Organic and Biological Chemistry

Research Output 1983 2019

2007
15 Citations (Scopus)

Haeme-regulated degradation of δ-aminolevulinate synthase 1 in rat liver mitochondria

Yoshino, K., Munakata, H., Kuge, O., Ito, A. & Ogishima, T., Oct 1 2007, In : Journal of biochemistry. 142, 4, p. 453-458 6 p.

Research output: Contribution to journalArticle

Mitochondria
Liver Mitochondrion
Heme
Liver
Rats
65 Citations (Scopus)

Klotho-related protein is a novel cytosolic neutral β- glycosylceramidase

Hayashi, Y., Okino, N., Kakuta, Y., Shikanai, T., Tani, M., Narimatsu, H. & Ito, M., Oct 19 2007, In : Journal of Biological Chemistry. 282, 42, p. 30889-30900 12 p.

Research output: Contribution to journalArticle

Lactase-Phlorizin Hydrolase
Glucosylceramides
Proteins
Enzymes
Substrates
91 Citations (Scopus)

Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis

Chida, D., Nakagawa, S., Nagai, S., Sagara, H., Katsumata, H., Imaki, T., Suzuki, H., Mitani, F., Ogishima, T., Shimizu, C., Kotaki, H., Kakuta, S., Sudo, K., Koike, T., Kubo, M. & Iwakura, Y., Nov 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 46, p. 18205-18210 6 p.

Research output: Contribution to journalArticle

Receptor, Melanocortin, Type 2
Gluconeogenesis
Adrenal Glands
Knockout Mice
Adrenocorticotropic Hormone
28 Citations (Scopus)
Endocrine Disruptors
Phenol
Estrogen Receptors
Hydroxyl Radical
Hydrogen
4 Citations (Scopus)

Spatial orientation of mitochondrial processing peptidase and a preprotein revealed by fluorescence resonance energy transfer

Nishino, T. G., Kitano, K., Kojima, K., Ogishima, T., Ito, A. & Kitada, S., Jun 1 2007, In : Journal of biochemistry. 141, 6, p. 889-895 7 p.

Research output: Contribution to journalArticle

Fluorescence Resonance Energy Transfer
Yeast
Yeasts
Glycine
mitochondrial processing peptidase
146 Citations (Scopus)

Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERRγ

Matsushima, A., Kakuta, Y., Teramoto, T., Koshiba, T., Liu, X., Okada, H., Tokunaga, T., Kawabata, S. I., Kimura, M. & Shimohigashi, Y., Oct 1 2007, In : Journal of biochemistry. 142, 4, p. 517-524 8 p.

Research output: Contribution to journalArticle

Endocrine Disruptors
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Estrogens
Ligands
26 Citations (Scopus)

Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: A mechanism involving an initial effect on gonadotropin synthesis in the pituitary

Taketoh, J., Mutoh, J., Takeda, T., Ogishima, T., Takeda, S., Ishii, Y., Ishida, T. & Yamada, H., Mar 13 2007, In : Life Sciences. 80, 14, p. 1259-1267 9 p.

Research output: Contribution to journalArticle

Maternal Exposure
Gonadotropins
Cytochrome P-450 Enzyme System
Luteinizing Hormone
Multifetal Pregnancy Reduction
2006

a-helix peptides for bio-panning in the phage display method to obtain the antibodies specific for conformation-change nuclear receptors

Okada, H., Tokunaga, T., Shirasu, N., Matsushima, A., Nose, T. & Shimohigashi, Y., 2006, Science 2005. p. 209-210

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Conformation change of α-helix peptide for sensing of deactivation of nuclear peceptor: Immunoassay using polyclonal antibody specific for the C-terminal a-helix 12 of estrogen-related receptor γ (ERRγ)

Tokunaga, T., Liu, X., Okada, H., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 176

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

43 Citations (Scopus)

Cytocidal actions of parasporin-2, an anti-tumor crystal toxin from Bacillus thuringiensis

Kitada, S., Abe, Y., Shimada, H., Kusaka, Y., Matsuo, Y., Katayama, H., Okumura, S., Akao, T., Mizuki, E., Kuge, O., Sasaguri, Y., Ohba, M. & Ito, A., Sep 8 2006, In : Journal of Biological Chemistry. 281, 36, p. 26350-26360 11 p.

