Organic and Biological Chemistry

Research Output 1983 2020

Chapter (peer-reviewed)

Functional role of the C-terminal Helix 12 peptide in the receptor activation mechanism of estrogen-related receptor γ (ERRγ)

Liu, X., Matsushima, A., Nose, T., Okada, H. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 435–436

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Functional role of the Phe-Phe stacking microswitch in the ORL1 nociceptin receptor activation

Takesue, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 147-148

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Gene expression of a circadian pacemaker hormone peptide PDF in cricket Gryllus bimaculatus

Matsushima, A., Chuman, Y., Onoue, H., Ito, Y., Tomioka, K., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2001, Peptide Science 2000. p. 63-66

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

GPCR functional role of Phe-269 and Phe-221 in the molecular switching of ORL1 nociceptin receptor activation

Takesue, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 203-204

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Halogenated Phe-containing endomorphin-2 analogs with mixed agonist and antagonist activities

Nishio, K., Nishimura, H., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 25-26

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Highly potent peptide ligands for thrombin receptor

Fujita, T., Nose, T., Matsushima, A., Costa, T. & Shimohigashi, Y., 2000, Peptide Science 1999. p. 421-424

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

High-precision binding assay procedure of tachykinin receptor NK-1 for highly potent Substance P analogs

Kuramitsu, Y., Nishimura, H., Nakamura, R., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 213-214

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Homodimer function of human nuclear receptor ERR evidenced using -helix peptides in the dimer interface

Liu, X., Nakagawa, H., Sugiyama, M., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2018, Peptide Science 2017. p. 190 191 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Identification of affinity binding site of Cys(Npys)-elongated RYYRIK peptide antagonist by means of Cys→Ala mutated ORL1 nociceptin receptors

Matsushima, A., Nishimura, H., Inamine, S. & Shimohigashi, Y., 2013, Peptide Science 2012. p. 207-208

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Identification of circadian neuropeptide PDF mRNA isoforms in the housefly Musca domestica

Kawanaka, C., Matsushima, A., Takeda, Y., Shimohigashi, M. & Shimohigashi, Y., 2010, Peptide Science 2009. p. 145–146

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Identification of novel isoforms of the circadian neuropeptide PDF in the silk moth Bombyx mori and their expression in brain

Sato, S., Jonathan, C., Takeda, Y., Kaneki, A., Matsushima, A. & Shimohigashi, Y., 2006, Science 2005. p. 99-100

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Immunocytochemical identification of mature peptide formation for the circadian neuromodulator PDF in the housefly Musca domestica

Sumida, K., Honda, T., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Immunocytochemical studies on the circadian neuropeptide PDF in the Cricket Gryllus bimaculatus

Shimohigashi, M., Honda, T., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2005, Peptide Science 2004. p. 339-342

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Immunological confirmation of circadian-related neuropeptide PDF-isoform peptide in the cricket Gryllus bimaculatus

Koga, K., Hiramura, D., Takeda, Y., Kaneki, A., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 262

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Importance of ligand Phe-phenyl group for activation of thrombin receptor

Fujita, T., Nose, T., Matsushima, A., Costa, T. & Shimohigashi, Y., 1999, Peptide Science 1998. p. 33-36

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Induced-fit type ligand binding guided by free-rotatory Leu residue present in the 7th α-helix peptide in the estrogen-related receptor γ (ERRγ)

Matsushima, A., Okada, H., Liu, X., Tokunaga, T., Teramoto, T., Kakuta, Y. & Shimohigashi, Y., 2009, Peptide Science 2008. p. 521-522

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Influence Analysis of the Circadian Evening Pacemaker Neuropeptide hugγ Gene in the Bisphenol A-exposed Fruit Fly Drosophila Brain

Umeno, S., Matsuo, A., Matsuyama, Y., Nakamura, M., Takeda, Y., Sumiyoshi, M., Liu, X., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 455-456

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Localization profiles of circadian neuropeptide PDF in brain of the cricket Gryllus bimaculatus

Honda, T., Chuman, Y., Matsushima, A., Nose, T., Sakaguchi, K., Onoue, H., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2004, Peptide Science 2003. p. 483-486

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Localization profiles of the precursor protein of circadian rhythm pacemaker hormone PDF in Gryllus brain

