Organic and Biological Chemistry

Research Output 1983 2020

Structural characteristics of Drosophila estrogen-related receptor ligand binding domain to capture the peptide and non-peptide ligands

Liu, X., Matsushima, A., Shirasu, N., Tominaga, Y., Shimohigashi, M., Shimohigashi, Y. & Nose, T., 2005, Peptide Science 2004. p. 303-304

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural characteristics of the N-Terminal octapeptide repeat region of Prion protein in self-polymerization

Horiuchi, Y., Kawano, M., Yokotani, S., Honda, T., Matsushima, A., Nose, T. & Shimohigashi, Y., 2005, Peptide Science 2004. p. 317-318

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural Characteristics of Thr-Gly Dipeptide Repeat in the Drosophila Clock Protein PERIOD

Matsuo, A., Nishimura, H., Masayuki, N., Koga, K., Sumiyoshi, M., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., Mar 2012, Peptide Science 2011. p. 351-352 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural characterization of the house fly PDF, a circadian rhythm pacemaker hormone

Matsushima, A., Nose, T., Tomioka, K., Shimohigashi, M. & Shimohigashi, Y., 2003, Peptide Science 2002. p. 333-336

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

26 Citations (Scopus)

Structural differences in 5′-flanking regions of rat cytochrome P-450aldo and P-45011β genes

Mukai, K., Imai, M., Shimada, H., Okada, Y., Ogishima, T. & Ishimura, Y., Nov 14 1991, In : Biochemical and Biophysical Research Communications. 180, 3, p. 1187-1193 7 p.

Research output: Contribution to journalArticle

5' Flanking Region
Cytochromes
Rats
Genes
Nuclease Protection Assays

Structural Essentials of Hyperalgesic Nociceptin ORL1 Receptor for Ligand Binding and Receptor Activation

Nishimura, H., Li, J., Isozaki, K., Abe, Y., Inamine, S., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2012, Peptide Science 2011. p. 33-34

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural essentials of hyperalgesic nococeptin ORL1 receptor for ligand binding and receptor activation

Nishimura, H., Li, J., Isozaki, K., Abe, Y., Inamine, S., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2011, Peptide Science 2010. p. 128

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

146 Citations (Scopus)

Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERRγ

Matsushima, A., Kakuta, Y., Teramoto, T., Koshiba, T., Liu, X., Okada, H., Tokunaga, T., Kawabata, S. I., Kimura, M. & Shimohigashi, Y., Oct 1 2007, In : Journal of biochemistry. 142, 4, p. 517-524 8 p.

Research output: Contribution to journalArticle

Endocrine Disruptors
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Estrogens
Ligands
17 Citations (Scopus)

Structural isoforms of the circadian neuropeptide PDF expressed in the optic lobes of the cricket Gryllus bimaculatus: Immunocytochemical evidence from specific monoclonal antibodies

Honda, T., Matsushima, A., Sumida, K., Chuman, Y., Sakaguchi, K., Onoue, H., Meinertzhagen, I. A., Shimohigashi, Y. & Shimohigashi, M., Nov 20 2006, In : Journal of Comparative Neurology. 499, 3, p. 404-421 18 p.

Research output: Contribution to journalArticle

Gryllidae
Neuropeptides
Protein Isoforms
Monoclonal Antibodies
Peptides

Structural requirement of housefly FMRFamide peptides in its receptor activation

Matsushima, A., Koretsune, Y., Kaneki, A., Isozaki, K., Shimohigashi, M. & Shimohigashi, Y., 2008, Peptide Science 2007. p. 313-314

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural requirements of the N-terminal octapeptide repeat of prion protein

Kawano, M., Horiuchi, Y., Honda, T., Yokotani, S., Matsushima, A., Nose, T. & Shimohigashi, Y., 2004, Peptide Science 2003. p. 483-486

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structure-activity studies of FMRFamide-related peptides in activating the specific receptor present in the housefly Musca domestica

Matsushima, A., Koretsune, Y., Kaneki, A., Isozaki, K., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 174

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structure-activity Studies on the Halogenated Phe-containing Neuropeptide Substance P Analogs

Kuramitsu, Y., Nishimura, H., Nakamura, M., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 319-320

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structure-Activity Studies on the Halogenated Phe-containing Neuropeptide Substance P Analogs

Kuramitsu, Y., Nishimura, H., Nakamura, R., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., Mar 2014, Peptide Science 2013. p. 319-320 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structure and function of nuclear localization signal peptide present in circadian rhythm hormone peptide precursor

Matsushima, A., Chuman, Y., Sato, S., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2002, Peptide Science 2001. p. 159-162

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structure-function analysis of nociceptin receptor ORL1 by the site-directed mutagenesis