Research output: Contribution to journalArticle

Bacillus thuringiensis
Bacilli
Tumors
Cells
Crystals

Design and synthesis of a-helix peptide binding to prion protein N-terminal octarepeat domain

Koga, K., Sato, S., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 2006, Science 2005. p. 209-210

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

238 Citations (Scopus)

Endocrine disruptor bisphenol A strongly binds to human estrogen-related receptor γ (ERRγ) with high constitutive activity

Takayanagi, S., Tokunaga, T., Liu, X., Okada, H., Matsushima, A. & Shimohigashi, Y., Dec 1 2006, In : Toxicology Letters. 167, 2, p. 95-105 11 p.

Research output: Contribution to journalArticle

Endocrine Disruptors
Estrogen Receptors
Estrogens
Cytoplasmic and Nuclear Receptors
Assays

Identification of novel isoforms of the circadian neuropeptide PDF in the silk moth Bombyx mori and their expression in brain

Sato, S., Jonathan, C., Takeda, Y., Kaneki, A., Matsushima, A. & Shimohigashi, Y., 2006, Science 2005. p. 99-100

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Immunological confirmation of circadian-related neuropeptide PDF-isoform peptide in the cricket Gryllus bimaculatus

Koga, K., Hiramura, D., Takeda, Y., Kaneki, A., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 262

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Molecular cloning and in situ hybridization of circadian neuropeptide PDF receptor in the fruit fly Drosophila melanogaster

Kaneki, A., Yoshida, T., Isozaki, K., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 263

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Monoclonal antibody sensing assay for conformation change induced by metal binding to prion protein N-terminal octarepear domain

Yokotani, S., Honda, T., Kawano, M., Matsushima, A. & Shimohigashi, Y., 2006, Science 2005. p. 455-456

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Multiple post-transcriptional regulations in circadian pacemaker neuropeptide pdf gene

Takeda, Y., Sumiyoshi, M., Koga, K., Ito, M., Matsushima, A., Shimohigashi, Y. & Shimohigashi, M., 2006, Peptide Science 2006. p. 260

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

32 Citations (Scopus)
Infantile Refsum's Disease
Zellweger Syndrome
Mutation
Peroxisomes
Genes
2 Citations (Scopus)

Neutral ceramidase as an integral modulator for the generation of S1P and S1P-mediated signaling

Ito, M., Tani, M. & Yoshimura, Y., 2006, Sphingolipid Biology. Springer Japan, p. 183-196 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neutral Ceramidase
Modulators
Ceramides
Enzymes
Bacteria
3 Citations (Scopus)

Phosphatidylserine is involved in gene expression from Sindbis virus subgenomic promoter

Saito, K., Nishijima, M. & Kuge, O., Jun 30 2006, In : Biochemical and Biophysical Research Communications. 345, 2, p. 878-885 8 p.

Research output: Contribution to journalArticle

Sindbis Virus
Phosphatidylserines
Viruses
Gene expression
RNA
4 Citations (Scopus)

Requirement of an IκB-β COOH terminal region protein for acidic-adaptation in CHO cells

Lao, Q., Fukamachi, T., Saito, H., Kuge, O., Nishijima, M. & Kobayashi, H., Apr 1 2006, In : Journal of cellular physiology. 207, 1, p. 238-243 6 p.

Research output: Contribution to journalArticle

CHO Cells
Transcription
Genes
p38 Mitogen-Activated Protein Kinases
Proteins
21 Citations (Scopus)

Rescue of cell growth by sphingosine with disruption of lipid microdomain formation in Saccharomyces cerevisiae deficient in sphingolipid biosynthesis

Tani, M., Kihara, A. & Igarashi, Y., Feb 15 2006, In : Biochemical Journal. 394, 1, p. 237-242 6 p.

Research output: Contribution to journalArticle

Sphingolipids
Sphingosine
Biosynthesis
Cell growth
Yeast

Specific dimerization of prion protein N-terminal domain

Matsushima, A., Horiuchi, Y., Yokotani, S., Kawano, M. & Shimohigashi, Y., 2006, Science 2005. p. 209-210

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

17 Citations (Scopus)

Structural isoforms of the circadian neuropeptide PDF expressed in the optic lobes of the cricket Gryllus bimaculatus: Immunocytochemical evidence from specific monoclonal antibodies

Honda, T., Matsushima, A., Sumida, K., Chuman, Y., Sakaguchi, K., Onoue, H., Meinertzhagen, I. A., Shimohigashi, Y. & Shimohigashi, M., Nov 20 2006, In : Journal of Comparative Neurology. 499, 3, p. 404-421 18 p.

