Organic and Biological Chemistry

Research Output 1983 2019

2013
16 Citations (Scopus)

An endocrine disruptor, bisphenol A, affects development in the protochordate Ciona intestinalis: Hatching rates and swimming behavior alter in a dose-dependent manner

Matsushima, A., Ryan, K., Shimohigashi, Y. & Meinertzhagen, I. A., Feb 1 2013, In : Environmental Pollution. 173, p. 257-263 7 p.

Research output: Contribution to journalArticle

Ciona intestinalis
Endocrine Disruptors
Mammals
Neurology
Polycarbonates
8 Citations (Scopus)

A novel sperm-activating and attracting factor from the ascidian Ascidia sydneiensis

Matsumori, N., Hiradate, Y., Shibata, H., Oishi, T., Shimma, S., Toyoda, M., Hayashi, F., Yoshida, M., Murata, M. & Morisawa, M., Jan 18 2013, In : Organic Letters. 15, 2, p. 294-297 4 p.

Research output: Contribution to journalArticle

tactics
Urochordata
Chemotaxis
Biological Products
Spermatozoa

Bisphenol-binding pocket of constitutively active nuclear receptor CAR: Docking modeling for close-packing

Matsuyama, Y., Liu, X., Nishimura, H., Matsushima, A., Nose, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 401-402

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

4 Citations (Scopus)

Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro

Vecchiola, A., Lagos, C. F., Fuentes, C. A., Allende, F., Campino, C., Valdivia, C., Tapia-Castillo, A., Ogishima, T., Mukai, K., Owen, G., Solari, S., Carvajal, C. A. & Fardella, C. E., Aug 13 2013, In : Reproductive Biology and Endocrinology. 11, 1, 76.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Progesterone
Estradiol
Aldosterone
Steroid 11-beta-Hydroxylase

Exploration of pharmacological chaperone for rescue of misfolded and/or unfolded ORL1 nociceptin receptor proteins

Nishimura, H., Inamine, S., Li, J., Matsushima, A. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 115-118

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

3 Citations (Scopus)

Guest responsivity of a two-dimensional coordination polymer incorporating a cholesterol-based co-ligand

Kajitani, K., Koshiyama, T., Hori, A., Ohtani, R., Mishima, A., Torikai, K., Ebine, M., Oishi, T., Takata, M., Kitagawa, S. & Ohba, M., Dec 7 2013, In : Dalton Transactions. 42, 45, p. 15893-15897 5 p.

Research output: Contribution to journalArticle

Polymers
Cholesterol
Ligands

Halogenated Phe-containing endomorphin-2 analogs with mixed agonist and antagonist activities

Nishio, K., Nishimura, H., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 25-26

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

High-precision binding assay procedure of tachykinin receptor NK-1 for highly potent Substance P analogs

Kuramitsu, Y., Nishimura, H., Nakamura, R., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 213-214

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Identification of affinity binding site of Cys(Npys)-elongated RYYRIK peptide antagonist by means of Cys→Ala mutated ORL1 nociceptin receptors

Matsushima, A., Nishimura, H., Inamine, S. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 207-208

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

19 Citations (Scopus)

Immunohistochemistry improves histopathologic diagnosis in primary aldosteronism

Volpe, C., Höög, A., Ogishima, T., Mukai, K., Lu, M., Thorén, M. & Hamberger, B., Apr 1 2013, In : Journal of Clinical Pathology. 66, 4, p. 351-354 4 p.

Research output: Contribution to journalArticle

Hyperaldosteronism
Aldosterone
Immunohistochemistry
Adenoma
Hyperplasia
18 Citations (Scopus)

Macrocytic anemia and mitochondriopathy resulting from a defect in sideroflexin 4

Hildick-Smith, G. J., Cooney, J. D., Garone, C., Kremer, L. S., Haack, T. B., Thon, J. N., Miyata, N., Lieber, D. S., Calvo, S. E., Akman, H. O., Yien, Y. Y., Huston, N. C., Branco, D. S., Shah, D. I., Freedman, M. L., Koehler, C. M., Italiano, J. E., Merkenschlager, A., Beblo, S., Strom, T. M. & 7 others, Meitinger, T., Freisinger, P., Donati, M. A., Prokisch, H., Mootha, V. K., DiMauro, S. & Paw, B. H., Nov 7 2013, In : American journal of human genetics. 93, 5, p. 906-914 9 p.

Research output: Contribution to journalArticle

Macrocytic Anemia
Zebrafish
Exome
Mitochondrial Diseases
Mutation
17 Citations (Scopus)

Synthesis and structure revision of the C43-C67 part of amphidinol 3

Ebine, M., Kanemoto, M., Manabe, Y., Konno, Y., Sakai, K., Matsumori, N., Murata, M. & Oishi, T., Jun 26 2013, In : Organic Letters. 15, 11, p. 2846-2849 4 p.