Honda, T., Chuman, Y., Matsushima, A., Asai, D., Nose, T., Sakaguchi, K., Onoue, H., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2003, Peptide Science 2002. p. 433-436

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Molecular cloning and in situ hybridization of circadian neuropeptide PDF receptor in the fruit fly Drosophila melanogaster

Kaneki, A., Yoshida, T., Isozaki, K., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 263

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Molecular recognition of prion protein via its N-terminal octapeptide repeat Structure

Horiuchi, Y., Hattori, E., Yokotani, S., Matsushima, A. & Shimohigashi, Y., 2009, Peptide Science 2008. p. 513-516

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Monoclonal antibody sensing assay for conformation change induced by metal binding to prion protein N-terminal octarepear domain

Yokotani, S., Honda, T., Kawano, M., Matsushima, A. & Shimohigashi, Y., 2006, Science 2005. p. 455-456

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Multiple and Simultaneous Cys→Ala Mutations of ORL1 Nociceptin Receptor to Identify the Affinity Binding site of Cys(Npys)-Elongated RYYRIK Peptide Antagonist

Matsushima, A., Nishimura, H., Inamine, S. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 413-414

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Multiple post-transcriptional regulations in circadian pacemaker neuropeptide pdf gene

Takeda, Y., Sumiyoshi, M., Koga, K., Ito, M., Matsushima, A., Shimohigashi, Y. & Shimohigashi, M., 2006, Peptide Science 2006. p. 260

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Mutual co-work between nuclear receptor ERalpha and ERRgamma requires their homodimerization

Liu, X., Shimohigashi, M., Sugiyama, M., Matsushima, A. & Shimohigashi, Y., 2018, Peptide Science 2017,. p. 198 199 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Optimization of the N-terminal group of Ac-RYYRIK-NH2 as ORL1 receptor antagonist

Li, J., Isozaki, K., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2008, Peptide Science 2007. p. 257-260

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

ORL1 Nociceptin receptor response of opioid peptides derived from proenkephalin precursor protein

Motomatsu, Y., Nishimura, H., Matsuyama, Y., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 181-182

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

PERIOD clock protein of the summer cicada Meimuna opalifera: cDNA cloning and structural analysis

Sato, S., Chuman, Y., Matsushima, A., Shimohigashi, Y., Tominaga, Y. & Shimohigashi, M., 2001, Comparative Biochemistry and Physiology. Vol. 130. p. 876

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Phe 2715.39 of Thronbin Receptor PAR-1 is a specific target of Phe-2-phenl group of its tethered ligand

Sugiyama, M., Fujita, T., Liu, X., Matsuyama, Y., Matsushima, A., Shimohigashi, M. & Shimohigashi, Y., 2018, Peptide Science 2017. p. 94 95 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

QCM-analyses of the intermolecular interaction between prion protein N-terminal domains having increased number of octapeptide repeat.

Sato, K., Horiuchi, Y., Matsushima, A. & Shimohigashi, Y., 2011, Peptide Science 2010. p. 128

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Receptor Binding Characteristics of Tritium-labeled Pure antagonist Peptide for Hyperalgesic nociceptin ORL1 receptor

Inamine, S., Nishimura, H., Li, J., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2012, Peptide Science 2011. p. 183-184

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Receptor selectivity and specificity of a series of opioid peptides latent in the proenkephalin precursor protein

Motomatsu, Y., Nishimura, H., Matsumoto, Y., Kuramitsu, Y., Inamine, S., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 201-202

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

SCN Circadian rhythm signal transduction neuropeptides evoke hypoactive phenotype differently in male and female mice

Sugiyama, M., Motomatsu, Y., Matsuyama, Y., Kajiyama, S., Kameda, T., Uchimura, E., Saito, T., Liu, X., Matsushima, A. & Shimohigashi, Y., 2016, Peptide Science 2015. p. 53-54

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Specific dimerization of prion protein N-terminal domain

Matsushima, A., Horiuchi, Y., Yokotani, S., Kawano, M. & Shimohigashi, Y., 2006, Science 2005. p. 209-210

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Specific Role of Phe Residues in Opioid Peptide Met-enkephalin- Arg-Phe in Binding to All Three Opioid Receptors

