Organic and Biological Chemistry

Research Output 1983 2020

21 Citations (Scopus)

Bioactive fluorinated derivative of amphotericin B

Matsumori, N., Umegawa, Y., Oishi, T. & Murata, M., Aug 1 2005, In : Bioorganic and Medicinal Chemistry Letters. 15, 15, p. 3565-3567 3 p.

Research output: Contribution to journalArticle

Amphotericin B
Derivatives
Fluorination
Fluorine
Halogenation

Biosynthetic Short Neuropeptides: A Rational Theory Based on Experimental Results for the Missing Pain-Relief Opioid Endomorphin Precursor Gene

Matsushima, A., Sese, J. & Koyanagi, K. O., Jan 1 2019, In : ChemBioChem. 20, 16, p. 2054-2058 5 p.

Research output: Contribution to journalArticle

Neuropeptides
Opioid Analgesics
Genes
Pain
Peptides

Bisphenol AF: Halogen bonding effect is a major driving force for the dual ERα-agonist and ERβ-antagonist activities

Liu, X., Suyama, K., Shiki, J., Torikai, K., Nose, T., Shimohigashi, M. & Shimohigashi, Y., Feb 1 2020, In : Bioorganic and Medicinal Chemistry. 28, 3, 115274.

Research output: Contribution to journalArticle

Halogens
Estrogen Receptors
Estrogens
Structure-Activity Relationship
Estrogen Receptor Antagonists
112 Citations (Scopus)

Bisphenol AF is a full agonist for the estrogen receptor ERα but a highly specific antagonist for ERβ

Matsushima, A., Liu, X., Okada, H., Shimohigashi, M. & Shimohigashi, Y., Sep 1 2010, In : Environmental Health Perspectives. 118, 9, p. 1267-1272 6 p.

Research output: Contribution to journalArticle

Estrogens
Reporter Genes
Estradiol
4,4'-hexafluorisopropylidene diphenol
Physiological Phenomena

Bisphenol A-induced Epigenetic Mutations in Circadian Pacemaker Neuropeptide mRNAs of Hyperactive Drosophila Fruit Flies

Matsuo, A., Umeno, S., Matsuyama, Y., Nakamura, M., Takeda, Y., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 457-458

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Bisphenol A-induced substantial peak decay of Drosophila circadian neuropeptide hugin mRNA expression

Shotaro, U., Matsuo, A., Matsuyama, Y., Nakamura, M., Koga, K., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 41-42

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Bisphenol A-specific nuclear receptor ERRγ: structure-function analysis of the two novel isoforms lacking vital peptide fragment in the ligand binding domain

Takeda, Y., Liu, X., Sumiyoshi, M., Matsushima, A., Shimohigashi, Y. & Shimohigashi, M., 2009, Peptide Science 2008. p. 517-518

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Bisphenol-binding pocket of constitutively active nuclear receptor CAR: Docking modeling for close-packing

Matsuyama, Y., Liu, X., Nishimura, H., Matsushima, A., Nose, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 401-402

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

8 Citations (Scopus)

C18:3-GM1a induces apoptosis in Neuro2a cells: Enzymatic remodeling of fatty acyl chains of glycosphingolipids

Nakagawa, T., Morotomi, A., Tani, M., Sueyoshi, N., Komori, H. & Ito, M., Dec 1 2005, In : Journal of Lipid Research. 46, 6, p. 1103-1112 10 p.

Research output: Contribution to journalArticle

Glycosphingolipids
Gangliosides
Apoptosis
Chemical activation
Lipids
2 Citations (Scopus)

Capturing of the free cysteine residue in the ligand-binding site by affinity labeling of the ORL1 nociceptin receptor

Matsushima, A., Nishimura, H., Inamine, S., Uemura, S. & Shimohigashi, Y., Dec 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 24, p. 7597-7602 6 p.

Research output: Contribution to journalArticle

Labeling
Ethylmaleimide
Cysteine
Binding Sites
Sulfhydryl Compounds
618 Citations (Scopus)

Catalytic asymmetric epoxidation of unfunctionalized olefins

Irie, R., Noda, K., Ito, Y., Matsumoto, N. & Katsuki, T., 1990, In : Tetrahedron Letters. 31, 50, p. 7345-7348 4 p.

Research output: Contribution to journalArticle

Epoxidation
Enantioselectivity
Alkenes
Manganese
Ligands
176 Citations (Scopus)

Catalytic asymmetric epoxidation of unfunctionalized olefins using chiral (salen)manganese(III) complexes

Irie, R., Noda, K., Ito, Y., Matsumoto, N. & Katsuki, T., 1991, In : Tetrahedron: Asymmetry. 2, 7, p. 481-494 14 p.

