Organic and Biological Chemistry

Research Output 1983 2020

Article
26 Citations (Scopus)

Structural differences in 5′-flanking regions of rat cytochrome P-450aldo and P-45011β genes

Mukai, K., Imai, M., Shimada, H., Okada, Y., Ogishima, T. & Ishimura, Y., Nov 14 1991, In : Biochemical and Biophysical Research Communications. 180, 3, p. 1187-1193 7 p.

Research output: Contribution to journalArticle

5' Flanking Region
Cytochromes
Rats
Genes
Nuclease Protection Assays
146 Citations (Scopus)

Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERRγ

Matsushima, A., Kakuta, Y., Teramoto, T., Koshiba, T., Liu, X., Okada, H., Tokunaga, T., Kawabata, S. I., Kimura, M. & Shimohigashi, Y., Oct 1 2007, In : Journal of biochemistry. 142, 4, p. 517-524 8 p.

Research output: Contribution to journalArticle

Endocrine Disruptors
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Estrogens
Ligands
17 Citations (Scopus)

Structural isoforms of the circadian neuropeptide PDF expressed in the optic lobes of the cricket Gryllus bimaculatus: Immunocytochemical evidence from specific monoclonal antibodies

Honda, T., Matsushima, A., Sumida, K., Chuman, Y., Sakaguchi, K., Onoue, H., Meinertzhagen, I. A., Shimohigashi, Y. & Shimohigashi, M., Nov 20 2006, In : Journal of Comparative Neurology. 499, 3, p. 404-421 18 p.

Research output: Contribution to journalArticle

Gryllidae
Neuropeptides
Protein Isoforms
Monoclonal Antibodies
Peptides
51 Citations (Scopus)

Subcellular localization of human neutral ceramidase expressed in HEK293 cells

Hwang, Y. H., Tani, M., Nakagawa, T., Okino, N. & Ito, M., May 27 2005, In : Biochemical and Biophysical Research Communications. 331, 1, p. 37-42 6 p.

Research output: Contribution to journalArticle

HEK293 Cells
Cell membranes
Neutral Ceramidase
Ceramidases
Mitochondria
22 Citations (Scopus)

Substrate recognition by mitochondrial processing peptidase toward the malate dehydrogenase precursor

Shimokata, K., Nishio, T., Song, M. C., Kitada, S., Ogishima, T. & Ito, A., Jan 1 1997, In : Journal of biochemistry. 122, 5, p. 1019-1023 5 p.

Research output: Contribution to journalArticle

Malate Dehydrogenase
Arginine
Peptides
Substrates
Protein Precursors
26 Citations (Scopus)

Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: A mechanism involving an initial effect on gonadotropin synthesis in the pituitary

Taketoh, J., Mutoh, J., Takeda, T., Ogishima, T., Takeda, S., Ishii, Y., Ishida, T. & Yamada, H., Mar 13 2007, In : Life Sciences. 80, 14, p. 1259-1267 9 p.

Research output: Contribution to journalArticle

Maternal Exposure
Gonadotropins
Cytochrome P-450 Enzyme System
Luteinizing Hormone
Multifetal Pregnancy Reduction
3 Citations (Scopus)

Syntheses and Biological Activities of the LMNO, ent-LMNO, and NOPQR(S) Ring Systems of Maitotoxin

Onoue, H., Marubayashi, R., Ishikawa, E., Konoki, K., Torikai, K., Ebine, M., Murata, M. & Oishi, T., Jan 1 2017, In : Journal of Organic Chemistry. 82, 18, p. 9595-9618 24 p.

Research output: Contribution to journalArticle

Bioactivity
Enantiomers
Aldehydes
Alkynes
Biological Products
11 Citations (Scopus)

Synthesis and biological activity of the C'D'E'F' ring system of maitotoxin

Kunitake, M., Oshima, T., Konoki, K., Ebine, M., Torikai, K., Murata, M. & Oishi, T., Jun 6 2014, In : Journal of Organic Chemistry. 79, 11, p. 4948-4962 15 p.

Research output: Contribution to journalArticle

Cyclization
Bioactivity
Rats
maitotoxin
allyl alcohol
8 Citations (Scopus)

Synthesis and biological activity of the QRS ring system of maitotoxin

Onoue, H., Baba, T., Konoki, K., Torikai, K., Ebine, M. & Oishi, T., Jan 1 2014, In : Chemistry Letters. 43, 12, p. 1904-1906 3 p.

