Organic and Biological Chemistry

Research Output 1983 2020

1998
21 Citations (Scopus)

Cooperative formation of a substrate binding pocket by α- and β- subunits of mitochondrial processing peptidase

Kojima, K., Kitada, S., Shimokata, K., Ogishima, T. & Ito, A., Dec 4 1998, In : Journal of Biological Chemistry. 273, 49, p. 32542-32546 5 p.

Research output: Contribution to journalArticle

Substrates
Peptides
Arginine
Protein Precursors
mitochondrial processing peptidase
38 Citations (Scopus)

Enzymatic synthesis of ω-amino-ceramide: Preparation of a sensitive fluorescent substrate for ceramidase

Tani, M., Kita, K., Komori, H., Nakagawa, T. & Ito, M., Oct 15 1998, In : Analytical Biochemistry. 263, 2, p. 183-188 6 p.

Research output: Contribution to journalArticle

Ceramidases
Ceramides
Trifluoroacetic Acid
Substrates
Enzymes
31 Citations (Scopus)

Glutamate residues required for substrate binding and cleavage activity in mitochondrial processing peptidase

Kitada, S., Kojima, K., Shimokata, K., Ogishima, T. & Ito, A., Dec 4 1998, In : Journal of Biological Chemistry. 273, 49, p. 32547-32553 7 p.

Research output: Contribution to journalArticle

Glutamic Acid
Substrates
Peptides
Glutamates
Mutation
16 Citations (Scopus)
Serine
Peptide Hydrolases
Peptides
Arginine
Substrates
81 Citations (Scopus)

Purification and characterization of a novel ceramidase from pseudomonas aeruginosa

Okino, N., Tani, M., Imayama, S. & Ito, M., Jun 5 1998, In : Journal of Biological Chemistry. 273, 23, p. 14368-14373 6 p.

Research output: Contribution to journalArticle

Ceramidases
Pseudomonas aeruginosa
Ceramides
Purification
Enzymes
37 Citations (Scopus)

Role of α-subunit of mitochondrial processing peptidase in substrate recognition

Shimokata, K., Kitada, S., Ogishima, T. & Ito, A., Sep 25 1998, In : Journal of Biological Chemistry. 273, 39, p. 25158-25163 6 p.

Research output: Contribution to journalArticle

Substrates
Processing
Adrenodoxin
Acidic Amino Acids
Peptides
62 Citations (Scopus)
ethylenediamine
Epoxidation
Manganese
Epoxy Compounds
Ions
1999
8 Citations (Scopus)
Arginine
Amino Acids
Protein Precursors
Mitochondrial Proteins
Peptide Hydrolases
204 Citations (Scopus)

Asymmetric catalysis of new generation chiral metallosalen complexes

Ito, Y. & Katsuki, T., Apr 1 1999, In : Bulletin of the Chemical Society of Japan. 72, 4, p. 603-619 17 p.

Research output: Contribution to journalArticle

Catalysis
Epoxidation
Manganese
Derivatives
Styrene
31 Citations (Scopus)

cis-selective aziridination of cis- or trans-α,β-unsaturated amides using diaziridine

Hori, K., Sugihara, H., Ito, Y. N. & Katsuki, T., Jul 9 1999, In : Tetrahedron Letters. 40, 28, p. 5207-5210 4 p.

Research output: Contribution to journalArticle

Amides
Nitrogen
Atoms
Geometry
Substrates
64 Citations (Scopus)

Convergent synthesis of the ABCDE ring framework of ciguatoxin

Maeda, K., Oishi, T., Oguri, H. & Hirama, M., Jun 21 1999, In : Chemical Communications. 12, p. 1063-1064 2 p.

Research output: Contribution to journalArticle

Ciguatoxins
Alkylation
47 Citations (Scopus)

Convergent synthesis of the IJKLM ring fragment of ciguatoxin CTX3C

Oishi, T., Nagumo, Y., Shoji, M., Le Brazidec, J. Y., Uehara, H. & Hirama, M., Oct 21 1999, In : Chemical Communications. 20, p. 2035-2036 2 p.