Research output: Contribution to journalArticle

epoxidation
Epoxidation
Alkenes
Manganese
alkenes
45 Citations (Scopus)

Catalytic epoxidation with molecular oxygen using nickel complex

Irie, R., Ito, Y. & Katsuki, T., Nov 18 1991, In : Tetrahedron Letters. 32, 47, p. 6891-6894 4 p.

Research output: Contribution to journalArticle

Epoxidation
Molecular oxygen
Alkenes
Nickel
Oxygen

cDNA cloning and in situ hybridization studies of sulfated peptide, sulfakinin, on housefly Musca domestica

Matsushima, A., Yokotani, S., Shimohigashi, Y., Tominaga, Y. & Shimohigashi, M., 2004, Peptide Science 2003. p. 459-462

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

cDNA cloning and mRNA expression of the circadian neuropeptide PDF in the silk moth Bombyx mori

Sato, S., Sumida, K., Hiramura, D., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004. p. 197-200

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

21 Citations (Scopus)

cDNA cloning and nuclear localization of the circadian neuropeptide designated as pigment-dispersing factor PDF in the cricket Gryllus bimaculatus

Chuman, Y., Matsushima, A., Sato, S., Tomioka, K., Tominaga, Y., Meinertzhagen, I. A., Shimohigashi, Y. & Shimohigashi, M., Jan 1 2002, In : Journal of Biochemistry. 131, 6, p. 895-903 9 p.

Research output: Contribution to journalArticle

Gryllidae
Cloning
Neuropeptides
Pigments
Insects

cDNA cloning of a circadian rhythm pacemaker hormone PDF of the house fly Musca domestica

Matsushima, A., Chuman, Y., Sato, S., Shimohigashi, Y., Tominaga, Y. & Shimohigashi, M., 2001, Comparative Biochemistry and Physiology. p. 876

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

cDNA Cloning of circadian rhythm pacemaker neuropeptide PDF in Gryllus bimaculatus and its neuclear localization

Chuman, Y., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., 2001, Peptide Science 2000. p. 59-62

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

cDNA cloning of PDF peptide precursors in housefly and last summer cicada

Sato, S., Matsushima, A., Chuman, Y., Tominaga, K., Shimohigashi, Y. & Shimohigashi, M., 2002, Peptide Science 2001. p. 139-142

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

19 Citations (Scopus)

cDNA cloning of the housefly pigment-dispersing factor (PDF) precursor protein and its peptides comparison among the insect circadian neuropeptides

Matsushima, A., Sato, S., Chuman, Y., Takeda, Y., Yokotani, S., Nose, T., Tominaga, Y., Shimohigashi, M. & Shimohigashi, Y., Feb 1 2004, In : Journal of Peptide Science. 10, 2, p. 82-91 10 p.

Research output: Contribution to journalArticle

Houseflies
Protein Precursors
Cloning
Neuropeptides
Pigments

Cell death or survival against oxidative stress

Miyata, N., Okumoto, K. & Fujiki, Y., Jan 1 2018, Subcellular Biochemistry. Springer New York, p. 463-471 9 p. (Subcellular Biochemistry; vol. 89).

Research output: Chapter in Book/Report/Conference proceedingChapter

Peroxisomes
Oxidative stress
Cell death
Catalase
Cell Survival
8 Citations (Scopus)

Change in activity of serine palmitoyltransferase affects sensitivity to syringomycin E in yeast Saccharomyces cerevisiae

Toume, M. & Tani, M., Jan 1 2014, In : FEMS microbiology letters. 358, 1, p. 64-71 8 p.

Research output: Contribution to journalArticle

Serine C-Palmitoyltransferase
Sphingolipids
Saccharomyces cerevisiae
Yeasts
Pseudomonas syringae

Chemical syntheses of phenylalanine derivatives containing halogenated benzene ring as structural explorers for elucidation of molecular mechanisms of receptor interactions

Matsushima, A., Fujita, T., Okada, K., Yamauchi, Y., Nose, T. & Shimohigashi, Y., 2000, Peptide Science 1999. p. 141-142

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

12 Citations (Scopus)

Chiral Leaving Group: Synthesis of Optically Active Benzimidazole and its Application to Asymmetric Acylation

Ogata, M., Yoshimura, T., Fujii, H., Ito, Y. & Katsuki, T., Oct 1993, In : Synlett. 1993, 10, p. 728-730 3 p.

Research output: Contribution to journalArticle

Acylation
Amides
Derivatives
benzimidazole
mandelic acid

Circadian rhythm pacemaker neuropeptide 'PDF' in nocturnal insect cricket gryllus bimaculatus: cDNA cloning, mRNA expression, and nuclear localization

Chuman, Y., Matsushima, A., Nose, T., Shimohigashi, Y. & Shimohigashi, M., 2002, American Peptide Society 2001. p. 797-798

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

31 Citations (Scopus)

cis-selective aziridination of cis- or trans-α,β-unsaturated amides using diaziridine

Hori, K., Sugihara, H., Ito, Y. N. & Katsuki, T., Jul 9 1999, In : Tetrahedron Letters. 40, 28, p. 5207-5210 4 p.