Li, J., Isozaki, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 219–220

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

2 Citations (Scopus)

Structure-function relationship of complex sphingolipids in yeast

Tani, M., Jan 1 2016, In : Trends in Glycoscience and Glycotechnology. 28, 164, p. E109-E116

Research output: Contribution to journalReview article

Sphingolipids
Yeast
Yeasts
Saccharomyces cerevisiae
Ceramides

Structure-function relationship of complex sphingolipids in yeast

Tani, M., Jan 1 2016, In : Trends in Glycoscience and Glycotechnology. 28, 164, p. J107-J114

Research output: Contribution to journalReview article

Sphingolipids
Yeast
Yeasts
Saccharomyces cerevisiae
Ceramides

Structure-function studies between the hormone-disrupting chemical bisphenols and the nuclear receptors

Matsushima, A., Jan 1 2016, In : Seikagaku. 88, 6, p. 733-743 11 p.

Research output: Contribution to journalReview article

Benzhydryl Compounds
Phenols
Structure-Activity Relationship
Cytoplasmic and Nuclear Receptors
Hormones
51 Citations (Scopus)

Subcellular localization of human neutral ceramidase expressed in HEK293 cells

Hwang, Y. H., Tani, M., Nakagawa, T., Okino, N. & Ito, M., May 27 2005, In : Biochemical and Biophysical Research Communications. 331, 1, p. 37-42 6 p.

Research output: Contribution to journalArticle

HEK293 Cells
Cell membranes
Neutral Ceramidase
Ceramidases
Mitochondria
22 Citations (Scopus)

Substrate recognition by mitochondrial processing peptidase toward the malate dehydrogenase precursor

Shimokata, K., Nishio, T., Song, M. C., Kitada, S., Ogishima, T. & Ito, A., Jan 1 1997, In : Journal of biochemistry. 122, 5, p. 1019-1023 5 p.

Research output: Contribution to journalArticle

Malate Dehydrogenase
Arginine
Peptides
Substrates
Protein Precursors
26 Citations (Scopus)

Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: A mechanism involving an initial effect on gonadotropin synthesis in the pituitary

Taketoh, J., Mutoh, J., Takeda, T., Ogishima, T., Takeda, S., Ishii, Y., Ishida, T. & Yamada, H., Mar 13 2007, In : Life Sciences. 80, 14, p. 1259-1267 9 p.

Research output: Contribution to journalArticle

Maternal Exposure
Gonadotropins
Cytochrome P-450 Enzyme System
Luteinizing Hormone
Multifetal Pregnancy Reduction
3 Citations (Scopus)

Syntheses and Biological Activities of the LMNO, ent-LMNO, and NOPQR(S) Ring Systems of Maitotoxin

Onoue, H., Marubayashi, R., Ishikawa, E., Konoki, K., Torikai, K., Ebine, M., Murata, M. & Oishi, T., Jan 1 2017, In : Journal of Organic Chemistry. 82, 18, p. 9595-9618 24 p.

Research output: Contribution to journalArticle

Bioactivity
Enantiomers
Aldehydes
Alkynes
Biological Products
11 Citations (Scopus)

Synthesis and biological activity of the C'D'E'F' ring system of maitotoxin

Kunitake, M., Oshima, T., Konoki, K., Ebine, M., Torikai, K., Murata, M. & Oishi, T., Jun 6 2014, In : Journal of Organic Chemistry. 79, 11, p. 4948-4962 15 p.

Research output: Contribution to journalArticle

Cyclization
Bioactivity
Rats
maitotoxin
allyl alcohol
8 Citations (Scopus)

Synthesis and biological activity of the QRS ring system of maitotoxin

Onoue, H., Baba, T., Konoki, K., Torikai, K., Ebine, M. & Oishi, T., Jan 1 2014, In : Chemistry Letters. 43, 12, p. 1904-1906 3 p.

Research output: Contribution to journalArticle

Bioactivity
Acetals
Methylation
Polyethers
Ladders
1 Citation (Scopus)

Synthesis and complete structure determination of a sperm-activating and -attracting factor isolated from the ascidian ascidia sydneiensis

Watanabe, T., Shibata, H., Ebine, M., Tsuchikawa, H., Matsumori, N., Murata, M., Yoshida, M., Morisawa, M., Lin, S., Yamauchi, K., Sakai, K. & Oishi, T., Apr 27 2018, In : Journal of Natural Products. 81, 4, p. 985-997 13 p.

Research output: Contribution to journalArticle

Ergosterol
Urochordata
Biological Products
Ketones
Eggs
10 Citations (Scopus)

Synthesis and DNA cleaving activity of water-soluble non-conjugated thienyl tetraynes

Torikai, K., Otsuka, Y., Nishimura, M., Sumida, M., Kawai, T., Sekiguchi, K. & Ueda, I., May 15 2008, In : Bioorganic and Medicinal Chemistry. 16, 10, p. 5441-5451 11 p.

