Organic and Biological Chemistry

Research Output 1979 2019

2016
4 Citations (Scopus)

Specific affinity-labeling of the nociceptin ORL1 receptor using a thiol-activated Cys(Npys)-containing peptide ligand

Matsushima, A., Nishimura, H., Matsuyama, Y., Liu, X., Costa, T. & Shimohigashi, Y., Nov 4 2016, In : Biopolymers. p. 460-469 10 p.

Research output: Contribution to journalArticle

Sulfhydryl Compounds
Labeling
Peptides
Ligands
Binding sites

Structure-function relationship of complex sphingolipids in yeast

Tani, M., Jan 1 2016, In : Trends in Glycoscience and Glycotechnology. 28, 164, p. J107-J114

Research output: Contribution to journalReview article

Sphingolipids
Yeast
Yeasts
Saccharomyces cerevisiae
Ceramides
2 Citations (Scopus)

Structure-function relationship of complex sphingolipids in yeast

Tani, M., Jan 1 2016, In : Trends in Glycoscience and Glycotechnology. 28, 164, p. E109-E116

Research output: Contribution to journalReview article

Sphingolipids
Yeast
Yeasts
Saccharomyces cerevisiae
Ceramides

Structure-function studies between the hormone-disrupting chemical bisphenols and the nuclear receptors

Matsushima, A., Jan 1 2016, In : Seikagaku. 88, 6, p. 733-743 11 p.

Research output: Contribution to journalReview article

Benzhydryl Compounds
Phenols
Structure-Activity Relationship
Cytoplasmic and Nuclear Receptors
Hormones
11 Citations (Scopus)

The Structure of the Bimolecular Complex between Amphotericin B and Ergosterol in Membranes Is Stabilized by Face-to-Face van der Waals Interaction with Their Rigid Cyclic Cores

Nakagawa, Y., Umegawa, Y., Matsushita, N., Yamamoto, T., Tsuchikawa, H., Hanashima, S., Oishi, T., Matsumori, N. & Murata, M., Jun 21 2016, In : Biochemistry. 55, 24, p. 3392-3402 11 p.

Research output: Contribution to journalArticle

Ergosterol
Amphotericin B
Membranes
Macrolides
Polyenes
4 Citations (Scopus)

Yeast lacking the amphiphysin family protein Rvs167 is sensitive to disruptions in sphingolipid levels

Toume, M. & Tani, M., Aug 1 2016, In : FEBS Journal. p. 2911-2928 18 p.

Research output: Contribution to journalArticle

Serine C-Palmitoyltransferase
Sphingolipids
Yeast
Yeasts
Biosynthesis
1 Citation (Scopus)

α-Helix-peptides comprising the human nuclear receptor ERRγ competitively provoke inhibition of functional homomeric dimerization

Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., Nov 4 2016, In : Biopolymers. p. 547-554 8 p.

Research output: Contribution to journalArticle

Dimerization
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Peptides
Estrogens

核内受容体が示す有害化学物質ビスフェノール応答

Translated title of the contribution: Structure-function studies between the hormone-disrupting chemical bisphenols and the nuclear receptorsMatsushima, A., Dec 2016, In : Seikagaku. The Journal of Japanese Biochemical Society. 88, 6, p. 733-43 11 p.

Research output: Contribution to journalArticle

2015
2 Citations (Scopus)

2-Naphthylmethoxymethyl as a Mildly Introducible and Oxidatively Removable Benzyloxymethyl-Type Protecting Group

Sato, T., Oishi, T. & Torikai, K., Jun 19 2015, In : Organic Letters. 17, 12, p. 3110-3113 4 p.

Research output: Contribution to journalArticle

Chlorides
Temperature
compatibility
chlorides
2,6-lutidine
8 Citations (Scopus)
Vacuolar Proton-Translocating ATPases
Sphingolipids
Saccharomyces cerevisiae
Yeasts
Ceramides

Alternative polyadenylation analyses of neuropeptide genes in bisphenol A-exposed hypoactive mouse brain

Sugiyama, M., Kajiyama, S., Saito, T., Uchimura, E., Motomatsu, Y., Matsuo, A., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 345-346

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

An in silico genomic search of endomorphin-like opioid peptides

Matsushima, A., Koyanagi, K. O., Nishimura, H., Inamine, S., Motomatsu, Y. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 281-282

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

A novel method identify and quantify the coactivator proteins that couple with human nuclear receptor: the use of interacting interface a-helix peptide for quantitative inhibition

Liu, X., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 203-204

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Bisphenol A-induced substantial peak decay of Drosophila circadian neuropeptide hugin mRNA expression

Shotaro, U., Matsuo, A., Matsuyama, Y., Nakamura, M., Koga, K., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 41-42

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

4 Citations (Scopus)

COX assembly factor ccdc56 regulates mitochondrial morphology by affecting mitochondrial recruitment of Drp1

Ban-Ishihara, R., Tomohiro-Takamiya, S., Tani, M., Baudier, J., Ishihara, N. & Kuge, O., Oct 7 2015, In : FEBS Letters. 589, 20, p. 3126-3132 7 p., 37349.