Research output: Contribution to journalArticle

Ciguatoxins
Cyclization
Ketones
ciguatoxin 3C
38 Citations (Scopus)

Enantioselective synthesis of the medium ring ethers, tetrahydrooxepin, oxocane and hexahydrooxonin, of ciguatoxin. Extensive ring-expansion and chemoenzymatic desymmetrization strategy

Oishi, T., Maruyama, M., Shoji, M., Maeda, K., Kumahara, N., Tanaka, S. I. & Hirama, M., Jun 11 1999, In : Tetrahedron. 55, 24, p. 7471-7498 28 p.

Research output: Contribution to journalArticle

Ciguatoxins
Acylation
Ethers
Lipase
Alcohols

Importance of ligand Phe-phenyl group for activation of thrombin receptor

Fujita, T., Nose, T., Matsushima, A., Costa, T. & Shimohigashi, Y., 1999, Peptide Science 1998. p. 33-36

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

22 Citations (Scopus)
Sphingolipids
Sphingomyelins
Hydrolysis
Assays
Carrier Proteins
37 Citations (Scopus)

Specific and sensitive assay for alkaline and neutral ceramidases involving C12-NBD-ceramide

Tani, M., Okino, N., Mitsutake, S. & Ito, M., 1999, In : Journal of Biochemistry. 125, 4, p. 746-749 4 p.

Research output: Contribution to journalArticle

Alkaline Ceramidase
Neutral Ceramidase
Assays
Ceramides
Enzymes
2000
6 Citations (Scopus)

Binding of glycoglycerolipid derived from membranes of Acholeplasma laidlawii PG8 and synthetic analogues to lymphoid cells

Toujima, S., Kuwano, K., Zhang, Y., Fujimoto, N., Hirama, M., Oishi, T., Fukuda, S., Nagumo, Y., Imai, H., Kikuchi, T. & Arai, S., Jan 1 2000, In : Microbiology. 146, 9, p. 2317-2323 7 p.

Research output: Contribution to journalArticle

Acholeplasma laidlawii
Lymphocytes
Cell Line
Membranes
T-Lymphocytes

Chemical syntheses of phenylalanine derivatives containing halogenated benzene ring as structural explorers for elucidation of molecular mechanisms of receptor interactions

Matsushima, A., Fujita, T., Okada, K., Yamauchi, Y., Nose, T. & Shimohigashi, Y., 2000, Peptide Science 1999. p. 141-142

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

17 Citations (Scopus)

Concise synthesis of 3-O-(2-O-α-D-glucopyranosyl-6-O-acyl-α-D-glucopyranosyl)-1,2-di-O-acyl-sn-g lycerols

Imai, H., Oishi, T., Kikuchi, T. & Hirama, M., Oct 20 2000, In : Tetrahedron. 56, 43, p. 8451-8459 9 p.

Research output: Contribution to journalArticle

Derivatives
24 Citations (Scopus)

Edge-to-face CH/π interaction between ligand Phe-phenyl and receptor aromatic group in the thrombin receptor activation

Matsushima, A., Fujita, T., Nose, T. & Shimohigashi, Y., Jan 1 2000, In : Journal of biochemistry. 128, 2, p. 225-232 8 p.

Research output: Contribution to journalArticle

Thrombin Receptors
Phenylalanine
Chemical activation
Ligands
Hydrogen
28 Citations (Scopus)

Enthalpy- and/or entropy-controlled asymmetric oxidation: Stereocontrolling factors in Mn-salen-catalyzed oxidation

Nishida, T., Miyafuji, A., Ito, Y. N. & Katsuki, T., Sep 2 2000, In : Tetrahedron Letters. 41, 36, p. 7053-7058 6 p.

