Organic and Biological Chemistry

Research Output 1983 2019

2011
1 Citation (Scopus)

The mucin box and signal/anchor sequence of rat neutral ceramidase recruit bacterial sphingomyelinase to the plasma membrane

Nakagawa, T., Tani, M., Sueyoshi, N. & Ito, M., Jun 6 2011, In : Bioscience, Biotechnology and Biochemistry. 75, 5, p. 987-990 4 p.

Research output: Contribution to journalArticle

Neutral Ceramidase
Sphingomyelin Phosphodiesterase
Mucins
Cell membranes
Protein Sorting Signals

The Trp Residue of Opioid Receptor TM5 is Present at the Cell Membrane Interface as a Molecular Anchor for Full Activation

Nishimura, H., Li, J., Inokuchi, N., Koikawa, S., Nose, T., Matsushima, A., Costa, T. & Shimohigashi, Y., Mar 2011, Peptide Science 2010. p. 175 1 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

13 Citations (Scopus)

Total synthesis of (-)-brevenal: A streamlined strategy for practical synthesis of polycyclic ethers

Ebine, M., Fuwa, H. & Sasaki, M., Dec 2 2011, In : Chemistry - A European Journal. 17, 49, p. 13754-13761 8 p.

Research output: Contribution to journalArticle

Ethers
Polyethers
Lactones
Bioactivity
Biological Products
2010
151 Citations (Scopus)

Adrenocortical zonation in humans under normal and pathological conditions

Nishimoto, K., Nakagawa, K., Li, D., Kosaka, T., Oya, M., Mikami, S., Shibata, H., Itoh, H., Mitani, F., Yamazaki, T., Ogishima, T., Suematsu, M. & Mukai, K., May 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 5, p. 2296-2305 10 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Steroid 11-beta-Hydroxylase
Aldosterone
Adenoma
Enzymes
109 Citations (Scopus)

Bisphenol AF is a full agonist for the estrogen receptor ERα but a highly specific antagonist for ERβ

Matsushima, A., Liu, X., Okada, H., Shimohigashi, M. & Shimohigashi, Y., Sep 1 2010, In : Environmental Health Perspectives. 118, 9, p. 1267-1272 6 p.

Research output: Contribution to journalArticle

Estrogens
Reporter Genes
Estradiol
4,4'-hexafluorisopropylidene diphenol
Physiological Phenomena
14 Citations (Scopus)
Acid resistance
Ceramides
Inositol
Yeast
Saccharomyces cerevisiae
10 Citations (Scopus)

Detection of Rap1A as a yessotoxin binding protein from blood cell membranes

Ujihara, S., Oishi, T., Mouri, R., Tamate, R., Konoki, K., Matsumori, N., Murata, M., Oshima, Y., Sugiyama, N., Tomita, M. & Ishihama, Y., Nov 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 22, p. 6443-6446 4 p.

Research output: Contribution to journalArticle

Cell membranes
Blood Cells
Carrier Proteins
Blood
Polyethers
16 Citations (Scopus)

Distinction of the binding modes for human nuclear receptor ERRγ between bisphenol A and 4-hydroxytamoxifen

Liu, X., Matsushima, A., Okada, H. & Shimohigashi, Y., Aug 1 2010, In : Journal of biochemistry. 148, 2, p. 247-254 8 p.

Research output: Contribution to journalArticle

Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Estrogens
Phenol
Hydrogen Bonding

Functional role of the C-terminal Helix 12 peptide in the receptor activation mechanism of estrogen-related receptor γ (ERRγ)

Liu, X., Matsushima, A., Nose, T., Okada, H. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 435–436

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

24 Citations (Scopus)

Highly efficient synthesis of medium-sized lactones via oxidative lactonization: Concise total synthesis of isolaurepanf

Ebine, M., Suga, Y., Fuwa, H. & Sasaki, M., Feb 23 2010, In : Organic and Biomolecular Chemistry. 8, 1, p. 39-42 4 p.

Research output: Contribution to journalArticle

Lactones
synthesis
TEMPO

Identification of circadian neuropeptide PDF mRNA isoforms in the housefly Musca domestica

Kawanaka, C., Matsushima, A., Takeda, Y., Shimohigashi, M. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 145–146

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

33 Citations (Scopus)

Mannosylinositol phosphorylceramide is a major sphingolipid component and is required for proper localization of plasma-membrane proteins in Schizosaccharomyces pombe

Nakase, M., Tani, M., Morita, T., Kitamoto, H. K., Kashiwazaki, J., Nakamura, T., Hosomi, A., Tanaka, N. & Takegawa, K., May 1 2010, In : Journal of Cell Science. 123, 9, p. 1578-1587 10 p.