Research output: Contribution to journalArticle

Gryllidae
Neuropeptides
Protein Isoforms
Monoclonal Antibodies
Peptides

Structure-activity studies of FMRFamide-related peptides in activating the specific receptor present in the housefly Musca domestica

Matsushima, A., Koretsune, Y., Kaneki, A., Isozaki, K., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 174

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

107 Citations (Scopus)

Total synthesis, structure revision, and absolute configuration of (-)-brevenal

Fuwa, H., Ebine, M., Bourdelais, A. J., Baden, D. G. & Sasaki, M., Dec 27 2006, In : Journal of the American Chemical Society. 128, 51, p. 16989-16999 11 p.

Research output: Contribution to journalArticle

Biological Products
Polyethers
Tides
Harmful Algal Bloom
Ethers
51 Citations (Scopus)

Total synthesis of the proposed structure of brevenal

Fuwa, H., Ebine, M. & Sasaki, M., Aug 2 2006, In : Journal of the American Chemical Society. 128, 30, p. 9648-9650 3 p.

Research output: Contribution to journalArticle

Biological Products
Skeleton
Ether
Polyethers
Ethers
2005
6 Citations (Scopus)

An IκB-β COOH terminal region protein is essential for the proliferation of CHO cells under acidic stress

Lao, Q., Kuge, O., Fukamachi, T., Kakegawa, T., Saito, H., Nishijima, M. & Kobayashi, H., Apr 1 2005, In : Journal of cellular physiology. 203, 1, p. 186-192 7 p.

Research output: Contribution to journalArticle

CHO Cells
Symporters
Proton-Translocating ATPases
Homeostasis
Protons
5 Citations (Scopus)

Ascorbate stimulates monooxygenase-dependent steroidogenesis in adrenal zona glomerulosa

Mitani, F., Ogishima, T., Mukai, K. & Suematsu, M., Dec 9 2005, In : Biochemical and Biophysical Research Communications. 338, 1, p. 483-490 8 p.

Research output: Contribution to journalArticle

Zona Glomerulosa
Mixed Function Oxygenases
Ascorbic Acid
Aldosterone
Adrenal Cortex

Bioactive conformation of a D-Trp-containing cardioexcitatory tripeptide isolated from the sea hare Aplysia

Yokotani, S., Matsushima, A., Nose, T., Morishita, F. & Shimohigashi, Y., 2005, Peptide Science 2004. p. 539-540

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

8 Citations (Scopus)

C18:3-GM1a induces apoptosis in Neuro2a cells: Enzymatic remodeling of fatty acyl chains of glycosphingolipids

Nakagawa, T., Morotomi, A., Tani, M., Sueyoshi, N., Komori, H. & Ito, M., Dec 1 2005, In : Journal of Lipid Research. 46, 6, p. 1103-1112 10 p.

Research output: Contribution to journalArticle

Glycosphingolipids
Gangliosides
Apoptosis
Chemical activation
Lipids

cDNA cloning and mRNA expression of the circadian neuropeptide PDF in the silk moth Bombyx mori

Sato, S., Sumida, K., Hiramura, D., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004. p. 197-200

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Conformation change-senseing assay using monoclonal antibody for N-terminal octapeptide repreat region of prion protein

Kawano, M., Honda, T., Horiuchi, Y., Yokotani, S., Matsushima, A., Nose, T. & Shimohigashi, Y., 2005, Peptide Science 2004.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

88 Citations (Scopus)

Convergent total synthesis of gymnocin-A and evaluation of synthetic analogues

Tsukano, C., Ebine, M. & Sasaki, M., Mar 30 2005, In : Journal of the American Chemical Society. 127, 12, p. 4326-4335 10 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Skeleton
Polyethers
Harmful Algal Bloom
Dinoflagellida

FMRFamide-related peptides in the nervous system of the housefly Musca domestica: cDNA cloning and actions on clam heart contraction.

Matsushima, A., Yokotani, S., Koretsune, Y., Meinertzhagen, I. A., Tominaga, Y., Shimohigashi, M. & Shimohigashi, Y., 2005, Peptide Science 2004. p. 157-160

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Immunocytochemical identification of mature peptide formation for the circadian neuromodulator PDF in the housefly Musca domestica

Sumida, K., Honda, T., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Immunocytochemical studies on the circadian neuropeptide PDF in the Cricket Gryllus bimaculatus

Shimohigashi, M., Honda, T., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004. p. 339-342

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

41 Citations (Scopus)

Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu

Tani, M., Igarashi, Y. & Ito, M., Nov 4 2005, In : Journal of Biological Chemistry. 280, 44, p. 36592-36600 9 p.