Research output: Contribution to journalArticle

Entropy
Enthalpy
Oxidation
Alkenes
Conformations
11 Citations (Scopus)

Enzymatic synthesis of [14C]ceramide, [14C]glycosphingolipids, and ω-aminoceramide

Ito, M., Mitsutake, S., Tani, M. & Kita, K., Jan 1 2000, In : Methods in enzymology. 311, p. 682-689 8 p.

Research output: Contribution to journalArticle

Carbon Radioisotopes
Amidohydrolases
Isotope Labeling
Glycosphingolipids
Ceramides
5 Citations (Scopus)

Exploration of the role of phenylalanine in the thrombin receptor tethered-ligand peptide by substitution with a series of trifluorophenylalanines

Matsushima, A., Fujita, T., Okada, K., Shirasu, N., Nose, T. & Shimohigashi, Y., Nov 1 2000, In : Bulletin of the Chemical Society of Japan. 73, 11, p. 2531-2538 8 p.

Research output: Contribution to journalArticle

thrombin receptor peptide SFLLRNP
Thrombin Receptors
Phenylalanine
Hydrogen
Substitution reactions
37 Citations (Scopus)

Glycine-rich region of mitochondrial processing peptidase α-subunit is essential for binding and cleavage of the precursor proteins

Nagao, Y., Kitada, S., Kojima, K., Toh, H., Kuhara, S., Ogishima, T. & Ito, A., Nov 3 2000, In : Journal of Biological Chemistry. 275, 44, p. 34552-34556 5 p.

Research output: Contribution to journalArticle

Protein Precursors
Glycine
Mutation
Enzymes
Peptides

Highly potent peptide ligands for thrombin receptor

Fujita, T., Nose, T., Matsushima, A., Costa, T. & Shimohigashi, Y., 2000, Peptide Science 1999. p. 421-424

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

92 Citations (Scopus)

Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases

Tani, M., Okino, N., Mori, K., Tanigawa, T., Izu, H. & Ito, M., Apr 14 2000, In : Journal of Biological Chemistry. 275, 15, p. 11229-11234 6 p.

Research output: Contribution to journalArticle

Alkaline Ceramidase
Neutral Ceramidase
Ceramidases
Cloning
Molecular Cloning
41 Citations (Scopus)

Neutral/alkaline and acid ceramidase activities are actively released by murine endothelial cells

Romiti, E., Meacci, E., Tani, M., Nuti, F., Farnararo, M., Ito, M. & Bruni, P., Sep 7 2000, In : Biochemical and Biophysical Research Communications. 275, 3, p. 746-751 6 p.

Research output: Contribution to journalArticle

Alkaline Ceramidase
Neutral Ceramidase
Acid Ceramidase
Endothelial cells
Endothelial Cells
71 Citations (Scopus)
Neutral Ceramidase
Ceramides
Liver
Purification
Ceramidases
16 Citations (Scopus)

Synthesis of a complete set of L-difluorophenylalanines, L-(F2)Phe, as molecular explorers for the CH/π interaction between peptide ligand and receptor

Fujita, T., Nose, T., Matsushima, A., Okada, K., Asai, D., Yamauchi, Y., Shirasu, N., Honda, T., Shigehiro, D. & Shimohigashi, Y., Feb 5 2000, In : Tetrahedron Letters. 41, 6, p. 923-927 5 p.

Research output: Contribution to journalArticle

thrombin receptor peptide SFLLRNP
Thrombin Receptors
Peptide Receptors
Hydrogen
Ligands
2001

Activity Enhancement by Introduction of two different halogen atoms into Phe-2-phenyl group of thrombin receptor tetherd-ligand analogs.

Fujita, T., Inoue, N., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2001, Peptide Science 2000. p. 135-138

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

23 Citations (Scopus)

A proposed common structure of substrates bound to mitochondrial processing peptidase

Kojima, K., Kitada, S., Ogishima, T. & Ito, A., Jan 19 2001, In : Journal of Biological Chemistry. 276, 3, p. 2115-2121 7 p.

