2

Kuge, O., Hasegawa, K., Ohsawa, T., Saito, K. & Nishijima, M., Oct 24 2003, In : Journal of Biological Chemistry. 278, 43, p. 42692-42698 7 p.

Research output: Contribution to journalArticle

Phosphatidylserines
Cricetulus
Purification
CDPdiacylglycerol-Serine O-Phosphatidyltransferase
Phosphatidylcholines
21 Citations (Scopus)

Purification and characterization of human phosphatidylserine synthases 1 and 2

Tomohiro, S., Kawaguti, A., Kawabe, Y., Kitada, S. & Kuge, O., Mar 1 2009, In : Biochemical Journal. 418, 2, p. 421-429 9 p.

Research output: Contribution to journalArticle

CDPdiacylglycerol-Serine O-Phosphatidyltransferase
Phosphatidylserines
Purification
Phosphatidylcholines
Mouse Ptdss2 protein
1 Citation (Scopus)

Radar chart deviation analysis of prion protein amino acid composition defines characteristic structural abnormalities of the N-terminal octapeptide tandem repeat

Yokotani, S., Nose, T., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., Sep 1 2008, In : Protein and Peptide Letters. 15, 9, p. 949-955 7 p.

Research output: Contribution to journalArticle

Radar
Tandem Repeat Sequences
Amino Acids
Aromatic Amino Acids
Prion Diseases
2 Citations (Scopus)

Recent applications of the suzuki-miyaura cross-coupling to complex polycyclic ether synthesis

Fuwa, H., Ebine, M. & Sasaki, M., Nov 2011, In : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 69, 11, p. 1251-1262 12 p.

Research output: Contribution to journalArticle

Biological Products
Ether
Ladders
Palladium
Bioactivity
3 Citations (Scopus)

Receptor-binding affinities of bisphenol A and its next-generation analogs for human nuclear receptors

Liu, X., Sakai, H., Nishigori, M., Suyama, K., Nawaji, T., Ikeda, S., Nishigouchi, M., Okada, H., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., Aug 15 2019, In : Toxicology and Applied Pharmacology. 377, 114610.

Research output: Contribution to journalArticle

Cytoplasmic and Nuclear Receptors
Assays
Endocrine Disruptors
Peroxisome Proliferator-Activated Receptors
Competitive Binding
29 Citations (Scopus)
Endocrine Disruptors
Phenol
Estrogen Receptors
Hydroxyl Radical
Hydrogen
8 Citations (Scopus)

Recognition and processing of a nuclear-encoded polyprotein precursor by mitochondrial processing peptidase

Oshima, T., Yamasaki, E., Ogishima, T., Kadowaki, K. I., Ito, A. & Kitada, S., Feb 1 2005, In : Biochemical Journal. 385, 3, p. 755-761 7 p.

Research output: Contribution to journalArticle

Polyproteins
Processing
Mitochondria
Succinate Dehydrogenase
mitochondrial processing peptidase
5 Citations (Scopus)

Recognition of mitochondrial protein precursor lacking arginine at position -2 by Mitochondrial Processing Peptidase: Processing of bovine cytochrome p450(SCC) precursor

Kojima, K., Yamasaki, E., Kitada, S., Ogishima, T. & Ito, A., Jan 1 2001, In : Journal of biochemistry. 130, 4, p. 497-502 6 p.

Research output: Contribution to journalArticle

Protein Precursors
Mitochondrial Proteins
Cytochrome P-450 Enzyme System
Arginine
Processing
56 Citations (Scopus)

Regulation of aldosterone synthase cytochrome P-450 in rat adrenals by angiotensin II and potassium

Shibata, H., Ogishima, T., Mitani, F., Suzuki, H., Murakami, M., Saruta, T. & Ishimura, Y., May 1 1991, In : Endocrinology. 128, 5, p. 2534-2539 6 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Angiotensin II
Potassium
Diet
Aldosterone
17 Citations (Scopus)

Remarkable solvent effect on the enantioface selectivity in the Diels- Alder reaction catalyzed by an aluminum complex of a newly prepared chiral menthol derivative

Naraku, G., Hori, K., Ito, Y. & Katsuki, T., Nov 24 1997, In : Tetrahedron Letters. 38, 47, p. 8231-8232 2 p.