Research output: Contribution to journalArticle

Amides
Nitrogen
Atoms
Geometry
Substrates
19 Citations (Scopus)

"Click-made" biaryl-linker improving efficiency in protein labelling for the membrane target protein of a bioactive compound

Nakamura, Y., Inomata, S., Ebine, M., Manabe, Y., Iwakura, I. & Ueda, M., Jan 1 2011, In : Organic and Biomolecular Chemistry. 9, 1, p. 83-85 3 p.

Research output: Contribution to journalArticle

activity (biology)
Labeling
marking
Membrane Proteins
membranes

Comparative analysis of the ligand binding domain secondary structures of human nuclear receptors

Matsuyama, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 337-338

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

39 Citations (Scopus)

Comprehensive molecular motion capture for sphingomyelin by site-specific deuterium labeling

Matsumori, N., Yasuda, T., Okazaki, H., Suzuki, T., Yamaguchi, T., Tsuchikawa, H., Doi, M., Oishi, T. & Murata, M., Oct 23 2012, In : Biochemistry. 51, 42, p. 8363-8370 8 p.

Research output: Contribution to journalArticle

Sphingomyelins
Deuterium
Labeling
Cholesterol
Sphingosine

Comprehensive structural analysis of the nociceptin ORL1 receptor by means of virtual and experimental Ala-scanning combinated methods

Matsushima, A., Nishimura, H., Liu, X., Takesue, Y., Matsuyama, Y. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 149-150

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

17 Citations (Scopus)

Concise synthesis of 3-O-(2-O-α-D-glucopyranosyl-6-O-acyl-α-D-glucopyranosyl)-1,2-di-O-acyl-sn-g lycerols

Imai, H., Oishi, T., Kikuchi, T. & Hirama, M., Oct 20 2000, In : Tetrahedron. 56, 43, p. 8451-8459 9 p.

Research output: Contribution to journalArticle

Derivatives
38 Citations (Scopus)

Concise synthesis of ciguatoxin ABC-ring fragments and surface plasmon resonance study of the interaction of their BSA conjugates with monoclonal antibodies

Nagumo, Y., Oguri, H., Shindo, Y., Sasaki, S. Y., Oishi, T., Hirama, M., Tomioka, Y., Mizugaki, M. & Tsumuraya, T., Aug 6 2001, In : Bioorganic and Medicinal Chemistry Letters. 11, 15, p. 2037-2040 4 p.

Research output: Contribution to journalArticle

Ciguatoxins
Surface Plasmon Resonance
Surface plasmon resonance
Bovine Serum Albumin
Monoclonal Antibodies
14 Citations (Scopus)

Confirmation of the absolute configuration at C45 of amphidinol 3

Manabe, Y., Ebine, M., Matsumori, N., Murata, M. & Oishi, T., Dec 3 2012, In : Journal of Natural Products. 75, 11, p. 2003-2006 4 p.

Research output: Contribution to journalArticle

Dinoflagellida
Biological Products
Degradation
Esters
Carbon

Conformation change of α-helix peptide for sensing of deactivation of nuclear peceptor: Immunoassay using polyclonal antibody specific for the C-terminal a-helix 12 of estrogen-related receptor γ (ERRγ)

Tokunaga, T., Liu, X., Okada, H., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 176

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Conformation change-senseing assay using monoclonal antibody for N-terminal octapeptide repreat region of prion protein

Kawano, M., Honda, T., Horiuchi, Y., Yokotani, S., Matsushima, A., Nose, T. & Shimohigashi, Y., 2005, Peptide Science 2004.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

7 Citations (Scopus)
Neutral Ceramidase
Enzyme activity
Tail
Amino Acids
Enzymes

Constitutive α-Helix-peptides Required for Functional Dimerization of Estrogen-related Receptor γ (ERRγ).

Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 429-430

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Contractile activity of Drosophila FMRFamide-related peptides in the Meretrix Lusoria heart muscle.

Tokunaga, T., Ohtani, M., Matsushima, A., Chuman, Y., Nose, T. & Shimohigashi, Y., 2002, Peptide Science 2001. p. 167-170

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

3 Citations (Scopus)
Ethers
Polyethers
Ladders
Ether
Cyclic Ethers
36 Citations (Scopus)

Convergent strategy for synthesizing polycyclic ether marine toxins: Synthesis of the ABCDE ring fragment of ciguatoxin CTX3C

Maruyama, M., Maeda, K., Oishi, T., Oguri, H. & Hirama, M., Jan 1 2001, In : Heterocycles. 54, 1, p. 93-99 7 p.