Research output: Contribution to journalArticle

Neutral Ceramidase
Ceramides
Cell membranes
Sphingosine
Metabolism
79 Citations (Scopus)

Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets

Tani, M., Sano, T., Ito, M. & Igarashi, Y., Nov 1 2005, In : Journal of Lipid Research. 46, 11, p. 2458-2467 10 p.

Research output: Contribution to journalArticle

Sphingosine
Platelets
Blood Platelets
Sphingomyelin Phosphodiesterase
Neutral Ceramidase
8 Citations (Scopus)

Recognition and processing of a nuclear-encoded polyprotein precursor by mitochondrial processing peptidase

Oshima, T., Yamasaki, E., Ogishima, T., Kadowaki, K. I., Ito, A. & Kitada, S., Feb 1 2005, In : Biochemical Journal. 385, 3, p. 755-761 7 p.

Research output: Contribution to journalArticle

Polyproteins
Processing
Mitochondria
Succinate Dehydrogenase
mitochondrial processing peptidase
149 Citations (Scopus)

Shuttling mechanism of peroxisome targeting signal type 1 receptor Pex5: ATP-independent import and ATP-dependent export

Miyata, N. & Fujiki, Y., Dec 1 2005, In : Molecular and cellular biology. 25, 24, p. 10822-10832 11 p.

Research output: Contribution to journalArticle

Peroxisomes
Adenosine Triphosphate
CHO Cells
Native Polyacrylamide Gel Electrophoresis
Cytosol

Structural characteristics of Drosophila estrogen-related receptor ligand binding domain to capture the peptide and non-peptide ligands

Liu, X., Matsushima, A., Shirasu, N., Tominaga, Y., Shimohigashi, M., Shimohigashi, Y. & Nose, T., 2005, Peptide Science 2004. p. 303-304

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural characteristics of the N-Terminal octapeptide repeat region of Prion protein in self-polymerization

Horiuchi, Y., Kawano, M., Yokotani, S., Honda, T., Matsushima, A., Nose, T. & Shimohigashi, Y., 2005, Peptide Science 2004. p. 317-318

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

51 Citations (Scopus)

Subcellular localization of human neutral ceramidase expressed in HEK293 cells

Hwang, Y. H., Tani, M., Nakagawa, T., Okino, N. & Ito, M., May 27 2005, In : Biochemical and Biophysical Research Communications. 331, 1, p. 37-42 6 p.

Research output: Contribution to journalArticle

HEK293 Cells
Cell membranes
Neutral Ceramidase
Ceramidases
Mitochondria

Triplicate alternative splicings that produce multiple variants of the PERIOD protein in the silk moth Bombyx mori by deletion/Insertion of peptides

Takeda, Y., Shirasu, N., Sato, S., Matsushima, A., Chuman, Y., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004. p. 203-206

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2004

cDNA cloning and in situ hybridization studies of sulfated peptide, sulfakinin, on housefly Musca domestica

Matsushima, A., Yokotani, S., Shimohigashi, Y., Tominaga, Y. & Shimohigashi, M., 2004, Peptide Science 2003. p. 459-462

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

19 Citations (Scopus)

cDNA cloning of the housefly pigment-dispersing factor (PDF) precursor protein and its peptides comparison among the insect circadian neuropeptides

Matsushima, A., Sato, S., Chuman, Y., Takeda, Y., Yokotani, S., Nose, T., Tominaga, Y., Shimohigashi, M. & Shimohigashi, Y., Feb 1 2004, In : Journal of Peptide Science. 10, 2, p. 82-91 10 p.

Research output: Contribution to journalArticle

Houseflies
Protein Precursors
Cloning
Neuropeptides
Pigments
7 Citations (Scopus)
Neutral Ceramidase
Enzyme activity
Tail
Amino Acids
Enzymes

Effect of the Phe-Phenyl H-F subsutitution in the sea hare Aplysia neuropeptide H-Asn-d-Phe-NH2 on the conformation and contraction activity

Kaneki, A., Matsushima, A., Takeda, Y., Yokotani, S., Ozaki, M., Shimohigashi, M. & Shimohigashi, Y., 2004, Peptide Science 2003. p. 459-462

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Effects of the Phe-Phenyl H→F Substitutions in the Sea Hare Aplysia Neuropeptide H-Asn-D-Trp-Phe-NH2 on the Conformation and Contractile Activity

Yokotani, S., Matsushima, A., Nose, T., Shimohigashi, Y. & Morishita, F., Mar 2004, Peptide Science 2003. p. 263-266 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)