Research output: Contribution to journalArticle

Sphingolipids
Schizosaccharomyces
Blood Proteins
Membrane Proteins
Cell Membrane
17 Citations (Scopus)
Sphingolipids
Saccharomyces cerevisiae
Yeasts
Enzymes
Growth

Structure-function analysis of nociceptin receptor ORL1 by the site-directed mutagenesis

Li, J., Isozaki, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 219–220

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

5 Citations (Scopus)

Synthesis and properties of fullerene (C70) complexes of 2,6-bis(porphyrin)-substituted pyrazine derivatives bound to a Pd(II) ion

Eda, Y., Itoh, K., Ito, Y. N., Fujitsuka, M., Majima, T. & Kawato, T., Sep 1 2010, In : Supramolecular Chemistry. 22, 9, p. 517-523 7 p.

Research output: Contribution to journalArticle

Pyrazines
Porphyrins
Ions
Derivatives
Association reactions
64 Citations (Scopus)

The AAA+ ATPase ATAD3A controls mitochondrial dynamics at the interface of the inner and outer membranes

Gilquin, B., Taillebourg, E., Cherradi, N., Hubstenberger, A., Gay, O., Merle, N., Assard, N., Fauvarque, M. O., Tomohiro, S., Kuge, O. & Baudier, J., Apr 2010, In : Molecular and cellular biology. 30, 8, p. 1984-1996 13 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Adenosine Triphosphatases
Membranes
Eukaryota
Drosophila

The direct measure of intermolecular interaction of prion protein N-terminal octapeptide repeats by the quarts crystal microbalance (QCM)

Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 207–208

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

The functional role of Trp present at the cell membrane interface in the opioid receptor activation

Nishimura, H., Li, J., Inokuchi, N., Koikawa, A., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 23–24

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

The preparation and purification of prion protein N-terminal domain with fluctuations in the number of octapeptide repeat

Sato, K., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 219–220

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

The role of the peptide PAP coded in pdf gene

Shimohigashi, M., Ito, T., Honda, T., Saito, M., Koga, K., Takahashi, K., Matsushima, A., Ueda, R., Tanimura, T., Shimohigashi, Y. & Matsumoto, A., 2010, Peptide Science 2009. p. 207–208

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2009
7 Citations (Scopus)

2,6-Bis(porphyrin)-substituted pyrazine: a new class of supramolecular synthon binding to a transition-metal ion and fullerene (C60)

Eda, Y., Itoh, K., Ito, Y. & Kawato, T., Jan 3 2009, In : Tetrahedron. 65, 1, p. 282-288 7 p.

Research output: Contribution to journalArticle

Pyrazines
Porphyrins
Transition metals
Metal ions
Metals

Bisphenol A-specific nuclear receptor ERRγ: structure-function analysis of the two novel isoforms lacking vital peptide fragment in the ligand binding domain

Takeda, Y., Liu, X., Sumiyoshi, M., Matsushima, A., Shimohigashi, Y. & Shimohigashi, M., 2009, Peptide Science 2008. p. 517-518

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

5 Citations (Scopus)

Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)14, (Arg/Lys)15]nociceptin on ORL1 receptor binding and activation

Nishimura, H., Li, J., Isozaki, K., Okada, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., Aug 1 2009, In : Bioorganic and Medicinal Chemistry. 17, 15, p. 5683-5687 5 p.

Research output: Contribution to journalArticle

Substitution reactions
Chemical activation
nociceptin
nociceptin receptor
Arg(14)-Lys(15)-nociceptin

ERα/ERRα nuclear receptor heterodimer directly linked by a flag peptide

Ikeda, S., Matsushima, A. & Shimohigashi, Y., 2009, Peptide Science 2008. p. 511-512

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Induced-fit type ligand binding guided by free-rotatory Leu residue present in the 7th α-helix peptide in the estrogen-related receptor γ (ERRγ)

Matsushima, A., Okada, H., Liu, X., Tokunaga, T., Teramoto, T., Kakuta, Y. & Shimohigashi, Y., 2009, Peptide Science 2008. p. 521-522

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

24 Citations (Scopus)

In vitro import of peroxisome-targeting signal type 2 (PTS2) receptor Pex7p into peroxisomes

Miyata, N., Hosoi, K. I., Mukai, S. & Fujiki, Y., May 1 2009, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1793, 5, p. 860-870 11 p.