Research output: Contribution to journalArticle

Atomic Force Microscopy
Electrophoresis
Escherichia coli
Water
Atomic force microscopy
5 Citations (Scopus)

Synthesis and properties of fullerene (C70) complexes of 2,6-bis(porphyrin)-substituted pyrazine derivatives bound to a Pd(II) ion

Eda, Y., Itoh, K., Ito, Y. N., Fujitsuka, M., Majima, T. & Kawato, T., Sep 1 2010, In : Supramolecular Chemistry. 22, 9, p. 517-523 7 p.

Research output: Contribution to journalArticle

Pyrazines
Porphyrins
Ions
Derivatives
Association reactions
3 Citations (Scopus)

Synthesis and Stereochemical Revision of the C31–C67 Fragment of Amphidinol 3

Wakamiya, Y., Ebine, M., Murayama, M., Omizu, H., Matsumori, N., Murata, M. & Oishi, T., May 22 2018, In : Angewandte Chemie - International Edition. 57, 21, p. 6060-6064 5 p.

Research output: Contribution to journalArticle

Degradation
Biological Products
Carbon
Nuclear magnetic resonance
Availability
17 Citations (Scopus)

Synthesis and structure revision of the C43-C67 part of amphidinol 3

Ebine, M., Kanemoto, M., Manabe, Y., Konno, Y., Sakai, K., Matsumori, N., Murata, M. & Oishi, T., Jun 26 2013, In : Organic Letters. 15, 11, p. 2846-2849 4 p.

Research output: Contribution to journalArticle

nuclear magnetic resonance
oxidation
synthesis
configurations
Nuclear magnetic resonance
1 Citation (Scopus)

Synthesis of 6/6/6-tricyclic ether system via Achmatowicz and intramolecular oxa-michael reactions

Yamamoto, H., Torikai, K., Ebine, M. & Oishi, T., Jan 1 2018, In : Heterocycles. 97, 1, p. 158-162 5 p.

Research output: Contribution to journalArticle

Ethers
Aldehydes
Isomers
Ether
Alcohols
5 Citations (Scopus)

Synthesis of 6-F-ergosterol and its influence on membrane-permeabilization of amphotericin B and amphidinol 3

Kasai, Y., Matsumori, N., Ueno, H., Nonomura, K., Yano, S., Michio, M. & Oishi, T., Mar 1 2011, In : Organic and Biomolecular Chemistry. 9, 5, p. 1437-1442 6 p.

Research output: Contribution to journalArticle

Amphotericin B
Ergosterol
membranes
Membranes
Sterols
16 Citations (Scopus)

Synthesis of a complete set of L-difluorophenylalanines, L-(F2)Phe, as molecular explorers for the CH/π interaction between peptide ligand and receptor

Fujita, T., Nose, T., Matsushima, A., Okada, K., Asai, D., Yamauchi, Y., Shirasu, N., Honda, T., Shigehiro, D. & Shimohigashi, Y., Feb 5 2000, In : Tetrahedron Letters. 41, 6, p. 923-927 5 p.

Research output: Contribution to journalArticle

thrombin receptor peptide SFLLRNP
Thrombin Receptors
Peptide Receptors
Hydrogen
Ligands

Synthesis of an analog of amphidinol 3 corresponding to the c31-c67 section

Koge, T., Wakamiya, Y., Ebine, M. & Oishi, T., Jan 1 2018, In : Heterocycles. 96, 7, p. 1197-1202 6 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship
Derivatives
amphidinol 3
polyol
2 Citations (Scopus)

Synthesis of anti-tubercular marine alkaloids denigrins A and B

Karak, M., Oishi, T. & Torikai, K., Jul 18 2018, In : Tetrahedron Letters. 59, 29, p. 2800-2803 4 p.

Research output: Contribution to journalArticle

Maleic Anhydrides
Alkaloids
Cross Reactions
Palladium
Salts
3 Citations (Scopus)

Synthesis of a truncated analog of amphidinol 3 corresponding to the C21C39/C52C67 section

Ebine, M., Takada, Y., Yanai, N. & Oishi, T., Jan 1 2017, In : Chemistry Letters. 46, 5, p. 662-664 3 p.

Research output: Contribution to journalArticle

Polyenes
amphidinol 3
21 Citations (Scopus)

Synthesis of endogenous sperm-activating and attracting factor isolated from ascidian Ciona intestinalis

Oishi, T., Tsuchikawa, H., Murata, M., Yoshida, M. & Morisawa, M., Aug 18 2003, In : Tetrahedron Letters. 44, 34, p. 6387-6389 3 p.