Motomatsu, Y., Nishimura, H., Matsumoto, Y., Inamine, S., Kuramitsu, Y., Matsushima, A. & Shimohigashi, Y., 2014, Peptide Science 2013. p. 317-318

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural Analysis of Delta Opioid Receptor Dimer by Bivalent Deltorphin II Analogs

Ito, N., Nishimura, H., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., Mar 2012, Peptide Science 2011. p. 173-174 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural analysis of PERIOD-PAS domain binding regions in insect clock protein TIMELESS

Sato, S., Oka, H., Matsushima, A., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2003, Peptide Science 2002. p. 429-432

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural and molecular evolutionary analysis of the ligand-binding domain of forty-eight human nuclear receptors

Matsuyama, Y., Nishimura, H., Liu, X., Matsushima, A. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 347-348

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural characteristics of Drosophila estrogen-related receptor ligand binding domain to capture the peptide and non-peptide ligands

Liu, X., Matsushima, A., Shirasu, N., Tominaga, Y., Shimohigashi, M., Shimohigashi, Y. & Nose, T., 2005, Peptide Science 2004. p. 303-304

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural characteristics of the N-Terminal octapeptide repeat region of Prion protein in self-polymerization

Horiuchi, Y., Kawano, M., Yokotani, S., Honda, T., Matsushima, A., Nose, T. & Shimohigashi, Y., 2005, Peptide Science 2004. p. 317-318

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural Characteristics of Thr-Gly Dipeptide Repeat in the Drosophila Clock Protein PERIOD

Matsuo, A., Nishimura, H., Masayuki, N., Koga, K., Sumiyoshi, M., Matsushima, A., Nose, T., Shimohigashi, M. & Shimohigashi, Y., Mar 2012, Peptide Science 2011. p. 351-352 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural characterization of the house fly PDF, a circadian rhythm pacemaker hormone

Matsushima, A., Nose, T., Tomioka, K., Shimohigashi, M. & Shimohigashi, Y., 2003, Peptide Science 2002. p. 333-336

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural Essentials of Hyperalgesic Nociceptin ORL1 Receptor for Ligand Binding and Receptor Activation

Nishimura, H., Li, J., Isozaki, K., Abe, Y., Inamine, S., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2012, Peptide Science 2011. p. 33-34

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural essentials of hyperalgesic nococeptin ORL1 receptor for ligand binding and receptor activation

Nishimura, H., Li, J., Isozaki, K., Abe, Y., Inamine, S., Matsushima, A., Nose, T., Costa, T. & Shimohigashi, Y., 2011, Peptide Science 2010. p. 128

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural requirement of housefly FMRFamide peptides in its receptor activation

Matsushima, A., Koretsune, Y., Kaneki, A., Isozaki, K., Shimohigashi, M. & Shimohigashi, Y., 2008, Peptide Science 2007. p. 313-314

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structural requirements of the N-terminal octapeptide repeat of prion protein

Kawano, M., Horiuchi, Y., Honda, T., Yokotani, S., Matsushima, A., Nose, T. & Shimohigashi, Y., 2004, Peptide Science 2003. p. 483-486

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structure-activity studies of FMRFamide-related peptides in activating the specific receptor present in the housefly Musca domestica

Matsushima, A., Koretsune, Y., Kaneki, A., Isozaki, K., Shimohigashi, M. & Shimohigashi, Y., 2006, Peptide Science 2006. p. 174

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structure-activity Studies on the Halogenated Phe-containing Neuropeptide Substance P Analogs

Kuramitsu, Y., Nishimura, H., Nakamura, M., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., 2015, Peptide Science 2014. p. 319-320

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structure-Activity Studies on the Halogenated Phe-containing Neuropeptide Substance P Analogs

Kuramitsu, Y., Nishimura, H., Nakamura, R., Suyama, K., Matsushima, A., Nose, T. & Shimohigashi, Y., Mar 2014, Peptide Science 2013. p. 319-320 2 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Structure and function of nuclear localization signal peptide present in circadian rhythm hormone peptide precursor

Matsushima, A., Chuman, Y., Sato, S., Tominaga, Y., Shimohigashi, Y. & Shimohigashi, M., 2002, Peptide Science 2001. p. 159-162

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)