Research output: Contribution to journalArticle

Bioactivity
Acetals
Methylation
Polyethers
Ladders
1 Citation (Scopus)

Synthesis and complete structure determination of a sperm-activating and -attracting factor isolated from the ascidian ascidia sydneiensis

Watanabe, T., Shibata, H., Ebine, M., Tsuchikawa, H., Matsumori, N., Murata, M., Yoshida, M., Morisawa, M., Lin, S., Yamauchi, K., Sakai, K. & Oishi, T., Apr 27 2018, In : Journal of Natural Products. 81, 4, p. 985-997 13 p.

Research output: Contribution to journalArticle

Ergosterol
Urochordata
Biological Products
Ketones
Eggs
10 Citations (Scopus)

Synthesis and DNA cleaving activity of water-soluble non-conjugated thienyl tetraynes

Torikai, K., Otsuka, Y., Nishimura, M., Sumida, M., Kawai, T., Sekiguchi, K. & Ueda, I., May 15 2008, In : Bioorganic and Medicinal Chemistry. 16, 10, p. 5441-5451 11 p.

Research output: Contribution to journalArticle

Atomic Force Microscopy
Electrophoresis
Escherichia coli
Water
Atomic force microscopy
5 Citations (Scopus)

Synthesis and properties of fullerene (C70) complexes of 2,6-bis(porphyrin)-substituted pyrazine derivatives bound to a Pd(II) ion

Eda, Y., Itoh, K., Ito, Y. N., Fujitsuka, M., Majima, T. & Kawato, T., Sep 1 2010, In : Supramolecular Chemistry. 22, 9, p. 517-523 7 p.

Research output: Contribution to journalArticle

Pyrazines
Porphyrins
Ions
Derivatives
Association reactions
3 Citations (Scopus)

Synthesis and Stereochemical Revision of the C31–C67 Fragment of Amphidinol 3

Wakamiya, Y., Ebine, M., Murayama, M., Omizu, H., Matsumori, N., Murata, M. & Oishi, T., May 22 2018, In : Angewandte Chemie - International Edition. 57, 21, p. 6060-6064 5 p.

Research output: Contribution to journalArticle

Degradation
Biological Products
Carbon
Nuclear magnetic resonance
Availability
17 Citations (Scopus)

Synthesis and structure revision of the C43-C67 part of amphidinol 3

Ebine, M., Kanemoto, M., Manabe, Y., Konno, Y., Sakai, K., Matsumori, N., Murata, M. & Oishi, T., Jun 26 2013, In : Organic Letters. 15, 11, p. 2846-2849 4 p.

Research output: Contribution to journalArticle

nuclear magnetic resonance
oxidation
synthesis
configurations
Nuclear magnetic resonance
1 Citation (Scopus)

Synthesis of 6/6/6-tricyclic ether system via Achmatowicz and intramolecular oxa-michael reactions

Yamamoto, H., Torikai, K., Ebine, M. & Oishi, T., Jan 1 2018, In : Heterocycles. 97, 1, p. 158-162 5 p.

Research output: Contribution to journalArticle

Ethers
Aldehydes
Isomers
Ether
Alcohols
5 Citations (Scopus)

Synthesis of 6-F-ergosterol and its influence on membrane-permeabilization of amphotericin B and amphidinol 3

Kasai, Y., Matsumori, N., Ueno, H., Nonomura, K., Yano, S., Michio, M. & Oishi, T., Mar 1 2011, In : Organic and Biomolecular Chemistry. 9, 5, p. 1437-1442 6 p.

Research output: Contribution to journalArticle

Amphotericin B
Ergosterol
membranes
Membranes
Sterols
16 Citations (Scopus)

Synthesis of a complete set of L-difluorophenylalanines, L-(F2)Phe, as molecular explorers for the CH/π interaction between peptide ligand and receptor

Fujita, T., Nose, T., Matsushima, A., Okada, K., Asai, D., Yamauchi, Y., Shirasu, N., Honda, T., Shigehiro, D. & Shimohigashi, Y., Feb 5 2000, In : Tetrahedron Letters. 41, 6, p. 923-927 5 p.

Research output: Contribution to journalArticle

thrombin receptor peptide SFLLRNP
Thrombin Receptors
Peptide Receptors
Hydrogen
Ligands

Synthesis of an analog of amphidinol 3 corresponding to the c31-c67 section

Koge, T., Wakamiya, Y., Ebine, M. & Oishi, T., Jan 1 2018, In : Heterocycles. 96, 7, p. 1197-1202 6 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Derivatives
amphidinol 3
polyol
2 Citations (Scopus)

Synthesis of anti-tubercular marine alkaloids denigrins A and B

Karak, M., Oishi, T. & Torikai, K., Jul 18 2018, In : Tetrahedron Letters. 59, 29, p. 2800-2803 4 p.