Research output: Contribution to journalArticle

Menthol
Enantiomers
Cycloaddition Reaction
Aluminum
Reaction products
4 Citations (Scopus)

Requirement of an IκB-β COOH terminal region protein for acidic-adaptation in CHO cells

Lao, Q., Fukamachi, T., Saito, H., Kuge, O., Nishijima, M. & Kobayashi, H., Apr 1 2006, In : Journal of cellular physiology. 207, 1, p. 238-243 6 p.

Research output: Contribution to journalArticle

CHO Cells
Transcription
Genes
p38 Mitogen-Activated Protein Kinases
Proteins
17 Citations (Scopus)
Sphingolipids
Saccharomyces cerevisiae
Yeasts
Enzymes
Growth
21 Citations (Scopus)

Rescue of cell growth by sphingosine with disruption of lipid microdomain formation in Saccharomyces cerevisiae deficient in sphingolipid biosynthesis

Tani, M., Kihara, A. & Igarashi, Y., Feb 15 2006, In : Biochemical Journal. 394, 1, p. 237-242 6 p.

Research output: Contribution to journalArticle

Sphingolipids
Sphingosine
Biosynthesis
Cell growth
Yeast
38 Citations (Scopus)

Ribosomal synthesis of dehydrobutyrine- and methyllanthionine-containing peptides

Goto, Y., Iwasaki, K., Torikai, K., Murakami, H. & Suga, H., Aug 7 2009, In : Chemical Communications. 23, p. 3419-3421 3 p.

Research output: Contribution to journalArticle

Isomerization
Peptides
Cyclic Peptides
Cysteine
dehydrobutyrine
31 Citations (Scopus)

Role of basic amino acids in the cleavage of synthetic peptide substrates by mitochondrial processing peptidase

Song, M. C., Shimokata, K., Kitada, S., Ogishima, T. & Ito, A., Jan 1 1996, In : Journal of biochemistry. 120, 6, p. 1163-1166 4 p.

Research output: Contribution to journalArticle

Basic Amino Acids
Ornithine-Oxo-Acid Transaminase
Peptides
Substrates
Processing
37 Citations (Scopus)

Role of α-subunit of mitochondrial processing peptidase in substrate recognition

Shimokata, K., Kitada, S., Ogishima, T. & Ito, A., Sep 25 1998, In : Journal of Biological Chemistry. 273, 39, p. 25158-25163 6 p.

Research output: Contribution to journalArticle

Substrates
Processing
Adrenodoxin
Acidic Amino Acids
Peptides
28 Citations (Scopus)

Selenium Compound Protects Corneal Epithelium against Oxidative Stress

Higuchi, A., Inoue, H., Kawakita, T., Ogishima, T. & Tsubota, K., Sep 25 2012, In : PloS one. 7, 9, e45612.

Research output: Contribution to journalArticle

Selenium Compounds
Corneal Epithelium
Lactoferrin
Oxidative stress
selenium
149 Citations (Scopus)

Shuttling mechanism of peroxisome targeting signal type 1 receptor Pex5: ATP-independent import and ATP-dependent export

Miyata, N. & Fujiki, Y., Dec 1 2005, In : Molecular and cellular biology. 25, 24, p. 10822-10832 11 p.

Research output: Contribution to journalArticle

Peroxisomes
Adenosine Triphosphate
CHO Cells
Native Polyacrylamide Gel Electrophoresis
Cytosol

Simple Apparatus for Adding Small Amounts of Powder Materials under an Inert Atmosphere

Karak, M., Joh, Y., Khodjaniyazov, K. U., Sagdullaev, S. S., Oishi, T. & Torikai, K., Jan 1 2019, In : Synlett. 30, 18, p. 2058-2061 4 p.

Research output: Contribution to journalArticle

Powders
Glycosylation
Syringes
Contamination
Moisture
4 Citations (Scopus)

Spatial orientation of mitochondrial processing peptidase and a preprotein revealed by fluorescence resonance energy transfer

Nishino, T. G., Kitano, K., Kojima, K., Ogishima, T., Ito, A. & Kitada, S., Jun 1 2007, In : Journal of biochemistry. 141, 6, p. 889-895 7 p.