Research output: Contribution to journalArticle

Peroxisomes
Adenosine Triphosphate
Ethylmaleimide
In Vitro Techniques
peroxisomal targeting signal 2 receptor
22 Citations (Scopus)

Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase

Inoue, T., Okino, N., Kakuta, Y., Hijikata, A., Okano, H., Goda, H. M., Tani, M., Sueyoshi, N., Kambayashi, K., Matsumura, H., Kai, Y. & Ito, M., Apr 3 2009, In : Journal of Biological Chemistry. 284, 14, p. 9566-9577 12 p.

Research output: Contribution to journalArticle

Neutral Ceramidase
Ceramides
Exotoxins
Hydrolysis
Ceramidases

Molecular recognition of prion protein via its N-terminal octapeptide repeat Structure

Horiuchi, Y., Hattori, E., Yokotani, S., Matsushima, A. & Shimohigashi, Y., 2009, Peptide Science 2008. p. 513-516

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

60 Citations (Scopus)

Placenta expressing the greatest quantity of bisphenol A receptor ERRγ among the human reproductive tissues: Predominant expression of type-1 ERRγ isoform

Takeda, Y., Liu, X., Sumiyoshi, M., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., Jul 1 2009, In : Journal of biochemistry. 146, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Placenta
Protein Isoforms
Estrogens
Tissue
21 Citations (Scopus)

Purification and characterization of human phosphatidylserine synthases 1 and 2

Tomohiro, S., Kawaguti, A., Kawabe, Y., Kitada, S. & Kuge, O., Mar 1 2009, In : Biochemical Journal. 418, 2, p. 421-429 9 p.

Research output: Contribution to journalArticle

CDPdiacylglycerol-Serine O-Phosphatidyltransferase
Phosphatidylserines
Purification
Phosphatidylcholines
Mouse Ptdss2 protein
38 Citations (Scopus)

Ribosomal synthesis of dehydrobutyrine- and methyllanthionine-containing peptides

Goto, Y., Iwasaki, K., Torikai, K., Murakami, H. & Suga, H., Aug 7 2009, In : Chemical Communications. 23, p. 3419-3421 3 p.

Research output: Contribution to journalArticle

Isomerization
Peptides
Cyclic Peptides
Cysteine
dehydrobutyrine
24 Citations (Scopus)
Cell membranes
Cysteine
Cell Membrane
Enzymes
Lipoylation
2008
59 Citations (Scopus)

Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase

Briggs, L. C., Baldwin, G. S., Miyata, N., Kondo, H., Zhang, X. & Freemont, P. S., May 16 2008, In : Journal of Biological Chemistry. 283, 20, p. 13745-13752 8 p.

Research output: Contribution to journalArticle

Adenosine Triphosphatases
Nucleotides
Adenosine Diphosphate
Endoplasmic Reticulum-Associated Degradation
Organelle Biogenesis
10 Citations (Scopus)

Cytochrome P-45017α in β-cells of rat pancreas and its local steroidogenesis

Ogishima, T., Mitani, F. & Suematsu, M., Jul 1 2008, In : Journal of Steroid Biochemistry and Molecular Biology. 111, 1-2, p. 80-86 7 p.

Research output: Contribution to journalArticle

Cytochromes
Lyases
Androstenedione
Rats
Pancreas
14 Citations (Scopus)

Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist

Li, J., Isozaki, K., Okada, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., Mar 1 2008, In : Bioorganic and Medicinal Chemistry. 16, 5, p. 2635-2644 10 p.

Research output: Contribution to journalArticle

Opioid Receptors
Peptide Library
Peptides
Carbon Monoxide
Analgesics
275 Citations (Scopus)

Direct evidence revealing structural elements essential for the high binding ability of bisphenol a to human estrogen-related receptor-γ

Okada, H., Tokunaga, T., Liu, X., Takayanagi, S., Matsushima, A. & Shimohigashi, Y., Jan 1 2008, In : Environmental Health Perspectives. 116, 1, p. 32-38 7 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Endocrine Disruptors
Phenol
Luciferases
Reporter Genes
20 Citations (Scopus)
Peroxisomes
Oligomers
Adenosine Triphosphate
Membranes
Adenosine Triphosphatases
54 Citations (Scopus)