Research output: Contribution to journalArticle

Ciguatoxins
Marine Toxins
Alkenes
Ether
ciguatoxin 3C
4 Citations (Scopus)

Convergent syntheses of the WXYZ ring of maitotoxin and the HIJK ring of brevisulcenal-F

Osato, N., Onoue, H., Toma, Y., Torikai, K., Ebine, M., Satake, M. & Oishi, T., Jan 1 2018, In : Chemistry Letters. 47, 3, p. 265-268 4 p.

Research output: Contribution to journalArticle

Ketones
Stereochemistry
Methylation
Lithium
Aldehydes
64 Citations (Scopus)

Convergent synthesis of the ABCDE ring framework of ciguatoxin

Maeda, K., Oishi, T., Oguri, H. & Hirama, M., Jun 21 1999, In : Chemical Communications. 12, p. 1063-1064 2 p.

Research output: Contribution to journalArticle

Ciguatoxins
Alkylation
50 Citations (Scopus)

Convergent synthesis of the EFGH ring fragment of ciguatoxin CTX3C

Imai, H., Uehara, H., Inoue, M., Oguri, H., Oishi, T. & Hirama, M., Aug 27 2001, In : Tetrahedron Letters. 42, 35, p. 6219-6222 4 p.

Research output: Contribution to journalArticle

Acetals
Cyclization
ciguatoxin 3C
47 Citations (Scopus)

Convergent synthesis of the IJKLM ring fragment of ciguatoxin CTX3C

Oishi, T., Nagumo, Y., Shoji, M., Le Brazidec, J. Y., Uehara, H. & Hirama, M., Oct 21 1999, In : Chemical Communications. 20, p. 2035-2036 2 p.

Research output: Contribution to journalArticle

Ciguatoxins
Cyclization
Ketones
ciguatoxin 3C
34 Citations (Scopus)

Convergent synthesis of trans-fused 6/n/6/6 (n=7, 8) tetracyclic ether system via α-cyano ethers

Oishi, T., Watanabe, K. & Murata, M., Sep 22 2003, In : Tetrahedron Letters. 44, 39, p. 7315-7319 5 p.

Research output: Contribution to journalArticle

Acetals
Ethers
Ether
Nitriles
4-methylpyridine
88 Citations (Scopus)

Convergent total synthesis of gymnocin-A and evaluation of synthetic analogues

Tsukano, C., Ebine, M. & Sasaki, M., Mar 30 2005, In : Journal of the American Chemical Society. 127, 12, p. 4326-4335 10 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Skeleton
Polyethers
Harmful Algal Bloom
Dinoflagellida
21 Citations (Scopus)

Cooperative formation of a substrate binding pocket by α- and β- subunits of mitochondrial processing peptidase

Kojima, K., Kitada, S., Shimokata, K., Ogishima, T. & Ito, A., Dec 4 1998, In : Journal of Biological Chemistry. 273, 49, p. 32542-32546 5 p.

Research output: Contribution to journalArticle

Substrates
Peptides
Arginine
Protein Precursors
mitochondrial processing peptidase
5 Citations (Scopus)

Cooperative function of Fmp30, Mdm31, and Mdm32 in Ups1-independent cardiolipin accumulation in the yeast Saccharomyces cerevisiae

Miyata, N., Goda, N., Matsuo, K., Hoketsu, T. & Kuge, O., Dec 1 2017, In : Scientific reports. 7, 1, 16447.

Research output: Contribution to journalArticle

Cardiolipins
Saccharomyces cerevisiae
Mitochondrial Membranes
Yeasts
Phosphatidic Acids
4 Citations (Scopus)

COX assembly factor ccdc56 regulates mitochondrial morphology by affecting mitochondrial recruitment of Drp1

Ban-Ishihara, R., Tomohiro-Takamiya, S., Tani, M., Baudier, J., Ishihara, N. & Kuge, O., Oct 7 2015, In : FEBS Letters. 589, 20, p. 3126-3132 7 p., 37349.

Research output: Contribution to journalArticle

Electron Transport Complex IV
Mitochondria
Personnel Selection
Mitochondrial Dynamics
Cell signaling
74 Citations (Scopus)

Cysteine ubiquitination of PTS1 receptor Pex5p regulates Pex5p recycling

Okumoto, K., Misono, S., Miyata, N., Matsumoto, Y., Mukai, S. & Fujiki, Y., Aug 1 2011, In : Traffic. 12, 8, p. 1067-1083 17 p.

Research output: Contribution to journalArticle

Peroxisomes
Ubiquitination
Recycling
Cysteine
Dithiothreitol