Research output: Contribution to journalArticle

Ciona intestinalis
Chenodeoxycholic Acid
Urochordata
Chemotactic Factors
Spermatozoa
8 Citations (Scopus)

Synthesis of mannosylinositol phosphorylceramides is involved in maintenance of cell integrity of yeast Saccharomyces cerevisiae

Morimoto, Y. & Tani, M., Feb 1 2015, In : Molecular Microbiology. 95, 4, p. 706-722 17 p.

Research output: Contribution to journalArticle

Saccharomyces cerevisiae
Yeasts
Maintenance
Mannans
Polysaccharides
4 Citations (Scopus)

Synthesis of pyrazine acetals by the biased reaction of symmetric 2,5-bis(chloromethyl) or 2,3,5,6-tetrakis(chloromethyl) substituents on pyrazine ring with sodium alkoxides

Eda, Y., Odazaki, Y., Mizutani, A., Ito, Y. & Kawato, T., Apr 14 2008, In : Tetrahedron Letters. 49, 16, p. 2519-2522 4 p.

Research output: Contribution to journalArticle

Pyrazines
Acetals
Sodium
Substitution reactions
2 Citations (Scopus)

Synthesis of the 1β-Methylcarbapenem Key Intermediates

Ito, Y. & Terashima, S., Jan 1 1993, Studies in Natural Products Chemistry. p. 145-177 33 p. (Studies in Natural Products Chemistry; vol. 12).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 beta-methylcarbapenem
21 Citations (Scopus)

Synthesis of the CDE/FG ring models of prymnesins: Reassignment of the relative configuration of the E/F ring juncture

Sasaki, M., Ebine, M., Takagi, H., Takakura, H., Shida, T., Satake, M., Oshima, Y., Igarashi, T. & Yasumoto, T., Apr 29 2004, In : Organic Letters. 6, 9, p. 1501-1504 4 p.

Research output: Contribution to journalArticle

red tide
Haptophyta
rings
Tides
synthesis
58 Citations (Scopus)

Synthetic study of ciguatoxin. Absolute configuration of the C2 hydroxy group

Oguri, H., Hishiyama, S., Sato, O., Oishi, T., Hirama, M., Murata, M., Yasumoto, T. & Harada, N., Mar 3 1997, In : Tetrahedron. 53, 9, p. 3057-3072 16 p.

Research output: Contribution to journalArticle

Ciguatoxins
Bromobenzoates
Stereochemistry
Alcohols
83 Citations (Scopus)

Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria

Tamura, Y., Harada, Y., Nishikawa, S. I., Yamano, K., Kamiya, M., Shiota, T., Kuroda, T., Kuge, O., Sesaki, H., Imai, K., Tomii, K. & Endo, T., May 7 2013, In : Cell metabolism. 17, 5, p. 709-718 10 p.

Research output: Contribution to journalArticle

Cytidine Diphosphate Diglycerides
Diacylglycerol Cholinephosphotransferase
Cardiolipins
Mitochondria
Phosphatidic Acids
64 Citations (Scopus)

The AAA+ ATPase ATAD3A controls mitochondrial dynamics at the interface of the inner and outer membranes

Gilquin, B., Taillebourg, E., Cherradi, N., Hubstenberger, A., Gay, O., Merle, N., Assard, N., Fauvarque, M. O., Tomohiro, S., Kuge, O. & Baudier, J., Apr 2010, In : Molecular and cellular biology. 30, 8, p. 1984-1996 13 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Adenosine Triphosphatases
Membranes
Eukaryota
Drosophila

The Conformation Change-sensing Antibodies for Retinoid-related Orphan Receptor Family

Nose, T., Nishigori, M., Liu, X., Tokunaga, T. & Shimohigashi, Y., Mar 2008, Peptide Science 2007. p. 497-492 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

The direct measure of intermolecular interaction of prion protein N-terminal octapeptide repeats by the quarts crystal microbalance (QCM)

Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 207–208

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

The effect of amino acid substitution on oligomerization of octapeptide repeat structure in prion protein

Hattori, E., Yokotani, S., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 2008, Peptide Science 2007. p. 239-242

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

95 Citations (Scopus)

The first asymmetric epoxidation using a combination of achiral (salen)manganese(III) complex and chiral amine

Hashihayata, T., Ito, Y. & Katsuki, T., Jul 14 1997, In : Tetrahedron. 53, 28, p. 9541-9552 12 p.

Research output: Contribution to journalArticle

sulfoxide
Epoxidation
Manganese
Amines
Sparteine

The functional role of Trp present at the cell membrane interface in the opioid receptor activation

Nishimura, H., Li, J., Inokuchi, N., Koikawa, A., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 23–24

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

The impact of bisphenol A-feeding on the Drosophila neuropeptide PDF mRNA structure

Matsuo, A., Nakamura, M., Takeda, Y., Matsuyama, Y., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 75-76

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)