Research output: Contribution to journalArticle

Maleic Anhydrides
Alkaloids
Cross Reactions
Palladium
Salts
3 Citations (Scopus)

Synthesis of a truncated analog of amphidinol 3 corresponding to the C21C39/C52C67 section

Ebine, M., Takada, Y., Yanai, N. & Oishi, T., Jan 1 2017, In : Chemistry Letters. 46, 5, p. 662-664 3 p.

Research output: Contribution to journalArticle

Polyenes
amphidinol 3
21 Citations (Scopus)

Synthesis of endogenous sperm-activating and attracting factor isolated from ascidian Ciona intestinalis

Oishi, T., Tsuchikawa, H., Murata, M., Yoshida, M. & Morisawa, M., Aug 18 2003, In : Tetrahedron Letters. 44, 34, p. 6387-6389 3 p.

Research output: Contribution to journalArticle

Ciona intestinalis
Chenodeoxycholic Acid
Urochordata
Chemotactic Factors
Spermatozoa
8 Citations (Scopus)

Synthesis of mannosylinositol phosphorylceramides is involved in maintenance of cell integrity of yeast Saccharomyces cerevisiae

Morimoto, Y. & Tani, M., Feb 1 2015, In : Molecular Microbiology. 95, 4, p. 706-722 17 p.

Research output: Contribution to journalArticle

Saccharomyces cerevisiae
Yeasts
Maintenance
Mannans
Polysaccharides
4 Citations (Scopus)

Synthesis of pyrazine acetals by the biased reaction of symmetric 2,5-bis(chloromethyl) or 2,3,5,6-tetrakis(chloromethyl) substituents on pyrazine ring with sodium alkoxides

Eda, Y., Odazaki, Y., Mizutani, A., Ito, Y. & Kawato, T., Apr 14 2008, In : Tetrahedron Letters. 49, 16, p. 2519-2522 4 p.

Research output: Contribution to journalArticle

Pyrazines
Acetals
Sodium
Substitution reactions
21 Citations (Scopus)

Synthesis of the CDE/FG ring models of prymnesins: Reassignment of the relative configuration of the E/F ring juncture

Sasaki, M., Ebine, M., Takagi, H., Takakura, H., Shida, T., Satake, M., Oshima, Y., Igarashi, T. & Yasumoto, T., Apr 29 2004, In : Organic Letters. 6, 9, p. 1501-1504 4 p.

Research output: Contribution to journalArticle

red tide
Haptophyta
rings
Tides
synthesis
58 Citations (Scopus)

Synthetic study of ciguatoxin. Absolute configuration of the C2 hydroxy group

Oguri, H., Hishiyama, S., Sato, O., Oishi, T., Hirama, M., Murata, M., Yasumoto, T. & Harada, N., Mar 3 1997, In : Tetrahedron. 53, 9, p. 3057-3072 16 p.

Research output: Contribution to journalArticle

Ciguatoxins
Bromobenzoates
Stereochemistry
Alcohols
83 Citations (Scopus)

Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria

Tamura, Y., Harada, Y., Nishikawa, S. I., Yamano, K., Kamiya, M., Shiota, T., Kuroda, T., Kuge, O., Sesaki, H., Imai, K., Tomii, K. & Endo, T., May 7 2013, In : Cell metabolism. 17, 5, p. 709-718 10 p.

Research output: Contribution to journalArticle

Cytidine Diphosphate Diglycerides
Diacylglycerol Cholinephosphotransferase
Cardiolipins
Mitochondria
Phosphatidic Acids
64 Citations (Scopus)

The AAA+ ATPase ATAD3A controls mitochondrial dynamics at the interface of the inner and outer membranes

Gilquin, B., Taillebourg, E., Cherradi, N., Hubstenberger, A., Gay, O., Merle, N., Assard, N., Fauvarque, M. O., Tomohiro, S., Kuge, O. & Baudier, J., Apr 2010, In : Molecular and cellular biology. 30, 8, p. 1984-1996 13 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Adenosine Triphosphatases
Membranes
Eukaryota
Drosophila
95 Citations (Scopus)

The first asymmetric epoxidation using a combination of achiral (salen)manganese(III) complex and chiral amine

Hashihayata, T., Ito, Y. & Katsuki, T., Jul 14 1997, In : Tetrahedron. 53, 28, p. 9541-9552 12 p.

Research output: Contribution to journalArticle

sulfoxide
Epoxidation
Manganese
Amines
Sparteine
1 Citation (Scopus)

The mucin box and signal/anchor sequence of rat neutral ceramidase recruit bacterial sphingomyelinase to the plasma membrane

Nakagawa, T., Tani, M., Sueyoshi, N. & Ito, M., Jun 6 2011, In : Bioscience, Biotechnology and Biochemistry. 75, 5, p. 987-990 4 p.