Research output: Contribution to journalArticle

Fluorescence Resonance Energy Transfer
Yeast
Yeasts
Glycine
mitochondrial processing peptidase
4 Citations (Scopus)

Specific affinity-labeling of the nociceptin ORL1 receptor using a thiol-activated Cys(Npys)-containing peptide ligand

Matsushima, A., Nishimura, H., Matsuyama, Y., Liu, X., Costa, T. & Shimohigashi, Y., Nov 4 2016, In : Biopolymers. p. 460-469 10 p.

Research output: Contribution to journalArticle

Sulfhydryl Compounds
Labeling
Peptides
Ligands
Binding sites
37 Citations (Scopus)

Specific and sensitive assay for alkaline and neutral ceramidases involving C12-NBD-ceramide

Tani, M., Okino, N., Mitsutake, S. & Ito, M., 1999, In : Journal of Biochemistry. 125, 4, p. 746-749 4 p.

Research output: Contribution to journalArticle

Alkaline Ceramidase
Neutral Ceramidase
Assays
Ceramides
Enzymes
25 Citations (Scopus)
Cell membranes
Cysteine
Cell Membrane
Enzymes
Lipoylation
36 Citations (Scopus)

Stereocontrolled synthesis of the HIJ ring system of ciguatoxin

Oishi, T., Maeda, K. & Hirama, M., Jan 1 1997, In : Chemical Communications. 14, p. 1289-1290 2 p.

Research output: Contribution to journalArticle

Ciguatoxins
Cyclization
Epoxy Compounds
Palladium
Acids
15 Citations (Scopus)

Stereoselective synthesis of the C1-C29 part of amphidinol 3

Tsuruda, T., Ebine, M., Umeda, A. & Oishi, T., Jan 16 2015, In : Journal of Organic Chemistry. 80, 2, p. 859-871 13 p.

Research output: Contribution to journalArticle

Lithium
Amides
amphidinol 3
10 Citations (Scopus)

Structural analysis and identification of novel isoforms of the circadian clock gene period in the silk moth Bombyx mori

Takeda, Y., Chuman, Y., Shirasu, N., Sato, S., Matsushima, A., Kaneki, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., Sep 1 2004, In : Zoological science. 21, 9, p. 903-915 13 p.

Research output: Contribution to journalArticle

Bombyx mori
silk
circadian rhythm
moths
alternative splicing
2 Citations (Scopus)

Structural Basis of Mitochondrial Scaffolds by Prohibitin Complexes: Insight into a Role of the Coiled-Coil Region

Yoshinaka, T., Kosako, H., Yoshizumi, T., Furukawa, R., Hirano, Y., Kuge, O., Tamada, T. & Koshiba, T., Sep 27 2019, In : iScience. 19, p. 1065-1078 14 p.

Research output: Contribution to journalArticle

Open Access
Signal Transduction
Mitochondria
Mitochondrial Dynamics
Biotin
prohibitin
26 Citations (Scopus)

Structural differences in 5′-flanking regions of rat cytochrome P-450aldo and P-45011β genes

Mukai, K., Imai, M., Shimada, H., Okada, Y., Ogishima, T. & Ishimura, Y., Nov 14 1991, In : Biochemical and Biophysical Research Communications. 180, 3, p. 1187-1193 7 p.

Research output: Contribution to journalArticle

5' Flanking Region
Cytochromes
Rats
Genes
Nuclease Protection Assays
146 Citations (Scopus)

Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERRγ

Matsushima, A., Kakuta, Y., Teramoto, T., Koshiba, T., Liu, X., Okada, H., Tokunaga, T., Kawabata, S. I., Kimura, M. & Shimohigashi, Y., Oct 1 2007, In : Journal of biochemistry. 142, 4, p. 517-524 8 p.

Research output: Contribution to journalArticle

Endocrine Disruptors
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Estrogens
Ligands
17 Citations (Scopus)

Structural isoforms of the circadian neuropeptide PDF expressed in the optic lobes of the cricket Gryllus bimaculatus: Immunocytochemical evidence from specific monoclonal antibodies

Honda, T., Matsushima, A., Sumida, K., Chuman, Y., Sakaguchi, K., Onoue, H., Meinertzhagen, I. A., Shimohigashi, Y. & Shimohigashi, M., Nov 20 2006, In : Journal of Comparative Neurology. 499, 3, p. 404-421 18 p.

Research output: Contribution to journalArticle

Gryllidae
Neuropeptides
Protein Isoforms
Monoclonal Antibodies
Peptides