Research output: Contribution to journalArticle

Introns
Substrates
Fluorescence Resonance Energy Transfer
Peptides
ethylenediamine

cDNA cloning of a circadian rhythm pacemaker hormone PDF of the house fly Musca domestica

Matsushima, A., Chuman, Y., Sato, S., Shimohigashi, Y., Tominaga, Y. & Shimohigashi, M., 2001, Comparative Biochemistry and Physiology. p. 876

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

cDNA Cloning of circadian rhythm pacemaker neuropeptide PDF in Gryllus bimaculatus and its neuclear localization

Chuman, Y., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., 2001, Peptide Science 2000. p. 59-62

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

38 Citations (Scopus)

Concise synthesis of ciguatoxin ABC-ring fragments and surface plasmon resonance study of the interaction of their BSA conjugates with monoclonal antibodies

Nagumo, Y., Oguri, H., Shindo, Y., Sasaki, S. Y., Oishi, T., Hirama, M., Tomioka, Y., Mizugaki, M. & Tsumuraya, T., Aug 6 2001, In : Bioorganic and Medicinal Chemistry Letters. 11, 15, p. 2037-2040 4 p.

Research output: Contribution to journalArticle

Ciguatoxins
Surface Plasmon Resonance
Surface plasmon resonance
Bovine Serum Albumin
Monoclonal Antibodies
36 Citations (Scopus)

Convergent strategy for synthesizing polycyclic ether marine toxins: Synthesis of the ABCDE ring fragment of ciguatoxin CTX3C

Maruyama, M., Maeda, K., Oishi, T., Oguri, H. & Hirama, M., Jan 1 2001, In : Heterocycles. 54, 1, p. 93-99 7 p.

Research output: Contribution to journalArticle

Ciguatoxins
Marine Toxins
Alkenes
Ether
ciguatoxin 3C
50 Citations (Scopus)

Convergent synthesis of the EFGH ring fragment of ciguatoxin CTX3C

Imai, H., Uehara, H., Inoue, M., Oguri, H., Oishi, T. & Hirama, M., Aug 27 2001, In : Tetrahedron Letters. 42, 35, p. 6219-6222 4 p.

Research output: Contribution to journalArticle

Acetals
Cyclization
ciguatoxin 3C

Gene expression of a circadian pacemaker hormone peptide PDF in cricket Gryllus bimaculatus

Matsushima, A., Chuman, Y., Onoue, H., Ito, Y., Tomioka, K., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2001, Peptide Science 2000. p. 63-66

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

13 Citations (Scopus)

Highly diastereoselective aziridination of α,β-unsaturated amides using diaziridine

Ishihara, H., Ito, Y. N. & Katsuki, T., Jan 1 2001, In : Chemistry Letters. 10, p. 984-985 2 p.

Research output: Contribution to journalArticle

Aziridines
Stereochemistry
Amides
Substrates
28 Citations (Scopus)

Highly stereocontrolled synthesis of the ABCD ring fragment of ciguatoxin CTX3C

Oishi, T., Tanaka, S. I., Ogasawara, Y., Maeda, K., Oguri, H. & Hirama, M., Jun 27 2001, In : Synlett. SPEC. ISS, p. 952-954 3 p.

Research output: Contribution to journalArticle

Alkylation
Derivatives
aminoindanol
ciguatoxin 3C

PERIOD clock protein of the summer cicada Meimuna opalifera: cDNA cloning and structural analysis

Sato, S., Chuman, Y., Matsushima, A., Shimohigashi, Y., Tominaga, Y. & Shimohigashi, M., 2001, Comparative Biochemistry and Physiology. Vol. 130. p. 876

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

92 Citations (Scopus)

Purification, Characterization, Molecular Cloning, and Subcellular Distribution of Neutral Ceramidase of Rat Kidney

Mitsutake, S., Tani, M., Okino, N., Mori, K., Ichinose, S., Omori, A., Iida, H., Nakamura, T. & Ito, M., Jul 13 2001, In : Journal of Biological Chemistry. 276, 28, p. 26249-26259 11 p.