Research output: Contribution to journalArticle

Electron Transport Complex IV
Mitochondria
Personnel Selection
Mitochondrial Dynamics
Cell signaling
6 Citations (Scopus)

Ergosteryl-β-glucosidase (Egh1) involved in sterylglucoside catabolism and vacuole formation in Saccharomyces cerevisiae

Watanabe, T., Tani, M., Ishibashi, Y., Endo, I., Okino, N. & Ito, M., Apr 14 2015, In : Glycobiology. 25, 10, p. 1079-1089 11 p.

Research output: Contribution to journalArticle

Glucosidases
Glucosides
Vacuoles
Yeast
Saccharomyces cerevisiae

GPCR functional role of Phe-269 and Phe-221 in the molecular switching of ORL1 nociceptin receptor activation

Takesue, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 203-204

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

12 Citations (Scopus)

Phospholipid methylation controls Atg32-mediated mitophagy and Atg8 recycling

Sakakibara, K., Eiyama, A., Suzuki, S. W., Sakoh-Nakatogawa, M., Okumura, N., Tani, M., Hashimoto, A., Nagumo, S., Kondo-Okamoto, N., Kondo-Kakuta, C., Asai, E., Kirisako, H., Nakatogawa, H., Kuge, O., Takao, T., Ohsumi, Y. & Okamoto, K., Nov 3 2015, In : EMBO Journal. 34, 21, p. 2703-2719 17 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Mitochondria
Methylation
Recycling
Phospholipids

Receptor selectivity and specificity of a series of opioid peptides latent in the proenkephalin precursor protein

Motomatsu, Y., Nishimura, H., Matsumoto, Y., Kuramitsu, Y., Inamine, S., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 201-202

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

15 Citations (Scopus)

Stereoselective synthesis of the C1-C29 part of amphidinol 3

Tsuruda, T., Ebine, M., Umeda, A. & Oishi, T., Jan 16 2015, In : Journal of Organic Chemistry. 80, 2, p. 859-871 13 p.

Research output: Contribution to journalArticle

Lithium
Amides
amphidinol 3

Structural and molecular evolutionary analysis of the ligand-binding domain of forty-eight human nuclear receptors

Matsuyama, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 347-348

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structure-activity Studies on the Halogenated Phe-containing Neuropeptide Substance P Analogs

Kuramitsu, Y., Nishimura, H., Nakamura, M., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 319-320

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

8 Citations (Scopus)

Synthesis of mannosylinositol phosphorylceramides is involved in maintenance of cell integrity of yeast Saccharomyces cerevisiae

Morimoto, Y. & Tani, M., Jan 1 2015, In : Molecular Microbiology. 95, 4, p. 706-722 17 p.

Research output: Contribution to journalArticle

Saccharomyces cerevisiae
Yeasts
Maintenance
Mannans
Polysaccharides

The molecular switching of ORL1 nociceptin receptor in activation/inactivation

Nishimura, H., Li, J., Isozaki, K., yuuki, T., Matsushima, A., Liu, X., Shimohigashi, M. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 201-202

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

1 Citation (Scopus)

Tuned Classical Thermal Aromatization Furnishing an Estrogenic Benzoacridine

Koga, R., Oishi, T. & Torikai, K., Dec 17 2015, In : Synlett. 26, 20, p. 2801-2805 5 p., st-2015-s0585-c.

Research output: Contribution to journalArticle

Aromatization
Estrogens
Derivatives
Pharmaceutical Preparations
Hot Temperature
1 Citation (Scopus)

VID22 is required for transcriptional activation of the PSD2 gene in the yeast Saccharomyces cerevisiae

Miyata, N., Miyoshi, T., Yamaguchi, T., Nakazono, T., Tani, M. & Kuge, O., Dec 15 2015, In : Biochemical Journal. 472, 3, p. 319-328 10 p.