Research output: Contribution to journalArticle

nuclear magnetic resonance
oxidation
synthesis
configurations
Nuclear magnetic resonance
81 Citations (Scopus)

Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria

Tamura, Y., Harada, Y., Nishikawa, S. I., Yamano, K., Kamiya, M., Shiota, T., Kuroda, T., Kuge, O., Sesaki, H., Imai, K., Tomii, K. & Endo, T., May 7 2013, In : Cell metabolism. 17, 5, p. 709-718 10 p.

Research output: Contribution to journalArticle

Cytidine Diphosphate Diglycerides
Diacylglycerol Cholinephosphotransferase
Cardiolipins
Mitochondria
Phosphatidic Acids

The impact of bisphenol A-feeding on the Drosophila neuropeptide PDF mRNA structure

Matsuo, A., Nakamura, M., Takeda, Y., Matsuyama, Y., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 75-76

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

6 Citations (Scopus)

Triazoyl-phenyl linker system enhancing the aqueous solubility of a molecular probe and its efficiency in affinity labeling of a target protein for jasmonate glucoside

Tamura, S., Inomata, S., Ebine, M., Genji, T., Iwakura, I., Mukai, M., Shoji, M., Sugai, T. & Ueda, M., Jan 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 1, p. 188-193 6 p.

Research output: Contribution to journalArticle

Molecular Probes
Glucosides
Solubility
Labeling
Proteins

Two different binding modes of peptide library-based antagonist acyl-RYYRIK amide in the orl1 nociceptin receptor

Inamine, S., Nishimura, H., Li, J., Matsushima, A., Costa, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 229-230

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2012

Affinity labeling of the ORL1 nociceptin receptor by Cys(Npys)-elongated RYYRIK peptide antagonist

Matsushima, A., Nishimura, H., Uemura, S., Li, J., Inamine, S. & Shimohigashi, Y., 2012, Peptide Science 2011. p. 179-180

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

7 Citations (Scopus)

Artificial ladder-shaped polyethers that inhibit maitotoxin-induced Ca 2+ influx in rat glioma C6 cells

Oishi, T., Konoki, K., Tamate, R., Torikai, K., Hasegawa, F., Matsumori, N. & Murata, M., Jun 1 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 11, p. 3619-3622 4 p.

Research output: Contribution to journalArticle

Dinoflagellida
Polyethers
Ladders
Glioma
Rats
41 Citations (Scopus)

AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase

Miyata, N., Okumoto, K., Mukai, S., Noguchi, M. & Fujiki, Y., Jan 1 2012, In : Traffic. 13, 1, p. 168-183 16 p.

Research output: Contribution to journalArticle

Peroxisomes
Adenosine Triphosphatases
Assays
Fibroblasts
Fractionation
38 Citations (Scopus)

Comprehensive molecular motion capture for sphingomyelin by site-specific deuterium labeling

Matsumori, N., Yasuda, T., Okazaki, H., Suzuki, T., Yamaguchi, T., Tsuchikawa, H., Doi, M., Oishi, T. & Murata, M., Oct 23 2012, In : Biochemistry. 51, 42, p. 8363-8370 8 p.

Research output: Contribution to journalArticle

Sphingomyelins
Deuterium
Labeling
Cholesterol
Sphingosine
14 Citations (Scopus)

Confirmation of the absolute configuration at C45 of amphidinol 3

Manabe, Y., Ebine, M., Matsumori, N., Murata, M. & Oishi, T., Dec 3 2012, In : Journal of Natural Products. 75, 11, p. 2003-2006 4 p.

Research output: Contribution to journalArticle

Dinoflagellida
Biological Products
Degradation
Esters
Carbon
3 Citations (Scopus)
Ethers
Polyethers
Ladders
Ether
Cyclic Ethers

Effects of the halogenation of Phe-phenyl group of two consecutive residues in endomorphin-2 on the interaction with the μ–opioid receptors

Nishio, K., Nishimura, H., Suyama, K., Abe, Y., Matsushima, A., Nose, T. & Shimohigashi, Y., 2012, Peptide Science 2011. p. 171-172

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

5 Citations (Scopus)

Expression of budding yeast IPT1 produces mannosyldiinositol phosphorylceramide in fission yeast and inhibits cell growth

Nakase, M., Tani, M. & Takegawa, K., May 1 2012, In : Microbiology. 158, 5, p. 1219-1228 10 p.

Research output: Contribution to journalArticle

Saccharomycetales
Schizosaccharomyces
Growth
Sphingolipids
Poisons
10 Citations (Scopus)

Fine spatial assembly for construction of the phenol-binding pocket to capture bisphenol a in the human nuclear receptor estrogen-related receptor γ

Liu, X., Matsushima, A., Nakamura, M., Costa, T., Nose, T. & Shimohigashi, Y., Apr 1 2012, In : Journal of biochemistry. 151, 4, p. 403-415 13 p.