Research output: Contribution to journalArticle

Neutral Ceramidase
Ceramidases
Cloning
Molecular Cloning
Purification
5 Citations (Scopus)

Recognition of mitochondrial protein precursor lacking arginine at position -2 by Mitochondrial Processing Peptidase: Processing of bovine cytochrome p450(SCC) precursor

Kojima, K., Yamasaki, E., Kitada, S., Ogishima, T. & Ito, A., Jan 1 2001, In : Journal of biochemistry. 130, 4, p. 497-502 6 p.

Research output: Contribution to journalArticle

Protein Precursors
Mitochondrial Proteins
Cytochrome P-450 Enzyme System
Arginine
Processing
2002
21 Citations (Scopus)

cDNA cloning and nuclear localization of the circadian neuropeptide designated as pigment-dispersing factor PDF in the cricket Gryllus bimaculatus

Chuman, Y., Matsushima, A., Sato, S., Tomioka, K., Tominaga, Y., Meinertzhagen, I. A., Shimohigashi, Y. & Shimohigashi, M., Jan 1 2002, In : Journal of Biochemistry. 131, 6, p. 895-903 9 p.

Research output: Contribution to journalArticle

Gryllidae
Cloning
Neuropeptides
Pigments
Insects

cDNA cloning of PDF peptide precursors in housefly and last summer cicada

Sato, S., Matsushima, A., Chuman, Y., Tominaga, K., Shimohigashi, Y. & Shimohigashi, M., 2002, Peptide Science 2001. p. 139-142

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Circadian rhythm pacemaker neuropeptide 'PDF' in nocturnal insect cricket gryllus bimaculatus: cDNA cloning, mRNA expression, and nuclear localization

Chuman, Y., Matsushima, A., Nose, T., Shimohigashi, Y. & Shimohigashi, M., 2002, American Peptide Society 2001. p. 797-798

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Contractile activity of Drosophila FMRFamide-related peptides in the Meretrix Lusoria heart muscle.

Tokunaga, T., Ohtani, M., Matsushima, A., Chuman, Y., Nose, T. & Shimohigashi, Y., 2002, Peptide Science 2001. p. 167-170

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Design and preparation of universal anti-PERIOD antibodies and their immunoresponses.

Asai, D., Tokunaga, T., Matsushima, A., Sato, S., Chuman, Y., Nose, T., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2002, Peptide Science 2001. p. 399-402

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

26 Citations (Scopus)

Highly diastereo- and enantioselective aziridination of α,β-unsaturated amides with diaziridine and mechanistic consideration on its stereochemistry

Ishihara, H., Hori, K., Sugihara, H., Ito, Y. & Katsuki, T., Dec 1 2002, In : Helvetica Chimica Acta. 85, 12, p. 4272-4286 15 p.

Research output: Contribution to journalArticle

Stereochemistry
Enantioselectivity
stereochemistry
Amides
amides
47 Citations (Scopus)

Molecular cloning and characterization of a secretory neutral ceramidase of Drosophila melanogaster

Yoshimura, Y., Okino, N., Tani, M. & Ito, M., Aug 2002, In : Journal of biochemistry. 132, 2, p. 229-236 8 p.

Research output: Contribution to journalArticle

Neutral Ceramidase
Ceramidases
Cloning
Molecular Cloning
Drosophila melanogaster

Structure and function of nuclear localization signal peptide present in circadian rhythm hormone peptide precursor

Matsushima, A., Chuman, Y., Sato, S., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2002, Peptide Science 2001. p. 159-162

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)