Research output: Contribution to journalArticle

Yeast
Transcriptional Activation
Saccharomyces cerevisiae
Genes
Yeasts
2 Citations (Scopus)

Voltammetric study of the boric acid-salicylaldehyde-H-acid ternary system and its application to the voltammetric determination of boron

Kajiwara, M., Ito, Y., Miyazaki, Y., Fujimori, T., Takehara, K. & Yoshimura, K., Feb 14 2015, In : Physical Chemistry Chemical Physics. 17, 6, p. 4578-4588 11 p.

Research output: Contribution to journalArticle

boric acids
Boron
Ternary systems
ternary systems
boron
2014
13 Citations (Scopus)

A characteristic back support structure in the bisphenol A-binding pocket in the human nuclear receptor ERRγ

Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., Jun 30 2014, In : PloS one. 9, 6, e101252.

Research output: Contribution to journalArticle

bisphenol A
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
receptors
estrogens
66 Citations (Scopus)

Adrenal nodularity and somatic mutations in primary aldosteronism: One node is the culprit?

Dekkers, T., Ter Meer, M., Lenders, J. W. M., Hermus, A. R. M., Schultze Kool, L., Langenhuijsen, J. F., Nishimoto, K., Ogishima, T., Mukai, K., Azizan, E. A. B., Tops, B., Deinum, J. & Küsters, B., Jan 1 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 7

Research output: Contribution to journalArticle

Hyperaldosteronism
Aldosterone
Adenoma
Mutation
Genes
6 Citations (Scopus)

AlCl3-mediated aldol cyclocondensation of 1,6- and 1,7-diones to cyclopentene and cyclohexene derivatives

Miyahara, Y. & Ito, Y., Jan 1 2014, In : Journal of Organic Chemistry. 79, 15, p. 6801-6807 7 p.

Research output: Contribution to journalArticle

Cyclopentanes
Condensation
Derivatives
Water
Temperature

Bisphenol A-induced Epigenetic Mutations in Circadian Pacemaker Neuropeptide mRNAs of Hyperactive Drosophila Fruit Flies

Matsuo, A., Umeno, S., Matsuyama, Y., Nakamura, M., Takeda, Y., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 457-458

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

8 Citations (Scopus)

Change in activity of serine palmitoyltransferase affects sensitivity to syringomycin E in yeast Saccharomyces cerevisiae

Toume, M. & Tani, M., Jan 1 2014, In : FEMS microbiology letters. 358, 1, p. 64-71 8 p.

Research output: Contribution to journalArticle

Serine C-Palmitoyltransferase
Sphingolipids
Saccharomyces cerevisiae
Yeasts
Pseudomonas syringae

Constitutive α-Helix-peptides Required for Functional Dimerization of Estrogen-related Receptor γ (ERRγ).

Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 429-430

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Expression and Mutation Analyses of Brain Neuropeptide Genes of Rndocrine-disrupting Bisphenol A-exposed Hypoactive Mouse

Sugiyama, M., Matsuo, A., Saito, T., Uchimura, E., Liu, X., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 453-454

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Functionally Essential Amino Acid Residues in ORL1 Nociceptin Receptor for Ligand-stimulated Receptor Activation

Nishimura, H., Li, J., abe, Y., Isozaki, K., Matsushima, A., Inamine, S., Costa, T. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 333-334

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Influence Analysis of the Circadian Evening Pacemaker Neuropeptide hugγ Gene in the Bisphenol A-exposed Fruit Fly Drosophila Brain

Umeno, S., Matsuo, A., Matsuyama, Y., Nakamura, M., Takeda, Y., Sumiyoshi, M., Liu, X., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 455-456

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

8 Citations (Scopus)
Phosphatidylserines
Phosphatases
Phosphatidylinositols
Phosphoric Monoester Hydrolases
Metabolism
12 Citations (Scopus)

Loss of hydroxyl groups from the ceramide moiety can modify the lateral diffusion of membrane proteins in S. cerevisiae

Uemura, S., Shishido, F., Tani, M., Mochizuki, T., Abe, F. & Inokuchi, J. I., Jan 1 2014, In : Journal of Lipid Research. 55, 7, p. 1343-1356 14 p.

Research output: Contribution to journalArticle

Ceramides
Protein S
Inositol
Hydroxyl Radical
Yeast

Multiple and Simultaneous Cys→Ala Mutations of ORL1 Nociceptin Receptor to Identify the Affinity Binding site of Cys(Npys)-Elongated RYYRIK Peptide Antagonist

Matsushima, A., Nishimura, H., Inamine, S. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 413-414

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

17 Citations (Scopus)
Neutral Ceramidase
Ceramides
Enzymes
Vertebrates
Zinc
3 Citations (Scopus)

N-methylthioacetylation of RYYRIK-NH2 with enhanced specific binding affinity and high antagonist activity for nociceptin ORL1 receptor

Li, J., Nishimura, H., Matsushima, A. & Shimohigashi, Y., Nov 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 21, p. 5721-5726 6 p.