Research output: Contribution to journalArticle

Cytoplasmic and Nuclear Receptors
Phenol
Estrogen Receptors
Estrogens
Benzene
25 Citations (Scopus)

Head-to-tail interaction between amphotericin b and ergosterol occurs in hydrated phospholipid membrane

Umegawa, Y., Nakagawa, Y., Tahara, K., Tsuchikawa, H., Matsumori, N., Oishi, T. & Murata, M., Jan 10 2012, In : Biochemistry. 51, 1, p. 83-89 7 p.

Research output: Contribution to journalArticle

Ergosterol
Amphotericin B
Phospholipids
Head
Membranes
13 Citations (Scopus)
Hydroxylation
Sphingolipids
Yeast
Ceramides
Saccharomyces cerevisiae
24 Citations (Scopus)

Impaired retrograde membrane traffic through endosomes in a mutant CHO cell defective in phosphatidylserine synthesis

Lee, S., Uchida, Y., Emoto, K., Umeda, M., Kuge, O., Taguchi, T. & Arai, H., Aug 1 2012, In : Genes to Cells. 17, 8, p. 728-736 9 p.

Research output: Contribution to journalArticle

CHO Cells
Endosomes
Phosphatidylserines
Membranes
Cell Membrane
10 Citations (Scopus)
Sphingolipids
Phosphatidylserines
Saccharomyces cerevisiae
Yeasts
Endosomes
28 Citations (Scopus)
Peroxisomes
Membranes
Adenosine Triphosphatases
peroxisome-targeting signal 1 receptor
Hydrolysis
29 Citations (Scopus)

NMR-based conformational analysis of sphingomyelin in bicelles

Yamaguchi, T., Suzuki, T., Yasuda, T., Oishi, T., Matsumori, N. & Murata, M., Jan 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 1, p. 270-278 9 p.

Research output: Contribution to journalArticle

Sphingomyelins
Nuclear magnetic resonance
Conformations
Lipid bilayers
Membranes

Receptor Binding Characteristics of Tritium-labeled Pure antagonist Peptide for Hyperalgesic nociceptin ORL1 receptor

Inamine, S., Nishimura, H., Li, J., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2012, Peptide Science 2011. p. 183-184

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

28 Citations (Scopus)

Selenium Compound Protects Corneal Epithelium against Oxidative Stress

Higuchi, A., Inoue, H., Kawakita, T., Ogishima, T. & Tsubota, K., Sep 25 2012, In : PloS one. 7, 9, e45612.

Research output: Contribution to journalArticle

Selenium Compounds
Corneal Epithelium
Lactoferrin
Oxidative stress
selenium

Structural Analysis of Delta Opioid Receptor Dimer by Bivalent Deltorphin II Analogs

Ito, N., Nishimura, H., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., Mar 2012, Peptide Science 2011. p. 173-174 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural Characteristics of Thr-Gly Dipeptide Repeat in the Drosophila Clock Protein PERIOD

Matsuo, A., Nishimura, H., Masayuki, N., Koga, K., Sumiyoshi, M., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., Mar 2012, Peptide Science 2011. p. 351-352 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural Essentials of Hyperalgesic Nociceptin ORL1 Receptor for Ligand Binding and Receptor Activation

Nishimura, H., Li, J., Isozaki, K., Abe, Y., Inamine, S., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2012, Peptide Science 2011. p. 33-34

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2011
2 Citations (Scopus)

Capturing of the free cysteine residue in the ligand-binding site by affinity labeling of the ORL1 nociceptin receptor

Matsushima, A., Nishimura, H., Inamine, S., Uemura, S. & Shimohigashi, Y., Dec 15 2011, In : Bioorganic and Medicinal Chemistry. 19, 24, p. 7597-7602 6 p.

Research output: Contribution to journalArticle

Labeling
Ethylmaleimide
Cysteine
Binding Sites
Sulfhydryl Compounds
19 Citations (Scopus)

"Click-made" biaryl-linker improving efficiency in protein labelling for the membrane target protein of a bioactive compound

Nakamura, Y., Inomata, S., Ebine, M., Manabe, Y., Iwakura, I. & Ueda, M., Jan 1 2011, In : Organic and Biomolecular Chemistry. 9, 1, p. 83-85 3 p.

Research output: Contribution to journalArticle

activity (biology)
Labeling
marking
Membrane Proteins
membranes
74 Citations (Scopus)

Cysteine ubiquitination of PTS1 receptor Pex5p regulates Pex5p recycling

Okumoto, K., Misono, S., Miyata, N., Matsumoto, Y., Mukai, S. & Fujiki, Y., Aug 1 2011, In : Traffic. 12, 8, p. 1067-1083 17 p.