ERRγ tethers strongly bisphenol A and 4-α-cumylphenol in an induced-fit manner

Matsushima, A., Teramoto, T., Okada, H., Liu, X., Tokunaga, T., Kakuta, Y. & Shimohigashi, Y., Aug 29 2008, In : Biochemical and Biophysical Research Communications. 373, 3, p. 408-413 6 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Phenol
Hydroxyl Radical
Crystal structure

Optimization of the N-terminal group of Ac-RYYRIK-NH2 as ORL1 receptor antagonist

Li, J., Isozaki, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2008, Peptide Science 2007. p. 257-260

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

1 Citation (Scopus)

Radar chart deviation analysis of prion protein amino acid composition defines characteristic structural abnormalities of the N-terminal octapeptide tandem repeat

Yokotani, S., Nose, T., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., Sep 1 2008, In : Protein and Peptide Letters. 15, 9, p. 949-955 7 p.

Research output: Contribution to journalArticle

Radar
Tandem Repeat Sequences
Amino Acids
Aromatic Amino Acids
Prion Diseases

Structural requirement of housefly FMRFamide peptides in its receptor activation

Matsushima, A., Koretsune, Y., Kaneki, A., Isozaki, K., Shimohigashi, M. & Shimohigashi, Y., 2008, Peptide Science 2007. p. 313-314

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

4 Citations (Scopus)

Synthesis of pyrazine acetals by the biased reaction of symmetric 2,5-bis(chloromethyl) or 2,3,5,6-tetrakis(chloromethyl) substituents on pyrazine ring with sodium alkoxides

Eda, Y., Odazaki, Y., Mizutani, A., Ito, Y. & Kawato, T., Apr 14 2008, In : Tetrahedron Letters. 49, 16, p. 2519-2522 4 p.

Research output: Contribution to journalArticle

Pyrazines
Acetals
Sodium
Substitution reactions

The Conformation Change-sensing Antibodies for Retinoid-related Orphan Receptor Family

Nose, T., Nishigori, M., Liu, X., Tokunaga, T. & Shimohigashi, Y., Mar 2008, Peptide Science 2007. p. 497-492 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

The effect of amino acid substitution on oligomerization of octapeptide repeat structure in prion protein

Hattori, E., Yokotani, S., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 2008, Peptide Science 2007. p. 239-242

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

The output mechanism of circadian pacemaker neuropeptide PDF in the regulation of bimodal locomotor distribution

Takeda, Y., Koga, K., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2008, Peptide Science 2007. p. 65-68

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

40 Citations (Scopus)

Total synthesis of (-)-brevenal: A concise synthetic entry to the pentacyclic polyether core

Ebine, M., Fuwa, H. & Sasaki, M., Jun 5 2008, In : Organic Letters. 10, 11, p. 2275-2278 4 p.

Research output: Contribution to journalArticle

Ribose
Polyethers
Alkenes
Biological Products
entry
2007
21 Citations (Scopus)

A protein from a parasitic microorganism, Rickettsia prowazekii, can cleave the signal sequences of proteins targeting mitochondria

Kitada, S., Uchiyama, T., Funatsu, T., Kitada, Y., Ogishima, T. & Ito, A., Feb 1 2007, In : Journal of bacteriology. 189, 3, p. 844-850 7 p.

Research output: Contribution to journalArticle

Rickettsia prowazekii
Protein Transport
Protein Sorting Signals
Mitochondria
Peptide Hydrolases
4 Citations (Scopus)

Double-labelled in situ hybridization reveals the lack of co-localization of mRNAs for the circadian neuropeptide PDF and FMRFamide in brains of the flies Musca domestica and Drosophila melanogaster

Matsushima, A., Takano, K., Yoshida, T., Takeda, Y., Yokotani, S., Shimohigashi, Y. & Shimohigashi, M., Jun 1 2007, In : Journal of biochemistry. 141, 6, p. 867-877 11 p.

Research output: Contribution to journalArticle

FMRFamide
Houseflies
Neuropeptides
Drosophila melanogaster
Pigments
15 Citations (Scopus)

Haeme-regulated degradation of δ-aminolevulinate synthase 1 in rat liver mitochondria

Yoshino, K., Munakata, H., Kuge, O., Ito, A. & Ogishima, T., Oct 1 2007, In : Journal of biochemistry. 142, 4, p. 453-458 6 p.

Research output: Contribution to journalArticle

Mitochondria
Liver Mitochondrion
Heme
Liver
Rats