Research output: Contribution to journalArticle

Peptide Library
Atoms
Peptides
Peptide Receptors
Neuropeptides
29 Citations (Scopus)

Pharmacologic rescue of an enzyme-trafficking defect in primary hyperoxaluria 1

Miyata, N., Steffen, J., Johnson, M. E., Fargue, S., Danpure, C. J. & Koehler, C. M., Oct 7 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 40, p. 14406-14411 6 p.

Research output: Contribution to journalArticle

Peroxisomes
Oxalates
Mitochondria
Enzymes
Pyridoxine

Specific Role of Phe Residues in Opioid Peptide Met-enkephalin- Arg-Phe in Binding to All Three Opioid Receptors

Motomatsu, Y., Nishimura, H., Matsumoto, Y., Inamine, S., Kuramitsu, Y., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 317-318

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structure-Activity Studies on the Halogenated Phe-containing Neuropeptide Substance P Analogs

Kuramitsu, Y., Nishimura, H., Nakamura, R., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., Mar 2014, Peptide Science 2013. p. 319-320 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

11 Citations (Scopus)

Synthesis and biological activity of the C'D'E'F' ring system of maitotoxin

Kunitake, M., Oshima, T., Konoki, K., Ebine, M., Torikai, K., Murata, M. & Oishi, T., Jun 6 2014, In : Journal of Organic Chemistry. 79, 11, p. 4948-4962 15 p.

Research output: Contribution to journalArticle

Cyclization
Bioactivity
Rats
maitotoxin
allyl alcohol
8 Citations (Scopus)

Synthesis and biological activity of the QRS ring system of maitotoxin

Onoue, H., Baba, T., Konoki, K., Torikai, K., Ebine, M. & Oishi, T., Jan 1 2014, In : Chemistry Letters. 43, 12, p. 1904-1906 3 p.

Research output: Contribution to journalArticle

Bioactivity
Acetals
Methylation
Polyethers
Ladders

Three-dimensional Docking Modeling to Human Nuclear Receptors for Exploration of Bisphenol-A Targeting Receptors

Matsuyama, Y., Liu, X., Nishimura, H., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 459-460

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

25 Citations (Scopus)

TMEM14C is required for erythroid mitochondrial heme metabolism

Yien, Y. Y., Robledo, R. F., Schultz, I. J., Takahashi-Makise, N., Gwynn, B., Bauer, D. E., Dass, A., Yi, G., Li, L., Hildick-Smith, G. J., Cooney, J. D., Pierce, E. L., Mohler, K., Dailey, T. A., Miyata, N., Kingsley, P. D., Garone, C., Hattangadi, S. M., Huang, H., Chen, W. & 15 others, Keenan, E. M., Shah, D. I., Schlaeger, T. M., Dimauro, S., Orkin, S. H., Cantor, A. B., Palis, J., Koehler, C. M., Lodish, H. F., Kaplan, J., Ward, D. M., Dailey, H. A., Phillips, J. D., Peters, L. L. & Paw, B. H., Oct 1 2014, In : Journal of Clinical Investigation. 124, 10, p. 4294-4304 11 p.

Research output: Contribution to journalArticle

Heme
Erythroid Cells
Erythropoiesis
Porphyrins
Anemia
2 Citations (Scopus)

Tritium-labelled isovaleryl-RYYRIK-NH2 as potential antagonist probe for ORL1 nociceptin receptor

Inamine, S., Nishimura, H., Li, J., Isozaki, K., Matsushima, A., Costa, T. & Shimohigashi, Y., Nov 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 21, p. 5902-5909 8 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Tritium
Opioid Receptors
Binding Sites
Conformations
2013
5 Citations (Scopus)

A facile and practical synthesis of Nicolaou's key intermediates, 2-methyl- and 2,6-dimethyltetrahydropyrans, toward the total synthesis of ladder-shaped polyethers

Nakashima, T., Baba, T., Onoue, H., Yamashita, W. & Torikai, K., Jul 24 2013, In : Synthesis (Germany). 45, 17, p. 2417-2425 9 p., SS-2013-F0387-OP.

Research output: Contribution to journalArticle

Polyethers
Ladders
Catalytic oxidation
Biological Products
Purification