Research output: Contribution to journalArticle

Peroxisomes
Ubiquitination
Recycling
Cysteine
Dithiothreitol
6 Citations (Scopus)

Design and synthesis of sphingomyelin-cholesterol conjugates and their formation of ordered membranes

Matsumori, N., Tanada, N., Nozu, K., Okazaki, H., Oishi, T. & Murata, M., Jul 25 2011, In : Chemistry - A European Journal. 17, 31, p. 8568-8575 8 p.

Research output: Contribution to journalArticle

Sphingomyelins
Cholesterol
Membranes
Lipids
Molecular recognition
55 Citations (Scopus)

Endocrine disrupter bisphenol a increases in situ estrogen production in the mouse urogenital sinus

Arase, S., Ishii, K., Igarashi, K., Aisaki, K., Yoshio, Y., Matsushima, A., Shimohigashi, Y., Arima, K., Kanno, J. & Sugimura, Y., Apr 1 2011, In : Biology of Reproduction. 84, 4, p. 734-742 9 p.

Research output: Contribution to journalArticle

Estrogens
Aromatase
Messenger RNA
Prostate
Up-Regulation

Exploration of the binding site of ORL1 nociceptin receptor antagonist

Inamine, S., Nishimura, H., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2011, Peptide Science 2010. p. 167

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

23 Citations (Scopus)

FMP30 is required for the maintenance of a normal cardiolipin level and mitochondrial morphology in the absence of mitochondrial phosphatidylethanolamine synthesis

Kuroda, T., Tani, M., Moriguchi, A., Tokunaga, S., Higuchi, T., Kitada, S. & Kuge, O., Apr 1 2011, In : Molecular Microbiology. 80, 1, p. 248-265 18 p.

Research output: Contribution to journalArticle

Cardiolipins
Maintenance
Mitochondrial Genes
Growth
Genes

Metabolic machinery of sphingolipid signaling molecules

Tani, M., Dec 1 2011, In : Seikagaku. 83, 7, p. 623-627 5 p.

Research output: Contribution to journalArticle

Biological Transport
Intracellular Space
Sphingolipids
Signal Transduction
Transferases (Other Substituted Phosphate Groups)
17 Citations (Scopus)

Pigment-dispersing factor affects nocturnal activity rhythms, photic entrainment, and the free-running period of the circadian clock in the cricket gryllus bimaculatus

Hassaneen, E., El-Din Sallam, A., Abo-Ghalia, A., Moriyama, Y., Karpova, S. G., Abdelsalam, S., Matsushima, A., Shimohigashi, Y. & Tomioka, K., Feb 1 2011, In : Journal of Biological Rhythms. 26, 1, p. 3-13 11 p.

Research output: Contribution to journalArticle

Gryllidae
Circadian Clocks
Photoperiod
Light
Double-Stranded RNA
2 Citations (Scopus)

Practical synthesis of DOPA derivative for biosynthetic production of potent antitumor natural products, saframycins and ecteinascidin 743

Torikai, K., Saruwatari, T., Kitano, T., Sano, T., Nakane, A., Noguchi, H. & Watanabe, K., Dec 1 2011, In : Letters in Organic Chemistry. 8, 10, p. 686-689 4 p.

Research output: Contribution to journalArticle

trabectedin
Biological Products
Purification
Crystallization
High Pressure Liquid Chromatography

QCM-analyses of the intermolecular interaction between prion protein N-terminal domains having increased number of octapeptide repeat.

Sato, K., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 2011, Peptide Science 2010. p. 128

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2 Citations (Scopus)

Recent applications of the suzuki-miyaura cross-coupling to complex polycyclic ether synthesis

Fuwa, H., Ebine, M. & Sasaki, M., Nov 2011, In : Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 69, 11, p. 1251-1262 12 p.

Research output: Contribution to journalArticle

Biological Products
Ether
Ladders
Palladium
Bioactivity

Structural essentials of hyperalgesic nococeptin ORL1 receptor for ligand binding and receptor activation

Nishimura, H., Li, J., Isozaki, K., Abe, Y., Inamine, S., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2011, Peptide Science 2010. p. 128

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

5 Citations (Scopus)

Synthesis of 6-F-ergosterol and its influence on membrane-permeabilization of amphotericin B and amphidinol 3

Kasai, Y., Matsumori, N., Ueno, H., Nonomura, K., Yano, S., Michio, M. & Oishi, T., Mar 1 2011, In : Organic and Biomolecular Chemistry. 9, 5, p. 1437-1442 6 p.

Research output: Contribution to journalArticle

Amphotericin B
Ergosterol
membranes
Membranes
Sterols