Research output: Contribution to journalArticle

Neutral Ceramidase
Sphingomyelin Phosphodiesterase
Mucins
Cell membranes
Protein Sorting Signals
12 Citations (Scopus)

The Structure of the Bimolecular Complex between Amphotericin B and Ergosterol in Membranes Is Stabilized by Face-to-Face van der Waals Interaction with Their Rigid Cyclic Cores

Nakagawa, Y., Umegawa, Y., Matsushita, N., Yamamoto, T., Tsuchikawa, H., Hanashima, S., Oishi, T., Matsumori, N. & Murata, M., Jun 21 2016, In : Biochemistry. 55, 24, p. 3392-3402 11 p.

Research output: Contribution to journalArticle

Ergosterol
Amphotericin B
Membranes
Macrolides
Polyenes
21 Citations (Scopus)

The VDAC2-BAK axis regulates peroxisomal membrane permeability

Hosoi, K., Miyata, N., Mukai, S., Furuki, S., Okumoto, K., Cheng, E. H. & Fujiki, Y., Mar 6 2017, In : Journal of Cell Biology. 216, 3, p. 709-722

Research output: Contribution to journalArticle

Peroxisomes
Permeability
Membranes
Peroxisomal Disorders
Inborn Genetic Diseases
25 Citations (Scopus)

TMEM14C is required for erythroid mitochondrial heme metabolism

Yien, Y. Y., Robledo, R. F., Schultz, I. J., Takahashi-Makise, N., Gwynn, B., Bauer, D. E., Dass, A., Yi, G., Li, L., Hildick-Smith, G. J., Cooney, J. D., Pierce, E. L., Mohler, K., Dailey, T. A., Miyata, N., Kingsley, P. D., Garone, C., Hattangadi, S. M., Huang, H., Chen, W. & 15 others, Keenan, E. M., Shah, D. I., Schlaeger, T. M., Dimauro, S., Orkin, S. H., Cantor, A. B., Palis, J., Koehler, C. M., Lodish, H. F., Kaplan, J., Ward, D. M., Dailey, H. A., Phillips, J. D., Peters, L. L. & Paw, B. H., Oct 1 2014, In : Journal of Clinical Investigation. 124, 10, p. 4294-4304 11 p.

Research output: Contribution to journalArticle

Heme
Erythroid Cells
Erythropoiesis
Porphyrins
Anemia
107 Citations (Scopus)

Total synthesis, structure revision, and absolute configuration of (-)-brevenal

Fuwa, H., Ebine, M., Bourdelais, A. J., Baden, D. G. & Sasaki, M., Dec 27 2006, In : Journal of the American Chemical Society. 128, 51, p. 16989-16999 11 p.

Research output: Contribution to journalArticle

Biological Products
Polyethers
Tides
Harmful Algal Bloom
Ethers
13 Citations (Scopus)

Total synthesis of (-)-brevenal: A streamlined strategy for practical synthesis of polycyclic ethers

Ebine, M., Fuwa, H. & Sasaki, M., Dec 2 2011, In : Chemistry - A European Journal. 17, 49, p. 13754-13761 8 p.

Research output: Contribution to journalArticle

Ethers
Polyethers
Lactones
Bioactivity
Biological Products
40 Citations (Scopus)

Total synthesis of (-)-brevenal: A concise synthetic entry to the pentacyclic polyether core

Ebine, M., Fuwa, H. & Sasaki, M., Jun 5 2008, In : Organic Letters. 10, 11, p. 2275-2278 4 p.

Research output: Contribution to journalArticle

Ribose
Polyethers
Alkenes
Biological Products
entry
51 Citations (Scopus)

Total synthesis of the proposed structure of brevenal

Fuwa, H., Ebine, M. & Sasaki, M., Aug 2 2006, In : Journal of the American Chemical Society. 128, 30, p. 9648-9650 3 p.

Research output: Contribution to journalArticle

Biological Products
Skeleton
Ether
Polyethers
Ethers
6 Citations (Scopus)

Triazoyl-phenyl linker system enhancing the aqueous solubility of a molecular probe and its efficiency in affinity labeling of a target protein for jasmonate glucoside

Tamura, S., Inomata, S., Ebine, M., Genji, T., Iwakura, I., Mukai, M., Shoji, M., Sugai, T. & Ueda, M., Jan 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 188-193 6 p.

Research output: Contribution to journalArticle

Molecular Probes
Glucosides
Solubility
Labeling
Proteins
2 Citations (Scopus)

Tritium-labelled isovaleryl-RYYRIK-NH2 as potential antagonist probe for ORL1 nociceptin receptor

Inamine, S., Nishimura, H., Li, J., Isozaki, K., Matsushima, A., Costa, T. & Shimohigashi, Y., Nov 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 21, p. 5902-5909 8 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Tritium
Opioid Receptors
Binding Sites
Conformations
1 Citation (Scopus)

Tuned Classical Thermal Aromatization Furnishing an Estrogenic Benzoacridine

Koga, R., Oishi, T. & Torikai, K., Dec 17 2015, In : Synlett. 26, 20, p. 2801-2805 5 p., st-2015-s0585-c.

Research output: Contribution to journalArticle

Aromatization
Estrogens
Derivatives
Pharmaceutical Preparations
Hot Temperature

Unified synthesis of the DEF and GhI ring systems of maitotoxin

Yasudomi, T., Yakushiji, H., Torikai, K., Ebine, M. & Oishi, T., Jan 1 2019, In : Chemistry Letters. 48, 9, p. 1156-1159 4 p.

Research output: Contribution to journalArticle

Acetals
Methylation
Ethers
Alkenes
Derivatives
1 Citation (Scopus)

VID22 is required for transcriptional activation of the PSD2 gene in the yeast Saccharomyces cerevisiae

Miyata, N., Miyoshi, T., Yamaguchi, T., Nakazono, T., Tani, M. & Kuge, O., Dec 15 2015, In : Biochemical Journal. 472, 3, p. 319-328 10 p.

Research output: Contribution to journalArticle

Yeast
Transcriptional Activation
Saccharomyces cerevisiae
Genes
Yeasts
2 Citations (Scopus)

Voltammetric study of the boric acid-salicylaldehyde-H-acid ternary system and its application to the voltammetric determination of boron

Kajiwara, M., Ito, Y. N., Miyazaki, Y., Fujimori, T., Takehara, K. & Yoshimura, K., Feb 14 2015, In : Physical Chemistry Chemical Physics. 17, 6, p. 4578-4588 11 p.

Research output: Contribution to journalArticle

boric acids
Boron
Ternary systems
ternary systems
boron
62 Citations (Scopus)
ethylenediamine
Epoxidation
Manganese
Epoxy Compounds
Ions
4 Citations (Scopus)

Yeast lacking the amphiphysin family protein Rvs167 is sensitive to disruptions in sphingolipid levels

Toume, M. & Tani, M., Aug 1 2016, In : FEBS Journal. p. 2911-2928 18 p.

Research output: Contribution to journalArticle

Serine C-Palmitoyltransferase
Sphingolipids
Yeast
Yeasts
Biosynthesis
154 Citations (Scopus)

Zone-specific expression of aldosterone synthase cytochrome p-450 and cytochrome p-45011β in rat adrenal cortex: Histochemical basis for the functional zonation

Ogishima, T., Suzuki, H., Hata, J. I., Mitani, F. & Ishimura, Y., May 1992, In : Endocrinology. 130, 5, p. 2971-2977 7 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Adrenal Cortex
Cytochromes
Zona Glomerulosa
Aldosterone
1 Citation (Scopus)

α-Helix-peptides comprising the human nuclear receptor ERRγ competitively provoke inhibition of functional homomeric dimerization

Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., Nov 4 2016, In : Biopolymers. p. 547-554 8 p.

Research output: Contribution to journalArticle

Dimerization
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Peptides
Estrogens

核内受容体が示す有害化学物質ビスフェノール応答

Translated title of the contribution: Structure-function studies between the hormone-disrupting chemical bisphenols and the nuclear receptorsMatsushima, A., Dec 2016, In : Seikagaku. The Journal of Japanese Biochemical Society. 88, 6, p. 733-43 11 p.

Research output: Contribution to journalArticle

Book
Chapter

Cell death or survival against oxidative stress

Miyata, N., Okumoto, K. & Fujiki, Y., Jan 1 2018, Subcellular Biochemistry. Springer New York, p. 463-471 9 p. (Subcellular Biochemistry; vol. 89).

Research output: Chapter in Book/Report/Conference proceedingChapter

Peroxisomes
Oxidative stress
Cell death
Catalase
Cell Survival

Identification of peroxisomal protein complexes with PTS receptors, pex5 and pex7, in mammalian cells

Okumoto, K., Miyata, N. & Fujiki, Y., Jan 1 2018, Subcellular Biochemistry. Springer New York, p. 287-298 12 p. (Subcellular Biochemistry; vol. 89).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cells
Proteins
Purification
Protein Interaction Maps
Peroxisomes